Complexes and methods of using same

ABSTRACT

The invention provides complexes of at least two polypeptides, and methods of using the same. Purified complexes of two polypeptides are provided, including chimeric complexes, and chimeric polypeptides and complexes thereof are also provided, as are nucleic acids encoding chimeric polypeptides and vectors and cells containing the same. Also provided are methods of identifying agents that disrupt polypeptide complexes, methods of identifying complex or polypeptide in a sample, and for removing the same, methods of determining altered expression of a polypeptide in a subject, and methods of treating/preventing disorders involving altered levels of complex or polypeptide.

RELATED APPLICATIONS

This application claims priority from U.S. Ser. No. 60/256,911 filed Feb. 14, 2002 the contents of which are incorporated by reference in their entirety.

FIELD OF THE INVENTION

The invention relates generally to polypeptides and complexes of two or more polypeptides, as well as to methods of use thereof.

BACKGROUND OF THE INVENTION

Greater than seventy types of human papilloma virus (HPV) are recognized, each type associated with a specific clinical manifestation. (Principles of Internal Medicine, Fauci et al, pp. 190-1100, 14^(th) edition, McGraw Hill). It is predicted that as many as 1-2% of sexually active individuals have genital warts induced predominantly by various types of HPV. Infection may results in a spectrum of epithelial proliferative disorders ranging from common warts through genital warts to invasive cervical cancer. Currently, HPV is the most common sexually transmitted disease and is the etiological agent for 99.7% of all cervical cancers including a number of other cancers such as cancer of the anogenital tract, cancer of the oral cavity, head, neck, and larynx (Walboomers, et al., J Pathol 189 (1): 12-9 (1999); Munoz, J Clin Virol 19 1-2): 1-5 (2000); Gillison, et. al., Curr Opin Oncol 13 (3): 183-8 (2001)). Cervical cancer has a very high survival rate (95% for Stage IA and 80% for Stage IIA) of five-years and is highly tractable to treatment when caught early. The progression of disease is relatively slow compared to many cancers. In later stages, such as IIB, III, or IVA, the five-year survival rate drops off precipitously (65, 40, and 20 percent, respectively) (Cannistra, et al., N Engl J Med 334 (16): 1030-8 (1996)).

HPV genomes are highly conserved and express only eight proteins two of which are capsid proteins (L1 and L2). The other proteins (E1, E2 and E4) are nonstructural and are involved in the replication and transcription of the HPV genome. E1 is a helicase and represents the only enzyme function that encodes HPV. The remaining proteins function via protein-protein or protein-DNA interactions within the infected cell.

HPV has to facilitate its own replication within terminally differentiating (non-replicating) host cells. Important to the viral proliferation is the expression of early genes from the viral genome, E5, E6, and E7. HPV pathogenesis requires the availability of epidermal and mucosal epithelial cells that are still capable of proliferation. E5, E6 and E7 proteins are involved in the aberrant proliferation of the epithelial basal layer such that there is enhanced proliferation and lateral expansion of the basal layer (zur Hausen, Biochim Biophys Acta 1288 (2): F55-78 (1996)).

Cancer caused by HPV is due to the integration, and subsequent expression, of viral E6 and E7 proteins. E6 interacts with p53 (Werness, et al., Science 248 (4951): 76-9 (1990)). and affects the expression of the catalytic subunit of telomerase (hTERT) and Rb (Dyson et al. Science 243(4893): 934-7 (1989); Kiyono et al., Natural 396(6706): 84-8 (1998)). E6 and E7 work synergistically to transform cells (Munger, et al. J Virol 63 (10): 4417-21 (1989); McDougall, Curr Top Microbiol Immunol 186: 101-19 (1994)). E5 is not required for long-term transformation, however it is known to interact with growth factor receptors that mediate cellular proliferation, such as the epidermal growth factor receptor, the platelet-derived growth factor-β receptor, and the colony-stimulating factor-1 receptor (Hwang, et al., Virology 211(1): 227-33 (1995)). The E6 and E7 proteins of HPV maintain infected keratinocytes in a cycling undifferentiated state by blocking p53- and RB-mediated cell-cycle control pathways. U.S. Pat. No. 5,532,348 describes the purification of the E6 protein and methods of blocking the inhibitory effect of E6 on tumor suppressor protein, p53. In oncogenic indications, HPV causes alteration in cyclin-cyclin-dependent kinase complexes, as a prelude to loss of genomic stability, predisposing the cell to neoplastic transformation. E6 and E7 proteins must persist in the cell for it to remain transformed (Tindle, Nature Rev Cancer 2 (1): 59-65 (2002)).

Existing diagnostic methodologies have been described in detail in Wright, et al., Jama 287 (16): 2120-9 (2002). Papanicolaou testing (Pap smear) is the front line screen for cervical cancer testing. However this methodology is limited to reproductive and anogenital screening and does not apply for screening patients for head and neck/larynx cancers. Furthermore, the methodology is not conclusive, ambiguous Pap smear results must be clarified by PCR testing for the presence of high-risk HPV strains (Schiffman, et al., J Clin Microbiol 33 (3): 545-50 (1995)). Following a positive result from PCR testing or multiple ASCUS (Atypical Squamous Cells of Undetermined Significance) results, colposcopy (visual exam of the cervical region) and possibly a biopsy are performed to determine if premalignant or malignant lesions are present (Wright, et al., Jama 287 (16): 2120-9 (2002)).

Current therapies for HPV infection are largely ablative, ineffective and limited. Immunomodulatory cytokines show promise for the suppression of HPV transcription, for example transforming growth factor-β and interleukin-1. Retinoic acid can suppress HPV infection and may have some effect on premalignant and malignant cervical lesions. Cidovovir™, an acyclic nuycleoside phosphonate, with a broad specificity for DNA viruses can suppress HPV infection as can the immunomodulatory drug Imiquimod™. Both drugs seem to act through the stimulation of cytokines (zur Hausen, Nat Rev Cancer 2 (5): 342-50 (2002)).

Other than the avoidance of contact, resolution of the disease has not been successful. Despite the current understanding of HPV infection and replication, the detection and prevention of HPV has been difficult because the nature of replication, expression, proliferation and host protein interactions are incredibly complex. Host defense responses to HPV infection are not largely understood. The ability to identify critical HPV-host protein interactions would not only help clarify how these complicated processes are regulated but could potentially identify important new therapeutic targets and diagnostic markers.

There remains a need to elucidate biochemical pathways that specifically affect the survival or condition of host cells and to determine what molecules and/or functional elements of such molecules are responsible for regulating such pathways. There is also a need for products and processes that permit the effective regulation of specific steps in such biochemical pathways. The identification of protein complexes associated with specific biological activities can be used to identify or prevent conditions associated with the absence or presence of these complexes.

SUMMARY OF THE INVENTION

The invention is based, in part, upon the identification of protein-protein interactions in and humans. Interacting proteins present in complexes according to the invention are shown in, e.g., Tables 1-7, in the second and fifth columns thereof (i.e., columns 2 and 5).

In one aspect, the invention provides a purified complex including a first interactor listed in Tables 1-7 column 2, and a second interactor recited in column 5 of Tables 1-7.

In another aspect, the invention provides an antibody which specifically binds polypeptide complexes according to the invention. The antibody preferably binds to a complex comprising one or more polypeptides with greater affinity than its affinity for either polypeptide that is not present in the complex.

Also provided by the invention are kits containing reagents that can specifically detect the complexes of the invention. In one embodiment, the reagent is a complex-specific antibody, while in other embodiments the reagent is an antibody specific for the first or second polypeptides of the complex.

In another aspect, the invention provides pharmaceutical compositions including the complexes described herein. Such compositions are formulated to be suitable for therapeutic administration in the treatment of deficiencies or diseases involving altered levels of the complexes of the invention.

In still another aspect, the invention provides methods of identifying an agent that disrupts a polypeptide complex by providing a complex described herein, contacting the complex with a test agent, and detecting the presence or amount of a polypeptide in the complex.

In a further aspect, the invention provides a method for inhibiting the interaction of a protein with a ligand by contacting a complex of the protein and ligand with an agent that blocks formation of the complex.

In yet another aspect, the invention provides a method of identifying a polypeptide complex in a subject by providing a biological sample from the subject and detecting, if present, the level of a complex, described herein, in the subject. In a specific embodiment, the invention encompasses a method to monitor protein interactions or formation of the protein complexes as an indicator of specific state or condition in response to treatment with a drug or pharmaceutical. An aspect of this embodiment includes the use of antibodies, specific for the protein complex, as a reagent in a method to determine the relative abundance of the complex under various conditions or in specific tissues. Recombinant proteins may be expressed with “epitope” tags in order to easily monitor their expression and interactions.

Also provided by the invention is a method for detecting a polypeptide in a biological sample by providing a biological sample containing a first polypeptide, and contacting the sample with a second polypeptide under conditions suitable to form a polypeptide complex.

In another aspect, the invention provides a method for the detection of protein complexes used in assays to detect protein-protein interactions, wherein the interactions include full-length proteins, as well as protein fragments that interact in cell-based and in vitro assays. In another aspect, the identified protein complexes can be used in a diagnostic assay for determining a specific disease or pathological condition or state, as well as for detection of a predisposition to a disease or pathological condition. Included in this aspect is a method for the use of labeled or fusion proteins for detection, and/or the use of antibodies specific for the individual proteins or the protein complex. The method measures the ability of the proteins to form the complex, and includes the identification of mutations or single nucleotide polymorphisms (SNPs), which may affect the ability of the proteins to form the complex or function normally.

In a further aspect, the invention provides a method for determining altered expression of a polypeptide in a subject by providing a biological sample from the subject, measuring the level of polypeptide complex in the sample, and comparing the level of the complex in the sample to the level of complex in a reference sample with a known polypeptide expression level. The present invention includes a method to modulate or regulate a specific phenotype by modulating protein components or complexes, which occur in a related pathway. This can be achieved through modulation with a drug or antibody or antisense oligonucleotides, the activity of a protein or complex, the ability of a protein or complex to interact with its biological partner, or the elimination of a protein from a pathway or a complex. Such changes can be observed through monitoring modulation in gene expression of target genes, or the presence or absence of phenotype specific markers. Included as an embodiment of this aspect are vectors, antibodies, libraries of compounds, gene specific antisense oligonucleotides, and cell lines.

In a still further aspect, the invention provides a method of treating or preventing a disease or disorder involving altered levels of a complex described herein or a polypeptide described herein, by administering, to a subject in need thereof, a therapeutically-effective amount of at least one molecule that modulates the function of the complex or polypeptide. In one embodiment, the agent modulates the function of a polypeptide selected from the polypeptides recited in Tables 1-7, columns 2, 3, 5 or 6.

In the specification and the appended claims, the singular forms include plural referents unless the context clearly dictates otherwise. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. All patents and publications cited in this specification are incorporated by reference herein in their entirety

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is is a graphical illustration showing the interactions between human host proteins and HPV 16 E5, HPV 16 E6 and HPV 16 E7 and the relevant biological events tied to the activity of proteins involved in host cell proliferation.

DETAILED DESCRIPTION OF THE INVENTION

Definitions

The term “pre-cancerous cervical lesions” is intended to refer to those abnormalities which clinically may be described as “pre-malignant” conditions and which may, without treatment, proceed to full malignancies.

The present invention makes possible the accurate diagnosis and treatment of infections associated with HPV. The invention further clarifies the mechanism of action or biochemical pathways that lead to phenotypes indicative of a disease or abnormal condition. Preferred protein interactions include interactions described in Tables 1-7, most preferred interactions include those described in Tables 4-7. The invention further provides complexes of interacting polypeptides which have not heretofore been shown to interact directly and methods of using these complexes. In another aspect, certain interactions and complexes reveal utilities for known molecules that have not previously been associated with HPV infection. In one embodiment, interactions between viral proteins and phosphatases that regulate the activity of growth factor receptors are disclosed.

Some interacting polypeptides were identified by determining which of the predicted open-reading frames (ORFs) of the yeast encode polypeptides that interact in a yeast two-hybrid system. The interacting pairs were identified to include (i) interactions that place functionally unclassified proteins in a biological context, (ii) novel interactions between proteins involved in the same biological function, (iii) novel interactions that link together biological functions into larger cellular processes (iv) and identification of potential therapeutic targets and/or diagnostic markers useful in a human clinical setting. In a specific embodiment, protein interactions and pathways in a natural host cell which interact with critical proteins of HPV 1a, HPV 16 or HPV 11 have been identified. The interactions provide a better understanding of the biology of HPV infection as they relate to clinically related HPV strains. More specifically, the present invention provides elucidation of the biochemistry in the strains of virus that are known, respectively, to cause warts, non-cancerous lesions, and tumors. All interactors identified in this invention are potential diagnostic markers for HPV infection and a subset of these have additional value as therapeutic targets. The interactions of the invention are listed in Tables 1 through 7 below. In one embodiment, tabular data depicted in the tables have been exemplified as in FIG. 1.

Prey identified from screens of different tissues were directly tested against all baits from HPV 1, 11, and 16 directly as well as the converse test which is the basis of the one-by-one matrix reaction through Pathcalling (see also U.S. Pat. Nos. 6,057,101 and 6,083,693). A subset of the observed interactions was observed to be specific for each strain tested and others were observed to be conserved interactions for all the strains tested. For example, those interactions that were specific for HPV 16 were analyzed for their potential role in the development of malignancies. Those interactions that were unique to low risk strains are indicative of low-risk infection and the associated consequences, such as common warts (HPV 1a) and benign cervical lesions (HPV 11). Interactions common to both HPV 11 and HPV 16 are relevant to cervical infection, while those common to HPV 1a and HPV 11 are relevant to benign response to infection. All of the above interactions, and the interactions common to any two or more HPV strains are relevant to the general phenomenon of warts.

New insights into novel interactions between proteins involved in the same biological function are also provided. In one embodiment, proteins involved in inactivation of the discs large tumor (DLG) suppressor have been described in Kuhne, et al., Oncogene 30:18(40) pp. 5487-596 (1999). The present invention describes the novel interaction between proteins HPV16 E6 or E7 with DLG that is related to proteosome-mediated degradation. In another embodiment, HPV16 E6 and ubiquitin-specific protease 9 as well as HPV16 E7 and proteosome 26S subunit are novel interactions. These protein interactions may indicate their involvement in proteosome-mediated degradation.

In another aspect, the interactions described by the present invention provide new insights into E6 and E7 mechanisms of action. E7 may enhance the transforming activity of E6 by binding to and inactivating downstream tumor suppressor effects of p53. Because E6 and E7 have several common interactors, concerted action on common biological pathways is indicated. E6 and E7 tranforming activity may also be mediated by interactions with other candidate tumor suppressor or proteins involved in cellular proliferation and apoptosis. Therefore, inhibition or regulation of these interactions are suitable as targets for candidate therapeutics.

In another embodiment, interaction was also identified between complexes of HPV16 E6 and TCP-1, proteosome subunit PMSC1 and syntaxin 4. The interactions have relevance to tumor suppression via protein folding, unfolding and trafficking pathways. Such interactions provide opportunities to develop tools against various pathologic situations in which signaling through these proteins via p53 which are involved in cancer.

The newly identified protein-protein interactions pf the present invention connect biological functions into larger cellular processes. For example, FIG. 1 depicts a diagram of the protein-protein interactions and the relevant biological events tied to the activity of proteins involved in host cell proliferation described in Table A. Viral proteins are depicted as hatched circles, human proteins as closed circles, and the solid lines between the circles represent the physical interactions observed as a consequence of the yeast two-hybrid matrix assay. The broken arrow indicates the predicted direct/indirect activity of PTPN2 as an enzyme that may directly or indirectly affect signal transduction activity of EGFR in the presence of its ligand (Boonstra, Rijken et al. 1995). TABLE A INT cbe_SEQ CG COMMON PT/AT/ cbe_SEQ CG ID COMMON ID ID Interactor A NAME INT A SMT/NA Interactor B NAME INT B PT/AT/SMT/NA Screen/Matrix/MS 160 cbe_251445 HPV 16 E6 NA cbe_2576474 PTPN2 SMT MatrixMating/PathCalling 165 cbe_251448 HPV 16 E7 NA cbe_422236 BCR1 SMT MatrixMating/PathCalling 198 cbe_422236 BCR1 SMT cbe_2576474 PTPN2 SMT MatrixMating 618 cbe_422236 BCR1 SMT cbe_251445 HPV 16 E6 NA MatrixMating

The viral life cycle of HPV has been well described in both general terms and in terms of HPV's role in cancer (zur Hausen 2002). In short, the basal layer of cells of epithelia depicted in this figure is typically infected by HPV as a result of the exposure of the cells to virus that has penetrated via microlesions. Viral proliferation, formation, and egress from the host is coordinated with the proliferation of the basal layer of cells and their differentiation into keratinocytes. As the keratinocytes mature they release the mature viral particles. Part of the viral life cycle includes the induction of the lateral proliferation of the basal layer. Under normal conditions the proliferation is in a vertical direction as indicated. The co-opting of the proliferative capacity of the basal layer of cells is essential for the successful reproduction of the virus; therefore it is essential that the virus take control of this process.

In some circumstances, co-opting of the proliferation results in a benign lesions. In other cases the results may lead to a cancer in a susceptible tissue such as the cervix. HPV16 is well known to induce cancers of the anogenital tract as well as oral-laryngeal cancers. This highly frequent consequence of chronic HPV 16 infection is the result of the integration of two viral proto-oncogenes, HPV 16 E6 and HPV 16 E7. One or both of these proteins is capable of transforming cells independently of viral infection when transformed into cells (Munger, Phelps et al. 1989; zur Hausen 2002). HPV 16 E5 is known to play a role early in infection by interacting with epidermal growth factor receptor (EGFR) (Hwang, Nottoli et al. 1995; zur Hausen 2002). EGFR is a growth factor receptor whose activity is controlled by its phosphorylation state. Phosphorylated EGFR (EGFR-P) is the consequence of ligand binding and leads to the induction of proliferative intracellular signals (Boonstra, Rijken et al. 1995). PTPN2 is a poorly characterized protein tyrosine phosphatase that can dephosphorylate phospho-tyrosine (Johnson, Cool et al. 1993). The importance of tyrosine dephosphorylation in regulating enzymatic activity has been demonstrated for EGFR (Boonstra, Rijken et al. 1995). Breakpoint cluster region 1 protein (BCR1) is a GTPase-activating protein (GAP) for RAC1 and CDC42 and promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them (Ahmed, Lee et al. 1994). CDC42 is well known to affect cell polarity (Takai, Sasaki et al. 2001).

Some newly disclosed interactions (INT 160, 165, 198, and 618) provide new biological context for these proteins as well as strongly indicating a previously unanticipated functional role for HPV 16 proteins as individual entities as well as components of a complex present in active infections. A diagnostic device that measures the presence of complexes of proteins is the basis to identify active infection as opposed to a late stage infection under which circumstances the transforming consequence of the infection is the result of the integration and aberrant expression of HPV 16 E6 and/or HPV 16 E7. HPV 16 E5 protein's role occurs early in the viral life cycle (zur Hausen 2002).

Novel interactions between HPV 16 and the cell polarity pathway controlled by CDC2 via the direct interactions between HPV 16 viral oncogenes E6 and E7 (INT 165 and INT 618, and indirectly via INT 160 and INT 198) indicates that agents which affect the activity of BCR1 and other GAPs or other effectors of CDC42, such as guanine nucleotide exchange factors (GEFs), or enzymes involved in the post translation modification of CDC42 but not previously associated with HPV infection, are drug targets for the treatment of HPV infection. Any existing agent that affects the activity of enzymes in the CDC42-mediated polarity pathway are suitable as drugs for the treatment of HPV infection. Therefore treatment of HPV infection includes treatment modes which inhibit the ability of HPV to cause basal layer cells proliferation.

In one embodiment, INT 160, INT 198, and INT 165 show direct and indirect interactions between HPV 16 viral oncogenes and PTPN2. Phosphatases play a role in the signal transduction pathways necessary for cellular proliferation (Carr, Wang et al. 2002) which has been indicated as a consequence of HPV infection of the basal layer cells (zur Hausen 2002). Agents that affect the activity of PTPN2 may be used to treat HPV16 infection. Treatment of the infection early will reduce the chance of HPV proto-oncogene insertion into the host genome, thereby reducing the probability of tumor induction. In summary, EGFR and CDC42 play roles in cellular proliferation. HPV co-opts the activity of these pathways via novel interaction with PTPN2 and BCR1 as identified by the present invention. Therefore, clinical intervention in these pathways is to treat HPV infection is encompassed by the present invention. Identification of the interactions described in FIG. 1 leads to diagnosis of an active HPV infection at an early stage possible to intervene in the course of the infection and the course of the disease leading to conditions as mild as warts and as severe as tumors.

The complexes disclosed herein are also useful, inter alia, in identifying agents that modulate cellular processes in which one or more members of the complex have previously been associated. For example, many of the interacting proteins identified by INT ID numbers as shown in Tables 1 through 7, have been previously implicated inter alia, in cell growth, cell division, and/or DNA synthesis, protein synthesis, folding or turnover and vesicle trafficking molecules. Accordingly, new agents which modulate cell growth, cell division, and/or DNA synthesis can be identified by evaluating the ability of a test agent to affect formation or dissolution of a complex having INT ID numbers described herein.

Complexes according to the invention can also be used in methods for identifying desired polypeptides in a biological sample by forming a complex of a first polypeptide and a second polypeptide that interacts with the first polypeptide. The presence of the complex indicates that the sample contains the first polypeptide.

The complexes of the invention are useful treating, e.g., alleviating a symptom of, preventing, diagnosing, or screening for compounds to treat or prevent disorders associated with HPV invention. For example, HPV, the human papilloma virus, has been linked to many cancers (e.g., cervical cancer) and intraepithelial neoplasias (commonly called dysplasias, i.e., abnormal cell growth that is generally considered to be precancerous when it occurs in the female reproductive system). Although most of the research that has been done on these conditions is in the female reproductive tract (especially the cervix, but also the vulva and vagina), the virus is linked to cancers and precancerous conditions in all of the following: eye, lung, skin, anus, penis, prostate, esophagus, and stomach.

Symptoms of HPV infection include for example, genital warts are growths or bumps that appear on the vulva, in or around the vagina or anus, on the cervix, or on the penis, scrotum, groin (where the genital area meets the inner thigh). They may be raised or flat, single or multiple, small or large.

The Pap test is the major front-line test for dysplasia. During this test, cells are taken from the cervical area and examined under a microscope for abnormalities. There are two different systems for classifying dysplasia.

The Bethesda, or SIL (squamous intraepithelial lesion) System looks only at individual cells, generally from a Pap test, and classifies them according to the degree of cell abnormality. These break down into:

ASCUS (atypical squamous cells of undetermined significance) means the cells aren't quite right, but they aren't clearly dysplastic, either. This can be caused by a lot of different factors, including hormonal changes, yeast or other infections, medications, or other sources of inflammation. HPV testing is sometimes done at this point. AGUS or AGCUS (atypical glandular cells of undetermined significance) is a finding of atypical glandular cells. This is less common, but since a different type of cancer (adenocarcinoma) develops from glandular (mainly the columnar) cells, this is usually followed up right away with more testing. Adenocarcinoma often doesn't have the extended precancerous phase that squamous cell carcinoma does.

LSIL—low grade squamous intraepithelial lesion—this is also called “mild dysplasia”, however, the true degree and extent of the dysplasia can only be determined upon further evaluation of the cervix itself. Since most LSIL “regresses”—that is, returns to normal without treatment, a woman with LSIL may be advised to return for another Pap test in a few months.

HSIL—high grade squamous intraepithelial lesion—this type of Pap result will always be evaluated further and treated, as it detects cell changes that have progressed beyond the mild stage.

CIN system—The other major system of classifying dysplasia is called the CIN system, for cervical intraepithelial neoplasia. There are corresponding classifications for vaginal and vulvar dysplasia called VAIN and VIN. This system of classification is based both on the degree of dysplasia in the individual cells (like SIL) and how far below the surface of the cervix the dysplasia goes.

CIN I—corresponds to mild dysplasia or LSIL. Additionally, the abnormal cells are only on the very surface of the cervix. As stated under SIL, most of these will regress back to normal over time. About 11% will progress to CIN 3. Only a very small percentage of CIN I leads to cancer.

CIN 2—corresponds to moderate dysplasia or HSIL. About half of the thickness of the epithelium is abnormal (dysplastic). Left alone, about 43% of CIN 2 will regress back to normal, and 20% will progress to CIN 3.

CIN 3—corresponds to severe dysplasia or HSIL. All or almost all of the epithelium is dysplastic. Although some CIN 3 will spontaneously regress, this is almost always treated since the next step is cancer. This is sometimes also referred to as carcinoma in situ.

These utilities, as well as additional utilities, are discussed in greater detail below.

Purified Polypeptide Complexes

In one aspect, the invention includes a purified complex that includes two or more polypeptides. In one embodiment, the invention provides purified complexes of two or more polypeptides. One of the polypeptides includes a polypeptide selected from the polypeptides recited in Tables 1 through 7, column 2 (referenced as cbe_SEQ ID Interactor A) and another includes a polypeptide selected from the polypeptides recited in Table 1 through 7, column 5 (referenced as cbe_SEQ ID Interactor B). In preferred embodiments the first and second polypeptides of the complex are the polypeptides enumerated in Tables 4-7. In some embodiments a first polypeptide is listed as a “bait” polypeptide and a second polypeptide is denoted as “prey” polypeptide, while in other embodiments the first polypeptide corresponds to a “prey” polypeptide and the second is a “bait” polypeptide.

By “corresponding polypeptide” is meant, with reference to Tables 1-7, the polypeptide recited in the same row, reading across from left to right or right to left, as a specific selected peptide. For example, in Table 3, in the first row, the corresponding polypeptide of cbe_(—)251059 is cbe_(—)2599246 (Prey 1054152) These protein pairs are designated as INT ID 137 as is indicated in Table 3. In the second row, however, the corresponding polypeptide of cbe_(—)251059 is cbe_(—)2789381 (Prey 775). These protein pairs are designated as INT ID 138.

Also as used herein, “protein” and “protein complex” are used synonymously with “polypeptide” and “polypeptide complex.” A “purified” polypeptide, protein or biologically active portion thereof is substantially free of cellular material or other contaminating proteins from the cell or tissue source from which the polypeptide is derived, or substantially free from chemical precursors or other chemicals when chemically synthesized. The language “substantially free of cellular material” includes preparations of protein in which the protein is separated from cellular components of the cells from which it is isolated or recombinantly produced. In one embodiment, the language “substantially free of cellular material” includes preparations of polypeptide complex having less than about 30% (by dry weight) of non-complex proteins (also referred to herein as a “contaminating protein”), more preferably less than about 20% of contaminating protein, still more preferably less than about 10% of contaminating protein, and most preferably less than about 5% non-complex protein. When the polypeptide or complex is recombinantly produced, it is also preferably substantially free of culture medium, i.e., culture medium represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the protein preparation. TABLE 1 HPV 1a specific interactions. INT cbe_SEQ ID COMMON cbe_SEQ ID COMMON PathCalling Screen and/or ID Interactor A NAME INT A PT/AT/SMT/NA Interactor B NAME INT B PT/AT/SMT/NA Matrix Assay 383 cbe_1710 QP-C NA cbe_251917 HPV 1a E2 NA PathCalling 384 cbe_22607 Hs.101882 NA cbe_251740 HPV 1a E1-E4 NA PathCalling 385 cbe_92628 FTHP1 NA cbe_251919 HPV 1a E6 NA PathCalling 393 cbe_251740 HPV 1a E1-E4 NA cbe_251740 HPV 1a E1-E4 NA MatrixMating 394 cbe_251740 HPV 1a E1-E4 NA cbe_251777 Prey2316 NA PathCalling 395 cbe_251740 HPV 1a E1-E4 NA cbe_251900 Prey2598 NA PathCalling 396 cbe_251740 HPV 1a E1-E4 NA cbe_1380530 RPL13 NA PathCalling 397 cbe_251740 HPV 1a E1-E4 NA cbe_1796502 CTNND2 NA PathCalling 398 cbe_251740 HPV 1a E1-E4 NA cbe_1807361 FLJ22729 NA PathCalling 399 cbe_251740 HPV 1a E1-E4 NA cbe_2685998 Prey2313 NA PathCalling 400 cbe_251740 HPV 1a E1-E4 NA cbe_2830508 Prey142356 NA PathCalling 401 cbe_251740 HPV 1a E1-E4 NA cbe_3478832 gbh_y14735 NA PathCalling 402 cbe_251740 HPV 1a E1-E4 NA cbe_3705944 TNFAIP1 NA PathCalling 403 cbe_251740 HPV 1a E1-E4 NA cbe_3764052 CKM SMT PathCalling 404 cbe_251740 HPV 1a E1-E4 NA cbe_3833533 TRIM29 NA PathCalling 405 cbe_251740 HPV 1a E1-E4 NA cbe_3927174 SCP2 SMT PathCalling 406 cbe_251740 HPV 1a E1-E4 NA cbe_4138433 KIFAP3 NA PathCalling 407 cbe_251740 HPV 1a E1-E4 NA cbe_4267981 TNNC1 NA PathCalling 408 cbe_251740 HPV 1a E1-E4 NA cbe_4383836 KIAA0905 NA PathCalling 409 cbe_251740 HPV 1a E1-E4 NA cbe_4567083 Prey1207 NA PathCalling 410 cbe_251917 HPV 1a E2 NA cbe_251976 Prey2777 NA MatrixMating/PathCalling 411 cbe_251917 HPV 1a E2 NA cbe_1469980 FLJ20259 NA MatrixMating/PathCalling 412 cbe_251917 HPV 1a E2 NA cbe_2826346 RPS10 NA PathCalling 413 cbe_251917 HPV 1a E2 NA cbe_2830508 Prey142356 NA PathCalling 414 cbe_251917 HPV 1a E2 NA cbe_3345510 COX6C SMT PathCalling 415 cbe_251917 HPV 1a E2 NA cbe_3583511 MGC3222 NA PathCalling 416 cbe_251917 HPV 1a E2 NA cbe_3625721 EIF2B2 NA PathCalling 417 cbe_251917 HPV 1a E2 NA cbe_3641816 ANKH NA PathCalling 418 cbe_251917 HPV 1a E2 NA cbe_3826540 Hs.98226 NA MatrixMating/PathCalling 419 cbe_251917 HPV 1a E2 NA cbe_4268532 Prey1053593 NA PathCalling 420 cbe_251917 HPV 1a E2 NA cbe_4269834 GNB2L1 NA MatrixMating/PathCalling 421 cbe_251917 HPV 1a E2 NA cbe_4270118 Hs.211143 NA PathCalling 422 cbe_251919 HPV 1a E6 NA cbe_251929 Prey2672 NA PathCalling 423 cbe_251919 HPV 1a E6 NA cbe_3461331 MET AT/PT/SMT PathCalling 424 cbe_251919 HPV 1a E6 NA cbe_3621798 XPO1 NA PathCalling 425 cbe_251919 HPV 1a E6 NA cbe_3665307 HK1 NA PathCalling 426 cbe_251919 HPV 1a E6 NA cbe_4267867 ANXA2 NA PathCalling 427 cbe_251925 HPV 1a E7 NA cbe_251953 Prey2724 NA MatrixMating/PathCalling 428 cbe_251925 HPV 1a E7 NA cbe_3753270 gbh_ac004503 NA MatrixMating/PathCalling 429 cbe_251925 HPV 1a E7 NA cbe_3760926 gbh_al359334 NA MatrixMating/PathCalling 430 cbe_251925 HPV 1a E7 NA cbe_3789063 AP2M1 NA MatrixMating 431 cbe_251925 HPV 1a E7 NA cbe_3810032 gbh_af142421 NA MatrixMating/PathCalling 432 cbe_251925 HPV 1a E7 NA cbe_3820530 PGAM1 SMT MatrixMating/PathCalling 309 cbe_251925 HPV 1a E7 NA cbe_3834015 TFPI AT/PT MatrixMating 433 cbe_251925 HPV 1a E7 NA cbe_4265947 RBP4 AT/PT MatrixMating/PathCalling 434 cbe_251925 HPV 1a E7 NA cbe_4267526 HRIHFB2206 NA MatrixMating/PathCalling 435 cbe_252016 HPV 1a L1 NA cbe_252039 Prey2919 NA PathCalling 436 cbe_252016 HPV 1a L1 NA cbe_2611002 NR1H4 SMT MatrixMating/PathCalling 437 cbe_252016 HPV 1a L1 NA cbe_2980052 ARHC SMT PathCalling 438 cbe_252016 HPV 1a L1 NA cbe_3800240 IVD SMT PathCalling 439 cbe_252016 HPV 1a L1 NA cbe_4268726 NR1H2 SMT PathCalling 440 cbe_252016 HPV 1a L1 NA cbe_4296923 SCGB1A1 AT/PT PathCalling 146 cbe_251088 HPV 16 E2 NA cbe_252041 HPV 1a L2 NA MatrixMating 441 cbe_252041 HPV 1a L2 NA cbe_252090 Prey2820 NA MatrixMating 442 cbe_252041 HPV 1a L2 NA cbe_2321045 WNT2B NA PathCalling 443 cbe_252041 HPV 1a L2 NA cbe_2603140 Prey146 NA MatrixMating/PathCalling 444 cbe_252041 HPV 1a L2 NA cbe_3222359 LOC51748 NA PathCalling 445 cbe_252041 HPV 1a L2 NA cbe_3456824 gbh_120086 AT PathCalling 446 cbe_252041 HPV 1a L2 NA cbe_3606990 Prey1053670 NA PathCalling 447 cbe_252041 HPV 1a L2 NA cbe_3770440 gbh_af217505 NA MatrixMating/PathCalling 448 cbe_252041 HPV 1a L2 NA cbe_3810791 EPHB1 NA MatrixMating/PathCalling 449 cbe_252041 HPV 1a L2 NA cbe_4248793 GSN AT/PT PathCalling 450 cbe_252041 HPV 1a L2 NA cbe_4268470 HSPE1 NA MatrixMating/PathCalling 451 cbe_252041 HPV 1a L2 NA cbe_4269628 RIL NA MatrixMating 452 cbe_252041 HPV 1a L2 NA cbe_4540466 PUM1 NA MatrixMating/PathCalling

TABLE 2 HPV11 specific interactions INT cbe_SEQ ID COMMON PT/AT/ cbe_SEQ ID COMMON NAME PathCalling Screen and/or ID Interactor A NAME INT A SMT/NA Interactor B INT B PT/AT/SMT/NA Matrix Assay 1 cbe_6464 Hs.19954 NA cbe_250781 HPV 11 E2 NA MatrixMating/PathCalling 2 cbe_244811 DGUOK SMT cbe_250777 HPV 11 E4 NA MatrixMating/PathCalling 5 cbe_250777 HPV 11 E4 NA cbe_862174 MT2A NA MatrixMating/PathCalling 6 cbe_250777 HPV 11 E4 NA cbe_1699351 SCO1 NA MatrixMating/PathCalling 7 cbe_250777 HPV 11 E4 NA cbe_4344185 SRA1 NA MatrixMating/PathCalling 8 cbe_250781 HPV 11 E2 NA cbe_251821 Prey2419 NA PathCalling 9 cbe_250781 HPV 11 E2 NA cbe_251826 Prey2429 NA PathCalling 10 cbe_250781 HPV 11 E2 NA cbe_251857 Prey2492 NA PathCalling 11 cbe_250781 HPV 11 E2 NA cbe_251858 Prey2494 NA PathCalling 12 cbe_250781 HPV 11 E2 NA cbe_366279 Prey2439 NA PathCalling 13 cbe_250781 HPV 11 E2 NA cbe_408167 Prey2412 NA PathCalling 14 cbe_250781 HPV 11 E2 NA cbe_3563252 Hs.306083 NA PathCalling 15 cbe_250781 HPV 11 E2 NA cbe_4269472 MRG15 NA PathCalling 16 cbe_250781 HPV 11 E2 NA cbe_4269571 KRT8 NA PathCalling 17 cbe_250808 HPV 11 E6 NA cbe_250809 Prey152 NA PathCalling 18 cbe_250808 HPV 11 E6 NA cbe_250895 Prey343 NA PathCalling 19 cbe_250808 HPV 11 E6 NA cbe_250904 Prey365 NA PathCalling 20 cbe_250808 HPV 11 E6 NA cbe_250906 Prey370 NA PathCalling 21 cbe_250808 HPV 11 E6 NA cbe_250907 Prey372 NA PathCalling 22 cbe_250808 HPV 11 E6 NA cbe_250908 Prey375 NA PathCalling 23 cbe_250808 HPV 11 E6 NA cbe_250912 Prey385 NA PathCalling 24 cbe_250808 HPV 11 E6 NA cbe_250922 Prey409 NA PathCalling 25 cbe_250808 HPV 11 E6 NA cbe_250924 Prey413 NA PathCalling 26 cbe_250808 HPV 11 E6 NA cbe_250925 Prey415 NA PathCalling 27 cbe_250808 HPV 11 E6 NA cbe_2541164 GPRK5 SMT PathCalling 28 cbe_250808 HPV 11 E6 NA cbe_3580897 HSPA5 NA PathCalling 29 cbe_250808 HPV 11 E6 NA cbe_3590661 NUP214 SMT MatrixMating/PathCalling 30 cbe_250808 HPV 11 E6 NA cbe_3694420 ARHGEF2 NA PathCalling 31 cbe_250808 HPV 11 E6 NA cbe_3929669 CD164 AT/PT PathCalling 32 cbe_250808 HPV 11 E6 NA cbe_4175362 MAPK9 SMT PathCalling 33 cbe_250808 HPV 11 E6 NA cbe_4268235 KIAA0410 NA MatrixMating/PathCalling 34 cbe_250834 HPV 11 E7 NA cbe_250878 Prey302 NA MatrixMating/PathCalling 35 cbe_250834 HPV 11 E7 NA cbe_250883 Prey244 NA MatrixMating/PathCalling 36 cbe_250834 HPV 11 E7 NA cbe_250888 Prey228 NA MatrixMating/PathCalling 37 cbe_250834 HPV 11 E7 NA cbe_3056756 KIAA0440 NA MatrixMating/PathCalling 38 cbe_250834 HPV 11 E7 NA cbe_3454406 gbh_af252829 NA MatrixMating/PathCalling 39 cbe_250834 HPV 11 E7 NA cbe_3760926 gbh_al359334 NA MatrixMating/PathCalling 40 cbe_250834 HPV 11 E7 NA cbe_3845697 Hs.191063 NA MatrixMating/PathCalling 41 cbe_250834 HPV 11 E7 NA cbe_4260642 PTPN21 SMT MatrixMating/PathCalling 42 cbe_250834 HPV 11 E7 NA cbe_4265947 RBP4 AT/PT MatrixMating/PathCalling 43 cbe_250834 HPV 11 E7 NA cbe_4268935 RPL26 NA MatrixMating/PathCalling 44 cbe_250834 HPV 11 E7 NA cbe_4269451 gbh_af038159 NA MatrixMating/PathCalling 45 cbe_250834 HPV 11 E7 NA cbe_4269681 Hs.224712 NA MatrixMating/PathCalling 46 cbe_250834 HPV 11 E7 NA cbe_4269818 Hs.73680 NA MatrixMating/PathCalling 47 cbe_250834 HPV 11 E7 NA cbe_4270015 RPS26 NA MatrixMating/PathCalling 48 cbe_250834 HPV 11 E7 NA cbe_4270441 Prey1052970 NA PathCalling 49 cbe_250834 HPV 11 E7 NA cbe_4280774 ITGB4 AT/PT MatrixMating/PathCalling 50 cbe_251663 HPV 11 E1 NA cbe_3643627 DKFZP434I1735 NA PathCalling 51 cbe_251663 HPV 11 E1 NA cbe_3842044 PSMB3 NA PathCalling 52 cbe_251663 HPV 11 E1 NA cbe_4269915 gbh_u23460 AT/SMT PathCalling 53 cbe_251663 HPV 11 E1 NA cbe_4270423 Prey1053526 AT PathCalling 99 cbe_251445 HPV 16 E6 NA cbe_4270015 RPS26 NA MatrixMating/PathCalling

TABLE 3 HPV16 specific interactions INT cbe_SEQ CG ID COMMON PT/AT/ cbe_SEQ CG ID COMMON PT/AT/ ID Interactor A NAME INT A SMT/NA Interactor B NAME INT B SMT/NA Screen/Matrix/MS 137 cbe_251059 HPV 16 E1-E4 NA cbe_2599246 Prey1054152 NA PathCalling 138 cbe_251059 HPV 16 E1-E4 NA cbe_2789381 Prey775 NA MatrixMating 139 cbe_251059 HPV 16 E1-E4 NA cbe_3472582 RABIF NA PathCalling 140 cbe_251059 HPV 16 E1-E4 NA cbe_3621899 pcnp NA PathCalling 141 cbe_251059 HPV 16 E1-E4 NA cbe_3880186 FLJ20343 NA MatrixMating/PathCalling 142 cbe_251059 HPV 16 E1-E4 NA cbe_4269156 PCDH1 AT/PT PathCalling 143 cbe_251059 HPV 16 E1-E4 NA cbe_4269329 SP260 AT PathCalling 144 cbe_251063 HPV 16 E1 NA cbe_251099 Prey802 NA MatrixMating/PathCalling 145 cbe_251063 HPV 16 E1 NA cbe_4465094 Prey1053092 NA PathCalling 146 cbe_251088 HPV 16 E2 NA cbe_252041 HPV 1a L2 NA MatrixMating 147 cbe_251088 HPV 16 E2 NA cbe_2321057 EFEMP1 AT/PT MatrixMating/PathCalling 148 cbe_251088 HPV 16 E2 NA cbe_3670766 ACTC NA MatrixMating/PathCalling 149 cbe_251088 HPV 16 E2 NA cbe_3922906 BSMAP AT PathCalling 150 cbe_251088 HPV 16 E2 NA cbe_4268208 DAD1 AT MatrixMating/PathCalling 151 cbe_251088 HPV 16 E2 NA cbe_4279962 DKKL1-pending AT/PT PathCalling 159 cbe_251445 HPV 16 E6 NA cbe_2253980 gbh_d38112_5 NA MatrixMating/PathCalling 160 cbe_251445 HPV 16 E6 NA cbe_2576474 PTPN2 SMT MatrixMating/PathCalling 161 cbe_251445 HPV 16 E6 NA cbe_4269405 gbh_af155653 NA MatrixMating/PathCalling 162 cbe_251445 HPV 16 E6 NA cbe_4269703 LOC51182 NA MatrixMating/PathCalling 99 cbe_251445 HPV 16 E6 NA cbe_4270015 RPS26 NA MatrixMating/PathCalling 163 cbe_251448 HPV 16 E7 NA cbe_251468 Prey1628 NA MatrixMating/PathCalling 164 cbe_251448 HPV 16 E7 NA cbe_251502 Prey1609 NA MatrixMating/PathCalling 165 cbe_251448 HPV 16 E7 NA cbe_422236 BCR1 SMT MatrixMating/PathCalling 166 cbe_251448 HPV 16 E7 NA cbe_2693325 Prey1673 NA MatrixMating/PathCalling 167 cbe_251448 HPV 16 E7 NA cbe_2898065 Prey1620 NA MatrixMating/PathCalling 168 cbe_251448 HPV 16 E7 NA cbe_3474077 KRT4 NA MatrixMating 169 cbe_251448 HPV 16 E7 NA cbe_3773649 EEF1A1L14 NA MatrixMating/PathCalling 170 cbe_251448 HPV 16 E7 NA cbe_3787129 LOC55828 NA MatrixMating/PathCalling 171 cbe_251448 HPV 16 E7 NA cbe_3789063 AP2M1 NA MatrixMating/PathCalling 172 cbe_251448 HPV 16 E7 NA cbe_3834015 TFPI AT/PT MatrixMating 173 cbe_251448 HPV 16 E7 NA cbe_3921620 MPP3 AT MatrixMating/PathCalling 174 cbe_251448 HPV 16 E7 NA cbe_4260642 PTPN21 SMT MatrixMating/PathCalling 175 cbe_251448 HPV 16 E7 NA cbe_4265947 RBP4 AT/PT MatrixMating 176 cbe_251448 HPV 16 E7 NA cbe_4268611 NDUFS3 SMT MatrixMating/PathCalling 177 cbe_251448 HPV 16 E7 NA cbe_4268684 MIZF NA MatrixMating/PathCalling 178 cbe_251448 HPV 16 E7 NA cbe_4268740 ZNF-U69274 NA MatrixMating/PathCalling 179 cbe_251448 HPV 16 E7 NA cbe_4269658 PSMC1 NA MatrixMating/PathCalling 180 cbe_251448 HPV 16 E7 NA cbe_4269876 SBP2 NA MatrixMating/PathCalling 181 cbe_251448 HPV 16 E7 NA cbe_4270186 STX4A AT MatrixMating/PathCalling 182 cbe_251737 HPV 16 L2 NA cbe_422227 Prey277610 NA PathCalling 183 cbe_251737 HPV 16 L2 NA cbe_422247 Prey277642 NA PathCalling 184 cbe_251737 HPV 16 L2 NA cbe_3056756 KIAA0440 NA MatrixMating/PathCalling 185 cbe_251737 HPV 16 L2 NA cbe_3473488 gbh_al121903 NA PathCalling 186 cbe_251737 HPV 16 L2 NA cbe_3575702 SUI1 NA PathCalling 187 cbe_251737 HPV 16 L2 NA cbe_3663966 KIAA1389 NA PathCalling 188 cbe_251737 HPV 16 L2 NA cbe_3849002 HSPC224 AT PathCalling 189 cbe_251737 HPV 16 L2 NA cbe_3884811 Hs.30289 NA PathCalling 190 cbe_251737 HPV 16 L2 NA cbe_4268684 MIZF NA MatrixMating 191 cbe_251737 HPV 16 L2 NA cbe_4270335 KIAA0276 NA PathCalling 192 cbe_251784 HPV 16 L1 NA cbe_251790 Prey2347 NA PathCalling 193 cbe_251784 HPV 16 L1 NA cbe_422204 Prey2335 NA PathCalling 194 cbe_251784 HPV 16 L1 NA cbe_552305 Prey2354 NA PathCalling 195 cbe_251784 HPV 16 L1 NA cbe_967711 Hs.201037 NA PathCalling 196 cbe_251784 HPV 16 L1 NA cbe_1505425 HCDI NA PathCalling 197 cbe_251784 HPV 16 L1 NA cbe_4281271 CRYAB NA PathCalling 316 cbe_2599246 Prey1054152 NA cbe_3929637 HPV 16 E5 AT/PT PathCalling 618 HPV 16 BCR1 SMT 251445 HPV 16 E6 NA MatrixMating E6422236 317 cbe_2830508 Prey142356 NA cbe_3929637 HPV 16 E5 AT/PT PathCalling

TABLE 4 HPV1a and HPV 11 specific interactions INT cbe_SEQ CG ID COMMON PT/AT/ cbe_SEQ CG ID COMMON PT/AT/ ID Interactor A NAME INT A SMT/NA Interactor B NAME INT B SMT/NA PathCalling Screen and/or Matrix Assay 137 cbe_251059 HPV 16 E1-E4 NA cbe_2599246 Prey1054152 NA PathCalling 138 cbe_251059 HPV 16 E1-E4 NA cbe_2789381 Prey775 NA MatrixMating 139 cbe_251059 HPV 16 E1-E4 NA cbe_3472582 RABIF NA PathCalling 140 cbe_251059 HPV 16 E1-E4 NA cbe_3621899 pcnp NA PathCalling 141 cbe_251059 HPV 16 E1-E4 NA cbe_3880186 FLJ20343 NA MatrixMating/PathCalling 142 cbe_251059 HPV 16 E1-E4 NA cbe_4269156 PCDH1 AT/PT PathCalling 143 cbe_251059 HPV 16 E1-E4 NA cbe_4269329 SP260 AT PathCalling 144 cbe_251063 HPV 16 E1 NA cbe_251099 Prey802 NA MatrixMating/PathCalling 145 cbe_251063 HPV 16 E1 NA cbe_4465094 Prey1053092 NA PathCalling 146 cbe_251088 HPV 16 E2 NA cbe_252041 HPV 1a L2 NA MatrixMating 147 cbe_251088 HPV 16 E2 NA cbe_2321057 EFEMP1 AT/PT MatrixMating/PathCalling 148 cbe_251088 HPV 16 E2 NA cbe_3670766 ACTC NA MatrixMating/PathCalling 149 cbe_251088 HPV 16 E2 NA cbe_3922906 BSMAP AT PathCalling 150 cbe_251088 HPV 16 E2 NA cbe_4268208 DAD1 AT MatrixMating/PathCalling 151 cbe_251088 HPV 16 E2 NA cbe_4279962 DKKL1-pending AT/PT PathCalling 159 cbe_251445 HPV 16 E6 NA cbe_2253980 gbh_d38112_5 NA MatrixMating/PathCalling 160 HPV 16 E6 NA cbe_2576474 PTPN2 AT/SMT MatrixMating/PathCalling 161 cbe_251445 HPV 16 E6 NA cbe_4269405 gbh_af155653 NA MatrixMating/PathCalling 162 cbe_251445 HPV 16 E6 NA cbe_4269703 LOC51182 NA MatrixMating/PathCalling 99 cbe_251445 HPV 16 E6 NA cbe_4270015 RPS26 NA MatrixMating/PathCalling 163 cbe_251448 HPV 16 E7 NA cbe_251468 Prey1628 NA MatrixMating/PathCalling 164 cbe_251448 HPV 16 E7 NA cbe_251502 Prey1609 NA MatrixMating/PathCalling 165 cbe_251448 HPV 16 E7 NA cbe_422236 BCR1 NA MatrixMating/PathCalling 166 cbe_251448 HPV 16 E7 NA cbe_2693325 Prey1673 NA MatrixMating/PathCalling 167 cbe_251448 HPV 16 E7 NA cbe_2898065 Prey1620 NA MatrixMating/PathCalling 168 cbe_251448 HPV 16 E7 NA cbe_3474077 KRT4 NA MatrixMating 169 cbe_251448 HPV 16 E7 NA cbe_3773649 EEF1A1L14 NA MatrixMating/PathCalling 170 cbe_251448 HPV 16 E7 NA cbe_3787129 LOC55828 NA MatrixMating/PathCalling 171 cbe_251448 HPV 16 E7 NA cbe_3789063 AP2M1 NA MatrixMating/PathCalling 172 cbe_251448 HPV 16 E7 NA cbe_3834015 TFPI AT/PT MatrixMating 173 cbe_251448 HPV 16 E7 NA cbe_3921620 MPP3 AT MatrixMating/PathCalling 174 cbe_251448 HPV 16 E7 NA cbe_4260642 PTPN21 SMT MatrixMating/PathCalling 175 cbe_251448 HPV 16 E7 NA cbe_4265947 RBP4 AT/PT MatrixMating 176 cbe_251448 HPV 16 E7 NA cbe_4268611 NDUFS3 SMT MatrixMating/PathCalling 177 cbe_251448 HPV 16 E7 NA cbe_4268684 MIZF NA MatrixMating/PathCalling 178 cbe_251448 HPV 16 E7 NA cbe_4268740 ZNF-U69274 NA MatrixMating/PathCalling 179 cbe_251448 HPV 16 E7 NA cbe_4269658 PSMC1 NA MatrixMating/PathCalling 180 cbe_251448 HPV 16 E7 NA cbe_4269876 SBP2 NA MatrixMating/PathCalling 181 cbe_251448 HPV 16 E7 NA cbe_4270186 STX4A AT MatrixMating/PathCalling 182 cbe_251737 HPV 16 L2 NA cbe_422227 Prey277610 NA PathCalling 183 cbe_251737 HPV 16 L2 NA cbe_422247 Prey277642 NA PathCalling 184 cbe_251737 HPV 16 L2 NA cbe_3056756 KIAA0440 NA MatrixMating/PathCalling 185 cbe_251737 HPV 16 L2 NA cbe_3473488 gbh_al12 1903 NA PathCalling 186 cbe_251737 HPV 16 L2 NA cbe_3575702 SUI1 NA PathCalling 187 cbe_251737 HPV 16 L2 NA cbe_3663966 KIAA1389 NA PathCalling 188 cbe_251737 HPV 16 L2 NA cbe_3849002 HSPC224 AT PathCalling 189 cbe_251737 HPV 16 L2 NA cbe_3884811 Hs.30289 NA PathCalling 190 cbe_251737 HPV 16 L2 NA cbe_4268684 MIZF NA MatrixMating 191 cbe_251737 HPV 16 L2 NA cbe_4270335 KIAA0276 NA PathCalling 192 cbe_251784 HPV 16 L1 NA cbe_251790 Prey2347 NA PathCalling 193 cbe_251784 HPV 16 L1 NA cbe_422204 Prey2335 NA PathCalling 194 cbe_251784 HPV 16 L1 NA cbe_552305 Prey2354 NA PathCalling 195 cbe_251784 HPV 16 L1 NA cbe_967711 Hs.201037 NA PathCalling 196 cbe_251784 HPV 16 L1 NA cbe_1505425 HCDI NA PathCalling 197 cbe_251784 HPV 16 L1 NA cbe_4281271 CRYAB NA PathCalling 316 cbe_2599246 Prey1054152 NA cbe_3929637 HPV 16 E5 AT/PT PathCalling 317 cbe_2830508 Prey142356 NA cbe_3929637 HPV 16 E5 AT/PT PathCalling Screen/Matrix/MS 137 cbe_251059 HPV 16 E1-E4 NA cbe_2599246 Prey1054152 NA PathCalling 138 cbe_251059 HPV 16 E1-E4 NA cbe_2789381 Prey775 NA MatrixMating 139 cbe_251059 HPV 16 E1-E4 NA cbe_3472582 RABIF NA PathCalling 140 cbe_251059 HPV 16 E1-E4 NA cbe_3621899 pcnp NA PathCalling 141 cbe_251059 HPV 16 E1-E4 NA cbe_3880186 FLJ20343 NA MatrixMating/PathCalling 142 cbe_251059 HPV 16 E1-E4 NA cbe_4269156 PCDH1 AT/PT PathCalling 143 cbe_251059 HPV 16 E1-E4 NA cbe_4269329 SP260 AT PathCalling

TABLE 5 HPV1a and HPV 16 specific interactions INT cbe_SEQ ID COMMON PT/AT/ cbe_SEQ ID COMMON PathCalling Screen and/or ID Interactor A NAME INT A SMT/NA Interactor B NAME INT B PT/AT/SMT/NA Matrix Assay 137 cbe_251059 HPV 16 E1-E4 NA cbe_2599246 Prey1054152 NA PathCalling 138 cbe_251059 HPV 16 E1-E4 NA cbe_2789381 Prey775 NA MatrixMating 139 cbe_251059 HPV 16 E1-E4 NA cbe_3472582 RABIF NA PathCalling 140 cbe_251059 HPV 16 E1-E4 NA cbe_3621899 pcnp NA PathCalling 141 cbe_251059 HPV 16 E1-E4 NA cbe_3880186 FLJ20343 NA MatrixMating/PathCalling 142 cbe_251059 HPV 16 E1-E4 NA cbe_4269156 PCDH1 AT/PT PathCalling 143 cbe_251059 HPV 16 E1-E4 NA cbe_4269329 SP260 AT PathCalling 144 cbe_251063 HPV 16 E1 NA cbe_251099 Prey802 NA MatrixMating/PathCalling 145 cbe_251063 HPV 16 E1 NA cbe_4465094 Prey1053092 NA PathCalling 146 cbe_251088 HPV 16 E2 NA cbe_252041 HPV 1a L2 NA MatrixMating 147 cbe_251088 HPV 16 E2 NA cbe_2321057 EFEMP1 AT/PT MatrixMating/PathCalling 148 cbe_251088 HPV 16 E2 NA cbe_3670766 ACTC NA MatrixMating/PathCalling 149 cbe_251088 HPV 16 E2 NA cbe_3922906 BSMAP AT PathCalling 150 cbe_251088 HPV 16 E2 NA cbe_4268208 DAD1 AT MatrixMating/PathCalling 151 cbe_251088 HPV 16 E2 NA cbe_4279962 DKKL1-pending AT/PT PathCalling 159 cbe_251445 HPV 16 E6 NA cbe_2253980 gbh_d38112_5 NA MatrixMating/PathCalling 160 cbe_251445 HPV 16 E6 NA cbe_2576474 PTPN2 AT/SMT MatrixMating/PathCalling 161 cbe_251445 HPV 16 E6 NA cbe_4269405 gbh_af155653 NA MatrixMating/PathCalling 162 cbe_251445 HPV 16 E6 NA cbe_4269703 LOC51182 NA MatrixMating/PathCalling 99 cbe_251445 HPV 16 E6 NA cbe_4270015 RPS26 NA MatrixMating/PathCalling 163 cbe_251448 HPV 16 E7 NA cbe_251468 Prey1628 NA MatrixMating/PathCalling 164 cbe_251448 HPV 16 E7 NA cbe_251502 Prey1609 NA MatrixMating/PathCalling 165 cbe_251448 HPV 16 E7 NA cbe_422236 BCR1 NA MatrixMating/PathCalling 166 cbe_251448 HPV 16 E7 NA cbe_2693325 Prey1673 NA MatrixMating/PathCalling 167 cbe_251448 HPV 16 E7 NA cbe_2898065 Prey1620 NA MatrixMating/PathCalling 168 cbe_251448 HPV 16 E7 NA cbe_3474077 KRT4 NA MatrixMating 169 cbe_251448 HPV 16 E7 NA cbe_3773649 EEF1A1L14 NA MatrixMating/PathCalling 170 cbe_251448 HPV 16 E7 NA cbe_3787129 LOC55828 NA MatrixMating/PathCalling 171 cbe_251448 HPV 16 E7 NA cbe_3789063 AP2M1 NA MatrixMating/PathCalling 172 cbe_251448 HPV 16 E7 NA cbe_3834015 TFPI AT/PT MatrixMating 173 cbe_251448 HPV 16 E7 NA cbe_3921620 MPP3 AT MatrixMating/PathCalling 174 cbe_251448 HPV 16 E7 NA cbe_4260642 PTPN21 SMT MatrixMating/PathCalling 175 cbe_251448 HPV 16 E7 NA cbe_4265947 RBP4 AT/PT MatrixMating 176 cbe_251448 HPV 16 E7 NA cbe_4268611 NDUFS3 SMT MatrixMating/PathCalling 177 cbe_251448 HPV 16 E7 NA cbe_4268684 MIZF NA MatrixMating/PathCalling 178 cbe_251448 HPV 16 E7 NA cbe_4268740 ZNF-U69274 NA MatrixMating/PathCalling 179 cbe_251448 HPV 16 E7 NA cbe_4269658 PSMC1 NA MatrixMating/PathCalling 180 cbe_251448 HPV 16 E7 NA cbe_4269876 SBP2 NA MatrixMating/PathCalling 181 cbe_251448 HPV 16 E7 NA cbe_4270186 STX4A AT MatrixMating/PathCalling 383 cbe_1710 QP-C NA cbe_251917 HPV 1a E2 NA PathCalling 410 cbe_251917 HPV 1a E2 NA cbe_251976 Prey2777 NA MatrixMating/PathCalling 411 cbe_251917 HPV 1a E2 NA cbe_1469980 FLJ20259 NA MatrixMating/PathCalling 412 cbe_251917 HPV 1a E2 NA cbe_2826346 RPS10 NA PathCalling 413 cbe_251917 HPV 1a E2 NA cbe_2830508 Prey142356 NA PathCalling 414 cbe_251917 HPV 1a E2 NA cbe_3345510 COX6C SMT PathCalling 415 cbe_251917 HPV 1a E2 NA cbe_3583511 MGC3222 NA PathCalling 416 cbe_251917 HPV 1a E2 NA cbe_3625721 EIF2B2 NA PathCalling 417 cbe_251917 HPV 1a E2 NA cbe_3641816 ANKH NA PathCalling 418 cbe_251917 HPV 1a E2 NA cbe_3826540 Hs.98226 NA MatrixMating/PathCalling 419 cbe_251917 HPV 1a E2 NA cbe_4268532 Prey1053593 NA PathCalling 420 cbe_251917 HPV 1a E2 NA cbe_4269834 GNB2L1 NA MatrixMating/PathCalling 421 cbe_251917 HPV 1a E2 NA cbe_4270118 Hs.211143 NA PathCalling 441 cbe_252041 HPV 1a L2 NA cbe_252090 Prey2820 NA MatrixMating 442 cbe_252041 HPV 1a L2 NA cbe_2321045 WNT2B NA PathCalling 443 cbe_252041 HPV 1a L2 NA cbe_2603140 Prey146 NA MatrixMating/PathCalling 444 cbe_252041 HPV 1a L2 NA cbe_3222359 LOC51748 NA PathCalling 445 cbe_252041 HPV 1a L2 NA cbe_3456824 gbh_l20086 AT PathCalling 446 cbe_252041 HPV 1a L2 NA cbe_3606990 Prey1053670 NA PathCalling 447 cbe_252041 HPV 1a L2 NA cbe_3770440 gbh_af217505 NA MatrixMating/PathCalling 448 cbe_252041 HPV 1a L2 NA cbe_3810791 EPHB1 NA MatrixMating/PathCalling 449 cbe_252041 HPV 1a L2 NA cbe_4248793 GSN AT/PT PathCalling 450 cbe_252041 HPV 1a L2 NA cbe_4268470 HSPE1 NA MatrixMating/PathCalling 451 cbe_252041 HPV 1a L2 NA cbe_4269628 RIL NA MatrixMating 452 cbe_252041 HPV 1a L2 NA cbe_4540466 PUM1 NA MatrixMating/PathCalling 576 cbe_252090 Prey2820 NA cbe_552975 HPV 1a E1 NA MatrixMating 579 cbe_71919 FLJ13236 NA cbe_552975 HPV 1a E1 NA PathCalling 580 cbe_251071 Prey734 NA cbe_552975 HPV 1a E1 NA MatrixMating 581 cbe_552975 HPV 1a E1 NA cbe_3001381 IRF1 NA MatrixMating 582 cbe_552975 HPV 1a E1 NA cbe_3340492 TRIP NA MatrixMating 583 cbe_552975 HPV 1a E1 NA cbe_3926508 TDE1 AT PathCalling 584 cbe_552975 HPV 1a E1 NA cbe_4269167 TLK2 SMT MatrixMating 585 cbe_552975 HPV 1a E1 NA cbe_4269681 Hs.224712 NA MatrixMating 586 cbe_552975 HPV 1a E1 NA cbe_4269703 LOC51182 NA MatrixMating 587 cbe_552975 HPV 1a E1 NA cbe_4269931 NDUFAB1 SMT MatrixMating 280 cbe_2585091 SLC5A6 AT/SMT cbe_3929637 HPV 16 E5 AT/PT MatrixMating/PathCalling 431 cbe_251925 HPV 1a E7 NA cbe_3810032 gbh_af142421 NA MatrixMating/PathCalling 316 cbe_2599246 Prey1054152 NA cbe_3929637 HPV 16 E5 AT/PT PathCalling 317 cbe_2830508 Prey142356 NA cbe_3929637 HPV 16 E5 AT/PT PathCalling

TABLE 6 HPV 11, and HPV 16 specific interactions cbe_SEQ ID COMMON PT/AT/ cbe_SEQ ID COMMON PathCalling Screen and/or INT ID Interactor A NAME INT A SMT/NA Interactor B NAME INT B PT/AT/SMT/NA Matrix Assay 34 cbe_250834 HPV 11 E7 NA cbe_250878 Prey302 NA MatrixMating/PathCalling 35 cbe_250834 HPV 11 E7 NA cbe_250883 Prey244 NA MatrixMating/PathCalling 36 cbe_250834 HPV 11 E7 NA cbe_250888 Prey228 NA MatrixMating/PathCalling 37 cbe_250834 HPV 11 E7 NA cbe_3056756 KIAA0440 NA MatrixMating/PathCalling 38 cbe_250834 HPV 11 E7 NA cbe_3454406 gbh_af252829 NA MatrixMating/PathCalling 39 cbe_250834 HPV 11 E7 NA cbe_3760926 gbh_al359334 NA MatrixMating/PathCalling 40 cbe_250834 HPV 11 E7 NA cbe_3845697 Hs.191063 NA MatrixMating/PathCalling 41 cbe_250834 HPV 11 E7 NA cbe_4260642 PTPN21 SMT MatrixMating/PathCalling 42 cbe_250834 HPV 11 E7 NA cbe_4265947 RBP4 AT/PT MatrixMating/PathCalling 43 cbe_250834 HPV 11 E7 NA cbe_4268935 RPL26 NA MatrixMating/PathCalling 44 cbe_250834 HPV 11 E7 NA cbe_4269451 gbh_af038189 NA MatrixMating/PathCalling 45 cbe_250834 HPV 11 E7 NA cbe_4269681 Hs.224712 NA MatrixMating/PathCalling 46 cbe_250834 HPV 11 E7 NA cbe_4269818 Hs.73680 NA MatrixMating/PathCalling 47 cbe_250834 HPV 11 E7 NA cbe_4270015 RPS26 NA MatrixMating/PathCalling 48 cbe_250834 HPV 11 E7 NA cbe_4270441 Prey1052970 NA PathCalling 49 cbe_250834 HPV 11 E7 NA cbe_4280774 ITGB4 AT/PT MatrixMating/PathCalling 159 cbe_251445 HPV 16 E6 NA cbe_2253980 gbh_d38112_5 NA MatrixMating/PathCalling 160 cbe_251445 HPV 16 E6 NA cbe_2576474 PTPN2 AT/SMT MatrixMating/PathCalling 161 cbe_251445 HPV 16 E6 NA cbe_4269405 gbh_af155653 NA MatrixMating/PathCalling 162 cbe_251445 HPV 16 E6 NA cbe_4269703 LOC51182 NA MatrixMating/PathCalling 99 cbe_251445 HPV 16 E6 NA cbe_4270015 RPS26 NA MatrixMating/PathCalling 163 cbe_251448 HPV 16 E7 NA cbe_251468 Prey1628 NA MatrixMating/PathCalling 164 cbe_251448 HPV 16 E7 NA cbe_251502 Prey1609 NA MatrixMating/PathCalling 165 cbe_251448 HPV 16 E7 NA cbe_422236 BCR1 NA MatrixMating/PathCalling 166 cbe_251448 HPV 16 E7 NA cbe_2693325 Prey1673 NA MatrixMating/PathCalling 167 cbe_251448 HPV 16 E7 NA cbe_2898065 Prey1620 NA MatrixMating/PathCalling 168 cbe_251448 HPV 16 E7 NA cbe_3474077 KRT4 NA MatrixMating 169 cbe_251448 HPV 16 E7 NA cbe_3773649 EEF1A1L14 NA MatrixMating/PathCalling 170 cbe_251448 HPV 16 E7 NA cbe_3787129 LOC55828 NA MatrixMating/PathCalling 171 cbe_251448 HPV 16 E7 NA cbe_3789063 AP2M1 NA MatrixMating/PathCalling 172 cbe_251448 HPV 16 E7 NA cbe_3834015 TFPI AT/PT MatrixMating 173 cbe_251448 HPV 16 E7 NA cbe_3921620 MPP3 AT MatrixMating/PathCalling 174 cbe_251448 HPV 16 E7 NA cbe_4260642 PTPN21 SMT MatrixMating/PathCalling 175 cbe_251448 HPV 16 E7 NA cbe_4265947 RBP4 AT/PT MatrixMating 176 cbe_251448 HPV 16 E7 NA cbe_4268611 NDUFS3 SMT MatrixMating/PathCalling 177 cbe_251448 HPV 16 E7 NA cbe_4268684 MIZF NA MatrixMating/PathCalling 178 cbe_251448 HPV 16 E7 NA cbe_4268740 ZNF-U69274 NA MatrixMating/PathCalling 179 cbe_251448 HPV 16 E7 NA cbe_4269658 PSMC1 NA MatrixMating/PathCalling 180 cbe_251448 HPV 16 E7 NA cbe_4269876 SBP2 NA MatrixMating/PathCalling 181 cbe_251448 HPV 16 E7 NA cbe_4270186 STX4A AT MatrixMating/PathCalling 182 cbe_251737 HPV 16 L2 NA cbe_422227 Prey277610 NA PathCalling 183 cbe_251737 HPV 16 L2 NA cbe_422247 Prey277642 NA PathCalling 184 cbe_251737 HPV 16 L2 NA cbe_3056756 KIAA0440 NA MatrixMating/PathCalling 185 cbe_251737 HPV 16 L2 NA cbe_3473488 gbh_al121903 NA PathCalling 186 cbe_251737 HPV 16 L2 NA cbe_3575702 SUI1 NA PathCalling 187 cbe_251737 HPV 16 L2 NA cbe_3663966 KIAA1389 NA PathCalling 188 cbe_251737 HPV 16 L2 NA cbe_3849002 HSPC224 AT PathCalling 189 cbe_251737 HPV 16 L2 NA cbe_3884811 Hs.30289 NA PathCalling 190 cbe_251737 HPV 16 L2 NA cbe_4268684 MIZF NA MatrixMating 191 cbe_251737 HPV 16 L2 NA cbe_4270335 KIAA0276 NA PathCalling

TABLE 7 HPV1a, HPV 11, and HPV 16 specific interactions INT cbe_SEQ ID COMMON cbe_SEQ ID COMMON PathCalling Screen and/or ID Interactor A NAME INT A PT/AT/SMT/NA Interactor B NAME INT B PT/AT/SMT/NA Matrix Assay 34 cbe_250834 HPV 11 E7 NA cbe_250878 Prey302 NA MatrixMating/PathCalling 35 cbe_250834 HPV 11 E7 NA cbe_250883 Prey244 NA MatrixMating/PathCalling 36 cbe_250834 HPV 11 E7 NA cbe_250888 Prey228 NA MatrixMating/PathCalling 37 cbe_250834 HPV 11 E7 NA cbe_3056756 KIAA0440 NA MatrixMating/PathCalling 38 cbe_250834 HPV 11 E7 NA cbe_3454406 gbh_af252829 NA MatrixMating/PathCalling 39 cbe_250834 HPV 11 E7 NA cbe_3760926 gbh_al359334 NA MatrixMating/PathCalling 40 cbe_250834 HPV 11 E7 NA cbe_3845697 Hs.191063 NA MatrixMating/PathCalling 41 cbe_250834 HPV 11 E7 NA cbe_4260642 PTPN21 SMT MatrixMating/PathCalling 42 cbe_250834 HPV 11 E7 NA cbe_4265947 RBP4 AT/PT MatrixMating/PathCalling 43 cbe_250834 HPV 11 E7 NA cbe_4268935 RPL26 NA MatrixMating/PathCalling 44 cbe_250834 HPV 11 E7 NA cbe_4269451 gbh_af038189 NA MatrixMating/PathCalling 45 cbe_250834 HPV 11 E7 NA cbe_4269681 Hs.224712 NA MatrixMating/PathCalling 46 cbe_250834 HPV 11 E7 NA cbe_4269818 Hs.73680 NA MatrixMating/PathCalling 47 cbe_250834 HPV 11 E7 NA cbe_4270015 RPS26 NA MatrixMating/PathCalling 48 cbe_250834 HPV 11 E7 NA cbe_4270441 Prey1052970 NA PathCalling 49 cbe_250834 HPV 11 E7 NA cbe_4280774 ITGB4 AT/PT MatrixMating/PathCalling 163 cbe_251448 HPV 16 E7 NA cbe_251468 Prey1628 NA MatrixMating/PathCalling 164 cbe_251448 HPV 16 E7 NA cbe_251502 Prey1609 NA MatrixMating/PathCalling 165 cbe_251448 HPV 16 E7 NA cbe_422236 BCR1 NA MatrixMating/PathCalling 166 cbe_251448 HPV 16 E7 NA cbe_2693325 Prey1673 NA MatrixMating/PathCalling 167 cbe_251448 HPV 16 E7 NA cbe_2898065 Prey1620 NA MatrixMating/PathCalling 168 cbe_251448 HPV 16 E7 NA cbe_3474077 KRT4 NA MatrixMating 169 cbe_251448 HPV 16 E7 NA cbe_3773649 EEF1A1L14 NA MatrixMating/PathCalling 170 cbe_251448 HPV 16 E7 NA cbe_3787129 LOC55828 NA MatrixMating/PathCalling 171 cbe_251448 HPV 16 E7 NA cbe_3789063 AP2M1 NA MatrixMating/PathCalling 172 cbe_251448 HPV 16 E7 NA cbe_3834015 TFPI AT/PT MatrixMating 173 cbe_251448 HPV 16 E7 NA cbe_3921620 MPP3 AT MatrixMating/PathCalling 174 cbe_251448 HPV 16 E7 NA cbe_4260642 PTPN21 SMT MatrixMating/PathCalling 175 cbe_251448 HPV 16 E7 NA cbe_4265947 RBP4 AT/PT MatrixMating 176 cbe_251448 HPV 16 E7 NA cbe_4268611 NDUFS3 SMT MatrixMating/PathCalling 177 cbe_251448 HPV 16 E7 NA cbe_4268684 MIZF NA MatrixMating/PathCalling 178 cbe_251448 HPV 16 E7 NA cbe_4268740 ZNF-U69274 NA MatrixMating/PathCalling 179 cbe_251448 HPV 16 E7 NA cbe_4269658 PSMC1 NA MatrixMating/PathCalling 180 cbe_251448 HPV 16 E7 NA cbe_4269876 SBP2 NA MatrixMating/PathCalling 181 cbe_251448 HPV 16 E7 NA cbe_4270186 STX4A AT MatrixMating/PathCalling 427 cbe_251925 HPV 1a E7 NA cbe_251953 Prey2724 NA MatrixMating/PathCalling 428 cbe_251925 HPV 1a E7 NA cbe_3753270 gbh_ac004503 NA MatrixMating/PathCalling 429 cbe_251925 HPV 1a E7 NA cbe_3760926 gbh_al359334 NA MatrixMating/PathCalling 430 cbe_251925 HPV 1a E7 NA cbe_3789063 AP2M1 NA MatrixMating 431 cbe_251925 HPV 1a E7 NA cbe_3810032 gbh_af142421 NA MatrixMating/PathCalling 432 cbe_251925 HPV 1a E7 NA cbe_3820530 PGAM1 SMT MatrixMating/PathCalling 309 cbe_251925 HPV 1a E7 NA cbe_3834015 TFPI AT/PT MatrixMating 433 cbe_251925 HPV 1a E7 NA cbe_4265947 RBP4 AT/PT MatrixMating/PathCalling 434 cbe_251925 HPV 1a E7 NA cbe_4267526 HRIHFB2206 NA MatrixMating/PathCalling

In certain embodiments, the first polypeptide is labeled. In other embodiments, the second polypeptide is labeled, while in some embodiments, both the first and second polypeptides are labeled. Labeling can be performed using any art-recognized method for labeling polypeptides. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include ¹²⁵I, ¹³¹I, ³⁵S or ³H.

The invention also includes complexes of two or more polypeptides in which at least one of the polypeptides is present as a fragment of a complex-forming polypeptide according to the invention. For example, one or more polypeptides may include an amino acid sequence sufficient to bind to its corresponding polypeptde. A binding domain of a given first polypeptide can be any number of amino acids sufficient to specifically bind to, and complex with, the corresponding second polypeptide under conditions suitable for complex formation. The binding domain can be the minimal number of amino acids required to retain binding affinity, or may be a larger fragment or derivative of the polypeptides listed in Tables 1 through 7, columns 2 and 5.

Procedures for identifying binding domains can be readily identified by one of ordinary skill in the art including the procedures described herein. For example, nucleic acid sequences containing various portions of a “bait” protein can be tested in a yeast two hybrid screening assay in combination with a nucleic acid encoding the corresponding “prey” protein.

In certain embodiments, the “bait” polypeptide of the complex are HPV derived proteins L1, L2, E2, E4, E5, E6 and E7. In some embodiments the “prey” protein of the complex are identified as cellular proliferation and transformation proteins, proteins involved in protein synthesis, folding or turnover and vesicle trafficking molecules when screened against several human prey libraries.

In other embodiments, the complexes are human ortholog complexes, chimeric complexes, or specific complexes implicated in fungal pathways, as discussed in detail below.

Polypeptides forming the complexes according to the invention can be made using techniques known in the art. For example, one or more of the polypeptides in the complex can be chemically synthesized using art-recognized methods for polypeptide synthesis. These methods are common in the art, including synthesis using a peptide synthesizer. See, e.g., Peptide Chemistry, A Practical Textbook, Bodasnsky, Ed. Springer-Verlag, 1988; Merrifield, Science 232: 241-247 (1986); Barany, et al, Intl. J. Peptide Protein Res. 30: 705-739 (1987); Kent, Ann. Rev. Biochem. 57:957-989 (1988), and Kaiser, et al, Science 243: 187-198 (1989).

Alternatively, polypeptides can be made by expressing one or both polypeptides from a nucleic acid and allowing the complex to form from the expressed polypeptides. Any known nucleic acids that express the polypeptides, whether yeast or human (or chimerics of these polypeptides) can be used, as can vectors and cells expressing these polypeptides. Sequences of yeast ORFs and human polypeptides as referenced in Tables 3 and 7 are publicly available, e.g. at the Saccharomyces Genome Database (SGD) and GenBank (see, e.g. Hudson et al., Genome Res. 7: 1169-1173 (1997). If desired, the complexes can then be recovered and isolated.

Recombinant cells expressing the polypeptide, or a fragment or derivative thereof, may be obtained using methods known in the art, and individual gene product or complex may be isolated and analyzed (See, e.g., e.g., as described in Sambrook et al., eds., MOLECULAR CLONING: A LABORATORY MANUAL, 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989; and Ausubel, et al., eds., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, New York, N.Y., 1993). This is achieved by assays that are based upon the physical and/or functional properties of the protein or complex. The assays can include, e.g., radioactive labeling of one or more of the polypeptide complex components, followed by analysis by gel electrophoresis, immunoassay, cross-linking to marker-labeled products. Polypeptide complex may be isolated and purified by standard methods known in the art (either from natural sources or recombinant host cells expressing the proteins/protein complex). These methods can include, e.g., column chromatography (e.g., ion exchange, affinity, gel exclusion, reverse-phase, high pressure, fast protein liquid, etc), differential centrifugation, differential solubility, or similar methods used for the purification of proteins.

Combinatorial libraries recognized in the art may be used to provide “prey” proteins. In a preferred embodiment, a keratinocyte library, one of the cell types from tissues normally infected by HPV strains is disclosed.

Complexes Useful for Identifying HPV Infection

The invention further provides complexes of polypeptides useful, inter alia, in identifying agents that inhibit viral proliferation and cell proliferation leading to cancer.

There have been recent breakthroughs in vaccine and immunotherapy for HPV infection (Koutsky, Ault et al. 2002), these therapeutic modes are still under investigation. If these, or other new modalities of therapy prove to be successful in treating HPV infection, it will be necessary to stage and monitor the progression of HPV-induced disease and the course of treatment. The tools described herein are certain to have utility for assessing the stage of disease and the success of treatment.

Protein interactions which are useful for identifying HPV infection are considered below.

Protein interactions that are unique to HPV 1a may be used, for example, in a diagnostic embodiment to determine if an infection by HPV is of a potentially cancer causing nature or not. An interaction that is unique to HPV 1a indicates that the infection is not of a kind that is known to cause cancer or cervical lesions. In one embodiment, an ELISA assay that uses an antibody against one of the non-viral proteins indicated in Tables 1 through 7 as a first antibody and an antibody specific for a virally encoded protein may be used to determine if an infection is actively producing viral protein. Those interactions (indicated “INT ID”) that correspond to the interaction between a protein encoded by the nucleotide sequence indicated by a SEQ ID for Interactor A (“SEQ ID INT A”) with the protein encoded by the nucleic acid represented by a SEQ ID for Interactor B (“SEQ ID INT B”), one or both of which may have a common name (indicated “COMMON NAME INT A”; “COMMON NAME INT B”) one or both of which may have utility as a protein therapeutic (PT), antibody target (AT), or a small molecule target (SMT), and/or may have a therapeutic utility for in indication that may or may not directly involve the interaction of HPV1a, HPV11, HPV16, a combination of the these viruses, or members of the family of viruses they represent (those that cause warts, non-cancerous lesions, or cancerous lesions of the anal-genital tract, and/or head/neck/oral cancers or the non-cancerous versions of the same and the like)(NA). In all cases the interactions have application in the diagnosis of any HPV infections and conditions induced by such infections, active or latent.

Interactions with any one or more PT, AT, SMT, and/or NA for which there exists or may be developed a molecule that therapeutically affects any one or more of the indicated proteins in an interaction with one or more HPV proteins of the strains listed or family members of such viruses may be used as a therapeutic agent for the treatment of HPV infections and/or the conditions caused directly or indirectly by HPV infection.

Chimeric Polypeptides, DNA, Vectors and Recombinant Cells

In a further aspect, the invention provides a chimeric polypeptide that includes sequences of two interacting proteins according to the invention. The interacting proteins can be, e.g., the interacting protein pairs disclosed in Tables 1-7, herein. Also included are chimeric polypeptides including multimers, i.e., sequences from two or more pairs of interacting proteins. An example of such a chimeric polypeptide is a polypeptide that includes amino acid sequences from INT A and INT B, and from INT ID Interactor A and INT ID Interactor B. The chimeric polypeptide includes a region of a first protein covalently linked, e.g. via peptide bond, to a region of a second protein.

In some embodiments, the chimeric polypeptide(s) of the complex include(s) six or more amino acids of a first protein covalently linked to six or more amino acids of a second protein. In other embodiments, the chimeric polypeptide includes at least one binding domain of a first or second protein.

Preferably, the chimeric polypeptide includes a region of amino acids of the first polypeptide able to bind to a second polypeptide. Alternatively, or in addition, the chimeric polypeptide includes a region of amino acids of the second polypeptide able to bind to the first polypeptide.

Nucleic acid encoding the chimeric polypeptide, as well as vectors and cells containing these nucleic acids, are within the scope of the present invention. The chimeric polypeptides can be constructed by expressing nucleic acids encoding chimeric polypeptides using recombinant methods, described above, then recovering the chimeric polypeptides, or by chemically synthesizing the chimeric polypeptides. Host-vector systems that can be used to express chimeric polypeptides include, e.g.: (i) mammalian cell systems which are infected with vaccinia virus, adenovirus; (ii) insect cell systems infected with baculovirus; (iii) yeast containing yeast vectors or (iv) bacteria transformed with bacteriophage, DNA, plasmid DNA, or cosmid DNA. Depending upon the host-vector system utilized, any one of a number of suitable transcription and translation elements may be used.

The expression of the specific proteins may be controlled by any promoter/enhancer known in the art including, e.g.: (i) the SV40 early promoter (see e.g., Bernoist & Chambon, Nature 290: 304-310 (1981)); (ii) the promoter contained within the 3′-terminus long terminal repeat of Rous Sarcoma Virus (see e.g., Yamamoto, et al., Cell 22: 787-797 (1980)); (iii) the Herpesvirus thymidine kinase promoter (see e.g., Wagner, et al., Proc. Natl. Acad. Sci. USA 78: 1441-1445 (1981)); (iv) the regulatory sequences of the metallothionein gene (see e.g., Brinster, et al., Nature 296: 39-42 (1982)); (v) prokaryotic expression vectors such as the p-lactamase promoter (see e.g., Villa-Kamaroff, et al., Proc. Natl. Acad. Sci. USA 75: 3727-3731 (1978)); (vi) the tac promoter (see e.g., DeBoer, et al., Proc. Natl. Acad. Sci. USA 80: 21-25 (1983)).

Plant promoter/enhancer sequences within plant expression vectors may also be utilized including, e.g.: (i) the nopaline synthetase promoter (see e.g., Herrar-Estrella, et al., Nature 303: 209-213 (1984)); (ii) the cauliflower mosaic virus 35S RNA promoter (see e.g., Garder, et al., Nuc. Acids Res. 9: 2871 (1981)) and (iii) the promoter of the photosynthetic enzyme ribulose bisphosphate carboxylase (see e.g., Herrera-Estrella, et al., Nature 310: 115-120 (1984)).

Promoter/enhancer elements from yeast and other fungi (e.g., the Gal4 promoter, the alcohol dehydrogenase promoter, the phosphoglycerol kinase promoter, the alkaline phosphatase promoter), as well as the following animal transcriptional control regions, which possess tissue specificity and have been used in transgenic animals, may be utilized in the production of proteins of the present invention.

Other animal transcriptional control sequences derived from animals include, e.g.: (i) the insulin gene control region active within pancreatic β-cells (see e.g., Hanahan, et al., Nature 315: 115-122 (1985)); (ii) the immunoglobulin gene control region active within lymphoid cells (see e.g., Grosschedl, et al., Cell 38: 647-658 (1984)); (iii) the albumin gene control region active within liver (see e.g., Pinckert, et al., Genes and Devel. 1: 268-276 (1987)); (iv) the myelin basic protein gene control region active within brain oligodendrocyte cells (see e.g., Readhead, et al., Cell 48: 703-712 (1987)); and (v) the gonadotrophin-releasing hormone gene control region active within the hypothalamus (see e.g., Mason, et al., Science 234: 1372-1378 (1986)).

The vector may include a promoter operably-linked to nucleic acid sequences which encode a chimeric polypeptide, one or more origins of replication, and optionally, one or more selectable markers (e.g., an antibiotic resistance gene). A host cell strain may be selected which modulates the expression of chimeric sequences, or modifies/processes the expressed proteins in a desired manner. Moreover, different host cells possess characteristic and specific mechanisms for the translational and post-translational processing and modification (e.g., glycosylation, phosphorylation, and the like) of expressed proteins. Appropriate cell lines or host systems may thus be chosen to ensure the desired modification and processing of the foreign protein is achieved. For example, protein expression within a bacterial system can be used to produce an unglycosylated core protein; whereas expression within mammalian cells ensures “native” glycosylation of a heterologous protein.

Antibodies Specific for Polypeptide Complexes

The invention further provides antibodies and antibody fragments (such as Fab or (Fab)₂ fragments) that bind specifically to the complexes described herein. By “specifically binds” is meant an antibody that recognizes and binds to a particular polypeptide complex of the invention, but which does not substantially recognize or bind to other molecules in a sample, or to any of the polypeptides of the complex when those polypeptides are not complexed.

For example, a purified complex, or a portion, variant, or fragment thereof, can be used as an immunogen to generate antibodies that specifically bind the complex using standard techniques for polyclonal and monoclonal antibody preparation.

A full-length polypeptide complex can be used, if desired. Alternatively, the invention provides antigenic fragments of polypeptide complexes for use as immunogens. In some embodiments, the antigenic complex fragment includes at least 6, 8, 10, 15, 20, or 30 or more amino acid residues of a polypeptide. In one embodiment, epitopes encompassed by the antigenic peptide include the binding domains of the polypeptides, or are located on the surface of the protein, e.g., hydrophilic regions.

If desired, peptides containing antigenic regions can be selected using hydropathy plots showing regions of hydrophilicity and hydrophobicity. These plots may be generated by any method well known in the art, including, for example, the Kyte Doolittle or the Hopp Woods methods, either with or without Fourier transformation. See, e.g., Hopp and Woods, Proc. Nat. Acad. Sci. USA 78:3824-3828 (1981); Kyte and Doolittle, J. Mol. Biol. 157:105-142 (1982).

The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that specifically binds (immunoreacts with) an antigen, such as a polypeptide complex. Such antibodies include, e.g., polyclonal, monoclonal, chimeric, single chain, Fab and F(ab′)₂ fragments, and an Fab expression library. In specific embodiments, antibodies to human ortholog complexes.

Various procedures known within the art may be used for the production of polyclonal or monoclonal antibodies. For example, for the production of polyclonal antibodies, various suitable host animals (e.g., rabbit, goat, mouse or other mammal) may be immunized by injection with the native protein, or a synthetic variant thereof, or a derivative of the foregoing. An appropriate immunogenic preparation can contain, for example, recombinantly expressed polypeptide complex. Alternatively, the immunogenic polypeptides or complex may be chemically synthesized, as discussed above. The preparation can further include an adjuvant. Various adjuvants used to increase the immunological response include, e.g., Freund's (complete and incomplete), mineral gels (e.g., aluminum hydroxide), surface active substances (e.g., lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, dinitrophenol, etc.), human adjuvants such as Bacille Calmette-Guerin and Corynebacterium parvum, or similar immunostimulatory agents. If desired, the antibody molecules directed against complex can be isolated from the mammal (e.g., from the blood) and further purified by well known techniques, such as protein A chromatography to obtain the IgG fraction.

The term “monoclonal antibody” or “monoclonal antibody composition”, as used herein, refers to a population of antibody molecules that contain only one species of an antigen binding site capable of immunoreacting with a particular epitope of a polypeptide complex. A monoclonal antibody composition thus typically displays a single binding affinity for a particular protein with which it immunoreacts. For preparation of monoclonal antibodies directed towards a particular complex, or polypeptide, any technique that provides for the production of antibody molecules by continuous cell line culture may be utilized. Such techniques include, e.g., the hybridoma technique (see Kohler & Milstein, Nature 256: 495-497 (1975)); the trioma technique; the human B-cell hybridoma technique (see Kozbor, et al., Immunol Today 4: 72 (1983)); and the EBV hybridoma technique to produce human monoclonal antibodies (see Cole, et al., In: Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., (1985) pp. 77-96). If desired, human monoclonal antibodies may be prepared by using human hybridomas (see Cote, et al., Proc. Natl. Acad. Sci. USA 80: 2026-2030 (1983)) or by transforming human B-cells with Epstein Barr Virus in vitro (see Cole, et al., In: Monoclonal Antibodies and Cancer Therapy, supra).

Methods can be adapted for the construction of Fab expression libraries (see e.g. Huse, et al., Science 246: 1275-1281 (1989)) to allow rapid and effective identification of monoclonal F_(ab) fragments with the desired specificity for the desired protein or derivatives, fragments, analogs or homologs thereof. Non-human antibodies can be “humanized” by techniques well known in the art. See e.g., U.S. Pat. No. 5,225,539. Antibody fragments that contain the idiotypes to a polypeptide or polypeptide complex may be produced by techniques known in the art including, e.g.: (i) an F_((ab′)2) fragment produced by pepsin digestion of an antibody molecule; (ii) an F_(ab) fragment generated by reducing the disulfide bridges of an F_((ab′)2) fragment; (iii) an F_(ab) fragment generated by the treatment of the antibody molecule with papain and a reducing agent and (iv) F_(v) fragments.

Chimeric and humanized monoclonal antibodies against the polypeptide complexes, or polypeptides, described herein are also within the scope of the invention, and can be produced by recombinant DNA techniques known in the art, for example using methods described in PCT International Application No. PCT/US86/02269; European Patent Application No. 184,187; European Patent Application No. 171,496; European Patent Application No. 173,494; PCT International Publication No. WO 86/01533; U.S. Pat. No. 4,816,567; European Patent Application No. 125,023; Better et al., Science 240: 1041-1043 (1988); Liu et al., Proc. Nat. Acad. Sci. USA 84: 3439-3443 (1987); Liu et al., J. Immunol. 139: 3521-3526 (1987); Sun et al., Proc. Nat. Acad. Sci. USA 84: 214-218 (1987); Nishimura et al., Cancer Res. 47: 999-1005 (1987); Wood et al., Nature 314: 446-449 (1985); Shaw et al., J. Natl. Cancer Inst. 80: 1553-1559 (1988); Morrison, Science 229: 1202-1207 (1985); Oi et al., BioTechniques 4: 214 (1986); U.S. Pat. No. 5,225,539; Jones et al., Nature 321: 552-525 (1986); Verhoeyan et al., Science 239: 1534 (1988); and Beidler et al., J. Immunol. 141: 4053-4060 (1988).

Methods for the screening of antibodies that possess the desired specificity include, e.g., enzyme-linked immunosorbent assay (ELISA) and other immunologically-mediated techniques known within the art. For example, selection of antibodies that are specific to a particular domain of a polypeptide complex is facilitated by generation of hybridomas that bind to the complex, or fragment thereof, possessing such a domain.

In certain embodiments of the invention, antibodies specific for the polypeptide complexes described herein may be used in various methods, such as detection of complex, and identification of agents which disrupt complexes. These methods are described in more detail, below. Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include ¹²⁵I, ¹³¹I, ³⁵S or ³H.

Polypeptide complex-specific, or polypeptide-specific antibodies, can also be used to isolate complexes using standard techniques, such as affinity chromatography or immunoprecipitation. Thus, the antibodies disclosed herein can facilitate the purification of specific polypeptide complexes from cells, as well as recombinantly produced complexes expressed in host cells.

Kits

In a specific embodiment, the invention provides kits containing a reagent, for example, an antibody described above, which can specifically detect a polypeptide complex, or a constituent polypeptide, described herein. Such kits can contain, for example, reaction vessels, reagents for detecting complex in sample, and reagents for development of detected complex, e.g. a secondary antibody coupled to a detectable marker. The label incorporated into the anti-complex, or anti-polypeptide antibody may include, e.g., a chemiluminescent, enzymatic, fluorescent, colorimetric or radioactive moiety. Kits of the present invention may be employed in diagnostic and/or clinical screening assays.

Pharmaceutical Compositions

The invention further provides pharmaceutical compositions of purified complexes suitable for administration to a subject, most preferably, a human, in the treatment of disorders involving altered levels of such complexes. Such preparations include a therapeutically-effective amount of a complex, and a pharmaceutically acceptable carrier. As utilized herein, the term “pharmaceutically acceptable” means approved by a regulatory agency of the Federal or a state government or listed in the U.S. Pharmacopoeia or other generally recognized pharmacopoeia for use in animals and, more particularly, in humans. The term “carrier” refers to a diluent, adjuvant, excipient, or vehicle with which the therapeutic is administered and includes, but is not limited to such sterile liquids as water and oils.

The therapeutic amount of a complex which will be effective in the treatment of a particular disorder or condition will depend on the nature of the disorder or condition, and may be determined by standard clinical techniques by those of average skill within the art. In addition, in vitro assays may optionally be employed to help identify optimal dosage ranges. The precise dose to be employed in the formulation will also depend on the route of administration, and the overall seriousness of the disease or disorder, and should be decided according to the judgment of the practitioner and each patient's circumstances. However, suitable dosage ranges for intravenous administration of the complexes of the present invention are generally about 20-500 micrograms (μg) of active compound per kilogram (Kg) body weight. Suitable dosage ranges for intranasal administration are generally about 0.01 pg/kg body weight to 1 mg/kg body weight. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems. Suppositories generally contain active ingredient in the range of 0.5% to 10% by weight; oral formulations preferably contain 10% to 95% active ingredient.

Various delivery systems are known and can be used to administer a pharmaceutical preparation of a complex of the invention including, e.g.: (i) encapsulation in liposomes, microparticles, microcapsules; (ii) recombinant cells capable of expressing the polypeptides of the complex; (iii) receptor-mediated endocytosis (see, e.g., Wu et al., J. Biol. Chem. 262: 4429-4432 (1987)); (iv) construction of a nucleic acid encoding the polypeptides of the complex as part of a retroviral or other vector, and the like.

Methods of administration include, e.g., intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, intranasal, epidural, and oral routes. The pharmaceutical preparations of the present invention may be administered by any convenient route, for example by infusion or bolus injection, by absorption through epithelial or mucocutaneous linings (e.g., oral mucosa, rectal and intestinal mucosa, etc.) and may be administered together with other biologically-active agents. Administration can be systemic or local. In addition, it may be advantageous to administer the pharmaceutical preparation into the central nervous system by any suitable route, including intraventricular and intrathecal injection. Intraventricular injection may be facilitated by an intraventricular catheter attached to a reservoir (e.g., an Ommaya reservoir). Pulmonary administration may also be employed by use of an inhaler or nebulizer, and formulation with an aerosolizing agent. It may also be desirable to administer the pharmaceutical preparation locally to the area in need of treatment; this may be achieved by, for example, and not by way of limitation, local infusion during surgery, topical application, by injection, by means of a catheter, by means of a suppository, or by means of an implant. In a specific embodiment, administration may be by direct injection at the site (or former site) of a malignant tumor or neoplastic or pre-neoplastic tissue.

Alternatively, pharmaceutical preparations of the invention may be delivered in a vesicle, in particular a liposome, (see, e.g., Langer, Science 249:1527-1533 (1990)) or via a controlled release system including, e.g., a delivery pump (see, e.g., Saudek, et al., New Engl. J. Med. 321: 574 (1989) and a semi-permeable polymeric material (see, e.g., Howard, et al., J. Neurosurg. 71: 105 (1989)). Additionally, the controlled release system can be placed in proximity of the therapeutic target (e.g., the brain), thus requiring only a fraction of the systemic dose. See, e.g., Goodson, In: Medical Applications of Controlled Release, 1984 (CRC Press, Bocca Raton, Fla.).

Screening, Diagnostic, and Therapeutic Methods

The invention further provides methods of identifying an agent which modulate formation or stability a polypeptide complex described herein. By modulate is meant to increase or decrease the rate at which the complex is assembled or dissembled, or to increase or decrease the stability of an assembled complex. Thus, an agent can be tested for its ability to disrupt a complex, or to promote formation or stability of a complex.

In one embodiment, the invention provides a method of identifying an agent that promotes disruption of a complex. The method includes providing a polypeptide complex, contacting the complex with a test agent, and detecting the presence of a polypeptide displaced from the complex. The presence of displaced polypeptide indicates the disruption of the complex by the agent. In some embodiments, the complex is a human ortholog complex, as described above, which includes “bait” and “prey” proteins selected from those recited in Tables 4 through 7. Agents which disrupt complexes of the invention may present novel modulators of cell processes and pathways in which the complexes participate. For example, agents which disrupt complexes involving EGFR proteins, DLG, ubiquitin 9 or may be selected as potential HPV therapeutics. In another embodiment, against which modulate the activity of BCR1, GAP or other effectors of CDC42-pathways are encompassed by the invention.

Any compound or other molecule (or mixture or aggregate thereof) can be used as a test agent. In some embodiments, the agent can be a small peptide, or other small molecule produced by e.g., combinatorial synthetic methods known in the art. Disruption of the complex by the test agent, e.g. binding of the agent to the complex, can be determined using art recognized methods, e.g., detection of polypeptide using polypeptide-specific antibodies, as described above. Bound agents can alternatively be identified by comparing the relative electrophoretic mobility of complexes exposed to the test agent to the mobility of complexes that have not been exposed to the test agent.

Agents identified in the screening assays can be further tested for their ability to alter and/or modulate cellular functions, particularly those functions in which the complex has been implicated. These functions include, e.g., control of cell-cycle progression; regulation of transcription; control of intracellular signal transduction, etc., as described in detail above.

In another embodiment, the invention provides methods for inhibiting the interaction of a polypeptide with a ligand, by contacting a complex of the protein and the ligand with an agent that disrupts the complex, as described above. In certain embodiments, the polypeptides are associated with protein synthesis, folding or turnover and vesicle trafficking molecules. In certain embodiments, the ligand is an interacting polypeptide, and the polypeptide and ligands are selected from those recited in Tables 1-7, preferably Tables 4-7, and most preferably interactions involving HPV 16. Inhibition of complex formation allows for modulation of cellular functions and pathways in which the targeted complexes participate.

In another embodiment, the invention provides a method for identifying a polypeptide complex in a subject. The method includes the steps of providing a biological sample from the subject, detecting, if present, the level of polypeptide complex. In some embodiments, the complex includes a first polypeptide (a “bait” polypeptide) selected from the polypeptides recited in Tables 4-7, column 2 or 3, and a second polypeptide (“prey” polypeptide) selected from the polypeptides recited in Tables 4-7, column 5 or 6. Any suitable biological sample potentially containing the complex may be employed, e.g. blood, urine, cerebral-spinal fluid, plasma, skin, etc. Complexes may be detected by, e.g., using complex-specific antibodies as described above. The method provides for diagnostic screening, including in the clinical setting, using, e.g., the kits described above.

In still another embodiment, the present invention provides methods for detecting a polypeptide in a biological sample, by providing a biological sample containing the polypeptide, contacting the sample with a corresponding polypeptide to form a complex under suitable conditions, and detecting the presence of the complex. A complex will form if the sample does, indeed, contain the first polypeptide. In some embodiments, the polypeptide being detecting is a “prey” protein selected from the polypeptides recited in Tables 1 through 7, columns 2 or 3, and is detected by complexing with the corresponding “bait” protein recited in Tables 1-7, column 5 or 6. Conversely, in other embodiments the polypeptide being detected is the “bait” protein. Alternatively, a yeast “bait” or “prey” ortholog may be employed to form a chimeric complex with the polypeptide in the biological sample.

In still another embodiment, the invention provides methods for removing a first polypeptide from a biological sample by contacting the biological sample with the corresponding second peptide to form a complex under conditions suitable for such formation. The complex is then removed from the sample, effectively removing the first polypeptide. As with the methods of detecting polypeptide described above, the polypeptide being removed may be either a “bait” or “prey” protein, and the second corresponding polypeptide used to remove it may be either a yeast or human ortholog polypeptide.

Methods of determining altered expression of a polypeptide in a subject, e.g. for diagnostic purposes, are also provided by the invention. Altered expression of proteins involved in cell processes and pathways can lead to deleterious effects in the subject. Altered expression of a polypeptide in a given pathway leads to altered formation of complexes which include the polypeptide, hence providing a means for indirect detection of the polypeptide level. The method involves providing a biological sample from a subject, measuring the level of a polypeptide complex of the invention in the sample, and comparing the level to the level of complex in a reference sample having known polypeptide expression. A higher or lower complex level in the sample versus the reference indicates altered expression of either of the polypeptides that forms the complex. The detection of altered expression of a polypeptide can be use to diagnose a given disease state, and or used to identify a subject with a predisposition for a disease state. Any suitable reference sample may be employed, but preferably the test sample and the reference sample are derived from the same medium, e.g. both are urine, etc. The reference sample should be suitably representative of the level polypeptide expressed in a control population.

The invention further provides methods for treating or preventing a disease or disorder involving altered levels of a polypeptide complex, or polypeptide, disclosed herein, by administering to a subject a therapeutically-effective amount of at least one molecule that modulates the function of the complex. As discussed above, altered levels of polypeptide complexes described herein may be implicated in disease states resulting from a deviation in normal function of the pathway in which a complex is implicated. For example, altered levels of the observed complex between E6 or E7 and DLG tumor suppressor or Ubiquitin protease 9 may be implicated in abrogation of p53 interactions. In subjects with a deleteriously high level of complex, modulation may consist, for example, by administering an agent which disrupts the complex, or an agent which does not disrupt, but down-regulates, the functional activity of the complex. Alternatively, modulation in subjects with a deleteriously low level of complex may be achieved by pharmaceutical administration of complex, constituent polypeptide, or an agent which up-regulates the functional activity of complex. Pharmaceutical preparations suitable for administration of complex are described above.

In one embodiment, a disease or disorder involving altered levels of a polypeptide selected from the polypeptides recited in Tables 1 through 7 or the corresponding polypeptides in columns 2 or 5, are treated by administering a molecule that modulates the function of the polypeptide. In certain embodiments, the modulating molecule is the corresponding polypeptide, e.g. administering a “prey” protein corresponding to a “bait” protein modulates the latter by forming a complex with it.

The details of one or more embodiments of the invention are set forth in the description above. Although any methods and materials similar or equivalent to those described herein can be used in the practice of the present invention, the preferred methods and materials are now described. For example, additional interactions can be identified using other two-hybrid systems (i.e. using a LexA binding domain fusion or HIS3 as a reporter gene), including variables such as different protein domains or genomic activation domain libraries. Other features, objects, and advantages of the invention will be apparent from the description and from the claims.

The practice of the present invention generally employs conventional techniques of molecular biology, microbiology, recombinant DNA, and immunology, which are within the skill of the art. Such techniques are explained fully in the literature. See for example J. Sambrook et al., “Molecular Cloning; A Laboratory Manual” (1989); “DNA Cloning”, Vol. I and II (D. N. Glover ed., 1985); “Oligonucleotide Synthesis” (M. J. Gait ed., 1984); “Nucleic Acid Hybridization” (B. D. Hames and S. J. Higgins eds., 1984); “Transcription and Translation” (B. D. Hames & S. J. Higgins eds., 1984); “Animal Cell Culture” (R. I. Freshney ed., 1986); “Immobilized Cells and Enzymes” (IRL Press, 1986); “A Practical Guide to Molecular Cloning” (B. Perbal, 1984); the series, “Methods in Enzymology” (Academic Press, Inc.); “Gene Transfer Vectors for Mammalian Cells” (J. H. Miller and M. P. Calos eds., 1987, Cold Spring Harbor Laboratory); Meth. Enzymol. (1987) 154 and 155 (Wu and Grossman, and Wu eds., respectively); “Immunochemical Methods in Cell and Molecular Biology” (Academic Press, London); “Protein Purification: Principles and Practice”, Third Ed. (Scopes, Springer-Verlag, N.Y., 1994); and “Handbook of Experimental Immunology”, Volumes I-IV (Weir and Blackwell, eds., 1986).

The following examples are presented in order to more fully illustrate the preferred embodiments of the invention. These examples should in no way be construed as limiting the scope of the invention, as defined by the appended claims.

EXAMPLE 1 SeqCalling™ Technology

cDNA was derived from various human samples representing multiple tissue types, normal and diseased states, physiological states, and developmental states from different donors. Samples were obtained as whole tissue, primary cells or tissue cultured primary cells or cell lines. Cells and cell lines may have been treated with biological or chemical agents that regulate gene expression, for example, growth factors, chemokines or steroids. The cDNA thus derived was then sequenced using CuraGen's proprietary SeqCalling technology. Sequence traces were evaluated manually and edited for corrections if appropriate. cDNA sequences from all samples were assembled together, sometimes including public human sequences, using bioinformatic programs to produce a consensus sequence for each assembly. Each assembly was included in CuraGen Corporation's database. Sequences were included as components for assembly when the extent of identity with another component was at least 95% over 50 bp. Each assembly represents a gene or portion thereof and includes information on variants, such as splice forms single nucleotide polymorphisms (SNPs), insertions, deletions and other sequence variations.

EXAMPLE 2 Identifying Nucleic Acids and Proteins by PathCalling™

The sequences of the HPV proteins and interactors in this application were derived by laboratory cloning of cDNA fragments and by in silico prediction of the sequence as described in Example A. cDNA fragments covering either the full length of the DNA sequence, or part of the sequence, or both, were cloned. In silico prediction was based on sequences available in CuraGen's proprietary sequence databases or in the public human sequence databases, and provided either the full-length DNA sequence, or some portion thereof.

cDNA libraries were derived from various human samples representing multiple tissue types, normal and diseased states, physiological states, and developmental states from different donors. Samples were obtained as whole tissue, primary cells or tissue cultured primary cells or cell lines. Cells and cell lines may have been treated with biological or chemical agents that regulate gene expression, for example, growth factors, chemokines or steroids.

Preparation of Yeast Cells

Yeast lysates were produced as follows: 1-1.5 ml samples from a yeast culture were removed, samples were frozen on dry ice. On ice, low-salt lysis Buffer was added to the cell pellets. Glass beads were added, the cells were resuspended by a brief vortexing. The cells were lysed by beating the beads for 90 sec. The lysate was placed on ice for 5 min and the beads beaten again for 90 sec. The sample were put back on ice. Once the lysate was recovered free of beads, the lysate was centrifuge at maximum speed in a microcentrifuge for 3 to 5 min at 4° C. and put back on ice. 25 to 50 μl were removed from the supernatant and mixed with an equal volume of 2× Protein Sample Buffer then saved for Western analysis.

Immunoprecipitation from Yeast

The lysate samples were thawed and the desired volume (based on the protein concentration) were put into a fresh microcentrifuge tube. All the samples were made into the same volume with fresh low-salt lysis Buffer. Antibody was diluted in Low-Salt Lysis Buffer (10 μl per sample) and mixed by vortexing. This was incubated on ice for 30 min.

ProteinA-Sepharose/Antibody Binding

Protein A-Sepharose beads were equilibrated with low-salt lysis Buffer by suspending the beads in low-salt Buffer, centrifuging briefly to sediment the beads and removing the supernatant. This equilibration was repeated then a wash step was peformed for 2 or 3 times. The Buffer-equilibrated beads were aliquoted into fresh 0.5 ml microcentrifuge tubes making sure that all the tubes had an equal amount of beads. The antibody/extract mixture was centrifuged in a microcentrifuge at full speed for 1 min at 4° C. The supernatant was recovered and added to the proteinA-Sepharose. The mixture was mixed in an end-over-end rotator for 1 to 2 hr at 4° C. then centrifuged briefly in a microcentrifuge (bringing the centrifuge up to full speed and then back down). The supernatant was removed. Keeping the samples on ice as much as possible, the beads were washed by adding 400 μl of bead Buffer. The beads were resuspended and centrifuged again. The supernatant was removed. The beads were resuspended in bead Buffer and the mixture transferred to a fresh tube. The old tube was rinsed with more bead-Buffer to recover residual beads to the new tube. The beads were centrifuged, the supernatant removed and the beads washed with Bead Buffer.

If the immunoprecipitate is only for analysis of radio-labeled proteins bound, the beads can be simply resuspended in protein sample Buffer, boiled for 90 sec and electrophoresed. If an enzymatic assay of some sort is involved, the beads should be washed in the reaction Buffer 1 or 2 times.

In cases where interactions cannot be validated in the yeast system, the interacting proteins are tagged with different epitopes at the N or the C-terminus and expressed in appropriate mammalian cell lines by transient transfection. The cells are grown for 48-72 h, lysed, and the substrate protein is immunoprecipitated using antibody specific to the epitope and analyzed by western blotting as described for the yeast system.

EXAMPLE 3 Yeast 2 Hybrid Analysis of Interactions

The cDNA thus derived was then directionally cloned into the appropriate two-hybrid vector (Gal4-activation domain (Gal4-AD) fusion). Such cDNA libraries as well as commercially available cDNA libraries from Clontech (Palo Alto, Calif.) were then transferred from E. coli into a CuraGen Corporation proprietary yeast strain (disclosed in U.S. Pat. Nos. 6,057,101 and 6,083,693, incorporated herein by reference in their entireties).

Gal4-binding domain (Gal4-BD) fusions of a CuraGen Corporation proprietary library of human sequences was used to screen multiple Gal4-AD fusion cDNA libraries resulting in the selection of yeast hybrid diploids in each of which the Gal4-AD fusion contains an individual cDNA. Each sample was amplified using the polymerase chain reaction (PCR) using non-specific primers at the cDNA insert boundaries.

Physical clone: the cDNA fragment derived by the screening procedure is a recombinant DNA covering the entire open reading frame. The cDNA was cloned into pACT2 plasmid (Clontech) and used to make the cDNA library. The recombinant plasmid was inserted into the host and selected by the yeast hybrid diploid generated during the screening procedure by the mating of both CuraGen Corporation proprietary yeast strains N₁O₆′ and YULH (U.S. Pat. Nos. 6,057,101 and 6,083,693) to provide the clones.

Interaction protein pairs are added to CuraGen's PathCalling™ Protein Interaction Database. This database allows for the discovery of novel pharmaceutical drug targets by virtue of their interactions and/or presence in pathologically related signaling pathways. Protein interactions are subsequently analyzed using bioinformatic tools within GeneScape™, which provides a means of visualization of binary protein interactions, protein complex formation, as well as complete cellular signaling pathways. Specifically, the sequences, which encode proteins identified by INT ID in Tables 1 through 3 were found to interact and resulted in the formation of a protein complex within a series of complexes resulting in identification of a protein interaction. The interaction is specifically relevant to HPV pathology. The specific interactions, which constitute the specific complexes, is useful for therapeutic intervention through the use of recombinant protein or antibody therapies, small molecule drugs, or gene therapy approaches. Protein interactions, which are identified through the mining of the PathCalling™ database, can be screened in vitro and in vivo to provide expression, functional, biochemical, and phenotypic information. Assays for expression, functional, biochemical, phenotypic, diagnostic, prognostic, monitoring of HPV-induced tumors' and/or lesions' response to therapy, immunization, therapeutic immunization, immunotherapy, tumor burden monitoring, ELISA assay to determine if an infection is active or latent, and the like may be used alone or in conjunction and include, but are not limited to the following technologies; RTQ-PCR, transfection of recombinant proteins, co-immunoprecipitation and mass spectrometry, FRET, Affinity Chromatography, Immunohistochemisty or Immunocytochemistry, gene CHIP hybridizations, antisense (i.e. knock-down, knock-up), GeneCalling experiments, and/or biochemical assays (phosphorylation, dephosphorylation, protease, etc . . . ).

Example D Protein-Protein Interactions

The amino acid sequences of the polypeptides involved in the novel protein-protein interactions and the nucleic acid sequences of the polynucleotides which encode them are listed below.

Protein SEQ IDs: TABLE 10 cbe_1380530 RPL13 ribosomal protein L13 length = 211 MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVR SEQ ID NO: 1 CPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQTNVQRLKEY RSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFA SLRMARANARLFGIRAKRAKEAAEQDVEKKK

TABLE 11 cbe_1469980 FLJ20259 hypothetical protein FLJ20259 length = 776 MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGN SEQ ID NO: 2 CIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQVQVQQSPQQVSAQLS PQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQI QAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTAS VLQPVKKRKVEMPITVSYAISGQPVATVLAIPQGQQQSYVSLRPDLLTVDSAHLYSATGT ITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEK MVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQ QPQQQTPQEQTPPPQQQQQQLQVTCSAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLE VWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEG EPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLP SHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSN PKDKSTSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGR NDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAIAVANASTMH

TABLE 12 cbe_1505425 HCDI HCDI protein length = 319 MGWRRKRVPQRGRKAPPPQLHGNINNLYFPIRWRDRLHWDSPNPAAECQRHEVTLVSRKP SEQ ID NO: 3 GPGRITWDELAASGLPSCDAAVNLAGENILNPLRRWNETFQKEVLGSRLETTQLLAKAIT KAPQPPKAWVLVTGVAYYQPSLTAEYDEDSPGGDFDFFSNLVTKWEAAARLPGDSTRQVV VRSGVVLGRGGGAMGHMLLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGV LNGVAPSSATNAEFAQTLGAALGRRAFIPLPSAVVQAVFGRQRAIMLLEGQKVIPQRTLA TGYQYSFPELGAALKEIVA

TABLE 13 cbe_1710 QP-C low molecular mass ubiquinone-binding protein (9.5 kD) length = 93 MGREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIY SEQ ID NO: 4 TWGTEEFERSKRRIQLPMKMTNEQRIRMTVPCL

TABLE 14 cbe_1796502 CTNND2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) length = 1225 MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQEL SEQ ID NO: 5 QFERLTRELEAERQIVASQLERCKLGSETGSMSSMSSAEEQFQWQSQDGQKDIEDELTTG LELVDSCIRSLQESGILDPQDYSTCERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLAL GETTPSQLPARGTQARATGQSFSQGTTSPAGHLAGPEPAPPPPPPPREPFAPSLGSAFHL PDAPPAAAAAALYYSSSTLPAPPRGGSPLAAPQGGSPTKLQRGGSAPEGATYAAPRGSSP KQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLS PTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHI DPIYEDRVYQKPPMRSLSQSQCDPLPPAHTGTYRTSTAPSSPGVDSVPLQRTGSQHGPQN AAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQK DPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDL LDHRMTEVHRSACGALRNLVYGKANDDNKIALKWCGGIPALVRLLRKTTDLEIRELVTGV LWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLR NVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETS QGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQM LWHPSIVKPYLTLLSECSNPDTLEGAACALQNLAAGSWKWSVYIRAAVRKEKGLPILVEL LRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKANSDDTV TAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYR DLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREM ISLKERKTDYECTGSNATYHGAKGEHTSRKDANTAQNTGISTLYRNSYGAPAEDIKHNQV SAQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDF YSAARPYSELNYETSHYPASPDSWV

TABLE 15 cbe_1807361 FLJ22729 hypothetical protein FLJ22729 length = 158 MRGIYSSSVYLEEISSIISKMPKADFYVLEKTGLSIQNSSLFPILLHFHIMEANLYALLN SEQ ID NO: 6 KTFAQDGQHQVLSMNRNAVGKHFELMIGDSRTSGKELVKQFLFDSILKADPRVFFPSDKI VHYRQMFLSTELQRVEELYDSLLQAIAFYELAVFDSQP

TABLE 16 cbe_2253980 Prey1135 Homo sapiens, clone MGC: 14302, mRNA, complete cds. length = 24 MHYSPDASTAFSSIAHITRDVNYG SEQ ID NO: 7

TABLE 17 cbe_244811 DGUOK deoxyguanosine kinase length = 189 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK SEQ ID NO: 8 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK VQLEPFPEKLLQARKPVQIFERSVYSDRLHFEALMNIPVLVLDVNDDFSEEVTKQEDLMR EVNTFVKNL

TABLE 18 cbe_250777 HPV 11 E4 Human papillomavirus 11 E4 length = 108 MVVPIIGKYVMAAQLYVLLHLYLALYEKYPLLNLLHTPPHRPPPLQCPPAPRKTACRRRL SEQ ID NO: 9 GSEHVDRPLTTPCVWPTSDPWTVQSTTSSLTITTSTKEGTTVTVQLRL

TABLE 19 cbe_250781 HPV 11 E2 Human papillomavirus 11 E2 length = 367 MEAIAKRLDACQDQLLELYEENSIDIHKHIMHWKCIRLESVLLHKAKQMGLSHIGLQVVP SEQ ID NO: 10 PLTVSETKGHNAIEMQMHLESLAKTQYGVEPWTLQDTSYEMWLTPPKRCFKKQGNTVEVK FDGCEDNVMEYVVWTHIYLQDNDSWVKVTSSVDAKGIYYTCGQFKTYYVNFNKEAQKYGS TNHWEVCYGSTVICSPASVSSTVREVSIAEPTTYTPAQTTAPTVSACTTEDGVSAPPRKR ARGPSTNNTLCVANIRSVDSTINNIVTDNYNKHQRRNNCHSAATPIVQLQGDSNCLKCFR YRLNDKYKHLFELASSTWHWASPEAPHKNAIVTLTYSSEEQRQQFLNSVKIPPTIRHKVG FMSLHLL

TABLE 20 cbe_250808 HPV 11 E6 Human papillomavirus 11 E6 length = 150 MESKDASTSATSIDQLCKTFNLSLHTLQIQCVFCRNALTTAEIYAYAYKNLKVVWRDNFP SEQ ID NO: 11 FAACACCLELQGKINQYRHFNYAAYAPTVEEETNEDILKVLIRCYLCHKPLCEIEKLKHI LGKARFIKLNNQWKGRCLHCWTTCMEDLLP

TABLE 21 cbe_250834 HPV 11 E7 Human papillomavirus 11 E7 length = 98 MHGRLVTLKDIVLDLQPPDPVGLHCYEQLEDSSEDEVDKVDKQDAQPLTQHYQILTCCCG SEQ ID NO: 12 CDSNVRLVVECTDGDIRQLQDLLLGTLNIVCPICAPKP

TABLE 22 cbe_251059 HPV 16 E1-E4 HPV 16 E1-E4 length = 92 MADPAAATKYPLLKLLGSTWPTTPPRPIPKPSPWAPKKHRRLSSDQDQSQTPETPATPLS SEQ ID NO: 13 CCTETQWTVLQSSLHLTAHTKDGLTVIVTLHP

TABLE 23 cbe_251063 HPV 16 E1 Human papillomavirus 16 E1 length = 649 MADPAGTNGEEGTGCNGWFYVEAVVEKKTGDAISDDENENDSDTGEDLVDFIVNDNDYLT SEQ ID NO: 14 QAETETAHALFTAQEAKQHRDAVQVLKRKYLGSPLSDISGCVDNNISPRLKAICIEKQSR AAKRRLFESEDSGYGNTEVETQQMLQVEGRHETETPCSQYSGGSGGGCSQYSSGSGGEGV SERHTICQTPLTNILNVLKTSNAKAAMLAKFKELYGVSFSELVRPFKSNKSTCCDWCIAA FGLTPSIADSIKTLLQQYCLYLHIQSLACSWGMVVLLLVRYKCGKNRETIEKLLSKLLCV SPMCMMIEPPKLRSTAAALYWYKTGISNISEVYGDTPEWIQRQTVLQHSFNDCTFELSQM VQWAYDNDIVDDSEIAYKYAQLADTNSNASAFLKSNSQAKIVKDCATMCRHYKRAEKKQM SMSQWIKYRCDRVDDGGDWKQIVMFLRYQGVEFMSFLTALKRFLQGIPKKNCILLYGAAN TGKSLFGMSLMKFLQGSVICFVNSKSHFWLQPLADAKIGMLDDATVPCWNYIDDNLRNAL DGNLVSMDVKHRPLVQLKCPPLLITSNINAGTDSRWPYLHNRLVVFTFPNEFPFDENGNP VYELNDKNWKSFFSRTWSRLSLHEDEDKENDGDSLPTFKCVSGQNTNTL

TABLE 24 cbe_251088 HPV 16 E2 Human papillomavirus 16 E2 length = 365 METLCQRLNVCQDKILTHYENDSTDLRDHIDYWKHMRLECAIYYKAREMGFKHINHQVVP SEQ ID NO: 15 TLAVSKNKALQAIELQLTLETIYNSQYSNEKWTLQDVSLEVYLTAPTGCIKKHGYTVEVQ FDGDICNTMHYTNWTHIYICEEASVTVVEGQVDYYGLYYVHEGIRTYFVQFKDDAEKYSK NKVWEVHAGGQVILCPTSVFSSNEVSSPEIIRQHLANHPAATHTKAVALGTEETQTTIQR PRSEPDTGNPCHTTKLLHRDSVDSAPILTAFNSSHKGRINCNSNTTPIVHLKGDANTLKC LRYRFKKHCTLYTAVSSTWHWTGHNVKHKSAIVTLTYDSEWQRDQFLSQVKIPKTITVST GFMSI

TABLE 25 cbe_251445 HPV 16 E6 Human papillomavirus 16 E6 length = 158 MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIV SEQ ID NO: 16 YRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPE EKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL

TABLE 26 cbe_251448 HPV 16 E7 Human papillomavirus 16 E7 length = 98 MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCK SEQ ID NO: 17 CDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP

TABLE 27 cbe_251663 HPV 11 E1 Human papillomavirus 11 E1 length = 649 MADDSGTENEGSGCTGWFMVEAIVEHTTGTQISEDEEEEVEDSGYDMVDFIDDRHITQNS SEQ ID NO: 18 VEAQALFNRQEADAHYATVQDLKRKYLGSPYVSPISNVANAVESEISPRLDAIKLTTQPK KVKRRLFETRELTDSGYGYSEVEAATQVEKHGDPENGGDGQERDTGRDIEGEGVEHREAE AVDDSTREHADTSGILELLKCKDIRSTLHGKFKDCFGLSFVDLIRPFKSDRTTCADWVVA GFGIHHSIADAFQKLIEPLSLYAHIQWLTNAWGMVLLVLIRFKVNKSRCTVARTLGTLLN IPENHMLIEPPKIQSGVRALYWFRTGISNASTVIGEAPEWITRQTVIEHSLADSQFKLTE MVQWAYDNDICEESEIAFEYAQRGDFDSNARAFLNSNMQAKYVKDCAIMCRHYKHAEMKK MSIKQWIKYRGTKVDSVGNWKPIVQFLRHQNIEFIPFLSKLKLWLHGTPKKNCIAIVGPP DTGKSCFCMSLIKFLGGTVISYVNSCSHFWLQPLTDAKVALLDDATQPCWTYMDTYMRNL LDGNPMSIDRKHRALTLIKCPPLLVTSNIDISKEEKYKYLHSRVTTFTFPNPFPFDRNGN AVYELSDANWKCFFERLSSSLDIEDSEDEEDGSNSQAFRCVPGSVVRTL

TABLE 28 cbe_251737 HPV 16 L2 Human papillomavirus 16 L2 length = 473 MRHKRSAKRTKRASATQLYKTCKQAGTCPPDIIPKVEGKTIAVQILQYGSMGVFFGGLGI SEQ ID NO: 19 GTGSGTGGRTGYIPLGTRPPTATDTLAPVRPPLTVDPVGPSDPSIVSLVEETSFIDAGAP TSVPSIPPDVSGFSITTSTDTTPAILDINNTVTTVTTHNNPTFTDPSVLQPPTPAETGGH FTLSSSTISTHNYEEIPMDTFIVSTNPNTVTSSTPIPGSRPVARLGLYSRTTQQVKVVDP AFVTTPTKLITYDNPAYEGIDVDNTLYFSSNDNSINIAPDPDFLDIVALHRPALTSRRTG IRYSRIGNKQTLRTRSGKSIGAKVHYYYDLSTIDPAEEIELQTITPSTYTTTSHAASPTS INNGLYDIYADDFITDTSTTPVPSVPSTSLSGYIPANTTIPFGGAYNIPLVSGPDIPINI TDQAPSLIPIVPGSPQYTIIADAGDFYLHPSYYMLRKRRKRLPYFFSDVSLAA

TABLE 29 cbe_251740 HPV 1a E1-E4 Human Papillomavirus 1a E1-E4 length = 125 MADNKAPQGLLGLLQYTPTTQPYPRVTPPSNRRPSTTPNSQDRGRPRRSDKDSRKHLYAD SEQ ID NO: 20 GLTDGEDPEVPEVEDEEKENQRPLGHPDLSLLRETLEVYTQRLKRDILQDLDDFCRKLGI HPWSV

TABLE 30 cbe_251784 HPV 16 L1 Human papillomavirus 16 L1 length = 531 MQVTFIYILVITCYENDVNVYHIFFQMSLWLPSEATVYLPPVPVSKVVSTDEYVARTNIY SEQ ID NO: 21 YHAGTSRLLAVGHPYFPIKKPNNNKILVPKVSGLQYRVFRIHLPDPNKFGFPDTSFYNPD TQRLVWACVGVEVGRGQPLGVGISGHPLLNKLDDTENASAYAANAGVDNRECISMDYKQT QLCLIGCKPPIGEHWOKGSPCTNVAVNPGDCPPLELINTVIQDGDMVHTGFGANDFTTLQ ANKSEVPLDICTSICKYPDYIKMVSEPYGDSLFFYLRREQMFVRHLFNRAGTVGENVPDD LYIKGSGSTANLASSNYFPTPSGSMVTSDAQIFNKPYWLQRAQCHNNGICWGNQLFVTVV DTTRSTNMSLCAAISTSETTYKNTNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYIHSM NSTILEDWNFGLQPPPGGTLEDTYRFVTQAIACQKHTPPAPKEDDPLKKYTFWEVNLKEK FSADLDQFPLGRKFLLQAGLKAKPKFTLGKRKATPTTSSTSTTAKRKKRIKL

TABLE 31 cbe_251917 HPV 1a E2 Human Papillomavirus 1a E2 length = 401 MENLSSRLDLLQEQLMNLYEQDSKLIEDQIKQWNLIRQEQVLFHFARKNGVMRIGLQAVP SEQ ID NO: 22 SLASSQEKAKTAIEMVLHLESLKDSPYGTEDWSLQDTSRELFLAPPAGTFKKSGSTLEVT YDNNPDNQTRHTIWNHVYYQNGDDVWRKVSSGVDAVGVYYLEHDGYKNYYVLFAEEASKY STTGQYAVNYRGKRFTNVMSSTSSPRAAGAPAVHSDYPTLSESDTAQQSTSIDYTELPGQ GETSQVRQRQQKTPVRRRPYGRRRSRSPRGGGRREGESTPSRTPGSVPSARDVGSIHTTP QKGHSSRLRRLLQEAWDPPVVCVKGGANQLKCLRYRLKASTQVDFDSTSTTWHWTDRKNT ERIGSARMLVKFIDEAQREKFLERVALPRSVSVFLGQFNGS

TABLE 32 cbe_251919 HPV 1a E6 Human Papillomavirus 1a E6 length = 140 MATPIRTVRQLSESLCIPYIDVLLPCNFCNYFLSNAEKLLFDHFDLHLVWRDNLVFGCCQ SEQ ID NO: 23 GCARTVSLLEFVLYYQESYEVPEIEElLDRPLLQIELRCVTCIKKLSVAEKLEVVSNGER VHRVRNRLKAKCSLCRLYAI

TABLE 33 cbe_251925 HPV 1a E7 Human Papillomavirus 1a E7 length = 93 MVGEMPALKDLVLQLEPSVLDLDLYCYEEVPPDDIEEELVSPQQPYAVVASCAYCEKLVR SEQ ID NO: 24 LTVLADHSAIRQLEELLLRSLNIVCPLCTLQRQ

TABLE 34 cbe_251976 FLJ23584 hypothetical protein FLJ23584 length = 234 MNPVPHWGEVFLLVGGEGEHLASQGTTPARDHRVGTSPASQQAQPESWRRRQRDKGVDPE SEQ ID NO: 25 KAPSLTRQSQNPPSLTAPLGMPSACSCLPCGPAPEAAIILAGPPTALTVLPKGTGLKKSK RLLLESLMRRRIAHLKWGLPRRILESYFLFNFLGSCSLTLAGARISGLNTGQELQAQQER YCEAQGSPPGLKSPERFQRVQRPDRKSSKLPIQARALERNRPHMSEPIKHFHPA

TABLE 35 cbe_252016 HPV 1a L1 Human Papillomavirus 1a L1 length = 508 MYNVFQMAVWLPAQNKFYLPPQPITRILSTDEYVTRTNLFYHATSERLLLVGHPLFEISS SEQ ID NO: 26 NQTVTIPKVSPNAFRVFRVRFADPNRFAFGDKAIFNPETERLVWGLRGIEIGRGQPLGIG ITGHPLLNKLDDAENPTNYINTHANGDSRQNTAFDAKQTQMFLVGCTPASGEHWTSSRCP GEQVKLGDCPRVQMIESVIEDCDMMDIGFGAMDFAALQQDKSDVPLDVVQATCKYPDYIR MNHEAYGNSMFFFARREQMYTRHFFTRGGSVGDKEAVPQSLYLTADAEPRTTLATTNYVG TPSGSMVSSDVQLFNRSYWLQRCQGQNNGICWRNQLFITVGDNTRGTSLSISMKNNASTT YSNANFNDFLRHTEEFDLSFIVQLCKVKLTPENLAYIHTMDPNILEDWQLSVSQPPTNPL EDQYRFLGSSLAAKCPEQAPPEPQTDPYSQYKFWEVDLTERMSEQLDQFPLGRKFLYQSG MTQRTATSSTTKRKTVRVSTSAKRRRKA

TABLE 36 cbe_252041 HPV 1a L2 Human Papillomavirus 1a L2 length = 507 MYRLRRKRAAPKDIYPSCKISNTCPPDIQNKIEHTTIADKILQYGSLGVFLGGLGIGTAR SEQ ID NO: 27 GSGGRIGYTPLGEGGGVRVATRPTPVRPTIPVETVGPSEIFPIDVVDPTGPAVIPLQDLG RDFPIPTVQVIAEIHPISDIPNIVASSTNEGESAILDVLRGNATIRTVSRTQYNNPSFTV ASTSNISAGEASTSDIVFVSNGSGDRVVGEDIPLVELNLGLETDTSSVVQETAFSSSTPI AERPSFRPSRFYNRRLYEQVQVQDPRFVEQPQSMVTFDNpAFEPELDEVSIIFQRDLDAL AQTPVPEFRDXIVYLSKPTFSREPGGRLRVSRLGKSSTRTRLGTAIGARTHFFYDLSSIA PEDSIELLPLGEHSQTTVISSNLGDTAFIQGETAEDDLEVISLETPQLYSEEELLDTNES VGENLQLTITNSEGEVSILDLTQSRVRPPFGTEDTSLHVYYPNSSKGTPIINPEESFTPL VIIALNNSTGDFELHPSLRKRRKRAYV

TABLE 37 cbe_2685998 Prey2313 Homo sapiens, clone IMAGE: 3625550, mRNA, partial cds. length = 361 AICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDREEEEEDGEEEEVEAVGAGA SEQ ID NO: 28 GWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRSSWDNMDYVWEEEDEEEDLDYYLGDM EEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQ LANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSV VPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRL TRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQ V

TABLE 38 cbe_2826346 RPS10 ribosomal protein S10 length = 165 MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKE SEQ ID NO: 29 QFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRG EADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ

TABLE 39 cbe_2830508 Prey292051 Homo sapiens, clone MGC: 12344, mRNA, complete cds. length = 20 MQLKTLSLATPPRETAVINL SEQ ID NO: 30

TABLE 40 cbe_3001381 IRF1 interferon regulatory factor 1 length = 325 MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAI SEQ ID NO: 31 HTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQR KERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLPDDHSSYTVPGYMQDLEVEQALT PALSPCAVSSTLPDWHIPVEVVPDSTSDLYNFQVSPMPSTSEATTDEDEEGKLPEDIMKL LEQSEWQPTNVDGKGYLLNEPGVQPTSVYGDFSCKEEPEIDSPGGDIGLSLQRVFTDLKN MDATWLDSLLTPVRLPSIQAIPCAP

TABLE 41 cbe_3056756 KIAA0440 signal-induced proliferation-associated 1 like 1 length = 1804 MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSE SEQ ID NO: 32 GSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGS SVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITI SELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTP TKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLR NAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTT TGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNE IGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRY IVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFR TSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLM KLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQ LDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGA QPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVF RDFLIAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASK KKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCS CRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNG LGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTV KVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQ VPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMA LARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKS TPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRL MRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQ GTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETE SHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSA RSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFM DTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKF HALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYP SLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWS NLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASK VDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNT IDMS

TABLE 42 cbe_3340492 TRIP TRAF interacting protein length = 469 MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQSFETAPSRTCPQCRIQVGKRTIIN SEQ ID NO: 33 KLFFDLAQEEENVLDREFLKNELDNVRAQLSQKDKEKRDSQVIIDTLRDTLEERNATVVS LQQALGKAEMLCSTLKKQMKYLEQQQDETKQAQEEAGRLRSKMKTMEQIELLLQSQLPEV EEMIRDMGVGQSAVEQLAVYCVSLKKEYENLKEARKASGEVADKLRKDLFSSRSKLQTVY SELDQAKLELKSAQKDLQSADKEIMSLKKKLTMLQETLNLPPVASETVDRLVLESPAPVE VNLKLRRPSFRDDIDLNATFDVDTPPARPSSSQHGYYEKLCLEKSHSPIQDVPKKICKGP RKESQLSLGGQSCAGEPDEELVGAFPIFVRNAILGQKQPKRPRSESSCSKDVVRTGFDGL GGRTKFIQPTDTVMIRPLPVKPKTKVKQRVRVKTVPSLFQAKLDTFLWS

TABLE 43 cbe_3345510 COX6C cytochrome c oxidase subunit VIc length = 75 MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMK SEQ ID NO: 34 DFEEMRKAGIFQSVK

TABLE 44 cbe_3454406 gbh_af252829 Homo sapiens chromosome 8 clone BAC 495D4 map 8q24, *** SEQUENCING length = 338 MGKKQNRKTGNSKTQSTSPPPKERSSSPATDQSWMENDFDELREEGFRRSNYSELREDIQ SEQ ID NO: 35 TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELREECRSLRSQCDQLEERVSA MEDEMNEMKQEGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDAENGTKLENTLQD IIQETFPNLARQANVQIQEIQRTPQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV TLKGKPIRLTADLSAETLQARREWCPILNILKEKNFQPRISYPAKLSFISEGEIKYFTDK QMLTDFVTSRPALKELLKEALNMERNNRYQPLQNHAKM

TABLE 45 cbe_3461331 MET met proto-oncogene (hepatocyte growth factor receptor) length = 1408 MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNNKYQLPNFTAETPIQNVILEEN SEQ ID NO: 36 HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTALIQSEVHCIFSPQIEEPSQCPDCVVSAW GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFNFLTDQSYIDVLPE FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEFMDRS ANCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF TTALQRVDLFMGQFSEVLLTSISTEIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT SISPKYGPNAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITG VGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFM LDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGWSIS TALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVD YRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPEL VQAVQHVVICPSSLIVHFNEVICRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDICEVS QFLTEGIIMKDPSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLI GFGLQVAKAMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTG AKLPVKWMALESLQTQKFTTKSDVWSFGVVLWELMTRGAPPYPDVNTFDITVYLLQGRRL LQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCV APYPSLLSSEDNADDEVDTRPASFWETS

TABLE 46 cbe_3473488 gbh_al121903 Human DNA sequence from clone RP1-155G6 on chromosome 20 Contains length = 641 VGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAI SEQ ID NO: 37 RCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAI DSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRV WVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDN MKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQLA RSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLD VDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELIQTID NIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQESHSF SKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRNYVDENRRDSWEEIQQ RLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQ FDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW

TABLE 47 cbe_3474077 KRT4 keratin 4 length = 534 MIARQQCVRGGPRGFSCGSAIVGGGKRGAFSSVSMSGGAGRCSSGGFGSRSLYNLRGNKS SEQ ID NO: 38 ISMSVAGSRQGACFGGAGGFGTGGFGAGGFGAGFGTGGFGGGFGGSFSGKGGPGFPVCPA GGIQEVTINQSLLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLE TKWNLLQQQTTTTSSKNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTK YEEEINKRTAAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTH VSDTSVVLSMDNNRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGD NLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEA ALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGS TSTGGISGGLGSGSGFGLSSGFGSGSGSGFGFGGSVSGSSSSKIISTTTLNKRR

TABLE 48 cbe_3563252 LOC91689 hypothetical gene supported by AL449243 length = 107 MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSGSVIVTRSGAILPKP SEQ ID NO: 39 VKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

TABLE 49 cbe_3575702 SUI1 putative translation initiation factor length = 113 MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLV SEQ ID NO: 40 KAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLVEIGLAKDDQLKVHGF

TABLE 50 cbe_3580897 HSPA5 heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) length = 654 MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR SEQ ID NO:41 ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL

TABLE 51 cbe_3583511 MGC3222 hypothetical protein MGC3222 length = 255 VVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEES SEQ ID NO:42 REYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHNNPSAMAVESFTATAPFVQIGRF FLSSGLIDKVDNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSG DDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEVSAVPYSYGGGTSMSF LPSSGYLIRSHYQGS

TABLE 52 cbe_3590661 NUP214 nucleoporin 214 kDa length = 2127 MRAAGAEGRKFAVERPGFRGQGRGRQRWLLRHTEGGAMGDEMDAMIPEREMKDFQFRALK SEQ ID NO:43 KVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDK VQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPK GKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADG TLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTL PPAPVLMLLSTDGVLCPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQA PQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVP SVSAPNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFSSASKPAASGP LSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKS LQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTE SDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPL DPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLAN NREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKT TIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDE VSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHG SSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMAS QAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQA KQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGF NFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNT TPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAD DSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAAT STSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATP LPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQS AQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVP PASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSS VFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQV SSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASST PTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFCQGGSVFGGTS AATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGG GFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKP TGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSP LGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGF SGFGSGTGGFSFGSNNSSVQGFGGWRS

TABLE 53 cbe_3606990 Prey1053670 Homo sapiens, Similar to CG5604 gene product, clone MGC:11330, mRNA, complete cds. length = 81 MSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLKLPEYS SEQ ID NO:44 SEEIMRERLLAATMEKGFHLN

TABLE 54 cbe_3621798 XPO1 exportin 1 (CRM1 homolog, yeast) length = 1071 MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAW SEQ ID NO:45 TRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCV EKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFD FSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGY IFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPL NTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEV EETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLM VSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKL HNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAII ASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFV QVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLL PNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNV YKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPL LDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEE YPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTL LQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKIST SLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLV QIKEFAGEDTSDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD

TABLE 55 cbe_3621899 PCNP PEST-containing nuclear protein length = 178 MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAAD SEQ ID NO:46 LPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSE PEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN

TABLE 56 cbe_3625721 EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39 kDa length = 351 MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMEL SEQ ID NO:47 IRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNE DFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKE AARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTIL ANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEG DILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL

TABLE 57 cbe_3641816 ANKH a nkylosis, progressive homolog (mouse) length = 492 MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMK SEQ ID NO:48 FFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHV DESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILL HSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHDIIPDRSGPELGGDATIRKMLSF WWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVY PAFDKNNPSNKLVSTSNTVTAAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVD FAFAELCVVPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLIASLVVLPY LGVHGATLGVGSLLAGFVGESTMVAIAACYVYRKQKKKMENESATEGEDSAMTDMPPTEE VTDIVEMREENE

TABLE 58 cbe_3643627 DKFZP434I1735 DKFZP434I1735 protein length = 1590 VILHPSISVRLAAAWCLHCIAVALPSYLTPLLDRCLERLTGHKSSPEAVTGFSFAVAALL SEQ ID NO:49 GAVKHCPLGIPHGKGKIIMTLAEDLLCSAAQNSRLSAQRTQAGWLLISALMTLGPAVVSH HLARVLLLWKCVFPASPKDLETEKSRGDSFTWQVTLEGRAGALCAIKSFVSHCGDLLTEE VTQRLLPPLPCAVDLLTQLSSILKMYGSPLKTPSVVYRQRLYELLILLPPETYEGNLCAI LRELAADLTAPDIQVAASTFLLPPLCHQDDLLILSPFLQETDHRFIEEQLLLGNGVACGS LEYDPYSIYEKDVEGDSVPKPLPPALSVISSASKLFGVVCAHVGETQRLLILEQLLDSIK HTKGARQQVVQLHVVSSVSSFLKYVAGSKGCLGPEEMKRFALTLVMGALESPNPLLRCAA AESWARLAQMVDDGAFTAGLAQVSFDKLKSARDVVTRTGHSLALGSLHRYLGGISSSQHL NSCIGILYTLAQDSTSPDVQTWALHSLSLIIDSAGPLYYVHVEPTLSLIIMLLLNVPPTH AEVHQSLGRCLNALITTLGPELQGNSTSISTLRTSCLLGCAVMQDNPDCLVQAQAISCLQ QLHMFAPRHVNLSSLVSCLCVNLCSPYLLLRRAVLACLRQLVQREAAEVSEHAVMLAKDS REELTPDANIREVGLEGALLILLDKETDERLCHDIKETLNYMLTSMAVEKLSLWLKLCKD VLAASADFTAVTCVDTMQEEEGDKGDDASVLTTRRDEKSHPFTNPRWATRVFAAECVCRI INQCENANSAHFDIALAQEMKKRDSRNDFLVLHLADLIRMAFMAATDHSDQLRLSGLEML LVVIRRFATVPEPEFPGHVILEQYQANVGAALRPAFTSETPPDVTAKACQVCSAWIASGV VSDLNDLRRVHQLLVSSLTKIQAGKEALSHLYNESASTMEILAVLKAWAEVYIIAVQRHK NHRQPLKTTTCLEDGIRNGSCSSDGLLDLVYADLGTLSRLWLAALQDFALLTLPSEFASQ LPAEGGAFYTAETSENAKLHYYNSWALILHATALWLTSTGFVVADPDEGASNLSRPVTPT SMCQGSSSGATIKSPEDVYTDRFHLILGISVEFLCSLRSDATMESITACLHALQALLDVP WPRSKIGSDQDLGIELLNVLHRVILTRESPSIQLASLEVVRQIICAAQEHVKEKRRSAEV DDGAAEKETLPEFGEGKDTGGLVPGKSLVFATLELCVCILVRQLPELNPKLTGSPGVKAT KPQILLEDGSRLVSAALVILSELPAVCSPEGSISILPTILYLTIGVLRETAVKLPGGQLS STVAASLQALKGILSSPMARAEKSRTAWTDLLRSALTTILDCWDPVDETHQELDEVSLLT AITVFILSTSPEVTTIPCLQKRCIDKFKATLEIKDPVVQIKTYQLLHSIFQYPNPAVSYP YIYSLASCIMEKLQEIDKRKPENTAELEIFQEGIKVLETLVTVAEEHHRAQLVACLLPIL ISFLLDENSLGSATSIMRNLHDFALQNLMQIGPQYSSVFKSLVASSPALKARLEAAIKGN QESVKVKIPTSKYTKSPGKNSSIQLKTSFL

TABLE 59 cbe_3663966 KIAA1389 KIAA1389 protein lenqth = 1514 FSTRYPLSIANYDHKAMVPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLDYVDSAL SEQ ID NO:50 LMGRDRDKPFKRRLKSESVETSLFRKLRTVKSEHETFKFTSELEESRLERGIRPWNCQRC FAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPTGQTGNCESPLGSKEDLN SKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSS HCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGP VAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLPLKE VLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNE TAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPY MPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYS VGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEY LKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPRKDAHLFSIGAIMWHVIARDFGQSA DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKVFYERGECVLLSSVDNC AEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQG SRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLD SEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTPDRLPCQQLLQQAQAAIPRSTS FDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARE REDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASAISAGSAAEGSMGDLSEISSHSSGSHH SGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPP PEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVLSKEDFLKLMLPDSPLVEEGR RKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFGSSRSSVLDQALPNDILFSTTPPYHST LPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEG LDSDEELGLLCHHTSYLDQRVASFCTLTDMQHGQDLEGAQELPLCVDPGSGKEFMDTTGE RSPSPLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATAQLR KFTEWFFTTIDKKS

TABLE 60 cbe_3665307 HK1 hexokinase 1 length = 905 MAKRALRDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP SEQ ID NO: 51 DGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAE CLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKA IKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDE GRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVK MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQ HVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLR RLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMR AEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRT VEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD AGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTC EVGLIVGTGSNACYNEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEY SLNAGKQRYEKNISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIES DRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLD RLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR TEASS

TABLE 61 cbe_3670766 ACTC actin, alpha, cardiac muscle length = 377 MCDDEETTALVCDNGSGLVKACFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA SEQ ID NO: 52 QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS KQEYDEAGPSIVHRKCF

TABLE 62 cbe_3694420 ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2 length = 958 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT SEQ ID NO: 53 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNNRNRTLSVESLIDEEVIYSELMSDFEMD EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES

TABLE 63 cbe_3705944 TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) length = 316 MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGR SEQ ID NO: 54 MEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMC QSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLL KNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVE FPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEETFELRDRVRRIHVKRY STYDDRQLGHQSTHRD

TABLE 64 cbe_3753270 gbh_ac004503 Homo sapiens chromosome 5, P1 clone 1354A7 (LBNL H47), complete length = 515 MALFVRLLALALALALGPAATLAGPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNRK SEQ ID NO: 55 YFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGVVGSTTTQL YTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRV LTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTIT NNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDP EALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVCCSGDMLTINGKAIISNKDILAT NGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSERLTLLAPLNSVF KDGTPPIDAHTRNLLRNHIIKDQLASKYLYHGQTLETLGGKKLRVFVYRNSLCIENSCIA AHDKRGRYGTLFTMDRVLTPPMGTVMDVLKGDNRF

TABLE 65 cbe_3764052 MARK4 MAP/microtubule affinity-regulating kinase 4 length = 381 MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTG SEQ ID NO: 56 VDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDD LDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMT EKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISM EKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLA HLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLM VEMEKKLEKGQSIDDMIPAQK

TABLE 66 cbe_3770440 gbh_af217505 Homo sapiens uncharacterized bone marrow protein BM028 mRNA, length = 116 MWTKKDAGKKVVPCRHDWHQTGGEVTISVYAKNSLPELSRVEANSTLLNVHIVFEGEKEF SEQ ID NO: 57 DQNVKLWGVIDVKRSYVTMTATKIEITMRKAEPMQWASLELPAAKKQEKQKDDTTD

TABLE 67 cbe_3772244 PIGQ phosphatidylinositol glycan, class Q length = 760 MVLKAFFPTCCVSTDSGLLVGRWVPEQSSAVVLAVLHFPFIPIQVKQLLAQVRQASQVGV SEQ ID NO: 58 AVLGTWCHCRQEPEESLGRFLESLGAVFPHEPWLRLCRERGGTFWSCEATHRQAPTAPGA PGEDQVMLIFYDQRQVLLSQLHLPTVLPDRQAGATTASTGGLAAVFDTVARSEVLFRSDR FDEGPVRLSHWQSEGVEASILAELARRASGPICLLLASLLSLVSAVSACRVFKLWPLSFL GSKLSTCEQLRHRLEHLTLIFSTRKAENPAQLMRKANTVASVLLDVALGLMLLSWLHGRS RIGHLADALVPVADHVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLWISYIH LMSPFVEHILWHVGLSACLGLTVALSLLSDIIALLTFHIYCFYVYGARLYCLKIHGLSSL WRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILLFLLPTTALYYLVFTLLRLLVVAV QGLIHLLVDLINSLPLYSLGLRLCRPYRLADKPTALQPRGAHLPPPQLWLPPQALLGRPV PQAVPWGAHLPLEAERGQAGLRELLARLAPPHGHSQPSALPGWHQLSWRMSCALWTLLCA PEHGRPCYHTLGLEVIGSEQMWGWPARLAALHHWHCLPWDPLPTCCGHHGGEHSNPRCPE HCPMPTLCTQVQRVRPPQQPQVECWSPWGLPSGSALAVGVEGPCQDEPPSPRHPLAPSAE QHPASGGLKQSLTPVPSGPGPSLPEPHGVYLRNFPGEVAL

TABLE 68 cbe_3773649 EEF1A1L14 eukaryotic translation elongation factor 1 alpha 1-like 14 length = 398 MQSERGITIDISLWKFETSKYYVTIIDAPGHRDFIQNMITGTSQADCAVLIVAAGVGEFE SEQ ID NO: 59 AGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYN PDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDK PLGLPLQDVYKICGIGTVPVGRVETGVLKPGMVVTFGPVNVTTEVKSVEMHHEALGEALP GDNVGFNVKNVSVKDVRRCNVAGDSKNDPPMEAAGFPAQVIILNHPGQISAGYAPVLDCH TAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGCF AVRDMRQTVAVGVIKAVDKKAACAGKVTKSAQKAQKAK

TABLE 69 cbe_3787129 LOC55828 zinc finger protein ZNF140-like protein length = 478 MSQVTFSDVAIDFSHEEWACLDSAQRDLYKDVMVQNYENLVSVGLSVTKPYVIMLLEDGK SEQ ID NO: 60 EPWMMEKKLSKAYPFPLSHSVPASVNFGFSALFEHCSEVTEIFELSELCVFWVLHFLSNS PNSTVEAFSRSKKKKKKKKKRQCFAFLIYFRLGIKMGKQGIINKEGYLYEDSPQPVTMEK VVKQSYEFSNSNKNLEYTECDTFRSTFHSKSTLSEPQNNSAEGNSHKYDILKKNLSKKSV IKSERINGGKKLLNSNKSGAAFNQSKSLTLPQTCNREKIYTCSECGKAFGKQSILSRHWR IHTGEKPYECRECGKTFSHGSSLTRHQISHSGEKPYKCIECGKAFSHGSSLTNHQSTHTG EKPYECMNCGKSFSRVSLLIQHLRIHTQEKRYECRICGKAFIHSSSLIHHQKSHTGEKPY ECRECGKAFCCSSHLTQHQRIHSMKYKYECNKCLKVFSSFSFLVQHQSIHTEEKPFEV

TABLE 70 cbe_3789063 AP2M1 adaptor-related protein complex 2, mu 1 subunit length = 435 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKR SEQ ID NO: 61 SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGY PQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLES VNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQS IAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTDDIILPFRVIPLVREVGRTK LEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKCKAKYKASENAIVWKIKRMAG MKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIK WVRYIGRSGIYETRC

TABLE 71 cbe_3800240 IVD isovaleryl Coenzyme A dehydrogenase length = 423 MATATRLLGWRVASWRLRPPLAGFVSQRAYSLLPVDDAINGLSEEQRQLRQTMAKFLQEH SEQ ID NO: 62 LAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYCGSGLGYLEHVLVMEEISRASG AVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKA EKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKL DKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLD HTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGV ILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNA DFH

TABLE 72 be_3810032 gbh_af142421 Homo sapiens QUAKING isoform 5 (QUAKING) mRNA, complete cds. length = 337 METKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRVRKDMYNDTLNGS SEQ ID NO: 63 TEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVR GKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAE GEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTP TPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYP IEPSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN

TABLE 73 cbe_3810791 EPHB1 EphB1 length = 984 MALDYLLLLLLASAVAANEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQV SEQ ID NO: 64 CNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSV IATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDY GACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYC NGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPI CTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIIC KKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPP QHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFN SSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLP LIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTY EDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK QRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTS SLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD YRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQ PLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAG HQKKILNSIHSMRVQISQSPTAMA

TABLE 74 cbe_3820530 PGAM1 phosphoglycerate mutase 1 (brain) length = 254 MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGCQALRDAGYEFDICFTSVQ SEQ ID NO: 65 KRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGCLTGLNKAETAAKHGEAQVKIWRRSYD VPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKR VLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVR KANEAVAAQCKAKK

TABLE 75 cbe_3825897 POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa length = 67 MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL SEQ ID NO: 66 NYAPLEK

TABLE 76 cbe_3826540 NYD-TSP1 testis-specific protein NYD-TSP1 length = 430 MASSAKSAEMPTISKTLNPTPDPHQEYLDPRITIALFEIGSHSPSSWGSLPFLKNSSHQV SEQ ID NO: 67 TEQQTAQKFNNLLKEIKDILKNMAGFEEKITEAKELFEETNITEDVSAHKENIRGLDKIN EMLSTNLPVSLAPEKEDNEKKQEMILETNITEDVSAHKENIRGLDKINEMLSTNLPVSLA PEKEDNEKKQQMIMENQNSENTAQVFARDLVNRLEEKKVLNETQQSQEKAKNRLNVQEET MKIRNNMEQLLQEAEHWSKQHTELSKLIKSYQKSQKDISETLGNNGVGFQTQPNNEVSAK HELEEQVKKLSHDTYSLQLMAALLENECQILQQRVEILKELHHQKQGTLQEKPIQINYKQ DKKNQKPSEAKKVEMYKQNKQAMKGTFWKKDRSCRSLDVCLNKKACNTQFNIHVARKALR GKMRSASSLR

TABLE 77 cbe_3833533 TRIM29 tripartite motif-containing 29 length = 588 MEAADASRSNGSSPEARDARSPSGPSGSLENGTKADGKDAKTTNGHGGEAAEGKSLGSAL SEQ ID NO: 68 KPGEGRSALFAGNEWRRPIIQFVESGDDKNSNYFSMDSMEGKRSPYAGLQLGAAKKPPVT FAEKGELRKSIFSESRKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNK QKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQ TCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIK SFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHED KQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNFKDDLLNVC MRHVEKMCKADLSRNFIERNEMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGG VRTSYQPSSPGRFTKETTQKNFNNLYGTKGNYTSRVWEYSSSIQNSDNDLPVVQGSSSFS LKGYPSLMRSQSPKAQPQTWKSGKQTMLSHYRPFYVNKGNGIGSNEAP

TABLE 78 cbe_3834015 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) length = 304 MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADD SEQ ID NO: 69 GPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQE KPDFCFLEEDPGICROYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPN GFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIG KCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKCGLIKTKRKRKKQRVKIAYEEIF VKNM

TABLE 79 cbe_3842044 PSMB3 proteosome (prosome, macropain) subunit, beta type, 3 length = 205 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQLVTTDFQKIFPMGDRLYIGLACLATDV SEQ ID NO: 70 QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV SGMGVIVHIIEKDKITTRTLKARMD

TABLE 80 cbe_3845697 Hs. 191063 Human DNA sequence from clone RP1-63M2 on chromosome 20 Contains the gene for CBFA2T2 (core-binding factor, runt domain, alpha subunit 2; translocated to, 2), part of a gene for a protein similar to ACTIN, the E2F1 (E2F transcription factor 1) gene, a nov length = 412 DRGREVSGRRSRVARRSGAFSPAAGPSPKVASVSGSRRVHRPSSLGRIAVVVDQGSGFTK SEQ ID NO: 71 AGFAGENQPRIVLKSSSLVPSWDRPVLPGAPGCELAGGVAPAHPIKHGVVADWEALEGLW ERLLVGGLRVCPEQWPVLVSDSPLAPPAGRERVAELLFETLAVPACHMASTALLALCSTG AFSGLAVEAGAGVCHATPIYAGHSWHQATFRLNVAGSTLSRYLRDLLVAANPDLLQQALP RKAITHLKKRSCYVSLDFEGDLRDPARHHPASFSVGNGCCVCLSSERFRCPEPIFQPGLL GQAEQGLPALAFRALQKMPKTLRTRLADTVVLAGGSTLFPGFAERLDKELEAQCRRHGYA ALRPHLVAKHGRGMAVWTGGSMVASLHSFQRRWITRAMYQECGSRLLYDVFN

TABLE 81 cbe_3849002 CKLF1 chemokine-like factor 1 length = 152 MDNVQPKIKHRPFCFSVKGHVKMLRLALTVTSMTFFIIAQAPEPYIVITGFEVTVILFFI SEQ ID NO: 72 LLYVLRLDRLMKWLFWPLLDIINSLVTTVFMLIVSVLALIPETTTLTVGGGVFALVTAVC CLADGALIYRKLLFNPSGPYQKKPVHEKKEVL

TABLE 82 cbe_3880186 FLJ20343 hypothetical protein FLJ20343 length = 501 MAQPHTTSVPYFARSPAPPPPSRSGAPPQPPATLRPSRRRTRPPRPADRRDAPADCAYLW SEQ ID NO: 73 RILTPRRGRARRSDVGARHRACGRRDVLLSRQGPANPEGARRVVGGQERVWPAVRRGRCG SMFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPL LAALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELIL HDALRLAYQTDNKKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGMKQEDNAII ElSLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSVEEKANTHLLLGMC LDACARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY IYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEISVQH IREELAELSKKSRPLTNSVKL

TABLE 83 cbe_3884811 RCP Rab coupling protein length = 649 MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERS SEQ ID NO: 74 LGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQCR RKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPT SKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLS FLGGLRSKNDVLSRSNVCINGNHVYLEQPQPTGEIKDSSPSSSPSPKGFRKKTLFSSTEN LAAGSWKEPAEGGGLSTDRDVSESSTKDSLKSMTLPTYRPAPLISGDLREKMAPANSEAT KEAKESKKPESRRSSLLSLMTGKKDVAKGSECENLLTVPGREKEGMLMGVKPGEDASGPA EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP RLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLV LKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGKM

TABLE 84 cbe_4138433 KIFAP3 kinesin-associated protein 3 length = 792 MQGEDARYLKRKVKGGNIDVHPSEKALIVHYEVEATILGEMGDPMLGERKECQKIIRLKS SEQ ID NO: 75 LNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDSLSGKEKKEKSSKPKDPPP FEGMEIDEVANINDMDEYIELLYEDTPDKVRGSALILQLARNPDNLEELLLNETALGALA RVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIGALCMNIIDHELKRHELWQEE LSKKKKAVDEDPENQTLRKDYEKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMR NKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDL LNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNDNYKQIANCVLYHISMDDRFKSMF AYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKD PLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWEL VLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNA QQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDII AEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDL FYNSDGLIASEGAISPDFFNDYHLQNGDVVGQHSFPGSLGMDGFGQPVGILGRPATAYGF RPDEPYYYGYGS

TABLE 85 cbe_4279962 DKKL1-pending soggy-1 gene length = 242 MGEASPPAPARRHLLVLLLLLSTLVIPSAAAPIHDADAQESSLGLTGLQSLLQGFSRLFL SEQ ID NO: 76 KGNLLRGIDSLFSAPMDFRGLPGNYHKEENQEHQLGNNTLSSHLQIDKMTDNKTGEVLIS ENVVASIQPAEGSFEGDLKVPRMEEKEALVPIQKATDSFHTELHPRVAFWIIKLPRRRSH QDALEGGHWLSEKRHRLQAIRDGLRKGTHKDVLEEGTESSSHSRLSPRKTHLLYILRPSR QL

TABLE 86 cbe_4281271 CRYAB crystallin, alpha B length = 175 MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSW SEQ ID NO: 77 FDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHR KYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK

TABLE 87 cbe_4344185 SRA1 steroid receptor RNA activator 1 length = 237 MTRCPAGQAEVEMAELYVKPCNKERGWNDPPQFSYGLQTQAGGPRRSLLTKRVAAPQDGS SEQ ID NO: 78 PRVPASETSPGPPPMGPPPPSSKAPRSPPVGSGPASGVEPTSFPVESEARLMEDVLRPLE QALEDCRGHTRKQVCDDISRRLALLQEQWAGCKLSIPVKKRMALLVQELSSHRWDAADDI HRSLMVDHVTEVSQWMVGVKRLIAEKRSLFSEEAANEEKSAATAEKNHTIPGFQQAS

TABLE 88 cbe_4383836 KIAA0905 yeast Sec31p homolog length = 1220 MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSC SEQ ID NO: 79 ATFSSSHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDK HTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQV QHILASASPSGRATVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPV IQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELP TNTQWCFDIQWCPRNPAVLSAASFDGRISVYSINGGSTDGLRQKQVDKLSSSFGNLDPFG TGQPLPPLQIPQQTAQHSIVLPLKKPPKWIRRPVGASFSFGGKLVTFENVRMPSHQGAEQ QQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQKKIDASQTEFEKNVWSFLKVN FEDDSRGKYLELLGYRKEDLGKKIALALNKVDGANVALKDSDQVAQSDGEESPAAEEQLL GEHIKEEKEESEFLPSSGGTFNISVSGDIDGLITQALLTGNFESAVDLCLHDNRMADAII LAIAGGQELLARTQKKYFAKSQSKITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYA KPDEFSALCDLLGTRLENEGDSLLQTQACLCYICAGNVEKLVACWTKAQDGSHPLSLQDL IEKVVILRKAVQLTQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIM QLRDRLCRAQGEPVAGHESPKIPYEKQQLPKGRPGPVAGHHQMPRVQTQQYYPHGENPPP PGFIMHGNVNPNASGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVA PPTSNAYPNTPYISSASSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGA PPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPKKKKMPENFMPPVPI TSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFS KPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTK RKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSE TSAFMPVLKVVLTQANKLGV

TABLE 89 cbe_4540466 PUM1 pumilio homolog 1 (Drosophila) length = 1186 MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNNPVVLTSGTGSQAQPQPAANQALAAGT SEQ ID NO: 80 HSSPVPGSIGVAGRSQDDANVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEH QVRSMDELNHDFQALALEGPANGEQLLPGKKFWETDESSKDGPKGIFLGDQWRDSAWGTS DHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGF GPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPG NCQNSANEVDLLGPNQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQF DYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLA PAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAA AAAATNSANQQTTPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFG QGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAA AAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNSNSQSSSL FSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRT SSSLTPIGHSFYNGLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNG SGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNR YPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNY VIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGH VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPD QTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASN VVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV MHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII

TABLE 90 cbe_4567083 LOC157378 hypothetical protein BC017881 length = 178 MEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNA SEQ ID NO: 81 IPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALAS RLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKS

TABLE 91 cbe_552975 HPV 1a E1 Human Papillomavirus 1a E1 length = 612 MADNKGTENDWFLVEATDCEETLEETSLGDLDNVSCVSDLSDLLDEAPQSQGNSLELFHK SEQ ID NO: 82 QESLESEQELNALKRKLLYSPQARSADETDIASISPRLETISITKQDKKRYRRQLFSQDD SGLELSLLQDETENIDESTQVDQQQKEHTGEVGAAGVNILKASNIRAALLSRFKDTAGVS FTDLTRSYKSNKTCCGDWVLAVWGVRENLIDSVKELLQTHCVYIQLEHAVTEKNRFLFLL VRFKAQKSRETVIKLITTILPVDASYILSEPPKSRSVAAALFWYKRSMSSTVFTWGTTLE WIAQQTLINHQLDSESPFELCKMVQWAYDNGHTEECKIAYYYAVLADEDENARAFLSSNS QAKYVKDCAQMVRHYLRAEMAQMSMSEWIFRKLDNVEGSGNWKEIVRFLRFQEVEFISFM IAFKDLLCGKPKKNCLLIFGPPNTGKSMFCTSLLKLLGGKVISYCNSKSQFWLQPLADAK IGLLDDATKPCWDYMDIYMRNALDGNTICIDLKHRAPQQIKCPPLLITSNIDVKSDTCWM YLHSRISAFKFAHEFPFKDNGDPGFSLTDENWKSFFERFWQQLELSDQEDEGNDGKPQQS LRLTARAANEPI

TABLE 92 cbe_552976 HPV 11 L2 Human papillomavirus 11 L2 length = 455 MKPRARRRKRASATQLYQTCKATGTCPPDVIPKVEHTTIADQILKWGSLGVFFGGLGIGT SEQ ID NO: 83 GAGSGGRAGYIPLGSSPKPAITGGPAARPPVLVEPVAPSDPSIVSLIEESAIINAGAPEV VPPTQGGFTITSSESTTPAILDVSVTNHTTTSVFQNPLFTEPSVIQPQPPVEASGHILIS APTITSQHVEDIPLDTFVVSSSDSGPTSSTPLPRAFPRPRVGLYSRALQQVQVTDPAFLS TPQRLVTYDNPVYEGEDVSLQFTHESIHNAPDEAFMDIIRLHRPAITSRRGLVRFSRIGQ RGSMYTRSGQHIGARIHYFQDISPVTQAAEEIELHPLVAAENDTFDIYAEPFDPIPDPVQ HSVTQSYLTSTPNTLSQSWGNTTVPLSIPSDWFVQSGPDITFPTASMGTPFSPVTPALPT GPVFITGSDFYLHPTWYFARRRRKRIPLFFTDVAA

TABLE 93 cbe_71919 FLJ13236 hypothetical protein FLJ13236 length = 341 MAKGLLVTYALWAVGGPACLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWKLPSFVAQAN SEQ ID NO: 84 RAQGQRQSPRGVTPPLSPIRFAAQVIVGIYFGLVALISLSSMVNFYIVALPLAVGLGVLL VAAVGNQTSDFKNTLGSAFLTSPIFYGRPIAILPISVAASITAQRHRRYKALVASEPLSV RLYRLGLAYLAFTGPLAYSALCNTAATLSYVAETFGSFLNWFSFFPLLGRLMEFVLLLPY RIWRLLMGETGFNSSCFQEWAKLYEFVHSFQDEKRQLAYQVLGLSEGATNEEIHRSYQEL VKVWHPDHNLDQTEEAQRHFLEIQAAYEVLSQPRKPWGSRR

TABLE 94 cbe_1380530 RPL13 ribosomal protein L13 length = 1110 ctttccgctcggctgttttcctgcgcaggagccgcagggccgtaggcagccatggcgccc SEQ ID NO: 85 agccggaatggcatggtcttgaagccccacttccacaaggactggcagcggcgcgtggcc acgtggttcaaccagccggcccgtaagatccgcagacgtaaggcccggcaagccaaggcg cgccgcatcgccccgcgccccgcgtcgggtcccatccggcccatcgtgcgctgccccacg gttcggtaccacacgaaggtgcgcgccggccgcggcttcagcctggaggagctcagggtg gccggcattcacaagaaggtggcccggaccatcggcatttctgtggatccgaggaggcgg aacaagtccacggagtccctgcaggccaacgtgcagcggctgaaggagtaccgctccaaa ctcatcctcttccccaggaagccctcggcccccaagaagggagacagttctgctgaagaa ctgaaactggccacccagctgaccggaccggtcatgcccgtccggaacgtctataagaag gagaaagctcgagtcatcactgaggaagagaagaatttcaaagccttcgctagtctccgt atggcccgtgccaacgcccggctcttcggcatacgggcaaaaagagccaaggaagccgca gaacaggatgttgaaaagaaaaaataaagccctcctggggacttggaatcagtcggcagt catgctgggtctccacgtggtgtgtttcgtgggaacaactgggcctgggatggggcttca ctgctgtgacttcctcctgccaggggatttggggctttcttgaaagacagtccaagccct ggataatgctttactttctgtgttgaagcactgttggttgtttggttagtgactgatgta aaacggttttcttgtggggaggttacagaggctgacttcagagtggacttgtgttttttc tttttaaagaggcaaggttgggctggtgctcacagctgtaatcccagcactttgaggttg gctgggagttcaagaccagcctggccaacatgtcagaactactaaaaataaagaaatcag ccatgaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 95 cbe_1469980 FLJ20259 hypothetical protein FLJ20259 length = 3101 gagggttgaatgtaagatggcgcccagggagctgtgaggagaaaaccctgtcggtcttgg SEQ ID NO: 86 agcgacgacggcagaaccagggtccctggcggtgcggcggggccggcgggtgcagcggag gcggcggcggcggcggcagtgacgtcgccggaatattagaagtcttaagaactcaggaca agcagcagaaatacatgcaacatggtgactggaaccctaaggactctgcaatatgaataa ttccctagagaacaccatctcctttgaagagtacatccgagtaaaggcacggtctgtccc gcaacacaggatgaaggaatttctggactcactggcctctaaggggccagaagcccttca ggagttccagcagacagccaccactaccatggtgtaccaacagggtgggaactgcatata cacagacagcactgaagtggctgggtctttgcttgaacttgcctgtccagtcaccaccag tgttcagccacaaacccagcaagaacagcagatccaggttcagcagccgcagcaggttca ggtccaggtgcaggtacagcagtctccgcaacaggtctcggctcagctctccccacaact caccgttcaccagcctactgagcaacccatccaggtccaggtgcagatccaaggccaggc accacagtcagcagccccctccattcagaccccgtctctgcagagtcccagtccctcgca gctgcaagcagctcagatccaggtgcagcacgtgcaagcagcccagcagatccaggctgc agaaatcccggaggagcacatcccacatcagcaaatccaggctcagctggtggctggcca gtctcttgctggtggtcagcagatccaaatccagaccgtgggtgccctttccccaccacc atcccagcagggctcaccccgggaaggggagcggcgggttggcacggccagtgtcctcca accagtgaagaagcgcaaagtggagatgcccatcactgtgtcctacgccatctcagggca gccggtggccaccgtgctggccattccacagggccagcagcagagttatgtgtctttgag gccagacttactgacagtagacagtgcccacctgtacagtgccactgggaccattactag ccctacaggagaaacctggaccatccctgtttattctgcccagccccggggggaccctca gcagcagagcattacccacattgccattccccaggaagcctacaacgcagttcacgtcag tggctcacccacagccctggcagctgttaagctggaggatgacaaggagaagatggtggg caccacatctgtagtgaaaaactcccatgaagaggtagtgcagacccttgcaaactctct ctttccagcacagttcatgaatggcaacatccacattccagtggctgtgcaggctgtggc aggcacgtaccagaatacggctcaaactgtccatatatgggacccccaacagcagccgca gcagcaaactccccaggaacagacaccaccaccacagcagcagcagcagcaactccaagt tacttgttcagctcaaactgtccaggttgctgaagttgaaccacagtcacagccacagcc ttccccagaacttctgcttccaaattctttgaagccagaagaagggcttgaagtatggaa aaactgggcccagaccaagaatgctgaactagagaaggatgctcagaacagattggcacc cattgggaggcgccaactgctgcgattccaggaagatctcatctcctctgctgtggcaga gttgaattatgggctctgtctaatgacacgggaagctcgaaatggagaaggtgaacccta tgacccagatgtgctctactatattttcctgtgtattcaaaagtatctttttgaaaatgg aagggtagatgacattttctccgatctttattatgttcggttcacggagtggctacatga agttctgaaggatgttcagccccgggtcactccacttggctatgtcttgcccagccacgt gactgaggagatgctatgggagtgcaagcagcttggggctcactccccctccaccttgct gaccaccctcatgttctttaataccaagtacttcctattgaagacagtggaccagcacat gaagctggccttctccaaggtcttgcgacagacaaagaagaacccctctaatcccaagga taaaagcacgagtatccggtacttgaaggcccttggaatacaccagactggccagaaagt tacagatgacatgtatgcagaacagacggaaaatccagagaatccattgagatgtcccat caagctctatgatttctacctcttcaaatgcccccagagtgtgaaaggccggaatgacac cttttacctgacacctgagccagtggtggcccccaacagcccaatctggtactcagtcca gcctatcagcagagagcagatgggacaaatgctgacgcggatcctggtgataagagaaat tcaggaggccatcgcagtggccaatgcaagcactatgcactgagatgccttggccatggc acaagagaaaccagccaggaaaaaccagacagactttcacactaaagaagaggcctccat ttttttttttcttttttttattggtgtagttacgaagcctttcaggctgcttctgtttaa aatataaaagaaaactttgccccctttgcatcttcataaacctgctgcggcagactcctc agccgatggtggctctgggtttccttgagtgtcatatgtcccagaaagttgctggctgac tcttttttgtctggggcctggggaaagggcttggactgtgaaaagaaatgtggccccttt ccatcttcaagagagatggaattaatgatggatggaccctggagggaatctccccagccg acttccactgggctgacagactttgctgaccacaggggaacgatgttcttttctttcttc atgatcagacataaacttagcatcttaatggaagaaaaatgaggggaacttcaattatga tttattaaagacaatttctattaaaaaaaaaaaaaaaaaaa

TABLE 96 cbe_1505425 HCDI HCDI protein length = 1522 agtcgctatgcgtgtcttgtgggtgagggagggcagaaagggagagtgctgggcgggctt SEQ ID NO: 87 agtcggagattgaggactgggaatccgcttccgggagggcactgtctagtgcacaggcaa cctggccttcgcctcctagcccgagaagccgaatctccctaatccctgtgacctgtgtca cctctgcatcgcgaggagggggataagtggggagaagtctggtgtcagatgggatggcgc cggaagagggtgccacagcggggacggaaggcgcccccaccccaactccacgggaatata aacaatttgtattttccgatcaggtggcgggacaggcttcattgggacagccctaaccca gctgctgaatgccagaggcacgaagtgacgttggtctcccgaaagcccgggcccggccgg atcacgtgggatgagctcgctgcatcggggctgccgagctgcgatgccgccgtcaacctg gccggagagaacatcctcaaccctctccgaagatggaatgaaaccttccaaaaagaggtt ctcggcagccgcctagagaccacccaattgctggctaaagccatcaccaaagccccacaa ccccccaaggcctgggtcttagtcacaggtgtagcttactaccagcccagtctgactgcg gagtatgatgaagacagcccaggaggggactttgactttttctccaacctcgtaaccaaa tgggaagctgcagccaggcttcctggagattctacacgccaggtggtggtgcgctcaggg gttgtgctgggccgtgggggtggtgccatgggccacatgctgctgccctttcgcctgggc ctggggggccccatcggctcaggccaccaattcttcccctggatacacatcggggacctg gcaggaatcctgacccatgcccttgaagcaaaccacgtgcacggggtcctgaatggagtg gctccatcctccgccactaatgctgagtttgcccagaccttgggtgctgccctgggccgc cgagccttcatccctctccccagcgctgtggtgcaagctgtctttgggcgacagcgtgcc atcatgctgctggagggccagaaggtgatcccacagcgaacactggccactggctaccag tattccttcccagagctaggggctgccttaaaggaaattgtagcctaagtaggtcgtggc aagggcctgaggcctgttcctcacaggcttccaggttaggcactgtgaataggctcagct cctctagagagctgaagccatctggttcttagattcctctcccagtcctctttcccattg ttctgttgctccaccttattgtctcaaggccgtaatctcatcaggttgggacattaatct tttcaactccttgtaagatttcccagtttggtttctctacatgtcctgcagctgccccac ttctcctttacgctgtgtagagaatgctctgcagtttaggcaataaaaataaattgtctc actaaaaaaaaaaaaaaaaaaa

TABLE 97 cbe_1710 QP-C low molecular mass ubiquinone-binding protein (9.5 kD) length = 428 aaaaataagtaggaagtgctcaattttaatttggttcagttttccggagggcgagctgag SEQ ID NO: 88 ccctggccgccgccacaatgggccgcgagtttgggaatctgacgcggatgcggcatgtga tcagctacagcttgtcaccgttcgagcagcgcgcctatccgcacgtcttcactaaaggaa tccccaatgttctgcgccgcattcgggagtctttctttcgcgtggtgccgcagtttgtag tgttttatcttatctacacatgggggactgaagagttcgagagatccaagaggaggatcc agctgcctatgaaaatgacaaatgagcaacgcatccggatgacggttccctgtctctgaa agacctttctctggaagaggagtctgcattgtagtgtctcaaagacacaataaacttcct atggtctg

TABLE 98 cbe_1796502 CTNND2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) length = 4746 gccagcatcccttgtcccgcggccggctcagacaacaaaagcggaagatgctgcagttgg SEQ ID NO: 89 gcaaggtcaggaccttgccttgaaagccgggcggcgccgcgcaacgcctcttcccggact gaggagctgtcgccggcggagggtgcatgtttgcgaggaagccgccgggcgccgcgcctt tgggagctatgcctgttccagaccagccttcatcagcctcagagaagacgagttccctga gccccggcttaaacacctccaacggggatggctctgaaacagaaaccacctctgccatcc tcgcctcagtcaaagaacaggaattacagtttgaaaggctgacccgagagctggaggctg aacggcagatcgtagccagccagctggagcgatgcaagctcggatccgagactggcagca tgagcagcatgagttcagcagaagagcagtttcagtggcagtcacaagatggtcaaaaag atatcgaagatgagcttacaacaggtctcgagctggtggactcctgtattaggtcactac aggaatcaggaatacttgacccacaggattattctacaggtgaaaggcccagcctgctct cccagagtgcacttcagctcaattccaaacctgaagggtctttccagtatccggccagct accatagcaaccagaccctggccctgggggaaaccaccccttcacagctcccggcccgag gcacacaagcccgagctacgggccagagcttcagccagggcacgaccagccgcgccggcc acctggcggggcccgagcccgcgccgccgccgccgccgccgccgcgggagccgttcgcgc ccagcctgggcagcgccttccacctgcccgacgcgccgcccgccgccgccgccgccgcgc tctactactccagctccacgctgcccgcgccgccgcgcgggggctccccgctggccgcgc cccagggcggttcgcccaccaagctgcagcgcggcggctcggcccccgagggcgccacct acgccgcgccgcgcggctcctcgcccaagcagtcgcccagccgcctggccaagtcctaca gcaccagctcgcccatcaacatcgtcgtgtcctcggccggcctgtccccgatccgcgtga cctcgccccccaccgtgcagtccaccatctcctcctcgcccatccaccagctgagctcca ccatcggcacgtacgccaccctgtcgcccaccaagcgcctggtccacgcgtccgagcagt acagcaagcactcgcaggagctgtatgccacggccaccctccagaggccgggcagcctgg cagctggttcccgagcctcatacagcagccagcatgggcacctgggcccagagttgcggg ccctgcagtccccagaacaccacatagatcccatctatgaagaccgcgtctatcagaagc cccctatgaggagtctcagccagagccagggggaccctctgccgccagcacacaccggca cctaccgcacgagcacagccccatcttcccctggtgtcgactccgtccccttgcagcgca caggcagccagcacggcccacagaatgccgccgcggccaccttccagagggccagctatg ccgccggcccagcctccaattacgcggacccctaccgacagctgcagtattgtccctctg ttgagtctccatacagcaaatccggccctgctctcccgcctgaaggcaccttggccaggt ccccgtccattgatagcattcagaaagatcccagagaatttggatggagagacccggaac tgccggaagtgattcagatgttgcagcaccagtttccctcggtccagtctaacgcggcag cctacttgcaacacctctgttttggagacaacaaaattaaagccgagataaggagacaag gaggcatccagctcctggtggacctgttggatcatcggatgaccgaagtccaccgtagtg cctgtggagctctgagaaacctggtgtatgggaaggccaacgatgataacaaaattgccc tgaaaaactgtggtggcatcccagcactggtgaggttactccgcaagacgactgacctgg agatccgggagctggtcacaggagtcctttggaacctctcctcatgcgatgcactcaaaa tgccaatcatccaggatgccctagcagtactgaccaacgcggtgattatcccccactcag gctgggaaaattcgcctcttcaggatgatcggaaaatacagctgcattcatcacaggtgc tgcgtaacgccaccgggtgcctaaggaatgttagttcggccggagaggaggcccgcagaa ggatgagagagtgtgatgggcttacggatgccttgctgtacgtgatccagtctgcgctgg ggagcagtgagatcgatagcaagaccgttgaaaactgtgtgtgcattttaaggaacctct cgtaccggctggcggcagaaacgtctcagggacagcacatgggcacggacgagctggacg ggctactctgtggcgaggccaatggcaaggatgctgagagctctgggtgctggggcaaga agaagaagaaaaagaaatcccaagatcagtgggatggagtaggacctcttccagactgtg ctgaaccaccaaaagggatccagatgctgtggcacccatcaatagtcaaaccctacctca cactgctctctgagtgctcaaatccagacacgctggaaggggcggcaggcgccctgcaga acttggctgcagggagctggaagtggtcagtatatatccgagccgctgtccgaaaagaga aaggcctgcccatcctcgtggagctgctccgaatagacaatgaccgtgtggtgtgcgcgg tggccactgcgctgcggaacatggccttggacgtcagaaataaggagctcatcggcaaat acgccatgcgagacctagtccacaggcttccaggagggaacaacagcaacaacactgcaa gcaaggccatgtcggatgacacagtgacagctgtctgctgcacactgcacgaagtgatta ccaagaacatggagaacgccaaggccttacgggatgccggtggcatcgagaagttggtcg gcatctccaaaagcaaaggagataaacactctccaaaagtggtcaaggctgcatctcagg tcctcaacagcatgtggcagtaccgagatctgaggagtctctacaaaaaggatggatggt cacaataccactttgtagcctcgtcttcaaccatcgagagggaccggcaaaggccctact cctcctcccgcacgccctccatctcccctgtgcgcgtgtctcccaacaaccgctcagcaa gtgccccagcttcacctcgggaaatgatcagcctcaaagaaaggaaaacagactacgagt gcaccggcagcaacgccacctaccacggagctaaaggcgaacacacttccaggaaagatg ccatgacagctcaaaacactggaatttcaactttgtataggaattcttatggtgcgcccg ctgaagacatcaaacacaaccaggtttcagcacagccagtcccacaggagcccagcagaa aagattacgagacctaccagccatttcagaattccacaagaaattacgatgagtccttct tcgaggaccaggtccaccatcgccctcccgccagcgagtacaccatgcacctgggtctca agtccaccggcaactacgttgacttctactcagctgcccgtccctacagtgaactgaact atgaaacgagccactacccggcctcccccgactcctgggtgtgaggagcagggcacaggc gctccgggaacagtgcatgtgcatgcataccacaagacatttctttctgttttgtttttt tctcctgcaaatttagtttgttaaagcctgttccataggaaggctgtgataaccagtaag gaaatattaagagctattttagaaagctaaatgaatcgcaagttaacttggaaatcagta gaaagctaaagtgatcctaaatatgacagtgggcagcacctttctagcgtgagctgtaaa gtaacgagaagtgctttatactgaacgtggttgatgggaggagagacgaggcattcgggc cggtggggcgtaagggttatcgttaagcacaagacacagaatagtttacacactgtgtgg gggacggcttctcacgctttgtttactctcttcatccgttgtgactctaggcttcaggtt gcattggggttcctctgtacagcaagatgtttcttgccttttgttaatgcattgttgtaa agtatttgatgtacattacagattaaagaagaaaagcgcgttgtgtatattacaccaatg ccgccgtgtttcctcatctatggttctaaatattgcttcaatttcaaacttttgaaagat gtatggatttccagtttttctttactttctcccagtatgttttaacaaaaaaaaaaaaaa gcaggaaaaaaggaatatttagcagtattgttcgttctgatatgtgaatttgtctgtgac aactaaacaaggcattcagcagtttctgacaattaacatacatcattccacactccttgt caacaaagtgctttttcactgcctaaaattttagatgtagatatttgaaatagatttttt catttataccagttttctttatgatgatacagtgttaaaagaaaataaattacaattgat ctgtca

TABLE 99 cbe_1807361 FLJ22729 hypothetical protein FLJ22729 length = 1278 aatggaggaagactggacctactgattcaacttggagatgagcgggtctgtcctcttcac SEQ ID NO: 90 ggcgggagagaggtggagatgctttctgaccccgtcgaggtcatccctgtactgggcctt acataatttctgctgtcggaaaaaatccactacacctaagaaaattactcccaatgttac tttttgtgatgaaaatgcaaaggagcccgaaaatgcacttgacaagctcttctcttcaga acagcaggcttccatcttgcatgtgttgaatacagcatctactaaagaacttgaagcttt ccgattgcttcgtggaagaaggtccatcaatatcgtagagcacagagaaaactttgggcc atttcagaatttagagagtttaatgaatgtgcccttgtttaagtataaaagtacagttca agtttgtaactccatactttgtccaaagactggacgggaaaaaagaaagtcaccggaaaa ccggttcctgagaaagctcctcaaaccagacatagaaagagaaagacttaagaattgcct gggctcaccttgatcgtaagttgacagtgctggactggcagcaaagtgaccgttggagtt taatgagaggaatatactcatcatcagtctatttagaagagatttcctcgatcatttcaa agatgcctaaagcagatttctatgttctggaaaaaacaggactatccattcagaactcat ctctgtttccaatactgttacattttcatatcatggaagccatgctgtatgccttattaa ataaaacttttgcccaggatgggcagcatcaggtgctgagcatgaatcgaaatgcagtgg ggaagcattttgaactgatgattggtgactcccggactagtggaaaagagctagtgaagc agtttctcttcgattctatactgaaggcggatcctcgggtgttcttcccatcagataaaa tagttcactacagacagatgtttttatctactgaactacaaagagtagaagagctttatg attcattattacaagctattgccttctatgaattagcagtgtttgactctcagccttaga attctgaggttaacgtgctaaagtataattattagctctaacgtaacaccaactgttgtg aacatccatgttattggaaaagaacacattttcagtgtattttagatgtttaaattctga cttttggctattaaatggtttacacaataagccaagaccaaatcaataaacattttatga gaaaaaaaaaaaaaaaaa

TABLE 100 cbe_2253980 Prey1135 Homo sapiens, clone MGC: 14302, mRNA, complete cds. length = 1863 ggcacgaggcaggggctctgctgcgacctttacggtagtgaggttagggacgatgggaga SEQ ID NO: 91 gcagctttgttcctgaagtgccgtcgaggattaggatcgagtttcttcgatcgtgagggc aattattagtggcctctagccccccagatggcatcttgaggagagagaatccacgctacg agaactaacatagtggacatcgcagttgtccgtagccgatttgcgggttacggagttgtt gcaagtaaagaaggggaaatccgagcgttctcgcgttggatttcctccacgtgtgaagtg ggaatggtagtgatatctcgtgctatctctgtcaagggcaagaaggagaaggaatttatt tgaggccctacgacgtggtgcggtggctcacgcctgtaatcccaacactttgggaggccg aggcaggcggatcatctgagatcgagagttcgagaccagcttgaccaacatggagaaacc ccgtctctactaaaagtacaaaattagccaggcatggtggcacatgcccgtaatcccagc tactcgggaggctgaggcaggagagtagcttgagcccaggaggcggaggttgtggtgagc cgagatcgcgccattgcacagcctgggcaacgagcgaaactccatctcaaaaaaataaat aaaaatttttttaaaaaaaaaaaaaaaaaactcgaggcaaaactaaccccctaataaaat taattaaccactcattcatcgacctccccaccccatccaacatctccgcatgatgaaact tcggctcactccttggcgcctgcctgatcctccaaatcaccacaggactattcctagcca tgcactactcaccagacgcctcaaccgccttttcatcaatcgcccacatcactcgagacg taaattatggctgaatcatccgctaccttcacgccaatggcgcctcaatattctttatct gcctcttcctacacatcgggcgaggcctatattacggatcatttctctactcagaaacct gaaacatcggcattatcctcctgcttgcaactatagcaacagccttcataggctatgtcc tcccgtgaggccaaatatcattctgaggggccacagtaattacaaacttactatccgcca tcccatacattgggacagacctagttcaatgaatctgaggaggctactcagtagacagtc ccaccctcacacgattctttacctttcacttcatcttgcccttcattattgcagccctag cagcactccacctcctattcttgcacgaaacgggatcaaacaaccccctaggaatcacct cccattccgataaaatcaccttccacccttactacacaatcaaagacgccctcggcttac ttctcttccttctctccttaatgacattaacactattctcaccagacctcctaggcgacc cagacaattataccctagccaaccccttaaacacccctccccacatcaagcccgaatgat atttcctattcgcctacacaattctccgatccgtccctaacaaactaggaggcgtccttg ccctattactatccatcctcatcctagcaataatccccatcctccatatatccaaacaac aaagcataatatttcgcccactaagccaatcactttattgactcctagccgcagacctcc tcattctaacctgaatcggaggacaaccagtaagctacccttttaccatcattggacaag tagcatccgtactatacttcacaacaatcctaatcctaataccaactatctccctaattg aaaacaaaatactcaaatgggcctaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaa

TABLE 101 cbe_22607 Hs. 101882 601276943F1 Homo sapiens cDNA, 5′ end length = 796 ccgcggccgctcgcagcttgctggcctctcccgcgcctcacgtcggactccgtctccgcg SEQ ID NO: 92 gcaggaagcagcatggaagctgaggacatccaggaggagttgacctgccccatctgcctg gactatttccaggacccggtgtccatcgagtgcggacacaacttctgccgcggctgcctg caccgcaacatgggcgccgggcggcaggaccgtatcccctgccccgaatgtcggcaccca tcggcgcccgccgcgctgcagacccaactgggccctggccaggctgactgagaagacgca gcgccggcgcctgggccccgtgcccccgggcctgtgcggccgccactgggagccgctgcg gctcttctgcgaggacgaccagcggccagtgtgcctggtgtgcagggagtcccaggagca ccagactcacgccatggcacccatcgacgaggcttcgagagctaccgggagaaacttctt aagtctcagcgtactctcgtggccaacgatgacgcacacgtcatgcatttacaggatgtc gacagtgacgaaccgccacacacgtggcaggataacgcatacggagtcacgcgaaatgag acatcacgcacggcgtttttaacagcgtggcaccacttcctggttgaagaacgaggacct gtctcttccagcagcttgcacaacgaagaagcacagaccagcacgacgctgaatgacacc acttcacactccgtccacttcgctcctgagaccctcttaaggggggacaacccgcccccc tgggcgtcacacccca

TABLE 102 cbe_244811 DGUOK deoxyguanosine kinase length = 880 aacggtgcgctggagcgagtgagcagcgatacctagggcggaagtgctctcggcggaagt SEQ ID NO: 93 gatcgctgtgtgaatcgtgggtgggatggccgcgggccgcctctttctaagtcggcttcg agcacccttcagttccatggccaagagcccactcgagggcgtttcctcctccagaggcct gcacgcggggcgcgggccccgaaggctctccatcgaaggcaacattgctgtgggaaagtc cacgtttgtgaagttactcacgaaaacttacccagaatggcacgtagctacagaacctgt agcaacatggcagaatatccaggctgctggcacccaaaaagcctgcactgcccaaagtct tggaaacttgctggatatgatgtaccgggagccagcacgatggtcctacacattccagac attttcctttttgagccgcctgaaagtacagctggagcccttccctgagaaactcttaca ggccaggaagccagtacagatctttgagaggtctgtgtacagtgacaggctccactttga ggctctgatgaacattccagtgctggtgttggatgtcaatgatgatttttctgaggaagt aaccaaacaagaagacctcatgagagaggtaaacacctttgtaaagaatctgtaaccaat accatgaagttcaggctgtgatctgggctccctgactttctgaagctagaaaaatgttgt gtctcccaaccacctttccatccccagcccctctcatccctggagcactctgccgctcaa gagctggtttgttaattattgttagactttgccattgttttcttttgtacctgaagcatt ttgaaaataaagtttacttaagttatgcttgtttttctaa

TABLE 103 cbe_250777 HPV 11 E4 Human papillomavirus 11 E4 length = 324 atggtagtaccaatcattgggaagtatgttatggcagcacagttatatgttctcctgcat SEQ ID NO: 94 ctgtatctagcactgtacgagaagtatccattgctgaacctactacatacacccccgcac agaccaccgcccctacagtgtccgcctgcaccacggaagacggcgtgtcggcgccgccta ggaagcgagcacgtggaccgtccactaacaacaccctgtgtgtggccaacatcagatccg tggacagtacaatcaacaacatcgtcactgacaattacaacaagcaccaaagaaggaaca actgtcacagtgcagctacgccta

TABLE 104 cbe_250781 HPV 11 E2 Human papillomavirus 11 E2 length = 1104 atggaagcaatagccaagcgtttagatgcgtgccaggatcagttgttagaactttatgaa SEQ ID NO: 95 gaaaacagtattgatatacacaaacacattatgcattggaaatgcatacgattggaaagt gtattactacacaaagcaaaacaaatgggcctgagccacatcgggttacaagtagtacca ccattaactgtgtcagagactaaaggacataatgctattgaaatgcaaatgcatttagaa tccttagcaaaaactcagtatggtgtggaaccttggacattacaggacaccagttatgaa atgtggctaacaccacccaaacggtgctttaaaaaacagggaaatactgtggaggtaaaa tttgatggctgtgaagacaatgtaatggagtatgtggtatggacacatatatacctgcag gacaacgactcatgggtaaaagtaactagttccgtagatgccaagggcatatattataca tgtggacaatttaaaacatattatgtaaattttaataaagaggcacaaaagtatggtagt accaatcattgggaagtatgttatggcagcacagttatatgttctcctgcatctgtatct agcactgtacgagaagtatccattgctgaacctactacatacacccccgcacagaccacc gcccctacagtgtccgcctgcaccacggaagacggcgtgtcggcgccgcctaggaagcga gcacgtggaccgtccactaacaacaccctgtgtgtggccaacatcagatccgtggacagt acaatcaacaacatcgtcactgacaattacaacaagcaccaaagaaggaacaactgtcac agtgcagctacgcctatagtgcaactgcaaggtgattccaattgtttaaaatgttttaga tatagactgaatgacaaatataaacatttgtttgaattagcatcttcaacgtggcattgg gcctcacctgaggcaccacataaaaatgcaattgtaacattaacatatagcagtgaggaa caacgtcagcaatttttaaacagtgtaaaaataccacccaccattaggcataaggtgggg tttatgtcattacatttattgtaa

TABLE 105 cbe_250808 HPV 11 E6 Human papillomavirus 11 E6 length = 453 atggaaagtaaagatgcctccacgtctgcaacatctatagaccagttgtgcaagacgttt SEQ ID NO: 96 aatctttctttgcacactctgcaaattcagtgcgtgttttgcaggaatgcactgaccacc gcagagatatatgcatatgcctataagaacctaaaggttgtgtggcgagacaactttccc tttgcagcgtgtgcctgttgcttagaactgcaagggaaaattaaccaatatagacacttt aattatgctgcatatgcacctacagtagaagaagaaaccaatgaagatattttaaaagtg ttaattcgttgttacctgtgtcacaagccgttgtgtgaaatagaaaaactaaagcacata ttgggaaaggcacgcttcataaaactaaataaccagtggaagggtcgttgcttacactgc tggacaacatgcatggaagacttgttaccctaa

TABLE 106 cbe_250809 Prey152 PathCalling Prey Sequence 152 length = 515 cgcggccgcgtcgacgagagaactagtctcgagttttttttcaagtcttttccttttttt SEQ ID NO: 97 ttctattttcctggttgagctatttactatttatttagaagagttctttatataatcaga aacctttgtcagctgtatgtgctgccaatgtcttctcccacaacgtgggttgccttttca cattcttactgataacttttgataaaaagatgttcttaccattagtaaaacttattgtct ctcctttgagtactgattttgaatatcttttaagaaatctctgccttctcccaaattatg aagatattcttatatgttaccttataaactttattattttactttccatatgtaaattta taaatcatctgaaattgtttttgtcaaaggaatgagaaaacaaaattcttacttaaaaaa atagcccatccacaaagtcttactgattgataatacattcgttcattcttttcccattgc actgcagtattgaatttctgtgtttctctgagaat

TABLE 107 cbe_250834 HPV 11 E7 Human papillomavirus 11 E7 length = 297 atgcatggaagacttgttaccctaaaggatatagtactagacctgcagcctcctgaccct SEQ ID NO: 98 gtagggttacattgctatgagcaattagaagacagctcagaagatgaggtggacaaggtg gacaaacaagacgcacaacctttaacacaacattaccaaatactgacctgttgctgtgga tgtgacagcaacgtccgactggttgtggagtgcacagacggagacatcagacaactacaa gaccttttgctgggcacactaaatattgtgtgtcccatctgcgcaccaaaaccataa

TABLE 108 cbe_250883 Prey244 PathCalling Prey Sequence 244 length = 447 aaaaaaagaaaaagaaaattctgccttatatttccattgaataaaactgacattccagaa SEQ ID NO: 99 agctgcattgtgttttatcctgtggattcatcacttctgtgtaccaccagaggtctgcat agtctggtctgaaaactgctgatttaaggccgggcgcagtggctcatgcctgtaatccca gcactttggaaggtcgaggcgggcggatcacctgaggttcaggaattcgagaccagcctg gccgacatggcgaggccccaactctactaaaaatatggaaattaggcatggtggtgggcg cctgtaattccagctgctcgggagactgagacaggagaatcgcctgaacccggaaggcgg aggttgcagtgagccgagatcgtgccattgcactccagcctgggcaacaagagcaaaagt ccatctcaaaaaaaaaaaaaaaaaccc

TABLE 109 cbe_250888 Prey228 PathCalling Prey Sequence 228 length = 507 aacagcttttcagataagaacaaggagcatagctttttcatcacagactctgatgcttct SEQ ID NO: 100 ggaggagatttttggagagaaagatcaggtgaacatacacaagaaaccaactcacctcat tcactgaaaaaggatgtagaaaatatggggaaagaagaacttcagaaggttttatttgaa caaatagatttacggagacgactggaacaagaattccaggtgttaaaaggaaacacatct ttcccagtattcaataattttcaggatcagatgaaaagggagctagcctaccgagaagaa atggtgcaacagttacaaattatcccctatgcagcaagtttgatcaggaaagaaaagctt ggcgcccatctcagcaaaagctaaaaggtgcacagaactacttactcttgttctcttgta agatacagcctgccatggagcacttctgacccgtgttaaagactgcagatcgaaagggct tgggaattaaatacaaaatcaggttca

TABLE 110 cbe_250907 Prey372 PathCalling Prey Sequence 372 length = 183 gtactttgtagtttttcatccctactctctttaactggaaatatagaaattagcacattc SEQ ID NO: 101 atgtcaaacactgtccctttctgtcatgttctggatgagcaattaatcttgtttatactg aataaaattttatttgagttgtgaacataaaaaaaaaaaaaaaaaaaaaaaaaaaaccca aaa

TABLE 111 cbe_250925 Prey415 PathCalling Prey Sequence 415 length = 448 cttagaggtagcagattgtcatatttgaatggaggatttgagtctgagaagtggctgaga SEQ ID NO: 102 gttattctgatacaaatagggtgtgcaatttttggtgagtcccattcatcagcttctaaa aaggagtagcagaaacacttgcacagcagcaggagttacttacccttcctgaatggctgc atcttcttaaggctgtttttttccctcctaaacagaaaatcatacattctgcaacaaaag ctggaaacatcctaaatgcctggaagcagtttagttttaagggttgaggccaggtgcggt ggcttggctgggcacagtggctcacacctgtaatcccagctactcaggaggctgaggcag gagaatcacttggaccagggaggtggaggttgcagtgagccaggattgtgccactgcact ccagcctgggcggcagagtgagactctc

TABLE 112 cbe_251059 HPV 16 E1-E4 HPV 16 E1-E4 length = 276 atggctgatcctgcagcagcaacgaagtatcctctcctgaaattattaggcagcacttgg SEQ ID NO: 103 ccaaccaccccgccgcgacccataccaaagccgtcgccttgggcaccgaagaaacacaga cgactatccagcgaccaagatcagagccagacaccggaaacccctgccacaccactaagt tgttgcacagagactcagtggacagtgctccaatcctcactgcatttaacagctcacaca aaggacggattaactgtaatagtaacactacaccca

TABLE 113 cbe_251063 HPV 16 E1 Human papillomavirus 16 E1 length = 1947 atggctgatcctgcaggtaccaatggggaagagggtacgggatgtaatggatggttttat SEQ ID NO: 104 gtagaggctgtagtggaaaaaaaaacaggggatgctatatcagatgacgagaacgaaaat gacagtgatacaggtgaagatttggtagattttatagtaaatgataatgattatttaaca caggcagaaacagagacagcacatgcgttgtttactgcacaggaagcaaaacaacataga gatgcagtacaggttctaaaacgaaagtatttgggtagtccacttagtgatattagtgga tgtgtagacaataatattagtcctagattaaaagctatatgtatagaaaaacaaagtaga gctgcaaaaaggagattatttgaaagcgaagacagcgggtatggcaatactgaagtggaa actcagcagatgttacaggtagaagggcgccatgagactgaaacaccatgtagtcagtat agtggtggaagtgggggtggttgcagtcagtacagtagtggaagtgggggagagggtgtt agtgaaagacacactatatgccaaacaccacttacaaatattttaaatgtactaaaaact agtaatgcaaaggcagcaatgttagcaaaatttaaagagttatacggggtgagtttttca gaattagtaagaccatttaaaagtaataaatcaacgtgttgcgattggtgtattgctgca tttggacttacacccagtatagctgacagtataaaaacactattacaacaatattgttta tatttacacattcaaagtttagcatgttcatggggaatggttgtgttactattagtaaga tataaatgtggaaaaaatagagaaacaattgaaaaattgctgtctaaactattatgtgtg tctccaatgtgtatgatgatagagcctccaaaattgcgtagtacagcagcagcattatat tggtataaaacaggtatatcaaatattagtgaagtgtatggagacacgccagaatggata caaagacaaacagtattacaacatagttttaatgattgtacatttgaattatcacagatg gtacaatgggcctacgataatgacatagtagacgatagtgaaattgcatataaatatgca caattggcagacactaatagtaatgcaagtgcctttctaaaaagtaattcacaggcaaaa attgtaaaggattgtgcaacaatgtgtagacattataaacgagcagaaaaaaaacaaatg agtatgagtcaatggataaaatatagatgtgatagggtagatgatggaggtgattggaag caaattgttatgtttttaaggtatcaaggtgtagagtttatgtcatttttaactgcatta aaaagatttttgcaaggcatacctaaaaaaaattgcatattactatatggtgcagctaac acaggtaaatcattatttggtatgagtttaatgaaatttctgcaagggtctgtaatatgt tttgtaaattctaaaagccatttttggttacaaccattagcagatgccaaaataggtatg ttagatgatgctacagtgccctgttggaactacatagatgacaatttaagaaatgcattg gatggaaatttagtttctatggatgtaaagcatagaccattggtacaactaaaatgccct ccattattaattacatctaacattaatgctggtacagattctaggtggccttatttacat aatagattggtggtgtttacatttcctaatgagtttccatttgacgaaaacggaaatcca gtgtatgagcttaatgataagaactggaaatcctttttctcaaggacgtggtccagatta agtttgcacgaggacgaggacaaggaaaacgatggagactctttgccaacgtttaaatgt gtgtcaggacaaaatactaacacatta

TABLE 114 cbe_251071 Prey734 PathCalling Prey Sequence 734 length = 473 cgcggccgcgtcgacccggttcccgggaggatgaagttcgtgtacaaagaagagcatccg SEQ ID NO: 105 ttcgagaagcgccgctctgagggcgagaagatccgaaagaaatacccggaccgggtgccg gtgatagtagaaaaggctcccaaagctcggataggagacctggacaaaaagaaatacctg gtgccttctgatctcacagttggtcagttctacttcttgatccggaagcgaattcatctc cgagctgaggatgccttgtttttctttgtcaacaatgtcattccacccaccagtgccaca atgggtcagctgtaccaggaacaccatgaagaagacttctttctctacattgcctacagt gacgaaagtgtctacggtctgtgaagctgctgcccctgagctggaggggggtctcattct acaaagagagaggtggccccctttctgacctctcctccttcagctcaacacac

TABLE 115 cbe_251088 HPV 16 E2 Human papillomavirus 16 E2 length = 1098 atggagactctttgccaacgtttaaatgtgtgtcaggacaaaatactaacacattatgaa SEQ ID NO: 106 aatgatagtacagacctacgtgaccatatagactattggaaacacatgcgcctagaatgt gctatttattacaaggccagagaaatgggatttaaacatattaaccaccaagtggtgcca acactggctgtatcaaagaataaagcattacaagcaattgaactgcaactaacgttagaa acaatatataactcacaatatagtaatgaaaagtggacattacaagacgttagccttgaa gtgtatttaactgcaccaacaggatgtataaaaaaacatggatatacagtggaagtgcag tttgatggagacatatgcaatacaatgcattatacaaactggacacatatatatatttgt gaagaagcatcagtaactgtggtagagggtcaagttgactattatggtttatattatgtt catgaaggaatacgaacatattttgtgcagtttaaagatgatgcagaaaaatatagtaaa aataaagtatgggaagttcatgcgggtggtcaggtaatattatgtcctacatctgtgttt agcagcaacgaagtatcctctcctgaaattattaggcagcacttggccaaccaccccgcc gcgacccataccaaagccgtcgccttgggcaccgaagaaacacagacgactatccagcga ccaagatcagagccagacaccggaaacccctgccacaccactaagttgttgcacagagac tcagtggacagtgctccaatcctcactgcatttaacagctcacacaaaggacggattaac tgtaatagtaacactacacccatagtacatttaaaaggtgatgctaatactttaaaatgt ttaagatatagatttaaaaagcattgtacattgtatactgcagtgtcgtctacatggcat tggacaggacataatgtaaaacataaaagtgcaattgttacacttacatatgatagtgaa tggcaacgtgaccaatttttgtctcaagttaaaataccaaaaactattacagtgtctact ggatttatgtctatatga

TABLE 116 cbe_251128 Prey870 PathCalling Prey Sequence 870 length = 490 gaggagcaatgccctgatgccctcctccttcgctctctatgggctggcttcagctaccat SEQ ID NO: 107 ctgtacagctgcagctccaaaatctcttccacagtccacacctcccactcagctccagat cccatcactgctgccagctggtcatccccccgaaggaggctcagagtctacctcccaggc ccttggccactgagctcttggagagtcctctctccctgtgccctttgcagctccaccaac ccaaccaccagctccctcctccaagcctcacattctccacctccaggctttgatcaggca cagaacgcccttccatggaatgcccctccatgcctgtgtntccaacctactgaatctggt ggactgactgcccgaatctgagacttaggtcagaaggcacctctgtgaagcctgccatga cacattataacatgcgtcacattatagtttaccatttacacattcaaaaaaaaaaaaaaa aaaaaaaacc

TABLE 117 cbe_251445 HPV 16 E6 Human papillomavirus 16 E6 length = 477 atgcaccaaaagagaactgcaatgtttcaggacccacaggagcgacccagaaagttacca SEQ ID NO: 108 cagttatgcacagagctgcaaacaactatacatgatataatattagaatgtgtgtactgc aagcaacagttactgcgacgtgaggtatatgactttgcttttcgggatttatgcatagta tatagagatgggaatccatatgctgtatgtgataaatgtttaaagttttattctaaaatt agtgagtatagacattattgttatagtttgtatggaacaacattagaacagcaatacaac aaaccgttgtgtgatttgttaattaggtgtattaactgtcaaaagccactgtgtcctgaa gaaaagcaaagacatctggacaaaaagcaaagattccataatataaggggtcggtggacc ggtcgatgtatgtcttgttgcagatcatcaagaacacgtagagaaacccagctgtaa

TABLE 118 cbe_251448 HPV 16 E7 Human papillomavirus 16 E7 length = 297 atgcatggagatacacctacattgcatgaatatatgttagatttgcaaccagagacaact SEQ ID NO: 109 gatctctactgttatgagcaattaaatgacagctcagaggaggaggatgaaatagatggt ccagctggacaagcagaaccggacagagcccattacaatattgtaaccttttgttgcaag tgtgactctacgcttcggttgtgcgtacaaagcacacacgtagacattcgtactttggaa gacctgttaatgggcacactaggaattgtgtgccccatctgttctcagaaaccataa

TABLE 119 cbe_251468 Prey1628 PathCalling Prey Sequence 1628 length = 486 gtcgacgcggccgcgggagctgatgggcagcctgcgccaccctggatcaccgtcactcgg SEQ ID NO: 110 cagaagcggagggggaccttggaccagccacccaaccaggaagacaagcctggggcactg accctgaagtctgaaccaggaaagcaagccaaggtgcccgagagaggccaggagcctgtg aagcaagctgactttgttcgcagcaagtctttcctgataacccctgtgaagcccgctgtg gaccggaagcagggggcaaagctcaacttcaaggaggggctgcaaagaggaatctcattg tcccatcagaacttggctcagtctgcagtgatgatggagaaggaactgcatcagctgaag agagccagttatgccagtacagatcagccatcctggatggaacttgccagaaagaaatct caagcttggagtgacatgccccagattataaaataggtgggcagtgtgctgataaagcat gtccac

TABLE 120 cbe_251502 Prey1609 PathCalling Prey Sequence 1609 length = 506 ttccccgcctctcggctagctccggcctcccggggcttctgggtttggagagtttgggga SEQ ID NO: 111 gcggagacacctcccgaggctcctccgcgttggaccctatttgcgagggcgggagcgggg tgggccgacggcgaagctccagaggtgggaccctctcccttcagcagctcttcctgactt catgattctgcccctcttctcattgcaggtcacaccgacaaatctgaagcgggtttgcca ggggagtgtacccgtctccccagcctgggccacccggtccacagggattccatttccggc cttacactccgctccacgatctcatccaggcgctgcagctgtgcagctgctctacagact gcagggacctgctgagacgaatccccggacgaggtgatggctggaccggcggaggaggcg ggagcccattgtcccgagagcctgtggcctctgcctccgcaggtgtcaccaagagtgacc tacacacgagtgagcccagggcaggc

TABLE 121 cbe_251663 HPV 11 E1 Human papillomavirus 11 E1 length = 1947 atggcggacgattcaggtacagaaaatgaggggtcggggtgtacaggatggtttatggta SEQ ID NO: 112 gaagccatagtagagcacactacaggtacacaaatatcagaagatgaggaagaggaggtg gaggacagtgggtatgacatggtggactttattgatgacaggcatattacacaaaattct gtggaagcacaggcattgtttaataggcaggaggcggatgctcattatgcgactgtgcag gacctaaaacgaaagtatttaggcagtccatatgtaagtcctataagcaatgtagctaat gcagtagaaagtgagataagtccacggttagacgccattaaacttacaacacagccaaaa aaggtaaagcgacggctgtttgaaacacgggaattaacggacagtggatatggctattct gaagtggaagctgcaacgcaggtagagaaacatggcgacccggaaaatgggggagatggt caggaaagggacacagggagggacatagagggtgagggggtggaacatagagaggcggaa gcagtagacgacagcacccgagagcatgcagacacatcaggaatattagaattactaaaa tgtaaggatatacgatctacattacatggtaagtttaaagactgctttgggctgtcattt gttgatttaattaggccatttaaaagtgatagaaccacatgtgccgattgggtggttgca ggatttggtatacatcatagcatagcagatgcatttcaaaagttaattgagccattaagt ttatatgcacatatacaatggcttacaaatgcatggggaatggtactattagtattaata aggtttaaagtaaataagagcagatgtaccgtggcacgtacattaggtacgttattaaat atacctgaaaatcacatgttaattgagcctcctaaaatacaaagtggcgtacgagccctg tattggtttaggacaggcatttcaaatgcaagtacagttataggggaggcgccggaatgg ataacgcgccagaccgttattgaacatagtttggctgacagtcaatttaaattaactgaa atggtgcagtgggcatatgataatgatatttgtgaagaaagtgagatagcatttgaatat gcacagcgtggagactttgactccaatgcaagggcctttttaaatagtaatatgcaggct aaatatgtaaaagattgtgcaattatgtgcagacattataaacatgcagaaatgaaaaag atgtctattaaacaatggattaagtataggggtactaaagttgacagtgtaggtaactgg aagccaattgtgcagtttctaagacatcaaaacatagaatttattccatttttaagcaaa ctaaaattatggctgcacggaacgcccaaaaaaaattgtatagccattgtagggccacct gacactgggaagtcgtgcttttgcatgagtttaattaagtttttggggggaacagttatt agttatgttaattcctgcagccatttctggctacagccactaacggatgcaaaagtggca ttattggatgatgccacacaaccatgttggacatatatggatacatatatgagaaaccta ttagatggtaatcctatgagcatagatagaaaacatagagcattaacattaattaagtgt ccaccgctactggttacatcaaatatagacattagcaaagaggagaaatacaaatattta catagtagagttaccacatttacatttccaaatccattcccctttgacagaaatgggaat gcagtatatgaactatcagatgcaaactggaaatgtttctttgaaagactgtcgtccagc ctagacattgaggattcagaggacgaggaagatggaagcaatagccaagcgtttagatgc gtgccaggatcagttgttagaacttta

TABLE 122 cbe_251737 HPV 16 L2 Human papillomavirus 16 L2 length = 1422 atgcgacacaaacgttctgcaaaacgcacaaaacgtgcatcggctacccaactttataaa SEQ ID NO: 113 acatgcaaacaggcaggtacatgtccacctgacattatacctaaggttgaaggcaaaact attgctgtacaaatattacaatatggaagtatgggtgtattttttggtgggttaggaatt ggaacagggtcgggtacaggcggacgcactgggtatattccattgggaacaaggcctccc acagctacagatacacttgctcctgtaagaccccctttaacagtagatcctgtgggccct tctgatccttctatagtttctttagtggaagaaactagttttattgatgctggtgcacca acatctgtaccttccattcccccagatgtatcaggatttagtattactacttcaactgat accacacctgctatattagatattaataatactgttactactgttactacacataataat cccactttcactgacccatctgtattgcagcctccaacacctgcagaaactggagggcat tttacactttcatcatccactattagtacacataattatgaagaaattcctatggataca tttattgttagcacaaaccctaacacagtaactagtagcacacccataccagggtctcgc ccagtggcacgcctaggattatatagtcgcacaacacaacaggttaaagttgtagaccct gcttttgtaaccactcccactaaacttattacatatgataatcctgcatatgaaggtata gatgtggataatacattatatttttctagtaatgataatagtattaatatagctccagat cctgactttttggatatagttgctttacataggccagcattaacctctaggcgtactggc attaggtacagtagaattggtaataaacaaacactacgtactcgtagtggaaaatctata ggtgctaaggtacattattattatgatttaagtactattgatcctgcagaagaaatagaa ttacaaactataacaccttctacatatactaccacttcacatgcagcctcacctacttct attaataatggattatatgatatttatgcagatgactttattacagatacttctacaacc ccggtaccatctgtaccctctacatctttatcaggttatattcctgcaaatacaacaatt ccttttggtggtgcatacaatattcctttagtatcaggtcctgatatacccattaatata actgaccaagctccttcattaattcctatagttccagggtctccacaatatacaattatt gctgatgcaggtgacttttatttacatcctagttattacatgttacgaaaacgacgtaaa cgtttaccatattttttttcagatgtctctttggctgcctag

TABLE 123 cbe_251740 HPV 1a E1-E4 Human Papillomavirus 1a E1-E4 length = 375 atggcagataataaagctccccaagggctgctggggctcctgcagtacactccgactacc SEQ ID NO: 114 caaccctatccgagagtgacaccgcccagcaatcgacgtccatcgactacaccgaactcc caggacagggggagacctcgcaggtccgacaaagacagcagaaaacacctgtacgcagac ggccttacggacggcgaagatccagaagtcccagaggtggaggacgaagagaaggagaat caacgccctctaggacacccggatctgtcccttctgcgcgagacgttggaagtatacaca caacgcctcaaaagggacattcttcaagacttagacgacttctgcaggaagcttgggatc cacccgtggtctgtg

TABLE 124 cbe_251784 HPV 16 L1 Human papillomavirus 16 L1 length = 1596 atgcaggtgacttttatttacatcctagttattacatgttacgaaaacgacgtaaacgtt SEQ ID NO: 115 taccatattttttttcagatgtctctttggctgcctagtgaggccactgtctacttgcct cctgtcccagtatctaaggttgtaagcacggatgaatatgttgcacgcacaaacatatat tatcatgcaggaacatccagactacttgcagttggacatccctattttcctattaaaaaa cctaacaataacaaaatattagttcctaaagtatcaggattacaatacagggtatttaga atacatttacctgaccccaataagtttggttttcctgacacctcattttataatccagat acacagcggctggtttgggcctgtgtaggtgttgaggtaggtcgtggtcagccattaggt gtgggcattagtggccatcctttattaaataaattggatgacacagaaaatgctagtgct tatgcagcaaatgcaggtgtggataatagagaatgtatatctatggattacaaacaaaca caattgtgtttaattggttgcaaaccacctataggggaacactggggcaaaggatcccca tgtaccaatgttgcagtaaatccaggtgattgtccaccattagagttaataaacacagtt attcaggatggtgatatggttcatactggctttggtgctatggactttactacattacag gctaacaaaagtgaagttccactggatatttgtacatctatttgcaaatatccagattat attaaaatggtgtcagaaccatatggcgacagcttatttttttatttacgaagggaacaa atgtttgttagacatttatttaatagggctggtactgttggtgaaaatgtaccagacgat ttatacattaaaggctctgggtctactgcaaatttagccagttcaaattattttcctaca cctagtggttctatggttacctctgatgcccaaatattcaataaaccttattggttacaa cgagcacagggccacaataatggcatttgttggggtaaccaactatttgttactgttgtt gatactacacgcagtacaaatatgtcattatgtgctgccatatctacttcagaaactaca tataaaaatactaactttaaggagtacctacgacatggggaggaatatgatttacagttt atttttcaactgtgcaaaataaccttaactgcagacgttatgacatacatacattctatg aattccactattttggaggactggaattttggtctacaacctcccccaggaggcacacta gaagatacttataggtttgtaacccaggcaattgcttgtcaaaaacatacacctccagca cctaaagaagatgatccccttaaaaaatacactttttgggaagtaaatttaaaggaaaag ttttctgcagacctagatcagtttcctttaggacgcaaatttttactacaagcaggattg aaggccaaaccaaaatttacattaggaaaacgaaaagctacacccaccacctcatctacc tctacaactgctaaacgcaaaaaacgtaagctgtaa

TABLE 125 cbe_251790 Prey2347 PathCalling Prey Sequence 2347 length = 313 gagacaccagcactagccagcaggtgccccttcctcaggcttctgagtttcagccccatg SEQ ID NO: 116 cgatcactcctccaagcttctaggttttaataattccaacttttccccctttgtccctca gaggtggtagctgcttccagaaattgctaccttcatgataccacagagttctcttttttg ctttttgagttcttcgataactagttaatgattccttatacttagctaaccattctctat attaaattctctctgttaaaacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaccaaaaaaa

TABLE 126 cbe_251821 Prey2419 PathCalling Prey Sequence 2419 length = 439 ctgaaatgcacatacatgctttagtgtaatgcagaatgcatttattggagaactcataaa SEQ ID NO: 117 catcctataaaattttcttccctgagatgcaactataaaacttggccttattctgagaat gcttaacatagatttcatccatactgtaacactgattttgttgttgttgtccttaaagca gctcagcttcctgaggtagtgttatgtctctgtggcaacaaggtgaaaatgtctagctta ttttgtcaaagtcaacaataatccacagactccagacctcaatatctgtcccaatttgcc attttactttagtgctccaaaaatatggcttatagaaaaaacaataggtgttttaaagag atttacctgaatgatatagagaatgtctagatattttctggctatcaggtaaaacctacc cttcaagatggtagaatat

TABLE 127 cbe_251826 Prey2429 PathCalling Prey Sequence 2429 length = 553 ctttcagcagcagcggtagagcagtgaccaggcgtctccgcgatgggccccggggacttc SEQ ID NO: 118 cgccgctgcagagagagaatttcccaggggctccagggactcccaggtagagcggagctt tggttcccacctcgtcccgcgtgcgacttcttcggggacggcaggagcacggacatccag gaggaggccctcgccgccagcccgctgctggaggacctcagacgacggctgacgcgcgcc ttccagtgggcggtgcagcgcgcgatctcgaggcgcgtgcaggaggcggcggcggcggcg gcggcgcgggaggagcagagctggacgggcgttgaggccaccctggccaggctgcgggcg gagctggtggaaatgcatttccaaaaccaccagctggctagaactttactggacctaaac atgaaagtgcagcaattgaaaaaggagtatgaactggaaattacatcagactcccaaagc ccaaaagatgatgctgcgaatccggaatanagaaatgcacacgcaagggctgggcgcggt ggctcacgcctgg

TABLE 128 cbe_251857 Prey2492 PathCalling Prey Sequence 2492 length = 54 ggatcagacattcgcgggacgagatcgacccaacgagggagcgcaacctgcctc SEQ ID NO: 119

TABLE 129 cbe_251900 Prey2598 PathCalling Prey Sequence 2598 length = 410 tggcgtgcggctttcgccgcgctattgcttgccaggtatggatcccggagcgcgcagagg SEQ ID NO: 120 agtccctgaggagctagggaccccaaaggcctttcaccgctgcgggccagtcctcagtca gctggagggtgggtcccacggaatcctgttagtttctaccacctcctcccccttctctgg agctggtggagcttcagaagtcctgtggagcgtcggctgggatcagtttgtctcggtgaa aagtaaactttgaaagctttccagagtgttgaatcttccaccagaaaacttgatcacatc aatatctgcagttccaatttcccaaaaagaagaagtagctgattttcagctttctgtgga ttctttattggaaaaagacaatgaccattcagaccagatatcaagtcaag

TABLE 130 cbe_251917 HPV 1a E2 Human Papillomavirus 1a E2 length = 1206 atggaaaacctcagcagtcgcttagacttactgcaagagcagctaatgaacctatatgaa SEQ ID NO: 121 caggacagtaaattgatagaagatcaaattaagcagtggaatctaattagacaagaacaa gttcttttccatttcgccagaaaaaatggggtaatgagaattggattgcaggcagttcca tctttagcgtcctcacaggagaaggcaaagacagctattgaaatggtgttacatttagag tctttaaaggactcaccttatggcacagaggattggtcacttcaagacactagcagagag ctgtttttggcacccccagctggcaccttcaagaagagtggcagcacacttgaggttacc tatgacaataaccctgataatcagacaaggcacacaatttggaatcatgtgtattatcaa aatggggacgatgtatggagaaaagtatccagtggtgttgatgctgtaggagtgtactat ttagaacacgatggctataaaaattattatgtgttatttgctgaggaggcctctaagtac agcacaacaggacaatatgctgtaaattacaggggtaaaaggtttacaaatgttatgtct tccactagctccccaagggctgctggggctcctgcagtacactccgactacccaacccta tccgagagtgacaccgcccagcaatcgacgtccatcgactacaccgaactcccaggacag ggggagacctcgcaggtccgacaaagacagcagaaaacacctgtacgcagacggccttac ggacggcgaagatccagaagtcccagaggtggaggacgaagagaaggagaatcaacgccc tctaggacacccggatctgtcccttctgcgcgagacgttggaagtatacacacaacgcct caaaagggacattcttcaagacttagacgacttctgcaggaagcttgggatccacccgtg gtctgtgtaaaagggggtgccaatcagcttaagtgtctcaggtacagacttaaagcatct actcaagttgactttgacagcataagcaccacatggcattggacagatagaaaaaacacc gagaggataggtagtgctagaatgttagtaaagtttattgatgaggctcaacgagagaag tttcttgagagagttgctttgcccagatcagtgtctgtgtttttgggacagtttaatggg tcttaa

TABLE 131 cbe_251919 HPV 1a E6 Human Papillomavirus 1a E6 length = 423 atggcgacaccaatccggaccgtcagacagctttccgaaagcctctgtatcccatatatt SEQ ID NO: 122 gatgttttattgccttgtaatttttgtaattattttttgtctaatgctgagaagctgctt tttgatcattttgatttgcatcttgtctggagagacaatttggtgtttggatgctgtcaa gggtgtgctagaactgttagcctattggagtttgttttatattatcaggagtcttatgag gtaccggaaatagaagaaattttggacagacctttattgcaaattgaactccgttgtgtt acatgcataaaaaaactgagtgttgctgaaaaattggaggttgtgtcaaacggagaaaga gtgcatagagttagaaacagacttaaagcaaagtgtagtttgtgtcgcttgtatgctata taa

TABLE 132 cbe_251925 HPV 1a E7 Human Papillomavirus 1a E7 length = 282 atggtgggcgaaatgccagcactaaaggacctggttcttcaacttgaaccaagcgtccta SEQ ID NO: 123 gatttagatctttattgttacgaggaggtgcctcctgatgacatagaggaggagttagtg tcgcctcagcaaccttatgctgtcgttgcttcctgtgcctattgcgagaaactggttcga ttgaccgtcctcgcggatcacagcgccattagacagctggaggaactccttctgcgatct ttgaacatcgtgtgcccactgtgcaccctacagcgacagtaa

TABLE 133 cbe_251929 Prey2672 PathCalling Prey Sequence 2672 length = 408 gtctctacaaataataaaaaattgtctgggcatggtggcctgtgcccgtagtcccagcta SEQ ID NO: 124 ctcaggagggtgaggtgggaggatcgcttgggcctaggaggtcaagcctgcagtgagttg taatcacgccactgcactccagcctgggcaacacagcgagatcctatttctcctatttct ctctgtctctctcacacacacacacacacacaaacacacacataatgtggaatgattaaa caaagctaattaacatatcggtcacctcctttaatttttccagcaagacatgtgaaattt attcttttagcctattttgaaatacatgtcatatatcattattaactatagtcaccctgg tgtgcgatggatctcaaaaacttattttttctgtctaactcaaacttt

TABLE 134 cbe_251953 Prey2724 PathCalling Prey Sequence 2724 length = 617 ggccgactcccaggatccgttgcggcgcggcggagcagccaatggcgagccccacagtct SEQ ID NO: 125 cgcgagagtgctcaggcgctcttcgtggctgccctcttagctgctagcggagctcctcag ggggcggccgggagcctacaattcctagaaagaaaatacgccattccggaaacagaactg cagttaagaccctcgaaaagatctaagatagtgtgcatcctataacacctgacgaatttc agaatgtgacaaagcgcagaggatgcattatttcaaaacaaaacagaaggctaaaatttg cagganaaagaaaatcagtaaaccgggaatcctcggactggattgtaagcaagatttgaa tgaattagaagctgaaggtatttaggctgtgatataganggtacatatttcatcccacag agaaaacataatactcgaaatttcgtgaaaaacgcaaactgtcggaaatctcctcagtcc gactaatgcgcgcttgacatgcgatgtgaatgccctctgtcggcgctgtcgctgacgcac atctgtccgtggtcgtctatcgatatgtgttgtgttatgctgtgtctatcgcgtcgctgt cactgtccggttgcctt

TABLE 135 cbe_251976 FLJ23584 hypothetical protein FLJ23584 length = 4992 ggctatcctactgcagctggctgcatcagatgtgccaggcctgccctctagctcccaaca SEQ ID NO: 126 ccatctgcctgatctaagctttgccatgttgttgtcactgctgggtgcctgtgctgtggt ggggccattccatggccctgagtgggagccagtgcagggcctgctctcccagaatcacag ctgcagggaccctcagtgctgtggcaacctgcttgtcctctgcctctttctggtctggca ggtccggcactgttggcaccaggtcaccaggacccgcttcagcacaaggaatgtcatcaa ggtgccactgcagaagcgggcagtgccctccatgaggtgcgaaactgtcttcaagctgac tcctgaattcttcagtcctggaaagtccaggggcctagattctcaacaatgcgcacaaag gcagagatggggataccggaggagcctccaggaatcatgggcccagaacctgctctctcc acagcacccatgtccaggcccaccttcgggtgtccacacccactctgagcccatcttttg taccacctccatttcaaacacctgtttactgcctcagaacagttcctggaaagcatggca ggtgccttggtgtctccatgatggtcagactcgccctgccttggacatgtgtcaagagat ggagcagctgctgcttcactcacaggaaaggttggtgtcactggagcctgtcatcagtgt gaggtctcgccccacctccatgaccttaaccacctctcttccaaacttactttcagctga gaggctgcagttctgcccccagagagctcctgcctgatccttcccaccaaacactgagaa tgtgcacttggaagtcttggcactgtcgaccagaggcctgggaaccagggggtaaaaacc agaaagcaggcagagaggatagtagagagacccaggctccaaggtgggtgaaccagacag ggagcagacgggaggatgcttcagaaatccaggcatctggggagtagttcccagtagact ttggaatggagggtgatgcagagactaacgtgttggagtgtgcaaaccagagactagtaa taagtgaaactgatggcgagatcttgacaccagggtgggacacccaggaccggatgggag ttgagagtagaaccaacattcaggaactagggaatagaaaccagagggaggctggaggtg agaatctccctgaaacccaggcacatatgggagagaaccaagaacagttaagatgtaaaa ttgatgcagagacccaaacacctgagtgggagaaccaggataagaatggaagtgaggatg ctgtggagacccagacatttgagaagaaggacaagaaagaggctggagaggaggatgggg aagagatccaggctcaaggattggggaagcaaggccagactggagatgagaatggtgagg agacccagacaccacagtgggagaaacaagatcagatgaaaggtgatgcggatgtggaaa ttcagatggaagaggggagaaacaaggatcaggttggaggtcaggatgctgcacaaaccc aatcatgtgggagggagaacgtgggagaagtaaaaaaagagaatagtgtagagacccagg ccttggattggggaaaacaggaatgtgttggaaatgggaatgttacagagatccagacac caaggtgggagaagcatgatcaaggtggaagtaagaaagctaagaagacccaagcatctg ggggagagaaccagaaacaattaagtcatgaaattcaagtggggtggggaaataagggcc tgagaagagatgaagatgctaaggaaacccagatagctaccaagaagaagctcagggaga taagagaaggattgggtggtgatccaggcactatggtggggaaaccggagacaagtagca agtgaaatttatagagaatttgagatactatgttgggagaatcagaactggattggaggt gaacatagagcagaaattcaggcatcagagaagagagaccaaagaaaggatggatgtgag gatggcacaaatatcctggcacccgaggctgagatccaggaacaattaaaaggtgaaact gatgtggagactcagagcaatgagccacttagagaagaggatggtacagacattcagtca ctagggaggagagaggttaaaggtgaggatgataaagacacccaggaacttgggaggaaa aatcagggtcagttaggaaatgaatttagtggaaagattcacataccaaaggggaagaat caggaacatattagaggcgaagatggtgcacatacccagatatctgagtcagggaactgg ggcaaattaacaagtcaaattgatggagaaatgcattcagcagaatggaagaaagatcag cagattggaggtgagaatggggcagaaattcagatacaagggaagagaaacctgagagaa gttggaggtgaggacggtgtaaagacctgggcacctgggaaagaaacccagagtcagttt agaagtgatcttggtagaaagatccttttatcagagtggaagagccagaagcagatggga agtgagaatggaacagaaattcaggctccagtggagagaaaccagagagaacctggaggt gaggacggtgtaaagactcagagacctaagagagagaacgaggaccagttagatagtgaa attggagggagccattcaccagggaggaggaactgggagctgattggaaaggatgttgca gaaaatcaggcatcagagaagagaaaccagagagaggttggaaacgaggacggtagaatg atctggaggcttaggggaaaaaactggaggcttagagcgaagaaacagactgttaaaaag taaagataatggaaagacccgtttatcagagtggaagaaccaggaacagggtggaggtgg gaatgatgaagaaattcaaatacaggggaagagaaacctgagagggaccacagctgatga tggtacagagacccaggctcctgcaggagatgaccagggacagttaagagttgaaattgc tgaagagatccaggtacaagggcaaggaaataagaatgacggtggagttgaggatgttgc agaactccaggatataggaagccagagaaagtgcacagatgaggatgttggagagcctcg agcaccaaggggaggaaacaaggatctggtcagaggagaggatgctgtgagggacagtct ccaagtcgactgttctgggagtgagaggcccacaggcaggaagcacagcctaccatggcc tccagccttcactggctatggatgtgggacccgggaacaggaacaggcagtggctgtgaa tggtttcatctctgccccctgtcctgagatgaatcctgtcccccactggggtgaagtctt cctgctggtgggtggggagggagagcatctggccagccagggcacaacccctgccaggga tcatagagtggggatcagtccagcctcccagcaggcccaacctgaatcctggagaagacg acaaagggacaaaggggtggatccagagaaggcccccagcctgactcggcagtcccaaaa ccctccgtctctgacagctcccttgggcatgccctctgcctgctcctgtctcccgtgtgg cccagccccggaagctgccatcattctagcgggtcctcccaccgccctcactgtcctgcc caaggggacaggcctcaagaagagcaaacgactgctcctggagtccctcatgcggaggag gattgcacacctgaagtggggtcttccccggcggatcctggagtcctatttcctgtttaa cttcttaggatcttgctcattgacccttgctggggcgaggctctctggactgaacacagg ccaggagctccaagcccagcaggaaaggtattgtgaggcccaaggctccccaccaggcct taagtccccagagaggttccagagggttcagcgcccagacagaaaaagctcgaaacttcc tatacaagccagagctctggagaggaacagaccgcacatgtcagagcccattaagcattt ccatccagcctgaaaaggccaggagagtcaggccaccagggggcgccagagaaccacagg agatccaggaagcgcttgctaggaccaagctcccagctcccaggacccccaggccggcag cggagtccaggagctggtgtggcccacaaagggtcggagagcctcccagtgagaacagta ggggcaggaaaatgatcaggtcaagggtctcccagctggcagagagggctcccagcagag tgaggacttcattctctagggcagaccacgcccactggaggaaggaatgtacatcctggg aggcctctaagctccccagactcaaatgccagcagctcacatactggagaagaggaagcc tggaatctacagggtgcagaggggctgggcagcagccttcctgccattctgcagaacctg tcagcttcaaagggaggctccactctgcggtggcaaagctgggcctgacccttctggcca agatgtcctggtccccacagctcgccaagcgcaagcacttggcccctaacctgagcctga gggaacctgattctactctgcctcccaaagtgggtgatcctcgtgcaggggaggacagca tcggagatcacactgcttcacagagggatcttcagctgcaaggtcactgctgtactgggg ccacccttcctaagacagagagtccccagggccaggaggcacctgggaacccaaatgggg ctccacagaatacacgagcctccaaaaagtttagtattatgaagcatctgaatttttttt ctcttccagaatggctttaaaaagtagactcaggcccagagtcctcaggacatatcagaa aagctttgagagtgtcctgatccctgcaaagcctctaataaattggtcatttgggcaaaa aaaaaaaaaaaa

TABLE 136 cbe_252016 HPV 1a L1 Human Papillomavirus 1a L1 length = 1527 atgtataatgtttttcagatggctgtctggttaccagcgcagaataagttctatcttcct SEQ ID NO: 127 ccccagcccatcactagaatcctgtccactgatgaatatgtaaccagaaccaatctcttc taccatgcaacatctgaacgtctactgctggtcggacatcctttgtttgagatctccagt aatcaaactgtaactataccaaaagtgtcaccaaatgcatttagagtttttagggtgcgt tttgctgatccaaatagatttgcatttggggataaggcaatttttaatccagaaacagaa agattagtttggggcctaagagggatagagataggtagaggccagcctttaggtatagga ataacgggccaccctcttttaaataagttagatgatgcagaaaatccaacaaattatatt aatactcatgcaaatggagattctagacaaaatactgcttttgatgcaaaacagacacaa atgttcctcgtcggctgtactcctgcttcaggtgaacactggacaagtagtcgttgccca ggggaacaagtgaaacttggggactgccccagggtgcaaatgatagagtctgtcatagaa gatggtgacatgatggatattggttttggggctatggattttgctgctttacagcaagac aagtctgatgtccctttagatgttgttcaagcaacatgcaaatatcctgattatatcaga atgaaccatgaagcctatggcaactctatgtttttttttgcacgtcgcgagcaaatgtat accaggcacttttttactcgcgggggttcggtgggtgataaggaggcagtcccacaaagc ctgtatttaacagcagatgctgaaccaagaacaactttagcaacaacaaattatgtaggc acaccaagtggctctatggtttcatctgatgtccaattgtttaatagatcttactggctt cagcgatgtcaaggccagaataatggcatttgctggagaaaccagttatttattacagtt ggagataataccagaggaacaagtttatctatcagtatgaaaaacaatgcaagtactaca tattccaatgctaattttaatgattttctaagacatactgaagaatttgatctttctttt atagttcagctttgtaaagtaaagttaactcccgaaaatctagcctacattcatacaatg gaccctaatattttagaggattggcaactatctgtatctcaaccacctaccaatcctcta gaagatcaatataggtttttagggtcttccttggcagcaaaatgtccagaacaggcgcct cctgagccccagactgatccttatagtcaatataaattctgggaagtcgatctcacagaa aggatgtccgaacaattagaccaatttccactaggaaggaaatttctatatcaaagtggc atgacacaacgtactgctactagttccaccacaaagcgcaaaacagtgcgtgtatctacg tcagccaagcgcaggcgtaaggcttag

TABLE 137 cbe_252041 HPV 1a L2 Human Papillomavirus 1a L2 length = 1524 atgtatcgcctacgtagaaaacgcgctgcccccaaagatatatacccctcatgcaaaata SEQ ID NO: 128 tcaaacacctgcccacctgacattcaaaataaaattgagcatacaacaattgctgataaa atattgcaatatggcagtctgggagtttttttgggaggtttgggcattggaacagccaga ggctctggaggaagaattggttatactcccctcggtgagggtggtggggttagagttgct actcgtccaactccagtaaggcctacaatacctgtggaaacagtaggccccagtgaaatt ttccccatagatgttgtagatcctacaggccctgctgttattcccctacaagatttaggt agagacttcccaataccaactgtgcaggttattgcagaaattcaccctatttctgacata ccaaacattgttgcatcttcaacaaatgaaggagaatctgccatattagatgtgttacga gggaatgcaaccatacgcactgtttcaagaacacaatacaataacccctctttcactgtt gcatctacatctaatataagtgctggagaagcatcaacatcagatattgtatttgttagc aatggttcaggtgacagggtggtgggcgaggatatccccttggtagaattaaacttaggc cttgaaacagacacatcttctgttgtacaagaaacagcattttccagcagcacaccaatt gctgaaagaccctcttttaggccctcaagattctataataggcgtctatatgaacaggtg caagtacaagaccctaggttcgttgagcagccacagtcaatggtcacttttgataatcca gcatttgagccagagcttgatgaggtgtctattatcttccaaagagacttagatgctctt gctcagacaccagtgcctgaatttagagatgtagtttatctgagcaagcccacattttcg cgggaaccagggggacggttaagggttagccgccttggcaaaagttcaactattcgtaca cgcctgggcacagcaattggcgccagaacccactttttctatgatttaagttctattgct ccagaagactcaattgaattattgcctttaggtgagcatagtcaaacaacagtcattagt tccaacttaggtgacacagcatttatacaaggtgagacagcagaggatgacttagaagtt atctctttagaaacaccacaattatattcagaagaagagcttttagacacaaacgaaagt gtgggcgaaaatttgcaacttactattactaactcagagggtgaggtttctatactagat ttaacacaaagcagagtcaggccaccttttggcactgaagatactagcttgcatgtatat tacccaaattcttctaaagggactccaataattaatcctgaagaatcatttacacctttg gttattatagctcttaacaactcaacaggggattttgagttacatcctagtcttagaaag cgtcgtaaaagagcttatgtataa

TABLE 138 cbe_252090 Prey2820 PathCalling Prey Sequence 2820 length = 535 gagcagcacattccacccatgctgagagccactggttgctcccagcttggtctgtatcct SEQ ID NO: 129 cctgagcagctcccaccccctgaaatgctttggagaagaaagaagaggaggccatgtttg gaaggaatgcagcagcagggccttgggggagtccccgcccgggtgagggctgtcacttac cacctggaggacctaagaaggcgtcagagcatcatcaacgaactgaagaaggcccagtgg ggcagctctggggctgcatctgagccagtggtgcttggcgaagagggctgtggattcccc agcaccaatgaataccctgatctggaagaggagagagcaacctatccacaggaagaggac cgttttctcactcctggcagggcccagctgctttggtctccctggagccccctggatcag gaggaggcttgtgcctccaggcagctgcactctctggcctcgttcagcactgtcacagcc agaaggaacccccttcacaatccctgggggatggagttggcagcgtctgaagagt

TABLE 139 cbe_2685998 Prey2313 Homo sapiens, clone IMAGE: 3625550, mRNA, partial cds. length = 1922 gcgccatctgcctcgattacttcacggaccccgtgtccatcggctgcgggcacaacttct SEQ ID NO: 130 gccgagtttgtgtaacccagttgtggggtggggaggatgaggaggacagagatgagttag atcgggaggaggaggaggaggacggagaggaggaggaagtggaggctgtgggggctggcg cggggtgggacacccccatgcgggatgaagactacgagggtgacatggaggaggaggtcg aggaggaagaagagggtgtgttctggaccagtggcatgagcaggtccagctgggacaaca tggactatgtgtgggaggaggaggacgaggaggaagacctggactactacttgggggaca tggaggaggaggacctgaggggggaggatgaggaggacgaggaggaagtgctggaggagg ttgaggaagaggatctagaccccgtcaccccactgcccccgcctccagcccctcggaggt gcttcacatgccctcagtgccgaaagagctttcctcggcggagcttccgccccaacctgc agctggccaatatggtccaggtgattcggcagatgcacccaacccctggtcgagggagcc gcgtgaccgatcagggcatctgtcccaaacaccaagaagccctgaagctcttctgcgagg tagacgaagaggccatctgtgtggtgtgccgagaatccaggagccacaaacagcacagcg tggtgccattggaggaggtggtgcaggagtacaaggccaaactgcaggggcacgtggaac cactgaggaagcacctggaggcagtgcagaagatgaaagccaaggaggagaggcgagtga cagaactgaagagccagatgaagtcagagctggcagcggtggcctcggagtttgggcgac tgacacggtttctggctgaagagcaggcagggctggaacggcgtctcagagagatgcatg aagcccagctggggcgtgcgggagccgcggctagtcgccttgcagaacaggccgcccagc tcagccgcctgctggcagaggcccaggagcggagccagcaggggggtctccggctgctcc aggtgtgaagaggtacagctgcagcccccagaggtctggtcccctgacccgtgccaaccc catagccatgacttcctgacagatgccatcgtgaggaaaatgagccggatgttctgtcag gctgcgagagtggacctgacgctggaccctgacacggctcacccggccctgatgctgtcc cctgaccgccggggggtccgcctggcagagcggcggcaggaggttgctgaccatcccaag cgcttctcggccgactgctgcgtactgggggcccagggcttccgctccggccggcactac tgggaggagcctaaagaaccctcctggcctccagctcagccttctctcacctactatgtc tgtccaacagaccggccagaatttagcttcacttgagagagatctggaatggtcgccatg attgaaaccacgcaccattacatcatcattacattaattacatcaacataaattatttct tcccccttcccttttccagcactcaaccaaggagcaaagctcatcccaccccacacccct cccaggtctgctcactgccaggctcctctcccctttgttcagtggagctggcttttctcc cagcccctttccatgcctttcactccatttggcaagctctgagggggagcctggggacgg gtttgggtccccaggaggagagccttgggtataatctatttttctaggagcctcttgcct tgtcacttgcagctttcgccctctgctttgatggctgaggtgaactcatgttctttggga aaagggaaggcgtgctgtggaaataaaatgtttatttgcttctcaaaaaaaaaaaaaaaa aa

TABLE 140 cbe_2693325 Prey1673 Prey1673, 194 bp. length = 194 tgtacactgccgcaatgtgggtgcagagctgagggactgagctggggcaccagggtgggc SEQ ID NO: 131 agattggcatgagggagagaggaggacctcaagttgggaagagaggcaaagtcagcactg gagacagggagtgaaggaagagctgaaggattcagctcctggccagatagttgggatgat gctcttttagatct

TABLE 141 cbe_2789381 Prey775 AL523176 LTI_NFL003_NBC3 Homo sapiens cDNA clone CS0DC001YA04 3 prime, mRNA sequence (AL523176.1: 98%/1043, p = 0.000000), 1498 bp. length = 1498 tactggagggccgggtcccagcctggatgttacccaaccccatgacggaccctttcattg SEQ ID NO: 132 cagcgatctgcacacgtgtgggtgtttccataggacattgtcaggcacagatggctggtc cgaagcacgtgcatttcagttttgaggctcctgtcctcaggcagtgtggactcaggccct gggagtcatgtggatgccagtagcctgggcccacagagctgctgggatgtggggggcata tcaagttgaagatggcaactctgatctgacgcctctgtgctcagggcccctggaggaggg gctactgccccttggcccttagacaacaggacagagaccagagggactgggcggcttgtc ccaggctactgggctgtggtctctgaccccctggaggcctccccacgcctcacagaacac agtgcagacggtgggcggggagagctcgaggggaggcccagccctgcaggtgggactggc tctccctccccagccacgagtatgccacagggggctttcaaaaccaggcagggccaagcc ttggccccactggaggtagagcaccttctgtggctcccgggtgcctttaggcccgtccag gagttggagcagaggagaagacccagactgtgcatagttccctgaggagggctagcctca ggtgccacagcctggttcggcctggcggccccaggacgcagcagcaaccttgggcttcct gcggggtgactaccttgccctccggccctgcccgttgactaactatgctctgtggttttg tttccagagaactcagattgcacagagctagactcgggcagccagagcggcgagctgagt aacaggggtaacacctccctgctgcccctccctctctctccctctctctccctctctctt taccctccccagggctccatctccgcctcaggggcttctccaccccaagtctggctccat tcctggccttctgttggtgacagacccccccctaaggtgctcgtttgggggctcttcagg cagcacctcagcctggcacccccactcccctgcacagcccccaggcctcaggaccccacc cctctgaggcccaggggagccctgttcacgctggtttctccccaggacccatgagcttcc tggctggcctgggccttgctgtgggactggccctgctcctgtactgctatccgccagacc ccaagggcctgccagggacccggcgcgtcctcggtttctcgcctgtcatcatcgacagac atgtcagccgctacctgctggccttcctggcagatgacctaggggggctctgacagaccc tggacccagggcctcacctgccactcaaccaaagagtcctcgagccggcccgccaagggg actgctgcttctttttctaaatgcatatttttcattatttataatttgtgtaaaaaacac accttcaccttacaaggtgctgaccatattaaatgttcaggttctctcaaaaaaaaaa

TABLE 142 cbe_2826346 RPS10 ribosomal protein S10 length = 598 ctccttcttttccagccccggtaccggaccctgcagccgcagagatgttgatgcctaaga SEQ ID NO: 133 agaaccggattgccatttatgaactcctttttaaggagggagtcatggtggccaagaagg atgtccacatgcctaagcacccggagctggcagacaagaatgtgcccaaccttcatgtca tgaaggccatgcagtctctcaagtcccgaggctacgtgaaggaacagtttgcctggagac atttctactggtaccttaccaatgagggtatccagtatctccgtgattaccttcatctgc ccccggagattgtgcctgccaccctacgccgtagccgtccagagactggcaggcctcggc ctaaaggtctggagggtgagcgacctgcgagactcacaagaggggaagctgacagagata cctacagacggagtgctgtgccacctggtgccgacaagaaagccgaggctggggctgggt cagcaaccgaattccagtttagaggcggatttggtcgtggacgtggtcagccacctcagt aaaattggagaggattcttttgcattgaataaacttacagccaaaaaaccttaaaaaa

TABLE 143 cbe_2830508 Prey292051 Homo sapiens, clone MGC: 12344, mRNA, complete cds. length = 769 catcaccccataaacaaataggtttggtcctagcctttctattagctcttagtaagatta SEQ ID NO: 134 cacatgcaagcatccccgttccagtgagttcaccctctaaatcaccacgatcaaaaggga caagcatcaagcacgcagcaatgcagctcaaaacgcttagcctagccacacccccacggg aaacagcagtgattaacctttagcaataaacgaaagtttaactaagctatactaacccca gggttggtcaatttcgtgccagccaccgcggtcacacgattaacccaagtcaatagaagc cggcgtaaagagtgttttagatcaccccctccccaataaagctaaaactcacctgagttg taaaaaactccagttgacacaaaatagactacgaaagtggctttaacatatctgaacaca caatagctaagacccaaactgggattagataccccactatgcttagccctaaacctcaac agttaaatcaacaaaactgctcgccagaacactacgagccacagcttaaaactcaaagga cctggcggtgcttcatatccctctagaggagcctgttctgtaatcgataaaccccgatca acctcaccacctcttgctcagcctatataccgccatcttcagcaaaccctgatgaaggct acaaagtaagcgcaagtacccacgtaaagacgttaggtcaaggtgtagcccatgaggtgg caagaaatgggctacattttctaccccagcaacaatatactctgccggc

TABLE 144 cbe_2898065 Prey1620 Homo sapiens, DKFZP434F162 protein, clone MGC: 21493 IMAGE: 3871231, mRNA, complete cds. length = 2156 gagctgaagagacctggagccgacagacgggtgaaggccatgccgccttctgggaaagtt SEQ ID NO: 135 ccccgaaaggagaatctgtggctacagtgtgagtgggggtcctgctcctttgtgtgctca accatggaaaagttctttgagcatgtcactcagcacctgcagcagcacctgcatggctct ggggaggaggaggaagaggaagaggaggatgacccacttgaggaagaattctcctgcttg tggcaggaatgtggcttttgttctctggactgttctgctgacctcatccgccatgtctac ttccactgctaccacaccaagctgaaacagtgggggctgcaggccttgcaaagccaggct gaccttggcccctgcatcctggacttccagagccggaacgtcatccctgatatccctgac cacttcctgtgtctgtgggagcactgtgagaattccttcgacaatcctgagtggttttat cggcatgtggaagcacacagtctgtgctgtgaatacgaagcagtcggcaaggacaacccg gtggtgctgtgtggctggaaaggctgtacctgcaccttcaaggaccgcagtaaacttcga gagcacctccgcagccatacccaggagaaagtggtagcctgccccacctgtgggggcatg tttgccaacaataccaagttcttagatcacatccgtcgccagacctcattggatcagcag cacttccagtgttctcactgttccaagagatttgccacagagcggctattgcgggaccac atgcgcaaccatgtgaatcactataagtgccctctgtgtgacatgacctgcccgctgcct tcctccctccgcaaccacatgcgctttcgtcacagtgaggaccggccctttaaatgtgac tgttgtgactacagctgcaagaatcttattgacctccagaagcacctggatacccacagc gaggagccagcctacaggtgtgattttgagaactgcaccttcagtgcccgatccctctgc tctatcaagtcccattaccgcaaagtacatgaaggagactctgagccaaggtacaaatgt catgtgtgtgacaaatgcttcacacggggcaacaacctcaccgtgcaccttcgcaagaag caccagttcaagtggccctcagggcatccccgttttcggtacaaggaacatgaagatggc tatatgcggctgcagctggttcgctacgagagtgtagagctgacacagcaactgctgcgg caaccacaagagggatcgggcctgggaacgtcgctgaacgagagcagcctgcagggcatt attctagaaacagtgccaggggagccaggacgtaaggaagaggaagaggagggcaagggt agcgaagggacagccctctcagcctctcaggacaaccccagttctgtcatccacgtggtg aatcagaccaatgcccaaggccagcaagagattgtctactatgtgctgtctgaagcccca ggggagcctcccccagtccctgagccaccttcagggggcatcatggaaaagcttcaagga atagctgaggagccagagatccagatggtttgaaggccgcagagccagaccatttcttcc ccaggtcctgaagtttgagccaggcaagtggcagtgcccctagtgggcagccgttgccaa tggatgcctttaggagtggtgccgagagcagtgtggtccactctggcctgggtttgcatc attctgcagactctaaagacttcccttttctgccagactacattttgtggggagcctgag gactctggattctttgaggggatcctggatgtgtgtgttcttgttaaagaggctgttatc aggcttaactataaccctcaagatctgcttgacagtgattaaatccttagctcacatcca ttcccatctttcgggctccttaggcccaaggatggcatgtgactggtccctgcaagggtc ctttctttgtcaccagccaaggcattgataaccaagtagccattttcctcttaaggtttc ctctacaaccccaaggactttcatgattatcctcagggacaggattggaggcattgagcg tgtttattaacaagatgtttttggtaataaaaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 145 cbe_3001381 IRF1 interferon regulatory factor 1 length = 2035 cgagccccgccgaaccgaggccacccggagccgtgcccagtccacgccggccgtgcccgg SEQ ID NO: 136 cggccttaagaaccaggcaacctctgccttcttccctcttccactcggagtcgcgctccg cgcgccctcactgcagcccctgcgtcgccgggaccctcgcgcgcgaccagccgaatcgct cctgcagcagagccaacatgcccatcactcggatgcgcatgagaccctggctagagatgc agattaattccaaccaaatcccggggctcatctggattaataaagaggagatgatcttcc agatcccatggaagcatgctgccaagcatggctgggacatcaacaaggatgcctgtttgt tccggagctgggccattcacacaggccgatacaaagcaggggaaaaggagccagatccca agacgtggaaggccaactttcgctgtgccatgaactccctgccagatatcgaggaggtga aagaccagagcaggaacaagggcagctcagctgtgcgagtgtaccggatgcttccacctc tcaccaagaaccagagaaaagaaagaaagtcgaagtccagccgagatgctaagagcaagg ccaagaggaagtcatgtggggattccagccctgataccttctctgatggactcagcagct ccactctgcctgatgaccacagcagctacacagttccaggctacatgcaggacttggagg tggagcaggccctgactccagcactgtcgccatgtgctgtcagcagcactctccccgact ggcacatcccagtggaagttgtgccggacagcaccagtgatctgtacaacttccaggtgt cacccatgccctccacctctgaagctacaacagatgaggatgaggaagggaaattacctg aggacatcatgaagctcttggagcagtcggagtggcagccaacaaacgtggatgggaagg ggtacctactcaatgaacctggagtccagcccacctctgtctatggagactttagctgta aggaggagccagaaattgacagcccagggggggatattgggctgagtctacagcgtgtct tcacagatctgaagaacatggatgccacctggctggacagcctgctgaccccagtccggt tgccctccatccaggccattccctgtgcaccgtagcagggcccctgggcccctcttattc ctctaggcaagcaggacctggcatcatggtggatatggtgcagagaagctggacttctgt gggcccctcaacagccaagtgtgaccccactgccaagtggggatgggcctccctccttgg gtcattgacctctcagggcctggcaggccagtgtctgggtttttcttgtggtgtaaagct ggccctgcctcctgggaagatgaggttctgagaccagtgtatcaggtcagggacttggac aggagtcagtgtctggctttttcctctgagcccagctgcctggagagggtctcgctgtca ctggctggctcctaggggaacagaccagtgaccccagaaaagcataacaccaatcccagg gctggctctgcactaagcgaaaattgcactaaatgaatctcgttccaaagaactacccct tttcagctgagccctggggactgttccaaagccagtgaatgtgaaggaaactcccctcct tcggggcaatgctccctcagcctcagaggagctctaccctgctccctgctttggctgagg ggcttgggaaaaaaacttggcactttttcgtgtggatcttgccacatttctgatcagagg tgtacactaacatttcccccgagctcttggcctttgcatttatttatacagtgccttgct cggggcccaccaccccctcaagccccagcagccctcaacaggcccagggagggaagtgtg agcgccttggtatgacttaaaattggaaatgtcatctaaccattaagtcatgtgtgaaca cataaggacgtgtgtaaatatgtacatttgtctttttataaaaagtaaaattgtt

TABLE 146 cbe_3056756 KIAA0440 signal-induced proliferation-associated 1 like 1 length = 6028 ggtgtggacgttgtctaaatttcggtagccatggcacaagaatataagaaagcatgggat SEQ ID NO: 137 tatggcaaccacagaatctcagtagtacaagttccattcagttttttctgaaagaaagcc ctctgttaaagtgaagcaaagaaactgttgtggattataacgtttagaagttccaatttt tcagtgctttacaaataaagcatcatttaaccttttaaatgaaaaagattaagatctcat gcaactgttgtattttctggaagccattctccaaaagggaagtgcacatttaaaacacag atatgatggtccttgctgcagggatttaagtctacttgcttttacatcatgaccagcttg aaacggtcacagacagaaaggcctcttgccactgacagggcctctgttgttggcacagac ggcacccccaaagtccacactgatgatttctacatgcggcgcttccggtcccaaaatggc agcttaggatcatcagttatggctcctgtaggacccccccgaagtgaaggttctcaccat ataacctcaacccccggagtcccaaaaatgggggtaagggcaaggattgcagattggccc ccaagaaaggaaaacataaaagaatctagccgttcaagccaggaaatagaaacctcaagt tgccttgatagcctgtcctccaaaagcagtcctgtgagtcagggaagttctgttagcctc aattccaatgactcagccatgctgaaaagcatacagaacacgctgaaaaacaagacaaga ccgtcggagaacatggactccagatttctcatgcctgaagcctaccccagctcccccaga aaagctcttcgcagaatacgccagcgaagcaacagtgatatcaccataagtgaacttgat gtggatagctttgatgaatgtatctcacctacatacaagactggaccatcactgcacagg gaatatggtagcacatcttcaattgataaacagggaacatctggagaaagcttttttgat ttgttaaagggctacaaagatgacaaatctgatcgaggtccaactccaaccaagctcagt gactttctcattactggtggtggcaagggttctggtttctctttggatgtaatagacggg cctatctcacagagagagaacctcaggctttttaaggaaagggaaaaaccactcaagcga cgttcaaaatctgaaactggagactcctctatttttcgtaaattgcgcaatgccaaaggt gaagaacttgggaagtcatcagatcttgaagataaccgatcagaagactctgtcaggccc tggacatgtccaaagtgctttgcccactatgatgtccagagtatattatttgatttgaat gaggcaattatgaacaggcacaatgttattaagaggagaaacaccaccactggagcttcc gcagctgccgtggcatccttggtctctggacctctgtctcattcagccagttttagctcc ccaatgggcagcacagaggacctgaattccaaaggaagcctcagcatggaccagggagat gataaaagcaatgagcttgtaatgagctgtccatattttcggaatgagataggtggagaa ggggagaggaaaatcagcctttcaaaatcaaattctggctcctttagtggatgtgaaagt gcctcctttgagtctacccttagttcccattgcacaaatgcaggagtggcagtacttgaa gtgcccaaggagaacttggtgttgcacctagatagagtgaaaagatacatcgtggaacac gtagatctgggtgcatactattatagaaaatttttctaccagaaggaacactggaactat tttggggctgatgagaatcttggtccagtggctgtgagcattcgaagggaaaaaccagat gaaatgaaagaaaatggatctccgtacaactaccgaataatttttagaactagtgagctc atgacactgagaggttcggtcctggaggacgccattccgtcgacagccaagcactcgaca gccagaggcctgcctctcaaagaagtgctggagcacgtggttcctgagctcaatgtccag tgcctgcggttggccttcaacacacccaaggtcacagagcagctcatgaaactggatgaa caagggctgaactaccagcagaaagtaggcatcatgtactgcaaagctggacagagcact gaagaagagatgtacaacaatgagtcagctggcccagcctttgaagaattccttcaacta ttgggagagcgagttcggctcaaaggatttgagaagtatcgagcacagcttgataccaaa actgactccactggaacccattctctgtacacaacatacaaagattatgaaattatgttc catgtttctaccatgctgccatacacacccaacaacaaacaacagctcctgaggaagcgg cacattggaaatgatatcgtaacaattgttttccaagagcctggagcacagccattcagc ccaaaaaacatccgatcccacttccagcacgttttcgtcatcgtcagggtgcacaatccg tgctctgacagtgtctgttatagtgtggctgttaccaggtccagagatgtgccttccttt gggcctcccattcctaaaggggtcactttccctaagtcaaatgtgttcagggacttcctt ttggcgaaagtgattaatgcagaaaatgctgctcataaatcggagaagtttcgggccatg gcaactcggacccgccaggaatacctgaaagatctggcagaaaagaatgtcaccaacacc cctatcgacccttctggcaagtttccgttcatctctctggcttccaagaagaaggaaaag tctaagccatatccaggagccgagctcagcagcatgggggccattgtatgggcagtccgg gctgaagactacaacaaggccatggaactagactgccttttagggatctccaatgagttc attgtgctcattgaacaggaaacaaagagcgtggtcttcaattgttcctgtagagatgtg atagggtggacttcaactgacaccagcctcaaaatcttctatgaacgaggagaatgtgtt tcagtgggtagttttattaacattgaggagatcaaagagattgtcaaaaggttgcagttt gtttcaaaaggctgtgaatcggtggagatgactctgcgaagaaatgggctaggacagctt ggcttccatgtcaactatgagggcattgtggcggatgtggagccctacggttatgcctgg caggcagggctgaggcagggcagtcgcctggtggagatctgcaaggtggcggtagccact ctgagccatgagcagatgatcgacctcctgagaacatctgtcacggtgaaggttgtcatc attcccccgcatgatgactgcaccccgcggaggagttgctctgaaacctaccgcatgcca gtgatggagtacaaaatgaatgaaggtgtttcatacgaattcaagtttcccttccgaaat aataacaagtggcagaggaacgccagcaaggggcctcattcacctcaagtcccgtcccag gtgcagagtcccatgacctcgcggctgaatgctggaaaaggagatgggaagatgcctcct ccagaaagagccgccaacatccctcgaagcatctccagtgacgggcgcccactagagagg cggctgtctcctggttcggacatctatgtgacggtctcatccatggctttagcaagatcc cagtgtcggaactctcctagcaacttgtcttcatccagtgatactggttctgtggggggc acttacaggcagaagtccatgcccgaagggtttggagtgagccgtagatccccagcctcc attgacaggcagaacacccagtcagatattggtggcagcggaaaatccacgcctagctgg caaagaagtgaggatagcattgctgaccagatggcttacagttatagaggacctcaggat ttcaattcttttgtcctcgagcagcatgaatatacagagccaacatgccatctcccagca gtatcaaaggtactgccagctttccgagagagccccagtgggagattaatgcggcaggat ccagtggttcatttgtctccaaacaaacaagggcattctgatagccactactcgagccac tccagtagcaatactctctccagcaatgcgtcaagtgcccatagtgatgagaagtggtac gatggggaccgcacagaatccgaactcaacagctataactatctgcaaggcacctctgct gacagtggcattgacaccacctcttatggccccagccacggcagcacagcctcgctgggg gctgccacatcgtcacctcgctcagggccaggcaaggagaaagtggcacccctatggcac agctccagtgaagtaatctccatggcagatcggactttggagacagagagccacggcctg gaccggaaaacagagtcttccctgagcttagacatacacagcaagagccaagccggctcg acccctctgacaagggagaacagcaccttcagtataaacgatgctgcttcccacacaagt accatgagctcccgacactctgccagcccagtggttttcaccagtgcccggagttcacct aaagaagagcttcatccagctgccccctcacagctcgcaccatccttctcctcctcttcc tcctcctcctctggtcctaggagtttttaccctcgccagggcgctactagcaagtacctg attggatggaaaaaacccgaaggaaccataaactccgtgggatttatggacacgagaaag cgtcatcagagcgatggcaatgaaatagcccacaccaggctgcgtgcctcaaccagagac ctccgggcatctcctaagccaacctccaagtccaccattgaagaagatctaaagaaacta attgatcttgaaagcccaactcctgaatcacagaagagttttaagttccacgcactctcc tctcctcagtctcctttccccagcacccccacctcacggcgggccttgcacagaacactg tcggacgagagcatttacaatagccagagggagcactttttcacctccagggcgtcactt ctggaccaagccctgcccaacgacgtcctcttcagtagcacgtacccttctctccccaag tcgctcccgttgaggaggccttcttacaccttaggaatgaaatcgctgcatggagagttc tcagcctcggacagctccctcactgacatccaggagacccgcaggcagcctatgcccgac cctggcctgatgcccctgcctgacactgctgcagacttggattggtccaacctggtagat gctgccaaagcctatgaggtccagagagcctcattttttgctgctagtgatgaaaaccat cgccccttgagtgctgcatccaacagtgatcagctggaggaccaggctctggcccagatg aagccttacagcagcagtaaagactcctctcccactctggcttctaaagtggaccagctg gaaggtatgctgaagatgcttcgggaagatttgaagaaggaaaaagaagacaaagctcac cttcaggcggaggtgcagcacctgcgagaggacaacctgaggctacaggaggagtcccag aacgcctcggacaagctgaagaagttcacagaatgggtcttcaacaccatagacatgagc tagggaaggctgaggaggacaggagaagggcccagacactccctccagtgagtgtcctgc agcccttattccctccatagaaagcatcctcagagcaccttccctggcttcctactctgc cccctttcggggagtgcacaacacaatagttgcagatcaacaatcatcacctgccttttg tagaaaagaaaaacaaaaaaagtaaataaaaattttaaacagtaaaataaaagtttaact gctaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 147 cbe_3340492 TRIP TRAF interacting protein length = 2007 gtgcggtggagcgaaatttgaagcaagcggaggcggggcgctctacgaagccggacctgt SEQ ID NO: 138 agcagtttctttggctgcctgggccccttgagtccagccatcatgcctatccgtgctctg tgcactatctgctccgacttcttcgatcactcccgcgacgtggccgccatccactgcggc cacaccttccacttgcagtgcctaattcagtcctttgagacagcaccaagtcggacctgc ccacagtgccgaatccaggttggcaaaagaaccattatcaataagctcttctttgatctt gcccaggaggaggagaatgtcttggatcgagaattcttaaagaatgaactggacaatgtc agagcccagctttcccagaaagacaaggagaaacgagacagccaggtcatcatcgacact ctgcgggatacgctggaagaacgcaatgctactgtggtatctctgcagcaggccttgggc aaggccgagatgctgtgctccacactgaaaaagcagatgaagtacttagagcagcagcag gatgagaccaaacaagcacaagaggaggcgggccggctcaggagcaagatgaagaccatg gagcagattgagcttctactccagagccagctccctgaggtggaggagatgatccgagac atgggtgtgggacagtcagcggtggaacagctggctgtgtactgtgtgtctctcaagaaa gagtacgagaatctaaaagaggcacggaaggcctcaggggaggtggctgacaagctgagg aaggatttgttttcctccagaagcaagttgcagacagtctactctgaattggatcaggcc aagttagaactgaagtcagcccagaaggacttacagagtgctgacaaggaaatcatgagc ctgaaaaagaagctaacgatgctgcaggaaaccttgaacctgccaccagtggccagtgag actgtcgaccgcctggttttagagagcccagcccctgtggaggtgaatctgaagctccgc cggccatccttccgtgatgatattgatctcaatgctacctttgatgtggatactccccca gcccggccctccagctcccagcatggttactacgaaaaactttgcctagagaagtcacac tccccaattcaggatgtccccaagaagatatgcaaaggccccaggaaggagtcccagctc tcactgggtggccagagctgtgcaggagagccagatgaggaactggttggtgccttccct atttttgtccggaatgccatcctaggccagaaacagcccaaaaggcccaggtcagagtcc tcttgcagcaaagatgtggtaaggacaggcttcgatgggctcggtggccggacaaaattc atccagcctactgacacagtcatgatccgcccattgcctgttaagcccaagaccaaggtt aagcagagggtgagggtgaagaccgtgccttctctcttccaggccaagctggacaccttc ctgtggtcgtgagaacagtgagtctgaccaatggccagacacatgcctgcaacttgtagg tcaaggactgtccaggcagggtttgtggacagagccctactttcgggaccagcctgaggt gtaagggcagacaaacaggtgagggtgagtgtgacacccagagactgctcttcctgccct caccctgccccactcctacgactgggagctgacatgaccagcccactgatcctgtcagca ggtcctgctctgttgccaggctcttgtttatagccatgatcagatgtggtcagactcttt ctgggcctggagaccacggtcacttgttgactgtctctgtggaccagagtgcttgaggca tctcaggcagcctcagcccaagcttctacctgcctttgacttgcttctagcatagcctgg gccaagcagggtggggaatggaggatagacatgggatgtatggagaggatggaagatttt cccgaaaaaaaaaaaaaaaaaaaaaaa

TABLE 148 che_3345510 COX6C cytochrome c oxidase subunit VIc length = 444 ctttagtcaggaaggacgttggtgttgaggttagcatacgtatcaaggacagtaactacc SEQ ID NO: 139 atggctcccgaagttttgccaaaacctcggatgcgtggccttctggccaggcgtctgcga aatcatatggctgtagcattcgtgctatccctgggggttgcagctttgtataagtttcgt gtggctgatcaaagaaagaaggcatacgcagatttctacagaaactacgatgtcatgaaa gattttgaggagatgaggaaggctggtatctttcagagtgtaaagtaatcttggaatata aagaatttcttcaggttgaattacctagaagtttgtcactgacttgtgttcctgaactat gacacatgaatatgtgggctaagaaatagttcctcttgataaataaacaattaacaaata ctttgaaaaaaaaaaaaaaaaaaa

TABLE 149 che_3454406 gbh_af252829 Homo sapiens chromosome 8 clone BAC 495D4 map 8g24, *** SEQUENCING length = 488 ccgagcagcctaactgggaggcaccccccagcagaggcacactgacacctcacacggcag SEQ ID NO: 140 ggtattccaacagacctgcagctgagggtcctgtctgttagaaggaaaactaacaaccag aaaggacatctacaccgaaaacccatctgtacatcaccatcatcaaagaccaaaagtaga taaaaccacaaagatggggaaaaaacagaacagaaaaactggaaactctaaaacgcagag cgcctctcctcctccaaaggaacgcagttcctcaccagcaatggaacaaagctggatgga gaatgattttgacgagctgagagaagaaggcttcagacgatcaaattactctgagctacg ggaggacattcaaaccaaaggcaaagaagttggaaactttgaaaaaaatttagaagaatg tataactagaataaccaatacagagaagtgcttaaaggagctgatggagctgaaaaccaa ggctcgag

TABLE 150 cbe_3461331 MET met proto-oncogene (hepatocyte growth factor receptor) length = 4620 cgccctcgccgcccgcggcgccccgagcgctttgtgagcagatgcggagccgagtggagg SEQ ID NO: 141 gcgcgagccagatgcggggcgacagctgacttgctgagaggaggcggggaggcgcggagc gcgcgtgtggtccttgcgccgctgacttctccactggttcctgggcaccgaaagataaac ctctcataatgaaggcccccgctgtgcttgcacctggcatcctcgtgctcctgtttacct tggtgcagaggagcaatggggagtgtaaagaggcactagcaaagtccgagatgaatgtga atatgaagtatcagcttcccaacttcaccgcggaaacacccatccagaatgtcattctac atgagcatcacattttccttggtgccactaactacatttatgttttaaatgaggaagacc ttcagaaggttgctgagtacaagactgggcctgtgctggaacacccagattgtttcccat gtcaggactgcagcagcaaagccaatttatcaggaggtgtttggaaagataacatcaaca tggctctagttgtcgacacctactatgatgatcaactcattagctgtggcagcgtcaaca gagggacctgccagcgacatgtctttccccacaatcatactgctgacatacagtcggagg ttcactgcatattctccccacagatagaagagcccagccagtgtcctgactgtgtggtga gcgccctgggagccaaagtcctttcatctgtaaaggaccggttcatcaacttctttgtag gcaataccataaattcttcttatttcccagatcatccattgcattcgatatcagtgagaa ggctaaaggaaacgaaagatggttttatgtttttgacggaccagtcctacattgatgttt tacctgagttcagagattcttaccccattaagtatgtccatgcctttgaaagcaacaatt ttatttacttcttgacggtccaaagggaaactctagatgctcagacttttcacacaagaa taatcaggttctgttccataaactctggattgcattcctacatggaaatgcctctggagt gtattctcacagaaaagagaaaaaagagatccacaaagaaggaagtgtttaatatacttc aggctgcgtatgtcagcaagcctggggcccagcttgctagacaaataggagccagcctga atgatgacattcttttcggggtgttcgcacaaagcaagccagattctgccgaaccaatgg atcgatctgccatgtgtgcattccctatcaaatatgtcaacgacttcttcaacaagatcg tcaacaaaaacaatgtgagatgtctccagcatttttacggacccaatcatgagcactgct ttaataggacacttctgagaaattcatcaggctgtgaagcgcgccgtgatgaatatcgaa cagagtttaccacagctttgcagcgcgttgacttattcatgggtcaattcagcgaagtcc tcttaacatctatatccaccttcattaaaggagacctcaccatagctaatcttgggacat cagagggtcgcttcatgcaggttgtggtttctcgatcaggaccatcaacccctcatgtga attttctcctggactcccatccagtgtctccagaagtgattgtggagcatacattaaacc aaaatggctacacactggttatcactgggaagaagatcacgaagatcccattgaatggct tgggctgcagacatttccagtcctgcagtcaatgcctctctgccccaccctttgttcagt gtggctggtgccacgacaaatgtgtgcgatcggaggaatgcctgagcgggacatggactc aacagatctgtctgcctgcaatctacaaggttttcccaaatagtgcaccccttgaaggag ggacaaggctgaccatatgtggctgggactttggatttcggaggaataataaatttgatt taaagaaaactagagttctccttggaaatgagagctgcaccttgactttaagtgagagca cgatgaatacattgaaatgcacagttggtcctgccatgaataagcatttcaatatgtcca taattatttcaaatggccacgggacaacacaatacagtacattctcctatgtggatcctg taataacaagtatttcgccgaaatacggtcctatggctggtggcactttacttactttaa ctggaaattacctaaacagtgggaattctagacacatttcaattggtggaaaaacatgta ctttaaaaagtgtgtcaaacagtattcttgaatgttataccccagcccaaaccatttcaa ctgagtttgctgttaaattgaaaattgacttagccaaccgagagacaagcatcttcagtt accgtgaagatcccattgtctatgaaattcatccaaccaaatcttttattagtacttggt ggaaagaacctctcaacattgtcagttttctattttgctttgccagtggtgggagcacaa taacaggtgttgggaaaaacctgaattcagttagtgtcccgagaatggtcataaatgtgc atgaagcaggaaggaactttacagtggcatgtcaacatcgctctaattcagagataatct gttgtaccactccttccctgcaacagctgaatctgcaactccccctgaaaaccaaagcct ttttcatgttagatgggatcctttccaaatactttgatctcatttatgtacataatcctg tgtttaagccttttgaaaagccagtgatgatctcaatgggcaatgaaaatgtactggaaa ttaagggaaatgatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaata agagctgtgagaatatacacttacattctgaagccgttttatgcacggtccccaatgacc tgctgaaattgaacagcgagctaaatatagagtggaagcaagcaatttcttcaaccgtcc ttggaaaagtaatagttcaaccagatcagaatttcacaggattgattgctggtgttgtct caatatcaacagcactgttattactacttgggtttttcctgtggctgaaaaagagaaagc aaattaaagatctgggcagtgaattagttcgctacgatgcaagagtacacactcctcatt tggataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaat ctgtagactaccgagctacttttccagaagatcagtttcctaattcatctcagaacggtt catgccgacaagtgcagtatcctctgacagacatgtcccccatcctaactagtggggact ctgatatatccagtccattactgcaaaatactgtccacattgacctcagtgctctaaatc cagagctggtccaggcagtgcagcatgtagtgattgggcccagtagcctgattgtgcatt tcaatgaagtcataggaagagggcattttggttgtgtatatcatgggactttgttggaca atgatggcaagaaaattcactgtgctgtgaaatccttgaacagaatcactgacataggag aagtttcccaatttctgaccgagggaatcatcatgaaagattttagtcatcccaatgtcc tctcgctcctgggaatctgcctgcgaagtgaagggtctccgctggtggtcctaccataca tgaaacatggagatcttcgaaatttcattcgaaatgagactcataatccaactgtaaaag atcttattggctttggtcttcaagtagccaaagcgatgaaatatcttgcaagcaaaaagt ttgtccacagagacttggctgcaagaaactgtatgctggatgaaaaattcacagtcaagg ttgctgattttggtcttgccagagacatgtatgataaagaatactatagtgtacacaaca aaacaggtgcaaagctgccagtgaagtggatggctttggaaagtctgcaaactcaaaagt ttaccaccaagtcagatgtgtggtcctttggcgtcgtcctctgggagctgatgacaagag gagccccaccttatcctgacgtaaacacctttgatataactgtttacttgttgcaaggga gaagactcctacaacccgaatactgcccagaccccttatatgaagtaatgctaaaatgct ggcaccctaaagccgaaatgcgcccatccttttctgaactggtgtcccggatatcagcga tcttctctactttcattggggagcactatgtccatgtgaacgctacttatgtgaacgtaa aatgtgtcgctccgtatccttctctgttgtcatcagaagataacgctgatgatgaggtgg acacacgaccagcctccttctgggagacatcatagtgctagtactatgtcaaagcaacag tccacactttgtccaatggttttttcactgcctgacctttaaaaggccatcgatattctt tgctccttgccataggacttgtattgttatttaaattactggattctaaggaatttctta tctgacagagcatcagaaccagaggcttggtcccacaggccagggaccaatgcgctgcag

TABLE 151 cbe_3473488 gbh_al121903 Human DNA sequence from clone RP1-155G6 on chromosome 20 Contains length = 5694 aagaaaattgcaatgaaagaaacaaaagagctaacgattgcaaccaaatctactaagcag SEQ ID NO: 142 aatgtagctagtgaaaagcagcggcggctgctgtacaacttagagatggagcaaatggct aaaacagccaaagctctgatggaggctgtgagccatgccaaagccccgtttaccagtgcc actcacctggaccatgtccggccaatgttcaaactggtgtggacgccactattggcagcc tacagcatcggactccagaactgtgatgacactgaagtggcctccttgtgtttggaaggc atccgatgtgcaatccgaatcgcctgcatctttggaatgcagctggaacgagatgcctat gttcaggctcttgctcgcttctccctactcacagccagctccagcatcacagaaatgaag cagaaaaacatcgacaccattaagacgcttatcacagtggctcacaccgatggcaactac cttgggaattcctggcatgagatcttgaaatgcatcagccagctggagctcgctcagctg ataggaaccggtgtgaagacgcgctacctgtctggatctgggcgtgaaagagaagggagc ctgaagggccacacattggcaggagaagagttcatgggccttggcctcggtaatttggtg agtggcggagtggataaaagacagatggccagcttccaagaatcggttggtgagaccagc tcgcagagtgtggttgtagctgtggacaggatttttactgggtctaccagactggatgga aatgcaatagttgactttgtccgctggctgtgtgctgtgtccatggatgaactggcttcc ccccaccatcctcgcatgttcagcttgcagaagattgtggagatatcatactacaacatg aatcggatccgactacagtggtctcgaatatggcatgtgattggagatcacttcaataag gttggctgcaaccctaatgaagatgtggctatctttgctgttgactcattaaggcaactc tccatgaagtttcttgagaagggtgaattagccaacttccgtttccagaaagattttctg aggccctttgagcatattatgaagaaaaacaggtctcccaccatccgggacatggcgatc cgctgcattgcccagatggtgaactcccaggcggccaacatccgctcaggctggaagaac atctttgccgtgttccaccaggcagcctctgatcatgatgggaacattgtggagctggcc ttccagaccacttgccacattgtcacaactattttccagcaccattttcctgcagccatc gattcctttcaggatgctgtgaagtgcttatcagagttcgcctgcaacgccgctttccct gacacgagcatggaagcgattcggctcatccgcttctgtggcaaatacgtctctgagagg cctcgggtgctacaagaatacacaagtgatgacatgaatgtagctcctggtgacagagtc tgggtccgaggctggttccccatcttattcgaactctcctgcatcattaatagatgcaag ttagatgtacgaacaaggggactcacagtcatgtttgagatcatgaagagctatggccac acctttgagaagcactggtggcaggacctgttcagaatcgtgtttcggatttttgacaat atgaaactccctgagcaactgtcagagaaatctgagtggatgacaacaacctgcaatcac gcactttatgctatttgtgatgtttttacccagttttatgaagctttgaatgaagttctt ctttctgatgtatttgcacaattgcagtggtgtgtcaaacaagataatgaacagttggcg cgatcaggtacaaattgcttagaaaacttagtaatatccaatggagagaaattcagtcct gaagtctgggatgaaacctgcaactgtatgttggatattttcaaaacaaccatcccacat gttttgctgacatggagacctgtaggaatggaggaagattcatcagaaaagcatttggat gtggatctggaccgccagtctttaagcagcatagataaaaatccctctgagaggggacag agccagctctctaacccaacagatgacagctggaagggtagaccatacgcaaatcagaaa ctgtttgccagcctcctcatcaagtgtgtggtccagttggaattgatacagaccattgac aacattgtgttctaccctgcgacgagcaaaaaggaggatgcagagcacatggttgccgcc cagcaagacacgctggatgcagatatccacatagagacggaggatcagggcatgtataag tacatgtcttcccagcacctcttcaagctgttggactgtttgcaggaatcccattcattc tcaaaggccttcaactccaattacgagcagcggactgtcctgtggcgagcaggttttaag ggcaagtctaaacccaatcttctaaaacaagaaaccagcagcctggcctgttgtttgagg atcctgtttcgaatgtatgttgatgagaaccgcagggattcctgggaagaaatacagcag agacttttaactgtttgcagtgaagctcttgcctatttcatcactgtgaattctgagagc catcgggaggcctggacaagtctcttgttgttacttctaactaaaaccctcaaaataaat gatgaaaagttcaaagcacatgcttcaatgtactacccctacttgtgtgaaattatgcag tttgacctgatccctgagctccgagcagttctgcggaagttcttcctacggataggtgtt gtgtataagatatggataccagaagagccatcacaggtaccagcagcactgtcaccagtg tggtagccctggctgcccaggccagtgctgcagctctgcagaatgttcagcatgccattt ctgactggcacatctcgtgaagtttcatagaaacaaggagttggcatcttggatctcaga atggcctggaaacggatggcctctacgctgttccatcacagtctccaactaaggcttatg gtatttcattaaactgttgcatacccagttagcacagtaggtggggagtctgcttcattt ctatcattccatttttctgattaaactgtcaaatctgtcattgcatatgccatcgttttc tagcaaaatcccatgattggctataaacgttttgtaagaagtcactctccttgaaaatac tgaacatagctgtataggtttgtgattattagagaatatgttaataaaacttcttgtaac ggctaactgccacctaaaatatgctgggttttctgttgtttgagtgtgttagagaaattt gaatgtttttgtcagttacgagtcagccgtaattagattagtttaaggacaggtcaggat tagagaagagttgtttttgtgttttgttaatgtctgagtgatttttaaagtattttacaa aaagatattgaaaatttggttgaaggcagagtttagtaattaagttagaattaagagttt tgcgaggttaaaaaaatgtgcctcgtggatctccctgttttagtaacatggagagaaaaa gtctacacgaaaaagtgaacaatttaatgaagatgattagccttccttgaaataagtatt tgtggatgggtgttaaattaaaatttccagaatacactgtccatctcacacactgtgaaa tctaatatatgaagtagtaatgaaaatgaagtagtaatttaaccagagttcatttatcct tgaataaacctttttattttcacctcagaaaagtgagtgtactggcagttagtgtcactg ctttgcacagtccccattaaaggaccctccagagagggacagtaactgtgcatgagaagc cgctcccataagcctcctcagccagatgtcatgggtggaactggagctgtgtcggggcca gcacagctgaactgtgacaatggcaggaggtggcatgtgcccagcacttccattaatctg agcctaggagttgaattctttggcaaggttggattctgaggtccttattatgttaatgat ggtgcaatactctcacctgcagtagaactgagttctgctgcagcttgtgtaaaagtgggc agtacacaagtacgtcccaaagcctgtgagcagtatacgtggatgctcacccatgagaag gagcacacacgcctcattctctgccctcacccactgctcacctagagcatcgctgagcgt tagacaaagtgttacacagaatgattaaaactttcagacttctacctatgctctttagtc ctgtaaattgggttgtattgatgtcaactctggtgccttagaagttagtagtttgggaac ctatctgtaaaatcagatgttttttctttgtagagaaggatttctggtgcttttgcttac taagagaccgatattcttaagttgttttcttgttttaacagccttgagaaatgtttggtt ttggccagcagaattcttgtctacttttttctttcccaaaaagtgttttttaatttctct accaaagaaaaaatgagcaggtttaggtttttacatgacttatatacattagataaaagg agctgtataatttagcaggaaaggactagggagaatactttactgtgagtggaaaatgtt agcacatttgactggtttgccctggaatccactgcacctttacactgcaccatgaaacct acactccctggtatcatagcgcgtcatcacctcaacaagtcagtcgtctccattgatatt tgtacaaaaggtatacatggggaacacgtgttcattcattaagtccatcttgcgtgcagc tatatccctgattggttatttttcctttccttctgaggttctcatgtcattttcttcatc ggatgtgactaaaatttttctggtgtcttctgccctctctttaattttgcctcttgaggg gtagcagatgtgtcagtgcattttattacttgctgaaacattcaggcttacatttcttat tagtttagtattttaaaagatttaattttctgaatgaggcatttgaattgtaccagcaat ggacttttaaaaaattggatgtaaaaccattcagggtgatttttcttgtcagtggacagt gacgaacagagatttgaaatcccttacctccaataataagccattcagcctaaattcatt tttatgaataaatctcttctttctcatggtaaatgtggcttgtgccactcaaacactagt gaaagggtatgtacaaccgcaacatcaggccaggacaccatttatttaaccaagtaatgg aggagagtgaaacattttccaaggccttatttctttttcagaatgctttaagtgttgatt atgtgtgctgggtctctagagaagtttttatttgttacaatactgctgctttgagcaatt ttgtttctcttcattgtctgttaggggaatcaccagctttggcatcttaacaacaaacag tggatgggtaatttttatttctgatacgcatctttagagtcaaatatatcttttccctgt actcctcatgtacaaccaaagaacatacattatgaaaattgtattataatatctggaaac acaacattttcctctggcagttacttttgtacgaaatgaaaaaaaaaaaaaaaa

TABLE 152 cbe_3474077 KRT4 keratin 4 length = 2617 gacttgctccggtttgcagagctaggaggtggcaggctgtgcgctcaaactcaggctgtc SEQ ID NO: 143 taactccacattctgtggggtgagaggatgggtgatggggtgtcttttctggaggaggga ggtgctgtgagcctagcgagatggaggtacagtgggtgtgggcctggagcgctgggccca ggcaggggcttctgattaggaagccctggggcaccagttcaggttctcccagagagtagt gtgatgggatccagtaacctgtgccctccagatgacttctgtaggtgtgtttagtgacat gctcaacgggtgcgggaaggatgggcttgtgccaagggccaagcccagagatgtttcaga tttttccctttatgcccctgcaaccaagccctgctgctccaggacatataagagacgaag gctgagggctccagcactcaccggcctgggccctgtcacttctctgatagctcccagctc gctctctgcagccatgattgccagacagcagtgtgtccgaggcgggccccggggcttcag ctgtggctcggccattgtaggcggtggcaagagaggtgccttcagctcagtctccatgtc tggaggtgctggccgatgctcttctgggggatttggcagcagaagcctctacaacctcag ggggaacaaaagcatctccatgagtgtggctgggtcacgacaaggtgcctgctttggggg tgctggaggctttggcactggtggctttggtgccggcggcttcggagctggtttcggcac tggtggctttggtggtggatttgggggctccttcagtggtaagggtggccctggcttccc cgtctgccccgctgggggaattcaggaggtcaccatcaaccagagcttgctcacccccct ccacgtggagattgaccctgagatccagaaagtccggacggaagagcgcgaacagatcaa gctcctcaacaacaagtttgcctccttcatcgacaaggtgcagttcttagagcaacagaa taaggtcctggagaccaaatggaacctgctccagcagcagacgaccaccacctccagcaa aaaccttgagcccctctttgagacctacctcagtgtcctgaggaagcagctagatacctt gggcaatgacaaagggcgcctgcagtctgagctgaagaccatgcaggacagcgtggagga cttcaagactaagtatgaagaggagatcaacaaacgcacagcagccgagaatgactttgt ggtcctaaagaaggacgtggatgctgcctacctgaacaaggtggagttggaggccaaggt ggacagtcttaatgacgagatcaacttcctgaaggtcctctatgatgcggagctgtccca gatgcagacccatgtcagcgacacgtccgtggtcctttccatggacaacaaccgcaacct ggacctggacagcattattgccgaggtccgtgcccagtacgaggagattgcccagaggag caaggctgaggctgaagccctgtaccagaccaaggtccagcagctccagatctcggttga ccaacatggtgacaacctgaagaacaccaagagtgaaattgcagagctcaacaggatgat ccagaggctgcgggcagagatcgagaacatcaagaagcagtgccagactcttcaggtatc cgtggctgatgcagagcagcgaggtgagaatgcccttaaagatgcccacagcaagcgcgt agagctggaggctgccctgcagcaggccaaggaggagctggcacgaatgctgcgtgagta ccaggagctcatgagtgtgaagctggccttggacatcgagatcgccacctaccgcaaact gctggagggcgaggagtacagaatgtctggagaatgccagagtgccgtgagcatctctgt ggtcagcggtagcaccagcactggaggcatcagcggaggattaggaagtggctccgggtt tggcctgagtagtggctttggctccggctctggaagtggctttgggtttggtggcagtgt ctctggcagttccagcagcaagatcatctctaccaccaccctgaacaagagacgatagag gagacgaggtccctgcagctcactgtgtccagctgggcccagcactggtgtctctgtgct tccttcacttcacctccatcctctgtctctggggctcatcttactagtatcccctccact atcccatgggctctctctgccccaggatgatcttctgtgctgggacagggactctgcctc ttggagtttggtagctacttcttgatttgggcctggtgacccacctggaatgggaaggat gtcagctgacctctcacctcccatgggcagagaagaaaatgaccaggagtgtcatctcca gaattattggggtcacatatgtcccttcccagtccaatgccatctcccactagatcctgt attatccatctacatcagaaccaaactacttctccaacacccggcagcacttggccctgc aagcttaggatgagaaccacttagtgtcccattctactcctctcattccctcttatccat ctgcaggtgaatcttcaataaaatgcttttgtcattc

TABLE 153 cbe_3563252 LOC91689 hypothetical gene supported by AL449243 length = 1586 agcgggctttcttcccgagggcggcacgagggctgggcggtggggtgcgggtgcccgggt SEQ ID NO: 144 gaggggcggagctgggggcatggcgtccggagcggctcgctggctagtattggcacccgt caggtccggggctctccggagcgggcctagcttgaggaaagatggcgatgtctccgccgc atggagcggctcaggccggagcctggtaccgtcggggtcagtcatcgttacccgcagcgg cgccattttgcccaaaccggtgaaaatgtccttcggccttctgcgtgtgttctccattgt gatcccctttctctatgtcgggacactcattagcaagaactttgctgctctacttgagga acatgacatttttgttccagaggatgatgatgatgatgactaacaggaattacagaaagg agaaagcactaactgaagaaatggtgatgctctcagtttctctgccttccctatcagcag aaaggctcggggaaggccctcagcctcccagtctggtgaagcttcctgtatggtccatga ccgtattccaccccaggctctgggaggctccctgagatgtgctgtccactaagcactgca caaacaagcaatcaaattatgaataaacataataaatatcagccgtgcgtgactgagtga tggctgcagtttctcagtatccctaggttctagttggtgcagttgtctctgctgtccttt atttatgggagaaacataggcccaggctatccaggctgcagtggagcctggtgaactatt ctgggggccctgggaactattttcattgtttacaaaagcccaacagaaactgtgcatttt cccttaagaaagcttcatgggctaactaaagcctcatgccattctgtgttcagtgccagt catgacagctctgcttgttagcatactacttaaatataactagaatgattcaaaactcgg gttctgtgatatgaggatatagataggttttcatctatttcctggcttataactcccaaa acccttgttttaggcttttgttataatgttgggcacttcgggcctcagaaaacagcaggc tgtttctcagatcttctcctgacctcctttcacctgctgctttttctccccaaggcaggc catagaaactaaaagtataatcttcctttgcccatcttccagttggccataaaaagaatc ctctgacctaccttgtctgattttaggtcatgagacccccatttcagaagggattctgcc ccatacctgagaggaagaaatgtagacaggccttgttggacttccccactccatctgtat tagattatgcctcttttgtccaatcccatttctccagtgttgtccatgcttcaatcatcc ctatccaatgaggtctccataaaaggcccaagaagacaggtttagagagctttcggagaa cagaacacttggctttgcaaagtggcacgcctggagagaacttggaagctccacgcccct tctatacctcaccctatgcatctcttcagctgtatcttttgtgatatcctttataataaa ccagtaaacggaaaaaaaaaaaaaaa

TABLE 154 cbe_3575702 SUI1 putative translation initiation factor length = 1324 cggcacgagcgccgccgaggattcagcagcctcccccttgagccccctcgcttcccgacg SEQ ID NO: 145 ttccgttcccccctgcccgccttctcccgccaccgccgccgccgccttccgcaggccgtt tccaccgaggaaaaggaatcgtatcgtatgtccgctatccagaacctccactctttcgac ccctttgctgatgcaagtaagggtgatgacctgcttcctgctggcactgaggattatatc catataagaattcaacagagaaacggcaggaagacccttactactgtccaagggatcgct gatgattacgataaaaagaaactagtgaaggcgtttaagaaaaagtttgcctgcaatggt actgtaattgagcatccggaatatggagaagtaattcagctacagggtgaccaacgcaag aacatatgccagttcctcgtagagattggactggctaaggacgatcagctgaaggttcat gggttttaagtgcttgtggctcactgaagcttaagtgaggatttccttgcaatgagtaga atttcccttctctcccttgtcacaggtttaaaaacctcacagcttgtataatgtaaccat ttggggtccgcttttaacttggactagtgtaactccttcatgcaataaactgaaaagagc catgctgtctagtcttgaagtccctcatttaaacagaggtcaagcaataggcgcctggca gtgtcaagcctgaaaccaagcaataccgtcatgtttcagccaagcccagagccctaagat tacaaacaactatggccggaacctcctcagctctccctctgcagagttccctaccctaag agaatgttaccacctgaacagtcctcggtgaatctgagaggagaggatggggtaaggcag aagcaccagctgtactactagaagggagcttttggtggtagatcccctggtgtctccaac ctgactaggtggacagagctcaaagaggccctcttaccgctagcgaggtgataggacatc tggcttgccacaaaggtctgttcgaccagacatatcctagctaagggatgtccaaacatc agaatgtgaggccaaccttctatcagagttaaacttttgacaagggaacaaatctcaaac tgatccatcagtcatgtagctagctgtagagcttgcaacttaatagcagcagctgcccaa tgccatgtgaagtaacaaactggtttttggtttttttttccccttcagttttaatgttat gtgtaatgtatttaaacccttatttaaataaaacttgttttcagaaaaaaaaaaaaaaaa aaaa

TABLE 155 cbe_3580897 HSPA5 heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) length = 3925 acagcacagacagattgacctattggggtgtttcgcgagtgtgagagggaagcgccgcgg SEQ ID NO: 146 cctgtatttctagacctgcccttcgcctggttcgtggcgccttgtgaccccgggcccctg ccgcctgcaagtcggaaattgcgctgtgctcctgtgctacggcctgtggctggactgcct gctgctgcccaactggctggcaagatgaagctctccctggtggccgcgatgctgctgctg ctcagcgcggcgcgggccgaggaggaggacaagaaggaggacgtgggcacggtggtcggc atcgacctggggaccacctactcctgcgtcggcgtgttcaagaacggccgcgtggagatc atcgccaacgatcagggcaaccgcatcacgccgtcctatgtcgccttcactcctgaaggg gaacgtctgattggcgatgccgccaagaaccagctcacctccaaccccgagaacacggtc tttgacgccaagcggctcatcggccgcacgtggaatgacccgtctgtgcagcaggacatc aagttcttgccgttcaaggtggttgaaaagaaaactaaaccatacattcaagttgatatt ggaggtgggcaaacaaagacatttgctcctgaagaaatttctgccatggttctcactaaa atgaaagaaaccgctgaggcttatttgggaaagaaggttacccatgcagttgttactgta ccagcctattttaatgatgcccaacgccaagcaaccaaagacgctggaactattgctggc ctaaatgttatgaggatcatcaacgagcctacggcagctgctattgcttatggcctggat aagagggagggggagaagaacatcctggtgtttgacctgggtggcggaaccttcgatgtg tctcttctcaccattgacaatggtgtcttcgaagttgtggccactaatggagatactcat ctgggtggagaagactttgaccagcgtgtcatggaacacttcatcaaactgtacaaaaag aagacgggcaaagatgtcaggaaagacaatagagctgtgcagaaactccggcgcgaggta gaaaaggccaaacgggccctgtcttctcagcatcaagcaagaattgaaattgagtccttc tatgaaggagaagacttttctgagaccctgactcgggccaaatttgaagagctcaacatg gatctgttccggtctactatgaagcccgtccagaaagtgttggaagattctgatttgaag aagtctgatattgatgaaattgttcttgttggtggctcgactcgaattccaaagattcag caactggttaaagagttcttcaatggcaaggaaccatcccgtggcataaacccagatgaa gctgtagcgtatggtgctgctgtccaggctggtgtgctctctggtgatcaagatacaggt gacctggtactgcttgatgtatgtccccttacacttggtattgaaactgtgggaggtgtc atgaccaaactgattccaaggaacacagtggtgcctaccaagaagtctcagatcttttct acagcttctgataatcaaccaactgttacaatcaaggtctatgaaggtgaaagacccctg acaaaagacaatcatcttctgggtacatttgatctgactggaattcctcctgctcctcgt ggggtcccacagattgaagtcacctttgagatagatgtgaatggtattcttcgagtgaca gctgaagacaagggtacagggaacaaaaataagatcacaatcaccaatgaccagaatcgc ctgacacctgaagaaatcgaaaggatggttaatgatgctgagaagtttgctgaggaagac aaaaagctcaaggagcgcattgatactagaaatgagttggaaagctatgcctattctcta aagaatcagattggagataaagaaaagctgggaggtaaactttcctctgaagataaggag accatggaaaaagctgtagaagaaaagattgaatggctggaaagccaccaagatgctgac attgaagacttcaaagctaagaagaaggaactggaagaaattgttcaaccaattatcagc aaactctatggaagtgcaggccctcccccaactggtgaagaggatacagcagaaaaagat gagttgtagacactgatctgctagtgctgtaatattgtaaatactggactcaggaacttt tgttaggaaaaaattgaaagaacttaagtctcgaatgtaattggaatcttcacctcagag tggagttgaaactgctatagcctaagcggctgtttactgcttttcattagcagttgctca catgtctttgggtgggggggagaagaagaattggccatcttaaaaagcaggtaaaaaacc tgggttagggtgtgtgttcaccttcaaaatgttctatttaacaactgggtcatgtgcatc tggtgtaggaagttttttctaccataagtgacaccaataaatgtttgttatttacactgg tctaatgtttgtgagaagcttctaattagatcaattacttattttaggaaatttaagact agatactcgtgtgtggggtgaggggagggagtatttggtatgttgggataaggaaacact tctatttaatgcttccagggattttttttttttttttttaaccctcctgggcccaagtga tccttccacctcagtctcccagctaattgagaccacaggcttgttaccaccatgctcggc ttttgcattaatctaagaaaaggggagagaagttaatccacatctttactcaggcaaggg gcatttcacagtgcccaagagtggggttttcttgaacatacttggtttcctatttcccct tatctttctaaaactgcctttctggtggctttttttaaaattattactaatgatgctttt atagctgcttggattctctgagaaatgatggggagtgagtgatcactggtattaacttta tacacttggatttcatttgtaactttaggatgtaaaggtatattgtgaaccctagctgtg tcagaatctccatccctgaaatttctcattagtggtactggggtgggatcttggatggtg acattgaaactacactaaatcccctcactatgaatgggttgttaaaggcaatggtttgtg tcaaaactggtttaggattacttagattgtgttcctgaagaaaagagtccaggtaaatgg tatgatcaataaaggacaggctggtgctaacataaaatccaatattgtaatcctagcact ttgggaggccaaggcgggtggatcacaaggtcaagagatagagaccatctttgccaacat ggtgaaactccatctctactgaaaatacaaaaattagctgggcgtggtagtgcaagctga aggctgaggcaggagaatcactcgaacccgggaggcagaggttgcagtgagccgagatca caccactgtactccagcccggcactccagcctggcgacaagagtgagactccacctcaaa aaaaaaaaaaagaatccaatactgcccaaggataggtattttatagatgggcaactggct gaaaggttaattctctagggctagtagaactggatcccaacaccaaactcttaattagac ctaggcctcagctgcactgcccgaaaagcatttgggcagaccctgagcagaatactggtc tcaggccaagcccaatacagccattaaagatgacctacagtgctgtgtaccctggggcaa tagggttaaatggtagttagcaactagggctagtcttcccttacctcaaaggctctcact accgtggaccacctagtctgtaactctttctgaggagctgttactgaatattaaaaagat agacttcaaaaaaaaaaaaaaaaaa

TABLE 156 cbe_3583511 MGC3222 hypothetical protein MGC3222 length = 5765 gtggtgtctcccgacagcatccacagtgtggctccggagaatgaaggaaggctggtgcac SEQ ID NO: 147 atcattggcgccttacggacatccaagcttttgtctgatccaaactatggggtccatctt ccggctgtgaaactgcggaggcacgtggagatgtaccaatgggtagaaactgaggagtcc agggagtacaccgaggatgggcaggtgaagaaggagacgaggtattcctacaacactgaa tggaggtcagaaatcatcaacagcaaaaacttcgaccgagagattggccacaataacccc agtgccatggcagtggagtcattcacggcaacagccccctttgtccaaattggcaggttt ttcctctcgtcaggcctcatcgacaaagtcgacaacttcaagtccctgagcctatccaag ctggaggaccctcatgtggacatcattcgccgtggagactttttctaccacagcgaaaat cccaagtatccagaggtgggagacttgcgtgtctccttttcctatgctggactgagcggc gatgaccctgacctgggcccagctcacgtggtcactgtgattgcccggcagcggggtgac cagctagtcccattctccaccaagtctggggataccttactgctcctgcaccacggggac ttctcagcagaggtgagtgctgtgccctactcgtacggtggaggaacaagcatgtccttc cttccttccagtggttatttaataagatcacactaccaggggtcatagccagtgaatgag gcaagaagaagaaatagcggaatgttgagtatgcctcatcaaagtgtttgaccaggagtg tttcagattccagatttttttggatttgcaggtatttgtatatacataatgagatctctt ggggatgagaaccaagtctaaacacagaatctatttatgtttcatgtatactttgtacac atcgcctgaaggtgattttatacaatgcaacccgtcacatggggtcaagtgtgggatttc cactagtggcgtcatgttggcattcagaaagttttggattttggagcacttcagcatttg ggtttttggattgtggatgctgagtctgtcatgaaccctcagtgtgcaggactgtgctag gcactaaactcactgtgcctcacagactgtccggtagaggagtgagagtgacagaaactc gtaagtactgatgcatcgtgccgagtgttggaaagaggagaacaggtgctctgataccag tggacgtcagagtagaacatccgtttctgcagtgatcaagcagggcctctgacaagtgag ttttgctgacgagaaggggttaaccctagaagaatcagtgatcagtcagttccagcaaga acagcccagtctgggcacgaaagggttcaccttctaagggggcacccggagtgctgtggc cacagcccagagcggggagagggagtgggtgggggggctccaccaaagtctgtgtccttc cagaacattaggagggcggggaagggttttgggcctcagctacctgagtatccctctccc attgtaaatagggagggctatgcctaccccgggtcccaaggagaaggggtgccaagatgt gctgattagttcagttctgtgccttaaaagttagcctgtcttctctaggcaggcaatcct tctctgcagcagaagaattgagtctttagtttttctgttgttgatgaacacaggtatccc tggtggggcactctatacctgccctaaccaggactgctggggttttcattccagagtggc cagaaagggtcaaggcagcagacaggcatcaggggttagctgtgaccttttgttcctatt attagatcctcagcagccatctgtcccattagcctccagcttgtggtggtgcttgggcct caccaactcctggtacctggccagggctagggtgtggtcaggctgttgcccaggagccca gttaccaacctcagggtagggctgccacctcccagcctagaaggccatgagtcacccttc caccagcagctgagggtccccagcgagtttctaaaattaggaggcccagtccaggccttg ctctctctcccagggctgaggcccagctcacgcagccgcccctccagagaggagtggatg gggcccatggcttaggtaatgccccagaaaggaaggccctgcagtgcagatgctcaggcg gcctccttaccccctgggtctcctgctgcttagcagccccaaagccctgtcttcccccag cccagcccccacccccacacaaggtctggggtctctgccaagtagaaaaaaggcccagag ccaggcaggcagctcagggcaaaagtcaggatgccccgattccagtcccaggggcaggag agtacagctgcccaagcaggcacatcaaataaatggtgagtgataaatgtgacctgtttt tgttgttacggactctgagagagggcccgattcagatcagagggtcagggaaagccctct gaagaaatggggttcaagcaaagctcaaaagaatatgtaggaagctggccaggcatgact gcaggcaatcgctgtaggcagagcaaacccacgcgcagatacacaggcgagaggacactt gacctggactggggacagcagccagcagggtcagggcactggcagcagggtcggtgtccg gggggtgtggcagggctctggcaggtgactgtgtggagaacacagagtgggtgatagaag cagggccagtgaggctcctgcgggcagacagtggtaagagactcgggaatatgtggcctg gactggatggggtggtaggggaggagcgagccatgtctttcccatagatgtgagtgggtg ggtgggtgtgccatgtgctgagatggagaaggcgccagtgtcagcactagacaggctgag atgtcaagtggaaatgtcaaggaggtggtggaggtggtgggagctgcagggctgtgaggc ccgggagagggccagagctgcagctttaaattggagggtcacggcatgtggaggccaagg aagcagatgggatgtccggggagagagtatggactgaagcagctaaagaattgcagcatc taatggacaggaagaggggcagcgacagcgatggagcctgagaaggagggtgcagtgtcc ccaagccatgtggagaggttctgagattaaacagatcacacacatagcgcagagcatgct gcccagcagacatcctccaacctgctcaggggtggtgggcagggtcctgctcattccagg tgagaccgtgggctgagggctccaggtgctggcaggctctgagctgaggaaggcccgtac gttccacagagatctcatgccttgccctgtgctctgccagatgggcagaaggacttagcc ctataggaggcttgcccccgctccgtctggcctgttcagaaatggccaacagctcccgag ttggtacagccccctcaggacctgccctgccgactgggtacgccactggccctcagcatc ctgacctgcccccaccttgtcctgcaggaggtgtttcatagagaactaaggagcaactcc atgaagacctggggcctgcgggcagctggctggatggccatgttcatgggcctcaacctt atgacacggatcctctacaccttggtggactggtttcctgttttccgagacctggtcaac attggcctgaaagcctttgccttctgtgtggccacctcgctgaccctgctgaccgtggcg gctggctggctcttctaccgacccctgtgggccctcctcattgccggcctggcccttgtg cccatccttgttgctcggacacgggtgccagccaaaaagttggagtgaaaagaccctggc acccgcccgacacctgcgtgagccctaggatccaggtcctctctcacctctgacccagct ccatgccagagcaggagccccggtcaattttggactctgcaccccctctcctcttcaggg gccagacttggcagcatgtgcaccaggttggtgttcaccagctcatgtcttccccacatc tcttcttgccagtaagcagctttggtgggcagcagcagctcatgaatggcaagctgacag cttctcctgctgtttccttcctctcttggactgagtgggtacggccagccactcagccca ttggcagctgacaacgcagacacgctctacggaggcctgctgataaagggctcagccttg ccgtgtgctgcttctcatcactgcacacaagtgccatgctttgccaccaccaccaagcac atctgtgatcctgaagggcggccgttagtcattactgctgagtcctgggtcaccagcaga cacactgggcatggacccctcaaagcaggcacacccaaaacacaagtctgtggctagaac ctgatgtggtgtttaaaagagaagaaacactgaagatgtcctgaggagaaaagctggaca tatactgggcttcacacttatcttatggcttggcagaatctttgtagtgtgtgggatctc tgaaggccctatttaagtttttcttcgttactttgctgcttcatgtgtactttcctaccc caagaggaagttttctgaaataagatttaaaaacaaaacaaaaaaaacacttaatatttc agactgttacaggaaacaccctttagtctgtcagttgaattcagagcactgaaaggtgtt aaattggggtatgtggtttgattgataaaaagttacctctcagtattttgtgtcactgag aagctttacaatggatgcttttgaaacaagtatcagcaaaaggatttgttttcactctgg gaggagagggtggagaaagcacttgctttcatcctctggcatcggaaactcccctatgca cttgaagatggtttaaaagattaaagaaacgattaagagaaaaggttggaagctttatac taaatgggctccttcatggtgacgccccgtcaaccacaatcaagaactgaggcctgaggc tggttgtacaatgcccacgcctgcctggctgctttcacctgggagtgctttcgatgtggg cacctgggcttcctagggctgcttctgagtggttctttcacgtgttgtgtccatagcttt agtcttcctaaataagatccacccacacctaagtcacagaatttctaagttccccaacta ctctcacacccttttaaagataaagtatgttgtaaccaggatgtcttaaatgattctttg tgtaccttttctgtcatattcagaaaccgttttgtgcctgctgggagtaattcctttagc aattaagtatttggtagctgaataaggggtcagaacttctgaaaccagagatctgtaatc atctctattggcctggggtgcctgtgctataaatgagtttcttcacatgaaaaacacagc cagcccaagatgacttatctgggtttaggattcaatagtattcactaactgcttattaca tgagcaatttcatcaaatctccaaactcttaaaggatgctttcggaaaacacgctgtata cctagatgatgactaaatgcaaaatccttgggctttggtttttttctagtaaggatttta aataactgccgacttcaaaagtgttcttaaaacgaaagataatgttaagaaaaatttgaa agctttggaaaaccaaatttgtaatatcattgtattttttattaaaagttttgtaataaa tttct

TABLE 157 cbe_3590661 NUP214 nucleoporin 214 kDa length = 6614 ctgcgcgccgctggcgctgaggggaggaagtttgctgtcgagcggcctgggttccgtggg SEQ ID NO: 148 caaggccgtgggaggcagcgttggctgcttcgacacactgagggcggcgcgatgggagac gagatggatgccatgattcccgagcgggagatgaaggattttcagtttagagcgctaaag aaggtgagaatctttgactcccctgaggaattgcccaaggaacgctcgagtctgcttgct gtgtccaacaaatatggtctggtcttcgctggtggagccagtggcttgcagatttttcct actaaaaatcttcttattcaaaataaacccggagatgatcccaacaaaatagttgataaa gtccaaggcttgctagttcctatgaaattcccaatccatcacctggccttgagctgtgat aacctcacactctctgcgtgcatgatgtccagtgaatatggttccattattgcttttttt gatgttcgcacattctcaaatgaggctaaacagcaaaaacgcccatttgcctatcataag cttttgaaagatgcaggaggcatggtgattgatatgaagtggaaccccactgtcccctcc atggtggcagtttgtctggctgatggtagtattgctgtcctgcaagtcacggaaacagtg aaagtatgtgcaactcttccttccacggtagcagtaacctctgtgtgctggagccccaaa ggaaagcagctggcagtgggaaaacagaatggaactgtggtccagtatcttcctactttg caggaaaaaaaagtcattccttgtcctccgttttatgagtcagatcatcctgtcagagtt ctggatgtgctgtggattggtacctacgtcttcgccatagtgtatgctgctgcagatggg accctggaaacgtctccagatgtggtgatggctctactaccgaaaaaagaagaaaagcac ccagagatatttgtgaactttatggagccctgttatggcagctgcacggagagacagcat cattactacctcagttacattgaggaatgggatttagtgctggcagcatctgcggcttca acagaagttagtatccttgctcgacaaagtgatcagattaattgggaatcttggctactg gaggattctagtcgagctgaattgcctgtgacagacaagagtgatgactccttgcccatg ggagttgtcgtagactatacaaaccaagtggaaatcaccatcagtgatgaaaagactctt cctcctgctccagttctcatgttactttcaacagatggtgtgctttgtccattttatatg attaatcaaaatcctggggttaagtctctcatcaaaacaccagagcgactttcattagaa ggagagcgacagcccaagtcaccaggaagtactcccactaccccaacctcctctcaagcc ccacagaaactggatgcttctgcagctgcagcccctgcctctctgccaccttcatcacct gctgctcccattgccactttttctttgcttcctgctggtggagcccccactgtgttctcc tttggttcttcatctttgaagtcatctgctacggtcactggggagcccccttcatattcc agtggctccgacagctccaaagcagccccaggccctggcccatcaaccttctcttttgtt cccccttctaaagcctccctagcccccacccctgcagcgtctcctgtggctccatcagct gcttcattctcctttggatcatctggttttaagcctaccctggaaagcacaccagtgcca agtgtgtctgctccaaatatagcaatgaagccctccttcccaccctcaacctctgctgtc aaagtcaaccttagtgaaaagtttactgctgcagctacctctactcctgttagtagctcc cagagcgcacccccgatgtcgccattctcttctgcctccaagccagctgcttctggacca ctcagccaccccacacctctctcagcaccacctagttccgtgccattgaagtcctcagtc ttgccctcaccatcaggacgatctgctcagggcagttcaagcccagtgccctcaatggta cagaaatcacccaggataacccctccagcggcaaagccaggctctccccaggcaaagtca cttcagcctgctgttgcagaaaagcagggacatcagtggaaagattcagatcctgtaatg gctggaattggggaggagattgcacactttcagaaggagttggaagagttaaaagcccga acttccaaagcctgtttccaagtgggcacttctgaggagatgaagatgctgcgaacagaa tcagatgacttgcatacctttcttttggagattaaagagaccacagagtcgcttcatgga gatataagtagcctgaaaacaactttacttgagggctttgctggtgttgaggaagccaga gaacaaaatgaaagaaatcgtgactctggttatctgcatttgctttataaaagaccactg gatcccaagagtgaagctcagcttcaggaaattcggcgccttcatcagtatgtgaaattt gctgtccaagatgtgaatgatgttctagacttggagtgggatcagcatctggaacaaaag aaaaaacaaaggcacctgcttgtgccagagcgagagacactgtttaacaccctagccaac aatcgggaaatcatcaaccaacagaggaagaggctgaatcacctggtggatagtcttcag cagctccgcctttacaaacagacttccctgtggagcctgtcctcggctgttccttcccag agcagcattcacagttttgacagtgacctggaaagcctgtgcaatgctttgttgaaaacc accatagaatctcacaccaaatccttgcccaaagtaccagccaaactgtcccccatgaaa caggcacaactgagaaacttcttggccaagaggaagaccccaccagtgagatccactgct ccagccagcctgtctcgatcagcctttctgtctcagagatattatgaagacttggatgaa gtcagctcaacgtcatctgtctcccagtctctggagagtgaagatgcacggacgtcctgt aaagatgacgaggcagtggttcaggcccctcggcacgcccccgtggttcgcactccttcc atccagcccagtctcttgccccatgcagcaccttttgctaaatctcacctggttcatggt tcttcacctggtgtgatgggaacttcagtggctacatctgctagcaaaattattcctcaa ggggccgatagcacaatgcttgccacgaaaaccgtgaaacatggtgcacctagtccttcc caccccatctcagccccgcaggcagctgccgcagcagcactcaggcggcagatggccagt caggcaccagctgtaaacactttgactgaatcaacgttgaagaatgtccctcaagtggta aatgtgcaggaattgaagaataaccctgcaaccccttctacagccatgggttcttcagtg ccctactccacagccaaaacacctcacccagtgttgaccccagtggctgctaaccaagcc aagcaggggtctctaataaattcccttaagccatctgggcctacaccagcatccggtcag ttatcatctggtgacaaagcttcagggacagccaagatagaaacagctgtgacttcaacc ccatctgcttctgggcagttcagcaagcctttctcattttctccatcagggactggcttt aattttgggataatcacaccaacaccgtcttctaatttcactgctgcacaaggggcaaca ccctccactaaagagtcaagccagccggacgcattctcatctggtgggggaagcaaacct tcttatgaggccattcctgaaagctcacctccctcaggaatcacatccgcatcaaacacc accccaggagaacctgccgcatctagcagcagacctgtggcaccttctggaactgctctt tccaccacctctagtaagctggaaaccccaccgtccaagctgggagagcttctgtttcca agttctttggctggagagactctgggaagtttttcaggactgcgggttggccaagcagat gattctacaaaaccaaccaataaggcttcatccacaagcctaactagtacccagccaacc aagacgtcaggcgtgccctcagggtttaattttactgcccccccggtgttagggaagcac acggagccccctgtgacatcctctgcaaccaccacctcagtagcaccaccagcagccacc agcacttcctcaactgccgtttttggcagtctgccagtcaccagtgcaggatcctctggg gtcatcagttttggtgggacatctctaagtgctggcaagactagtttttcatttggaagc caacagaccaatagcacagtgcccccatctgccccaccaccaactacagctgccactccc cttccaacatcattccccacattgtcatttggtagcctcctgagttcagcaactaccccc tccctgcctatgtccgctggcagaagcacagaagaggccacttcatcagctttgcctgag aagccaggtgacagtgaggtctcagcatcagcagcctcacttctagaggagcaacagtca gcccagcttccccaggctcctccgcaaacttctgactctgttaaaaaagaacctgttctt gcccagcctgcagtcagcaactctggcactgcagcatctagtactagtcttgtagcactt tctgcagaggctaccccagccaccacgggggtccctgatgccaggacggaggcagtacca cctgcttcctccttttctgtgcctgggcagactgctgtcacagcagctgctatctcaagt gcaggccctgtggccgtcgaaacatcaagtacccccatagcctccagcaccacgtccatt gttgctcccggcccatctgcagaggcagcagcatttggtaccgtcacttctggctcatcc gtctttgctcagcctcctgctgccagttctagctcagctttcaaccagctcaccaacaac acagccactgccccctctgccacgcccgtgtttgggcaagtggcagccagcaccgcacca agtctgtttgggcagcagactggtagcacagccagcacagcagctgccacaccacaggtc agcagctcagggtttagcagcccagcttttggtaccacagccccaggggtctttggacag acaaccttcgggcaggcctcagtctttgggcagtcggcgagcagtgctgcaagtgtcttt tccttcagtcagcctgggttcagttccgtgcctgccttcggtcagcctgcttcctccact cccacatccaccagtggaagtgtctttggtgccgcctcaagtaccagtagctccagttcc ttctcatttggacagtcttctcccaacacaggaggggggctgtttggccaaagcaacgct cctgcttttgggcagagtcctggctttggacagggaggctctgtctttggtggtacctca gctgccaccacaacagcagcaacctctgggttcagcttttgccaagcttcaggttttggg tctagtaatactggttctgtgtttggtcaagcagccagtactggtggaatagtctttggc cagcaatcatcctcttccagtggtagcgtgtttgggtctggaaacactggaagaggggga ggtttcttcagtggccttggaggaaaacccagtcaggatgcagccaacaaaaacccattc agctcggccagtgggggctttggatccacagctacctcaaatacctctaacctatttgga aacagtggggccaagacatttggtggatttgccagctcgtcgtttggagagcagaaaccc actggcactttcagctctggaggaggaagtgtggcatcccaaggctttgggttttcctct ccaaacaaaacaggtggcttcggtgctgctccagtgtttggcagccctcctacttttggg ggatcccctgggtttggaggggtgccagcattcggttcagccccagcctttacaagccct ctgggctcgacgggaggcaaagtgttcggagagggcactgcagctgccagcgcaggagga ttcgggtttgggagcagcagcaacaccacatccttcggcacgctcgcgagtcagaatgcc cccactttcggatcactgtcccaacagacttctggttttgggacccagagtagcggattc tctggttttggatcaggcacaggagggttcagctttgggtcaaataactcgtctgtccag ggttttggtggctggcgaagctgagggcgtgtcagcaggcctttcgatccctgggaccaa ccgcatcctcagcttcttccccgagaaatgctggagcaggctgttcagaccgacgttgcc atcaaaacacatacacccagaaagaaacaacagaaaccaaaactcacaaggcgcatgatt acttgttttatatttcatgttgggttttccctcccactattaaacagtctgtttccgtac aaaaaaaaaaaaaa

TABLE 158 cbe_3606990 Prey1053670 Homo sapiens, Similar to CG5604 gene product, clone MGC: 11330, mRNA, complete cds. length = 1206 ggcacgaggctcaggaaaccagggctgtcacgtgtataacctcaggtttgtcacgtgtat SEQ ID NO: 149 aacctcaggaaaccagggctgtcacgtgtataacccaggtttcctgaggtttgtgagggt tttatgtggcatgtcttctgatgaaaggaaagcattcttgcagtttaccactggttgttc aactctacccccaggtggactggctaacctgcatcccaggctcacggttgtacgcaaggt tgatgctactgatgcaagctatccatcagtcaatacatgtgtgcattaccttaagttgcc tgaatattcttccgaggagatcatgagagagcgcctgctagctgctacaatggagaaagg ctttcatttcaattgagctttgaagtgcaatgggagacatcagagactttaaaaatacta gtgaagcctcttgtgtttgtgtgcagagaagtatatgatccaccatgctaatgacacttg cctttttttccaccattaaggctttaagaacatgtggaataagttttttagctgctaatg acaaaacaaatcctgtaactacccagccagcaagtatatagcacagaacactgtgttact ttacaagggcttatgtgactggaataaggtggtcccacttgactgttccaaagagcagct tctcagatcttcagtgttcactggtaaatttctaacagtgtatttgtgtaaagtttgtca tttcatactccatacactacagttgctgtcactgatccctgttttgctggcttttaagct acttggtcaaaaatcctgcttccttaaaacatagagaattaatgagcatctcaagctttt tcttttcctttttaatgatgcctgcactatcaagagtattctagtgttctctctttgttt ggcatataatcatgcaccaaactttttatttctttaaggtgggagtatatttttatttcc taaatgccatactatgaagatcaaagtcttaagtgtgtttgcagctcaaaaataaagatg tattaaggggggaaaacctggtctaagtgcaaggcacacttacagcgagttttactttcg gttgtattttctttgtatattataaacatttatttaacttgttgccgtttgaagtaaaaa atttccaaaatgtatgctcaacaataatcattaaaatgtttgcagcgtaaaaaaaaaaaa aaaaaa

TABLE 159 cbe_3621798 XPO1 exportin 1 (CRM1 homolog, yeast) length = 4148 aggaaggaaggagcagttggttcaatctctggtaatctatgccagcaattatgacaatgt SEQ ID NO: 150 tagcagaccatgcagctcgtcagctgcttgatttcagccaaaaactggatatcaacttat tagataatgtggtgaattgcttataccatggagaaggagcccagcaaagaatggctcaag aagtactgacacatttaaaggagcatcctgatgcttggacaagagtcgacacaattttgg aattttctcagaatatgaatacgaaatactatggactacaaattttggaaaatgtgataa aaacaaggtggaagattcttccaaggaaccagtgcgaaggaataaaaaaatacgttgttg gcctcattatcaagacgtcatctgacccaacttgtgtagagaaagaaaaggtgtatatcg gaaaattaaatatgatccttgttcagatactgaaacaagaatggcccaaacattggccaa cttttatcagtgatattgttggagcaagtaggaccagcgaaagtctctgtcaaaataata tggtgattcttaaactcttgagtgaagaagtatttgatttctctagtggacagataaccc aagtcaaatctaagcatttaaaagacagcatgtgcaatgaattctcacagatatttcaac tgtgtcagtttgtaatggaaaattctcaaaatgctccacttgtacatgcaaccttggaaa cattgctcagatttctgaactggattcccctgggatatatttttgagaccaaattaatca gcacattgatttataagttcctgaatgttccaatgtttcgaaatgtctctctgaagtgcc tcactgagattgctggtgtgagtgtaagccaatatgaagaacaatttgtaacactattta ctctgacaatgatgcaactaaagcagatgcttcctttaaataccaatattcgacttgcgt actcaaatggaaaagatgatgaacagaacttcattcaaaatctcagtttgtttctctgca cctttcttaaggaacatgatcaacttatagaaaaaagattaaatctcagggaaactctta tggaggcccttcattatatgttgttggtatctgaagtagaagaaactgaaatctttaaaa tttgtcttgaatactggaatcatttggctgctgaactctatagagagagtccattctcta catctgcctctccgttgctttctggaagtcaacattttgatgttcctcccaggagacagc tatatttgcccatgttattcaaggtccgtttattaatggttagtcgaatggctaaaccag aggaagtattggttgtagagaatgatcaaggagaagttgtgagagaattcatgaaggata cagattccataaatttgtataagaatatgagggaaacattggtttatcttactcatctgg attatgtagatacagaaagaataatgacagagaagcttcacaatcaagtgaatggtacag agtggtcatggaaaaatttgaatacattgtgttgggcaataggctccattagtggagcaa tgcatgaagaggacgaaaaacgatttcttgttactgttataaaggatctattaggattat gtgaacagaaaagaggcaaagataataaagctattattgcatcaaatatcatgtacatag taggtcaatacccacgttttttgagagctcactggaaatttctgaagactgtagttaaca agctgttcgaattcatgcatgagacccatgatggagtccaggatatggcttgtgatactt tcattaaaatagcccaaaaatgccgcaggcatttcgttcaggttcaggttggagaagtga tgccatttattgatgaaattttgaacaacattaacactattatttgtgatcttcagcctc aacaggttcatacgttttatgaagctgtggggtacatgattggtgcacaaacagatcaaa cagtacaagagcacttgatagaaaagtacatgttactccctaatcaagtgtgggatagta taatccagcaggcaaccaaaaatgtggatatactgaaagatcctgaaacagtcaagcagc ttggtagcattttgaaaacaaatgtgagagcctgcaaagctgttggacacccctttgtaa ttcagcttggaagaatttatttagatatgcttaatgtatacaagtgcctcagtgaaaata tttctgcagctatccaagctaatggtgaaatggttacaaagcaaccattgattagaagta tgcgaactgtaaaaagggaaactttaaagttaatatctggttgggtgagccgatccaatg atccacagatggtcgctgaaaattttgttccccctctgttggatgcagttctcattgatt atcagagaaatgtcccagctgctagagaaccagaagtgcttagtactatggccataattg tcaacaagttagggggacatataacagctgaaatacctcaaatatttgatgctgtttttg aatgcacattgaatatgataaataaggactttgaagaatatcctgaacatagaacgaact ttttcttactacttcaggctgtcaattctcattgtttcccagcattccttgctattccac ctacacagtttaaacttgttttggattccatcatttgggctttcaaacatactatgagga atgtcgcagatacgggcttacagatactttttacactcttacaaaatgttgcacaagaag aagctgcagctcagagtttttatcaaacttatttttgtgatattctccagcatatctttt ctgttgtgacagacacttcacatactgctggtttaacaatgcatgcatcaattcttgcat atatgtttaatttggttgaagaaggaaaaataagtacatcattaaatcctggaaatccag ttaacaaccaaatctttcttcaggaatatgtggctaatctccttaagtcggccttccctc acctacaagatgctcaagtaaagctctttgtgacagggcttttcagcttaaatcaagata ttcctgctttcaaggaacatttaagagatttcctagttcaaataaaggaatttgcaggtg aagacacttctgatttgtttttggaagagagagaaatagccctacggcaggctgatgaag agaaacataaacgtcaaatgtctgtccctggcatctttaatccacatgagattccagaag aaatgtgtgattaaaatccaaattcatgctgttttttttctctgcaactccgttagcaga ggaaaacagcatgtgggtatttgtcgaccaaaatgatgccaatttgtaaattaaaatgtc acctagtggccctttttcttatgtgtttttttgtataagaaattttctgtgaaatatcct tccattgtttaagcttttgttttggtcatctttatttagtttgcatgaagttgaaaatta aggcatttttaaaaattttacttcatgcccatttttgtggctgggctggggggaggaggc aaattcaatttgaacatatacttgtaattctaatgcaaaattatacaatttttcctgtaa acaataccaatttttaattagggagcattttccttctagtctatttcagcctagaagaaa agataatgagtaaaacaaattgcgttgtttaaaggattatagtgctgcattgtctgaagt tagcacctcttggactgaatcgtttgtctagactacatgtattacaaagtctctttggca agattgcagcaagatcatgtgcatatcatcccattgtaaagcgacttcaaaaatatggga acacagttagttatttttacacagttctttttgtttttgtgtgtgtgtgctgtcgcttgt cgacaacagctttttgttttcctcaatgaggagtgttgctcatttgtgagccttcattaa ctcgaagtgaaatggttaaaaatatttatcctgttagaataggctgcatctttttaacaa ctcattaaaaaacaaaacaactctggcttttgagatgacttatactaatttacattgttt accaagctgtagtgctttaagaacactacttaaaaagcaaaataaacttggtttacattt aaaaaaaa

TABLE 160 cbe_3621899 PCNP PEST-containing nuclear protein length = 602 ttttttttttttgagtttgacaaatttattggtactttagtaaagacattcatctcagtc SEQ ID NO: 151 atttctctctcccagcttgaccttaggttaatatttcatttgggtcaagaaaataatacg taggagaggtatgttattttaacaaacaggaaaatggacaaaaaattgatagtttgccta cattaaagtaagttaaattcatgtatcgatataattaaatcatgtaagaactaagagttc tatatacatttccattgtcttacttgggcttattctaaacttaaatgctagtgaacaaag tgttaggaatatacacaggctgcttctctggagttattaccaactaaaagacctcagcaa gcagctaccaccaataaaacagtctgaagctgcctccaaatataatattgtaggagtttt caaggaaatttttatactgtatgcntttgtcngtgactatgcntttaaagatgtgtttaa cggcnaatttaaaaaaagttcntataccatccaaaattcnaaaccacnccctaccatacc caatctaccaangtatatgtggtgngatcccaaaatggttggaagatgcatttccttccc cc

TABLE 161 cbe_3625721 EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39 kDa length = 1522 caggtgtggattccgccggtgaaggctgaaggcagctaccttaaagatgccgggatccgc SEQ ID NO: 152 agcgaagggctcggagttgtcagagaggatcgagagcttcgtggagaccctgaagcgggg tggtgggccgcgcagctccgaggaaatggctcgggagaccctagggttgctgcgccagat catcacggaccaccgctggagcaacgcgggggagctgatggagctgatccgcagagaggg caggaggatgacggccgctcagccctccgagaccaccgtgggcaacatggtgcggagagt gctcaagattatccgggaggagtatggcagactccatggacgcagcgacgagagtgatca gcaggagtccctgcacaaactgttgacatccggaggcctaaacgaggatttcagcttcca ttatgcccaactccagtccaacatcattgaggcgattaatgagctgctagtggagctgga agggacaatggagaacattgcagcccaggctctggagcacattcactccaatgaggtgat catgaccattggcttctcccgaacagtagaggccttcctcaaagaggctgcccgaaagag gaaattccatgtcattgtagcagagtgtgctcctttctgccagggtcatgaaatggctgt gaatttgtccaaagcaggtattgagacaactgtcatgactgatgctgccatttttgccgt tatgtcaagagtcaacaaggtgatcattggcacgaagaccatcctggccaatggggccct gagagctgtgacaggaactcacactctggcactggcagcaaaacaccattccaccccact catcgtctgtgcacctatgttcaaactttctccacagttccccaatgaagaagactcatt tcataagtttgtggctcctgaagaagtcctgccattcacagaaggggacattctggagaa ggtcagcgtgcattgccctgtgtttgactacgttcccccagagctcattaccctctttat ctccaacattggtgggaatgcaccttcctacatctaccgcctgatgagtgaactctacca tcctgatgatcatgttttatgaccgaccacacgtgtcctaagcagattgcttaggcagat acagaatgaagaggagacttgagtgttgctgctgaagcacatccttgcaatgtgggagtg cacaggagtccacctaaaaaaaaaatccttgatactgttgcctgcctttttagtcacccc gtaacaagggcacacatccagcactgtgtcttgcctttcagatcttaacagagcagcagg gcttaacttgttgattttggagcctcttagtgacctggttgcgtctgtgtcaggaactta aactttctggttcagtagtgtgttaaacataacactgaataccttactgggatacagatt tttgctcagaaatggctatgacactttttctaggctctaccaataaaagccacttgaagg ttcaaaaaaaaaaaaaaaaaaa

TABLE 162 cbe_3641816 ANKH ankylosis, progressive homolog (mouse) length = 4031 ctcttttttttcccggcagatctttgttgtgtgggagggcagcagggatggacttgagct SEQ ID NO: 153 tgcggatcccctgctagagcagccgcgctcggagaaggcgccgcagccgcgaggaggagc cgccgccgccgcgcccgaggccccgccgcccgcggcctctgtcggcccgcgccccgctcg cccgtcgcccccgtcgcccctcgcctccccgcagagtcccctcgcggcagcagatgtgtg tggggtcagcccacggcggggactatggtgaaattcccggcgctcacgcactactggccc ctgatccggttcttggtgcccctgggcatcaccaacatagccatcgacttcggggagcag gccttgaaccggggcattgctgctgtcaaggaggatgcagtcgagatgctggccagctac gggctggcgtactccctcatgaagttcttcacgggtcccatgagtgacttcaaaaatgtg ggcctggtgtttgtgaacagcaagagagacaggaccaaagccgtcctgtgtatggtggtg gcaggggccatcgctgccgtctttcacacactgatagcttatagtgatttaggatactac attatcaataaactgcaccatgtggacgagtcggtggggagcaagacgagaagggccttc ctgtacctcgccgcctttcctttcatggacgcaatggcatggacccatgctggcattctc ttaaaacacaaatacagtttcctggtgggatgtgcctcaatctcagatgtcatagctcag gttgtttttgtagccattttgcttcacagtcacctggaatgccgggagcccctgctcatc ccgatcctctccttgtacatgggcgcacttgtgcgctgcaccaccctgtgcctgggctac tacaagaacattcacgacatcatccctgacagaagtggcccggagctggggggagatgca acaataagaaagatgctgagcttctggtggcctttggctctaattctggccacacagaga atcagtcggcctattgtcaacctctttgtttcccgggaccttggtggcagttctgcagcc acagaggcagtggcgattttgacagccacataccctgtgggtcacatgccatacggctgg ttgacggaaatccgtgctgtgtatcctgctttcgacaagaataaccccagcaacaaactg gtgagcacgagcaacacagtcacggcagcccacatcaagaagttcaccttcgtctgcatg gctctgtcactcacgctctgtttcgtgatgttttggacacccaacgtgtctgagaaaatc ttgatagacatcatcggagtggactttgcctttgcagaactctgtgttgttcctttgcgg atcttctccttcttcccagttccagtcacagtgagggcgcatctcaccgggtggctgatg acactgaagaaaaccttcgtccttgcccccagctctgtgctgcggatcatcgtcctcatc gccagcctcgtggtcctaccctacctgggggtgcacggtgcgaccctgggcgtgggctcc ctcctggcgggctttgtgggagaatccaccatggtcgccatcgctgcgtgctatgtctac cggaagcagaaaaagaagatggagaatgagtcggccacggagggggaagactctgccatg acagacatgcctccgacagaggaggtgacagacatcgtggaaatgagagaggagaatgaa taaggcacgggacgccatgggcactgcagggacagtcagtcaggatgacacttcggcatc atctcttccctctcccatcgtattttgttcccttttttttgttttgttttggtaatgaaa gaggccttgatttaaaggtttcgtgtcaattctctagcatactgggtatgctcacactga cggggggacctagtgaatggtctttactgttgctatgtaaaaacaaacgaaacaactgac ttcatacccctgcctcacgaaaacccaaaagacacagctgcctcacggttgacgttgtgt cctcctcccctggacaatctcctcttggaaccaaaggactgcagctgtgccatcgcgcct cggtcaccctgcacagcaggccacagactctcctgtcccccttcatcgctcttaagaatc aacaggttaaaactcggcttcctttgatttgcttcccagtcacatggccgtacaaagaga tggagccccggtggcctcttaaatttcccttccgccacggagttcgaaaccatctactcc acacatgcaggaggcgggtggcacgctgcagcccggagtccccgttcacactgaggaacg gagacctgtgaccacagcaggctgacagatggacagaatctcccgtagaaaggtttggtt tgaaatgccccgggggcagcaaactgacatggttgaatgatagcatttcactctgcgttc tcctagatctgagcaagctgtcagttctcacccccaccgtgtatatacatgagctaactt ttttaaattgtcacaaaagcgcatctccagattccagaccctgccgcatgacttttcctg aaggcttgcttttccctcgcctttcctgaaggtcgcattagagcgagtcacatggagcat cctaactttgcattttagtttttacagtgaactgaagctttaagtctcatccagcattct aatgccaggttgctgtagggtaacttttgaagtagatatattacctggttctgctatcct tagtcataactctgcggtacaggtaattgagaatgtactacggtacttccctcccacacc atacgataaagcaagacattttataacgataccagagtcactatgtggtcctccctgaaa taacgcattcgaaatccatgcagtgcagtatatttttctaagttttggaaagcaggtttt ttcctttaaaaaaattatagacacggttcactaaattgatttagtcagaattcctagact gaaagaacctaaacaaaaaaatattttaaagatataaatatatgctgtatatgttatgta atttattttaggctataatacatttcctattttcgcattttcaataaaatgtctctaata caatacggtgattgcttgtgtgctcaacatacctgcagttgaaacgtattgtatcaatga acattgtaccttattggcagcagttttataaagtccgtcatttgcatttgaatgtaaggc tcagtaaatgacagaactatttttcattatgggtaactggggaataaatgggtcactgga gtaggaatagaagtgcaagctggaaaggcaaaaatgagaaagaaaaaggcaggccctttg tgtctaccgttttcagtgctgtgtgatcatattgttcctcacagcaaaaaagaatgcaag ggcataatgttagctgtgaacatgccagggttgcattcacattcctgggtacccagtgct gatggggtgtgcccacgtggggacatgtccttggcgtgcttcctcagagtggcttttcct ccattaatacatatatgagtactgaaaaattaagttgcatagctgctttgcagtggtttc agaggcagatctgagaagattaaaaaaaaatctcaaatgtatcagctttttttaaaggac attactagaaaattaaacagtattttttaacatgtgtgactttcatgcttctggggttgg agcttaaagatccaaactgagaaagcaggccgggcatggtggctcatgcctgtaatccca acactttgggaggccaaggagggtggatcacttaaggtcaggagtttgagaccagcctgg ccaacatggcgaaaccctgtctctactaaaaacataaaaattagctgggggtggtagcac atacctgtaatcccagctactcaggaggctgaggcaggagaatttgcttgatcctgggag gcagaggttgtagtgagccgagatcgcgccatcgcactccagcctgggtgacaagagcaa aactccatctc

TABLE 163 cbe_3643627 DKFZP434I1735 DKFZP434I1735 protein length = 5477 agttattcttcatcctagcatttctgttcgactagcagcagcttggtgtttacactgcat SEQ ID NO: 154 tgccgtggcattaccctcctacctaacaccactcttggatcgttgccttgaacggcttac tggacataagtcttcacctgaagcagtgactggcttcagttttgctgtagcagctttgtt gggagcagtaaaacattgtcctttaggaattcctcatggaaaaggcaagattattatgac attagcagaggatttgctgtgttctgctgctcaaaacagtcgcctttcagctcagcgcac acaagctggatggttgctgatttctgctctgatgacattaggtcctgcagttgttagcca tcaccttgctcgagttctgctgttgtggaagtgtgtctttccagcatctcctaaagatct agaaacagaaaagagccgaggagattcgtttacatggcaggtgaccctggaaggacgagc tggtgcactgtgtgctatcaagagctttgtttcccactgtggtgatcttcttactgagga agtaactcagcgtcttcttccaccacttccttgtgctgtggatttgctaactcagctttc ttcaatactaaaaatgtatggaagtcctttgaaaacaccgtcagtggtttatagacaaag actttatgaactgttgattttattacctcctgagacctatgaaggaaacctctgtgctat cctcagagagctggctgctgacttgactgcccctgatattcaggtggcagcatctacatt tttacttccacccctctgtcatcaggatgatcttttgatactaagtcctttcctacaaga gactgaccatagatttattgaagaacagctcctgcttggtaatggtgttgcttgcggaag tcttgaatatgacccttattcgatttatgagaaagatgtagagggagattcagtgcctaa gcccttacctccagcactatcagttattagttctgcatccaagctctttggggttgtatg cgctcatgtgggagaaactcaaaggcttcttatactggaacagcttttggacagtataaa gcacacaaaaggagctcgtcagcaagtggttcagttacatgttgtttcttcagtttctag tttcttgaagtacgtggctggctccaagggatgtttaggtccagaagaaatgaaaagatt tgccttaacattagttatgggagccctagaaagccccaaccccttgctgagatgtgcagc tgcagagtcatgggctagattagcccaaatggtagatgatggagcttttactgctggatt agctcaagttagctttgacaaattgaaatcagcaagggatgtggttaccagaacaggaca ctcattggccttggggtccctacataggtatttaggaggaataagttcttctcaacacct aaattcttgtattggaatcctttatactttggcgcaggacagcacttctcctgatgtgca gacctgggcattacattctctatcattgatcattgattctgctggcccactctattatgt gcatgtggaacctaccctttctcttattataatgttgttgttaaatgtgcctcctactca tgctgaagttcaccaaagccttggtcgctgtttgaatgcccttattaccacgttaggtcc agagctacaaggtaacagtacttcaatttctaccttaaggacttcctgtctactgggttg tgcagtaatgcaagataacccagactgccttgttcaagctcaggccatctcttgccttca gcagcttcatatgtttgctccacgacatgtcaacttgtctagcctggttagctgcctctg tgtgaatctttgtagcccctacttgttactgagaagagcagtactggcttgcttacgtca gcttgtacaaagagaagcagctgaagtttcagaacatgctgttatgcttgctaaggatag cagagaagagttgactccagatgctaacatcagagaagttggccttgagggggcattgtt gatcttactagacaaggagacagatgagagattatgccatgatatcaaagagactttaaa ttatatgcttacatctatggcagtggaaaaactctccctgtggttaaagctttgtaaaga tgtacttgctgcatcagctgattttacagctgtaacttgtgtggatacaatgcaagaaga agaaggagataaaggggatgatgcctcagtcctgaccaccagacgtgatgaaaaatccca tccttttaccaatccccgatgggctactagagtctttgctgctgaatgtgtctgtaggat aattaaccaatgtgagaatgctaacagtgcacattttgacattgctttagcacaagaaat gaaaaaaagagattcaagaaatgactttttggtactgcatcttgctgacttaattcgcat ggcttttatggctgccacagatcacagtgaccagctccgtctttctggccttgaaatgct gttagttgttattcggcgatttgcaactgttccagaaccagagtttccaggtcatgtgat tctggaacagtatcaagccaatgtaggagcagcgcttagaccagccttcacttcagagac accacctgatgtcactgccaaagcatgtcaggtttgcagtgcctggatagcaagtggagt tgtaagtgaccttaatgatctccgaagagttcatcagttgcttgtttcatcgttaactaa aatacaggctggaaaagaagctctaagtcacttatataatgaaagtgcttctaccatgga gatcttagctgtgcttaaagcctgggcagaggtctacataattgctgtgcaaagacataa aaaccacagacaacctttgaagactaccacctgtttagaagacggtatcagaaatggatc atgttcatcagatggactgcttgacttagtctatgcagatcttggcacactaagcagact ctggcttgctgcacttcaggattttgctcttttaactttgccttcagaatttgcctccca acttcctgctgaaggtggtgctttctacacagcagagactagtgaaaatgcaaaattgca ttattacaactcctgggcacttatcctccatgctacagcattgtggcttacaagcacggg ttttgttgttgctgacccagatgaaggagcatctaatctctccaggcctgtaacaccaac ttccatgtgtcagggttcatcatctggggctaccataaagtcccctgaggatgtctacac tgatagattccatcttattttaggaatcagcgtggaatttctatgttccttacgttcaga tgcaaccatggaaagcataactgcttgtttacatgcattgcaagcacttctagatgtacc ttggcccagatcaaaaattggcagtgatcaggacttgggtatagaattgctgaatgttct acatcgagtaattttaaccagagaatcaccttccattcagttggcttcacttgaagtggt aaggcagattatctgtgctgctcaagaacatgtgaaggaaaaaagacgaagtgcagaagt tgatgatggggctgctgaaaaggaaactctgccagagtttggagagggaaaggacaccgg aggacttgtgcctggaaagtctttggtctttgcaacactggaattgtgtgtatgcattct agttagacagctcccagaattaaaccctaaattgacaggtagcccaggagtaaaagctac gaagccacagatactattagaagatggaagtagattggtttcagctgcattggttatcct ttccgaacttcctgcagtgtgctctcctgaaggaagcatctcaattctccctactatatt gtacctcacaatcggggtcctcagagagactgctgtgaagttacctgggggccagttatc ttcgacagttgcagcttccctacaggctttaaaaggaatattatcttctcccatggcccg ggcagaaaagagccgtactgcttggactgaccttctccgaagtgccttaacaacaattct tgactgttgggatccagttgatgaaacacaccaagaacttgatgaagtcagtctacttac tgctatcacagtgtttattttgtctaccagtccagaagtaactaccatcccatgccttca gaagcgctgtattgataaatttaaagctactcttgagataaaagatcctgtggtacaaat caagacctaccagctcctacattccatctttcagtatccaaatccagctgtttcctaccc atacatttactctttagcatcctgtatcatggaaaaactgcaggaaatagacaagagaaa acctgaaaacactgctgagcttgagatcttccaagaaggcataaaggtcttagaaacact ggttactgttgctgaagaacaccatcgcgctcagctggtggcctgtcttttgcccatcct catttccttccttttggatgaaaattctctgggatcagcaacttccataatgagaaattt acatgactttgctctacaaaatctcatgcaaattggacctcagtattcatctgtttttaa aagtttagtggcttcttctccagccctaaaagcccgccttgaggctgctataaagggcaa tcaggaaagtgtcaaagtcaagataccaacatctaaatatactaagagtcctggaaaaaa ctcaagcatccaattaaagaccagtttcctctgattttttttttggaatagtaagcacct taatataataaatacttgatcattgcctttggtgacaaaagggacattgtagacacaagt gcccttagaggtctagttgattgttttaccttaaatagctgtgactcttcaaagtaacag catacttaacatttttgtgtgtgtgcgtggggtttgtgttttgttttgttttgtttttct atttaaaaagacaatggagctaacttgccaggaattttaagaaagtgctaaagaactaaa cttactaaacaatccactgctttaaaaatgaaatgaatttcttctaacagtccatacata tgtggtatacttaatactgtgacagatataaatatgactctagtgtaaattatctgcact aatattgtatcccaattgctgatttaaaattctgctttggcccggcacagtggctcatcc ctgtaattccagcactttggaaggccaaggcgggcggatcacgaggtcgggagtttgaga ccagcctgaccaacatggtgaaaccccgtctctactaaaaatacaaaaattagccgggtg tggtggcacacacctgtaatcccagctactcaggaggccgaggcaggaaaatcgcttgaa cctggcaggcagaggttgcagtgagccaagattgtgccactgcactccagcctgggcgac agagtgagactccatct

TABLE 164 cbe_3663966 KIAA1389 KIAA1389 protein length = 5801 caggcaaggcttatctggtgaaaacttttttgctatgctcagagggtaccgagtagaaaa SEQ ID NO: 155 ttatgacccaaaagggaccattgctttgtggtcataattttctactcggtaccctctgag catagcaaattatgaccacaaagcaatggtcccttttgggttccctgaatttttccgctg tgaccctgcaatctctccgagccttcatgcagcagcacagatttctaggggagaatttgt ccgcatctcaggattagattatgtggacagtgccctcctgatggggagagacagggacaa gcctttcaaacggaggttgaaatcagagtcggtggaaacatctctcttccgaaagcttcg aactgttaaaagtgagcacgaaactttcaagttcacgtctgagctggaggagagccgact ggagaggggcattcgcccttggaattgtcagcgatgttttgcacattatgatgtccagag cattttgtttaatatcaacgaagccatggctacgagggctaatgtggggaaaaggaaaaa cataaccactggggcatctgcagcatcccagactcagatgcctacgggccagacaggcaa ctgtgagtcccctttagggagcaaggaggacctcaactccaaagagaacctggatgccga tgagggtgatgggaaaagtaacgacctcgtccttagttgtccttactttagaaatgagac tggaggggaaggcgacaggcggattgcgctctctcgagccaactcatcctctttcagttc tggggaaagctgctctttcgaatcgtcactcagctctcactgcacaaatgcaggtgtctc cgtcttggaagtgcccagagaaaaccagcctattcacagggagaaagtgaagcgctacat catagaacacattgaccttggggcctattattaccgcaaattcttctatgggaaagagca ccaaaactactttggaatagatgaaaaccttggtccagtagcagtcagcatccggagaga gaaggtggaagatgccaaggagaaagaaggatcccagttcaactacagggtggctttcag gacaagtgagcttacaacactgagaggagcaattttagaagatgctataccctctactgc taggcatggtaccgcacgaggactacctctcaaagaagttttggaatacgtcattccaga gctgagcattcagtgtttgcgacaggcttccaactcacccaaggtctcagagcagctgct caagcttgatgaacaagggctgagctttcagcacaagatcgggatcctttattgcaaagc aggccagagcacagaggaagagatgtataacaatgagacggcgggaccagcttttgaaga attccttgatcttctgggccagagagtccgactgaaaggatttagtaaatatcgagctca gctagacaataagactgattccacgggcacgcactctctctataccacatacaaagacta cgaactcatgttccacgtgtcaaccctgcttccctacatgcccaacaacagacaacagct actgaggaaaaggcacataggaaatgacatcgtcaccatcgtcttccaggagcctggggc acttccttttactccaaaaagcatccggtctcactttcagcatgtctttgtcatagtcaa agtgcataatccatgtaccgaaaatgtgtgttatagtgttggagtttccagatcaaaaga tgtgccaccatttggcccaccgattcccaaaggtgtaacttttccaaagtcagccgtgtt ccgggacttccttttagccaaagtaatcaatgcagaaaatgcagcccataaatcagaaaa gtttcgagcaatggccactcgaacgaggcaggagtacttgaaagatctggcggagaactt tgtcacaaccgccaccgtggatacctctgtgaagttcagcttcattacgctgggtgcgaa gaaaaaggagaaggtaaagccaaggaaggatgcccacttgtttagcattggggccatcat gtggcacgtgatagcccgggacttcggccagtctgctgacattgaatgtcttctcgggat ctccaatgagttcatcatgttgattgaaaaggattccaagaatgttgtattcaactgttc ctgcagggatgtgattgggtggacatctggattagtgagtatcaaagtgttttacgaaag aggagaatgtgtcctcctgtcctcggtagacaactgtgctgaagacatcagggaaattgt tcagcgattagtaatagtgacgagaggctgcgagactgtggaaatgaccctgaggaggaa cgggctgggccagcttggcttccatgtgaattttgaaggaattgtcgcagatgtggaacc ttttggctttgcctggaaggctggccttcgccaagggagccgcctcgtggagatctgcaa agtagccgtggccactctgacccacgagcagatgatcgacctgctccgtacttctgtgac tgtgaaggtggtcatcatccagccccatgatgacggctcgccccgaagagggtgttcaga gctctgccggatccctatggtggaatataaactcgacagcgagggcaccccctgcgagta taaaacccccttcaggaggaacactacgtggcaccgggtgcccactcctgccctgcagcc cctctctagagcttcccccatccccggcacgcccgaccggctgccgtgccaacagctgct ccagcaggcccaggctgccattcctcgaagcacctccttcgaccggaagctgcccgatgg cacgagaagctcacccagcaaccagtcatcctccagcgaccctggacccggcgggagcgg accctggagaccacaagtgggctacgacgggtgccagtcccctctactgctcgaacacca gggctcaggccctttggaatgtgacggagccagggagagggaagacaccatggaagcaag caggcacccggaaaccaaatggcatggcccaccttccaaagtcctgggttcctataaaga aagagctctgcagaaagatggaagttgcaaagattcccccaataagctttctcacattgg ggataaaagttgctccagtcactccagcagcaacacgctctccagcaacacctccagcaa cagtgacgacaagcactttgggtctggcgacctgatggaccccgaattactggggctgac ctacatcaaaggggcctccaccgacagtggcatcgacacggccccctgcatgcctgccac catcctcggccctgtgcacctggcaggcagcaggtccctgatccacagccgggccgagca gtgggctgatgctgccgacgtctctgggcctgacgacgagccagccaagttatattctgt gcatggctacgcgtccgccatctccgccggcagtgctgcggaaggcagcatgggcgatct cagtgagatatcctctcattccagtggttctcaccattcaggaagcccttcagctcactg ttcaaaaagtagtgggtctctggattcatccaaagtctacatcgtgtctcacagcagcgg acaacaggttcccgggtccatgtccaagccctaccacagacaaggggcagtgaacaaata tgtcatcggctggaagaaatcggagggcagcccaccgcccgaggagcctgaagtgactga atgtcccgggatgtatagtgagatggatgtcatgtccacagcaactcagcatcagacagt ggtgggagatgctgttgcagagactcaacatgttctgtctaaagaagattttctgaaatt gatgcttcctgacagccccttagtggaggaggggcgaagaaagttttcgttctatgggaa cctgtctccaaggaggtcgctttaccgcacgctgtctgacgagagcatctgcagcaacag gagggggtcctcctttggcagttcccggagttccgtgcttgaccaggccctgcccaacga cattctgttcagcaccaccccaccctaccacagcacgctgcctccgcgggcccaccccgc acccagcatggggagcctgagaaatgagttctggttctccgatgggtccttatcagataa gtccaagtgcgcagatcctggcctgatgcccctcccggacacagccacagggttagattg gacccacctcgtggatgctgcacgggcatttgaaggtcttgactcagatgaagaactggg gctgctctgtcaccacacgtcctatctagaccagagggtggcatccttctgcaccctgac agatatgcagcatgggcaggacctggaaggggcccaagagctgcccttatgtgtagatcc aggcagtggcaaagagttcatggacacaactggggagcgttctccatcaccactgaccgg gaaagtcaatcagctggaattaattcttcgacaactccagaccgaccttcggaaggaaaa acaagacaaggccgttctccaagcagaagtgcagcacctgagacaggacaacatgagact gcaggaggagtcccagaccgcgacagctcagctgcggaaattcacagaatggtttttcac caccatcgacaaaaaatcttagccaatccgcacctcatcaagggaccactgggaaatgcc ccttgtccctttgaagtcacaaacatgtggtttttctgtgtgctttcaaccaatcgtaga tgtttttgctgttccattctgtgtagcaccattcaccacagcaggatagggagcctcgac tctttctcggtaaccacggcagagagcagcgccgatgtgaagatgaatgaatgtaactcc tggtgtgaagatgaatgtaaaccctggcgacagttgagacctttttcttttagactctgc taaaacagtgctctggcttgggcttacctcaagagggaagatagttgagttttatttcct gtatatcaggtgacctggtagagatgtaaagcaatttaccatagtttgggctttagtatt gtaaaataaacatgagaacaaataatcagacatatactttaatgttaaaggtgctctatt tttttggatgtacagtagttttatttccacagccacattaccatagcaataagaaaggag gcatagtacatagttggaaaagctttgtggggggattaaaaaaaaaaaaaagcactgttg tgtttaacactagttcagatgcagttaccttagagacttatttatttgcaggaacaaatg gtgcctgaatattaacagtgttctgattaaaaacaaaaaaaagatacatatgccttgtaa atggctcaccgagtggtcagtagtcacttcaactcttagttcacttttgtatagttgctc tgctggaaagaaatgagagtgaatctgcttactcactagaacttccctgtgtgctgtgag ccagcggaaccacttgtacaatgccagatttgtttatctttgtacagaagctttgatgaa gtgtcttgtatttaacacccttatttaagcttatttaaccttaaattgttaattttataa aatttggtttggcctgcactacgatgagggatggaggtagctgcaggctcagaagagact gagcttgcacagatcagaccgagaagcagggtgagagattctaacgactggatgctgcta gtaacacattgtttgtattgctttaccatttttaactgttagatttgagatgaacataca ttttgcttttttaataaatgtttaaaagaagtccacataag

TABLE 165 cbe_3665307 HK1 hexokinase 1 length = 3962 aaaacatctatcttgctgtgtttggacaggccagcccctgaaacatcttgggcaatggag SEQ ID NO: 156 ggttaacttctcaaagtttaataggcaagaccagcaaccatgcaacaaggacttcaacta accaactaaagaactgttccccagagcattgttcctgagaaggaaaagagtccaaacacc tacccacacctgctttgtgccaagaatccacagttggattgcaaggacagtgtatgttgt ccttttggaaaaatgagagtgagcccaaatgaagaacaagcaaaggcgttcaagacccag ctgttgagagtagaaaagcagaagaaaggacccgaggtcagcaagtgccctccccacaat ggggcagatctgccagcgagaatcggctacagcagctgaaaaaccaaaacttcatctact tgctgaaagtgagcattgttgatgctcttgagagcatcagccaggacattaatgtgcacc actgtggtggcgtggaaagatggcaaaaagagccctgcgtgattttattgacaagtatct ctatgccatgcggctctccgatgaaactctcatagatatcatgactcgcttcaggaagga gatgaagaatggcctctcccgggattttaatccaacagccacagtcaagatgttgccaac attcgtaaggtccattcctgatggctctgaaaagggagatttcattgccctggatcttgg tgggtcttcctttcgaattctgcgggtgcaagtgaatcatgagaaaaaccagaatgttca catggagtccgaggtttatgacaccccagagaacatcgtgcacggcagtggaagccagct ttttgatcatgttgctgagtgcctgggagatttcatggagaaaaggaagatcaaggacaa gaagttacctgtgggattcacgttttcttttccttgccaacaatccaaaatagatgaggc catcctgatcacctggacaaagcgatttaaagcgagcggagtggaaggagcagatgtggt caaactgcttaacaaagccatcaaaaagcgaggggactatgatgccaacatcgtagctgt ggtgaatgacacagtgggcaccatgatgacctgtggctatgacgaccagcactgtgaagt cggcctgatcatcggcactggcaccaatgcttgctacatggaggaactgaggcacattga tctggtggaaggagacgaggggaggatgtgtatcaatacagaatggggagcctttggaga cgatggatcattagaagacatccggacagagtttgacagggagatagaccggggatccct caaccctggaaaacagctgtttgagaagatggtcagtggcatgtacttgggagagctggt tcgactgatcctagtcaagatggccaaggagggcctcttatttgaagggcggatcacccc ggagctgctcacccgagggaagtttaacaccagtgatgtgtcagccatcgaaaagaataa ggaaggcctccacaatgccaaagaaatcctgacccgcctgggagtggagccgtccgatga tgactgtgtctcagtccagcacgtttgcaccattgtctcatttcgctcagccaacttggt ggctgccacactgggcgccatcttgaaccgcctgcgtgataacaagggcacacccaggct gcggaccacggttggtgtcgacggatctctttacaagacgcacccacagtattcccggcg tttccacaagactctaaggcgcttggtgccagactccgatgtgcgcttcctcctctcgga gagtggcagcggcaagggggctgccatggtgacggcggtggcctaccgcttggccgagca gcaccggcagatagaggagaccctggctcatttccacctcaccaaagacatgctgctgga ggtgaagaagaggatgcgggccgagatggagctggggctgaggaagcagacgcacaacaa tgccgtggttaagatgctgccctccttcgtccggagaactcccgacgggaccgagaatgg tgacttcttggccctggatcttggaggaaccaatttccgtgtgctgctggtgaaaatccg tagtgggaaaaagagaacggtggaaatgcacaacaagatctacgccattcctattgaaat catgcagggcactggggaagagctgtttgatcacattgtctcctgcatctctgacttctt ggactacatggggatcaaaggccccaggatgcctctgggcttcacgttctcatttccctg ccagcagacgagtctggacgcgggaatcttgatcacgtggacaaagggttttaaggcaac agactgcgtgggccacgatgtagtcaccttactaagggatgcgataaaaaggagagagga atttgacctggacgtggtggctgtggtcaacgacacagtgggcaccatgatgacctgtgc ttatgaggagcccacctgtgaggttggactcattgttgggaccggcagcaatgcctgcta catggaggagatgaagaacgtggagatggtggagggggaccaggggcagatgtgcatcaa catggagtggggggcctttggggacaacgggtgtctggatgatatcaggacacactacga cagactggtggacgaatattccctaaatgctgggaaacaaaggtatgagaagatgatcag tggtatgtacctgggtgaaatcgtccgcaacatcttaatcgacttcaccaagaagggatt cctcttccgagggcagatctctgagacgctgaagacccggggcatctttgagaccaagtt tctctctcagatcgagagtgaccgattagcactgctccaggtccgggctatcctccagca gctaggtctgaatagcacctgcgatgacagtatcctcgtcaagacagtgtgcggggtggt gtccaggagggccgcacagctgtgtggcgcaggcatggctgcggttgtggataagatccg cgagaacagaggactggaccgtctgaatgtgactgtgggagtggacgggacactctacaa gcttcatccacacttctccagaatcatgcaccagacggtgaaggaactgtcaccaaaatg taacgtgtccttcctcctgtctgaggatggcagcggcaagggggccgccctcatcacggc cgtgggcgtgcggttacgcacagaggcaagcagctaagagtccgggatccccagcctact gcctctccagcacttctctcttcaagcggcgaccccctaccctcccagcgagttgcgctg ggagacgctggcgccagggcctgccggcgcggggaggaaagcaaaatccaactaatggta tatattgtagggtacagaatagagcgtgtgctgttgataatatctctcacccggatccct cctcacttgccctgccactttgcatggtttgattttgacctggtcccccacgtgtgaagt gtagtggcatccatttctaatgtatgcattcatccaacagagttatttattggctggaga tggaaaatcacaccacctgacaggccttctgggcctccaaagcccatccttggggttccc cctccctgtgtgaaatgtattatcaccagcagacactgccgggcctccctcccgggggca ctgcctgaaggcgagtgtgggcatagcattagctgcttcctcccctcctggcacccactg tggcctggcatcgcatcgtggtgtgtcaatgccacaaaatcgtgtgtccgtggaaccagt cctagccgcgtgtgacagtcttgcattctgtttgtctcgtggggggaggtggacagtcct gcggaaatgtgtcttgtcttccatttggataaaaggaaccaaccaacaaacaatgccatc actggaatttcccaccgctttgtgagccgtgtcgtatgacctagtaaactttgtaccaat tc

TABLE 166 cbe_3670766 ACTC actin, alpha, cardiac muscle length = 1294 atgtgtgacgacgaggagaccaccgccctggtgtgcgacaacggctctgggctggtgaag SEQ ID NO: 157 gccggctttgcgggcgatgacgcgccccgcgctgtcttcccgtccatcgtgggccgcccg cggcaccagggagttatggtgggtatgggtcagaaggactcctacgtaggtgatgaagcc cagagcaagagaggcatcctgaccctgaagtatcccatcgagcatggtatcatcaccaac tgggacgacatggagaagatctggcaccacaccttctacaatgagctccgtgttgctccc gaggagcaccccaccctgctcacagaggccccgctgaaccccaaggccaaccgggagaag atgactcagatcatgtttgagaccttcaatgtccctgccatgtacgtggccatccaggca gtgctatccctgtatgcttctggccgtaccacaggcattgttctggactctggggatggt gtaactcacaatgtccccatctatgagggctacgctttgccccatgccatcatgcgtctg gatctggctggtcgggacctcactgactacctcatgaagatcctcactgagcgtggctac tcctttgtcaccactgctgaacgtgaaattgtccgtgacattaaagagaagctgtgctat gtcgccctggattttgagaatgagatggccacagctgcctcttcctcctccttggagaag agctatgaactgcctgatggccaagtcatcactatcggcaatgagcgcttccgctgtcct gagacactcttccagccctccttcattggtatggaatctgctggcatccatgaaacaact tacaatagcatcatgaagtgtgacattgatatccgcaaggacctgtatgccaacaatgtc ttatctggaggcaccactatgtaccctggtattgctgatcgtatgcagaaggaaatcact gctctggctcctagcaccatgaagattaagattattgctccccctgagcgtaaatactct gtctggattgggggctccatcttggcctctctgtccaccttccagcaaatgtggattagc aagcaagagtacgatgaggcaggcccatccattgtccaccgcaaatgcttctaagatgcc ttctctctccatctaccttccagtcaggatgacggtattatgcttcttggagtctcccaa accaccttccctcatctttcatcaatcattgtacagtttgtttacacacgtgcaatttgt ttgtgcttctaatatttattgctttataaataaa

TABLE 167 cbe_3694420 ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2 length = 4093 gggatcccgggagggagcggagcggacctgggcttggtcgcctccaagccggcgggaccg SEQ ID NO: 158 agtgctttaggccgctcgaaagaaagttgctccgacccgggaaaaggagaagatgaagga agccaaggatgcccgctataccaatgggcacctcttcaccaccatttcagtttcaggcat gaccatgtgctatgcctgtaacaagagcatcacagccaaggaagccctcatctgcccaac ctgcaatgtgactatccacaaccgctgtaaagacaccctcgccaactgtaccaaggtcaa gcagaagcaacagaaagcggccctgctgaagaacaacaccgccttgcagtccgtttctct tcgaagtaagacaaccatccgggagcggccaagctcggccatctacccctccgacagctt ccggcagtccctcctgggctcccgccgtggccgctcctccttgtctttagccaagagtgt ttctaccaccaacattgctggacatttcaatgatgagtctcccctggggctgcgccggat cctctcacagtccacagactccctcaacatgcggaaccgaaccctatccgtggaatccct cattgacgaagaggtaatctacagtgagctgatgagtgactttgagatggatgagaagga ctttgcagctgactcttggagtcttgctgtggacagcagcttcctgcagcagcataaaaa ggaggtgatgaagcagcaagatgtcatctatgagctaatccagacagagctgcaccatgt gaggacactgaagatcatgacccgcctcttccgcacggggatgctggaagagctacactt ggagccaggagtggtccagggcctgttcccctgcgtggacgagctcagtgacatccatac acgcttcctcagccagctattagaacgccgacgccaggccctgtgccctggcagcacccg gaactttgtcatccatcgcttgggtgatctgctcatcagccagttctcaggtcctagtgc ggagcagatgtgtaagacctactcggagttctgcagccgccacagcaaggccttaaagct ctataaggagctgtacgcccgagacaaacgcttccagcaattcatccggaaagtgacccg ccccgccgtgctcaagcggcacggggtacaggagtgcatcctgctggtgactcagcgcat caccaagtacccgttactcatcagccgcatcctgcagcattcccacgggatcgaggagga gcgccaggacctgaccacagcactggggctagtgaaggagctgctgtccaatgtggacga gggtatttatcagctggagaaaggggcccgtctgcaggagatctacaaccgcatggaccc tcgggcccaaaccccagtgcctggcaagggcccctttggccgagaggaacttctgaggcg caaactcatccacgatggctgcctgctctggaagacagcgacggggcgcttcaaagatgt gctagtgctgctgatgacagatgtactggtgtttctccaggaaaaggaccagaagtacat ctttcctaccctggacaagccttcagtggtatcgctgcagaatctaatcgtacgagacat tgccaaccaggagaaagggatgtttctgatcagcgcagccccacctgagatgtacgaggt gcacacagcatcccgggatgaccggagcacctggatccgggtcattcagcagagcgtgcg cacatgcccatccagggaggacttccccctgattgagacagaggatgaggcttacctgcg gcgaattaagatggagttgcagcagaaggaccgggcactggtggagctgctgcgagagaa ggtcgggctgtttgctgagatgacccatttccaggccgaagaggatggtggcagtgggat ggccctgcccaccctgcccaggggccttttccgctctgagtcccttgagtcccctcgtgg cgagcggctgctgcaggatgccatccgtgaggtggagggtctgaaagacctgctggtggg gccaggagtggaactgctcttgacaccccgagagccagccctgcccttggaaccagacag cggtggtaacacgagtcctggggtcactgccaatggtgaggccagaaccttcaatggctc cattgaactctgcagagctgactcagactctagccagagggatcgaaatggaaatcagct gagatcaccgcaagaggaggcgttacagcgattggtcaatctctatggacttctacatgg cctacaggcagctgtggcccagcaggacactctgatggaagcccggttccctgagggccc tgagcggcgggagaagctgtgccgagccaactctcgggatggggaggctggcagggctgg ggctgcccctgtggcccctgaaaagcaggccacggaactggcattactgcagcggcaaca tgcgctgctgcaggaggagctacggcgctgccggcggctaggtgaagaacgggcaaccga agctggcagcctggaggcccggctccgggagagtgagcaggcccgggcactgctggagcg tgaggccgaagaggctcgaaggcagctggccgccctgggccagaccgagccactcccagc tgaggccccctgggcccgcagacctgtggatcctcggcggcgcagcctccccgcaggcga tgccctgtacttgagtttcaaccccccacagcccagccgaggcactgaccgcctggatct acctgtcactactcgctctgtccatcgaaactttgaggaccgagagaggcaggaactggg gagccccgaagagcggctgcaagacagcagtgaccctgacactggcagcgaggaggaagg tagcagccgtctgtctccgccccacagtccacgagactttaccagaatgcaggacatccc ggaggagacggagagccgcgacggggaggctgtagcctccgagagctaagggggcccctc ccccctgccccgtgccccactgaagaacattactgagggggctaaccttggggactccaa tttgccaatgatgagggaacatttgaaagaactgcaaattgtccttgccagctcttggga tccttggatacctggggccatttaagaagctaggggaattaggccacaacaccccctggg acatccgaaagctacaccacagatgccagtggttcatgccttcttcccgcaactttagga aaatttatttatttattgtttattagttatggggggagaggggagatttaaaggaccagg gacatgggaaccaagccatagggatcagagggccttgtccttgaacactactggggtata ttcaggctcatccacgcagctgctgggttcttgccctaacggccctcccctgcaacatcc gtcttggaggagaggctgcagccacagcaccctactgccctttaaataaaggagggctgt gggcagggccatgtccctttctcctctcccctcaacctcttactgctgttctccctttct ccgtccttcatggaagccctgggagataacctggcttcctggagttgatggaataaaggt tggggtggccataatggtttgttgggggtgagggaaaaaacccacagggaccagaatgtt ttgttgttcttttgttttcttttttgtaccaaagtcaactgcacgtgttttatattttta agagatcgtaggcaattagagatcgaagcctcctatctccacatctctgaagaagttgag gggtgggggagagaatgacttctgccttcatctgcagtaacggggggacctatactgacc tcttccccagccatttagaaacaagttctagggtgggttggaaaatctccaagagccctg acctcatcttccacctcagcaaccatgacctgaaacctcagcgtgaatttgggggatttt tcagtggaacccttgcccccaaatgtcgaccagcccccaaatgtcgaagaattttcttct tgccaattttgttgtttaaaaaaaaaattcagggaaaattaaaaacctggaactccaaaa aaaaaaaaaaaaa

TABLE 168 cbe_3705944 TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) length = 3508 gccacccagctgagaggagaggcgcccccggggacgcactgagattatgaggctctggcc SEQ ID NO: 159 tccactggccactcactcgtgaccctttccaccacggcggagccttccaagcctacctcc tgccgtgtggtgatctacctgcagcgggagatgtcgggggacacctgcctgtgcccagcc tcaggggccaagcccaagctcagtggcttcaagggaggagggttgggcaacaagtatgtc cagctcaacgtgggcggctctctgtactacaccactgtgcgggccctgacccgccacgac accatgctcaaggccatgttcagtgggcgcatggaggtgctgaccgacaaagaaggctgg atcctcatagaccgttgtggaaagcactttggcaccattttgaattacctccgagatgac accatcaccctccctcagaaccggcaagaaatcaaggaattgatggctgaagcaaagtat tacctcatccaggggctggtgaatatgtgccagagtgccctgcaggacaagaaggactcc taccagcctgtgtgcaacatccccatcatcacatccctaaaggaggaggagcggctcatc gaatcctccaccaagcccgtggtgaagctgctgtacaacagaagcaacaacaagtattcc tacaccagcaactctgacgaccacctgctgaaaaacatcgagctgtttgacaagctctcc ctgcgcttcaacggccgcgtgctcttcatcaaggatgtcattggtgacgagatctgctgc tggtccttttatggccagggccgtaagctggcagaggtgtgctgtacctccatcgtgtat gccacggagaagaagcagaccaaggtggaattcccagaggcccgaatctatgaggagaca ctcaacgtcctactctatgagactccccgcgtccccgacaactccttgttggaggccaca agccgtagccgcagccaggcttcccccagtgaagatgaggagacctttgaactgcgggac cgtgtccgccgcatccacgtcaagcgctacagcacttacgatgaccggcagctcggccac cagtctacccatcgcgactgaccagaccctcagggagtcagggcacgggaggccctatct cccatcctgtggaacccgccccattggccaccccatgctgctgctgcctgggtctctgct ctagcacccagaggcatgacaggccctgctcagaggtcagagggtctgggcagaggaggg accacattcccctgccttgcccctgagcacttctggagactgcgtcctgtcctatctgct caccatcacccttcctgcccgacggagctgcttctgctccctggggcatatggactgacc cacctcctgctgagaaccttcccctaggccctgtgcagaaggctactgccccttaggcct cagctgggggaaaggcagttctggtgctgtagaggccctggtgcagaaagtgggacgtct tttttcctaaggtgtttaagcacaggcttgataagtttggtttttaaaaaataatctagg aaatgaataattctaaatctagtaatgaggaaactgagcatttcttttgccctccagggt gccaagaccctacatatgacagaacccttggcccttctccatgcctgtgggatctgtttc tttaaagcactttgtactgttattcaggaggttgataatctccttgacccatgtctttct accctaatccccacttccctgcagaatcaatctgagggaggggataaagaggaagcaata aaaaaaaaacatccgacagagcagctctggctttgcagcctggccagcagctcagagtgc accgaggagggaaggatggctaagctgggaccggcagtcctcacagggtgcctgtgagaa aggacattttacccccacatcatagtcacatcactgactcctaggtctagcacgactgct ctttgtgattctcttgagtacccttggcttccagccatgctgtcctcacatacggtaaag ccaaagagctgtcacatgggccagaaacatgagccacggcaggaagaccgtggagcccgt gggcactgcatggtgttggctggcatgcccatcagctgaggacagcaaactcccagcagc ccctacagaggtggcacatgcttggccacacatctactccctgcccacaccatctatgct cttggttggtgctggctgggatggcggttctgcccagtggtgtctctgagcgcgggatga caggagcaaccgaagcaccctgaaggccttcactccttgttgggtaactcagccatggag atgccaagcactagccaggaggtgagttcctctttagggctttggttttcattccttttt gtttggcttggccaaaccagaattcagcttatctgaattattttccaaaggaatgctgtc agggagggactgttctgccagcctaacaaagcaacgtagccacgtatagtacccactttc tgctctttggagagaacacaggttatcaagttcatctctcttgactactcttatgatagc tgatgccacagagcctatgggcaaatgccagacccagggttagacacaaggacctgaagt gacatgacggcgggacaggggaaatgtgactttctaattaggcattttatgttagtcaca gtcttgaatgtataaacagcactaagactctcaggtcaggtaccttggtgatcagctact agttcttccagccctcattgaggtaacaagataaagacaaatccacttctttggccaaat tcaggctttggctttatgactttcccacagagactggaatgcgtcagcctgagaccactg gcctattttctcagctgccctcttgaggtcctttaacactcaaattcccagctccccact gaggtgttgtgatgcttgccttttgacctccccatcccctttagtccctgcttactactt tgacattcacatcctcagtgtctcagtcttttttgccgagaaagcacagtagtctgggac tgggcatttatcttctctgactgaaaatctctccttggtcttaaggaaaatactaacatt gaactcactgacatgatcttagcttctttaatcagactttgtgacttaaaagtttggggg ttttctttgaaagtttccagccctattcagaaagcaactcttggctgtgtgcatttttca actccaagcagcccaggggtaagtaaacaaagtatggatgaaggtcagattttcttgtca gtttctgagaaacctggcagcctgctgttaacaacacaggccagtattgggttttattga atttggtatgtgaccaaggtcggcctaaaggatggcgcaggtcctgggcaggaaagaatt tttcctttatcacataactgtaatatttggttgctcagcataagtgatggaagcaaacac taatttctaataaaattgtgttaaactc

TABLE 169 cbe_3714119 Prey1053021 Sequence 1 from Patent WO0131003. length = 3331 gtgattactcactatagggctcgagcggccgcccgggcaggtctatggctgagcctgggc SEQ ID NO: 160 acagccaccatctctccgccagagtcaggggaagaactgagaggcgcataccccggctgt ggcggctgctgctctgggctgggaccgccttccaggtgacccagggaacgggaccggagc ttcatgcctgcaaagagtctgagtaccactatgagtacacggcgtgtgacagcacgggtt ccaggtggagggtcgccgtgccgcataccccgggcctgtgcaccagcctgcctgaccccg tcaagggcaccgagtgctccttctcctgcaacgccggggagtttctggatatgaaggacc agtcatgtaagccatgcgctgagggccgctactccctcggcacaggcattcggtttgatg agtgggatgagctgccccatggctttgccagcctctcagccaacatggagctggatgaca gtgctgctgagtccaccgggaactgtacttcgtccaagtgggttccccggggcgactaca tcgcctccaacacggacgaatgcacagccacactgatgtacgccgtcaacctgaagcaat ctggcaccgttaacttcgaatactactatccagactccagcatcatctttgagtttttcg ttcagaatgaccagtgccagcccaatgcagatgactccaggtggatgaagaccacagaga aaggatgggaattccacagtgtggagctaaatcgaggcaataatgtcctctattggagaa ccacagccttctcagtatggaccaaagtacccaagcctgtgctggtgagaaacattgcca taacaggggtggcctacacttcagaatgcttcccctgcaaacctggcacgtatgcagaca agcagggctcctctttctgcaaactttgcccagccaactcttattcaaataaaggagaaa cttcttgccaccagtgtgaccctgacaaatactcagagaaaggatcttcttcctgtaacg tgcgcccagcttgcacagacaaagattatttctacacacacacggcctgcgatgccaacg gagagacacaactcatgtacaaatgggccaagccgaaaatctgtagcgaggaccttgagg gggcagtgaagctgcctgcctctggtgtgaagacccactgcccaccctgcaacccaggct tcttcaaaaccaacaacagcacctgccagccctgcccatatggtccctactccaatggct cagactgtacccgctgccctgcagggactgaacctgctgtgggatttgaatacaaatggt ggaacacgctgcccacaaacatggaaacgaccgttctcagtgggatcaacttcgagtaca agggcatgacaggctgggaggtggctggtgatcacatttacacagctgctggagcctcag acaatgacttcatgattctcactctggttgtgccaggatttagacctccgcagtcggtga tggcagacacagagaataaagaggtggccagaatcacatttgtctttgagaccctctgtt ctgtgaactgtgagctctacttcatggtgggtgtgaattctaggaccaacactcctgtgg agacgtggaaaggttccaaaggcaaacagtcctatacctacatcattgaggagaacacta ccacgagcttcacctgggccttccagaggaccacttttcatgaggcaagcaggaagtaca ccaatgacgttgccaagatctactccatcaatgtcaccaatgttatgaatggtgtggcct cctactgccgtccctgtgccctagaagcctctgatgtgggctcctcctgcacctcttgtc ctgctggttactatattgaccgagattcaggaacctgccactcctgcccccctaacacaa ttctgaaagcccaccagccttatggtgtccaggcctgtgtgccctgtggtccagggacca agaacaacaagatccactctctgtgctacaacgattgcaccttctcacgcaacactccaa ccaggactttcaactacaacttctccgctttggcaaacaccgtcactcttgctggagggc caagcttcacttccaaagggttgaaatacttccatcactttaccctcagtctctgtggaa accagggtaggaaaatgtctgtgtgcaccgacaatgtcactgacctccggattcctgagg gtgagtcagggttctccaaatctatcacagcctacgtctgccaggcagtcatcatccccc cagaggtgacaggctacaaggccggggtttcctcacagcctgtcagccttgctgatcgac ttattggggtgacaacagatatgactctggatggaatcacctccccagctgaacttttcc acctggagtccttgggaataccggacgtgatcttcttttataggtccaatgatgtgaccc agtcctgcagttctgggagatcaaccaccatccgcgtcaggtgcagtccacagaaaactg tccctggaagtttgctgctgccaggaacgtgctcagatgggacctgtgatggctgcaact tccacttcctgtgggagagcgcggctgcttgcccgctctgctcagtggctgactaccatg ctatcgtcagcagctgtgtggctgggatccagaagactacttacgtgtggcgagaaccca agctatgctctggtggcatttctctgcctgagcagagagtcaccatctgcaaaaccatag atttctggctgaaagtgggcatctctgcaggcacctgtactgccatcctgctcaccgtct tgacctgctacttttggaaaaagaatcaaaaactagagtacaagtactccaagctggtga tgaatgctactctcaaggactgtgacctgccagcagctgacagctgcgccatcatggaag gcgaggatgtagaggacgacctcatctttaccagcaagaagtcactctttgggaagatca aatcatttacctccaagaggactcctgatggatttgactcagtgccgctgaagacatcct caggaggccccgacatggacctgtgagaggcactgcctgcctcacctgcctcctcacctt gcatagcacctttgcaagcctgcggcgatttgggtgccagcatcctgcaacacccactgc tggaaatctcttcattgtggccttatcagatgtttgaatttcagatctttttttatagag tacccaaaccctcctttctgcttgcctcaaacctgccaaatatacccacactttgtttgt aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 170 cbe_3753270 gbh_ac004503 Homo sapiens chromosome 5, P1 clone 1354A7 (LBNL H47), complete length = 2039 ccaggggcgcacgggttgggaggcgccaggcggcccgccctccttgcacgggccggccca SEQ ID NO: 161 gcttccccgcccctggcgtccgctccctcccgctcgcagcttacttaacctggcccgggc ggcggaggcgctctcacttccctggagccgcccgcttgcccgtcggtcgctagctcgctc ggtgcgcgtcgtcccgctccatggcgctcttcgtgcggctgctggctctcgccctggctc tggccctgggccccgccgcgaccctggcgggtcccgccaagtcgccctaccagctggtgc tgcagcacagcaggctccggggccgccagcacggccccaacgtgtgtgctgtgcagaagg ttattggcactaataggaagtacttcaccaactgcaagcagtggtaccaaaggaaaatct gtggcaaatcaacagtcatcatctacgagtgctgtcctggatatgaaaaggtccctgggg agaagggctgtccagcagccctaccactctcaaacctttacgagaccctgggagtcgttg gatccaccaccactcagctgtacacggaccgcacggagaagctgaggcctgagatggagg ggcccggcagcttcaccatcttcgcccctagcaacgaggcctgggcctccttgccagctg aagtgctggactccctggtcagcaatgtcaacattgagctgctcaatgccctccgctacc atatggtgggcaggcgagtcctgactgatgagctgaaacacggcatgaccctcacctcta tgtaccagaattccaacatccagatccaccactatcctaatgggattgtaactgtgaact gtgcccggctgctgaaagccgaccaccatgcaaccaacggggtggtgcacctcatcgata aggtcatctccaccatcaccaacaacatccagcagatcattgagatcgaggacacctttg agacccttcgggctgctgtggctgcatcagggctcaacacgatgcttgaaggtaacggcc agtacacgcttttggccccgaccaatgaggccttcgagaagatccctagtgagactttga accgtatcctgggcgacccagaagccctgagagacctgctgaacaaccacatcttgaagt cagctatgtgtgctgaagccatcgttgcggggctgtctgtagagaccctggagggcacga cactggaggtgggctgcagcggggacatgctcactatcaacgggaaggcgatcatctcca ataaagacatcctagccaccaacggggtgatccactacattgatgagctactcatcccag actcagccaagacactatttgaattggctgcagagtctgatgtgtccacagccattgacc ttttcagacaagccggcctcggcaatcatctctctggaagtgagcggttgaccctcctgg ctcccctgaattctgtattcaaagatggaacccctccaattgatgcccatacaaggaatt tgcttcggaaccacataattaaagaccagctggcctctaagtatctgtaccatggacaga ccctggaaactctgggcggcaaaaaactgagagtttttgtttatcgtaatagcctctgca ttgagaacagctgcatcgcggcccacggcaagagggggaggtacgggaccctgttcacga tggaccgggtgctgacccccccaatggggactgtcatggatgtcctgaagggagacaatc gctttaggtaattagttccatccccgggtggagcttctgcccagtggtcatgctggagtg ggatgtggggccccagctatttgtcaagctttcttctaccttggggattcaattaacact agcagtgcactgctgcgaccttccagacttgggatggggaaaaggcaagggtcgccttga aagcttacattgggaagaagggttacttctaagagtgtaatcttcacatgcatgggaagc agggaggggggactacatttttatgactgaagtgcaaggaaaacatcaccctctcattg

TABLE 171 cbe_3760926 gbh_al359334 Homo sapiens EST from clone 628609, 5′ end. length = 881 tctagtctgtttgttttccttgtgtgtgttttctgttttcgggttggtctttttgtttgc SEQ ID NO: 162 tttttctcttttttccccctgtgtggttgcctttgtcttttttctcttttgtgtcgtgtt ctttgtttttgtttgtgttagaccctcatcaatagatggagacatacagaaatagtcaaa ccacatctacaaaatgccagtatcaggcggcggcttcgaagccaaagtgatgtttggatg taaagtgaaatattagttggcggatgaagcagatagtgaggaaagttgagccaataatga cgtgaagtccgtggaagcctgtggtacaaaaaatgttgagccgtagatgccgtcggaaat ggtgaagggagactcgaagtactctgaggcttgtaggagggtaaaatagagacccagtaa aattgtaataagcagtgcttgaattatttggtttcggttgttttctattagactatggtg agctcaggtgattgatactcctgatgcgagtaatacggatgtgtttaggagtgggacttc taggggatttagcggggtgatgcctgttgggggccagtgccctcctaattggggggtagg ggctaggctggagtggtaaaaggctcagaaaaatcctgcgaagaaaaaaacttctgaggt aataaataggattatcccgtatcgaaggcctttttggacaggtggtgtgtgggtggcctt ggtatgtgctttctcgtgttacatcgcgccatcattggtatatggttagtgtgttggtta gtaggcctagtatgaggagcgttatggagtggagtgaaatcacatggctaggccggaggt cattaggagggctgagagggctcctgttacggggtcatggg

TABLE 172 cbe_3764052 MARK4 MAP/microtubule affinity-regulating kinase 4 length = 1620 tgggtcagtgtcacctccaggatacagacagccccccttcagcccagcccagccaggtct SEQ ID NO: 163 cctacaccgccaccatgccattcggtaacacccacaacaagttcaagctgaattacaagc ctgaggaggagtaccccgacctcagcaaacataacaaccacatggccaaggtactgaccc ttgaactctacaagaagctgcgggacaaggagactccatctggcttcactgtagacgatg tcatccagacaggagtggacaacccaggtcaccccttcatcatgaccgtgggctgcgtgg ctggtgatgaggagtcctacgaagttttcaaggaactctttgaccccatcatctcggatc gccacgggggctacaaacccactgacaagcacaagactgacctcaaccatgaaaacctca agggtggagacgacctggaccctaactacgtgctcagcagccgcgtccgcactggccgca gcatcaagggctacacgttgcccccacactgctcccgtggcgagcgccgggcggtggaga agctctctgtggaagctctcaacagcctgacgggcgagttcaaagggaagtactaccctc tgaagagcatgacggagaaggagcagcagcagctcatcgatgaccacttcctgttcgaca agcccgtgtccccgctgctgctggcctcaggcatggcccgcgactggcccgacgcccgtg gcatctggcacaatgacaacaagagcttcctggtgtgggtgaacgaggaggatcacctcc gggtcatctccatggagaaggggggcaacatgaaggaggttttccgccgcttctgcgtag ggctgcagaagattgaggagatctttaagaaagctggccaccccttcatgtggaaccagc acctgggctacgtgctcacctgcccatccaacctgggcactgggctgcgtggaggcgtgc atgtgaagctggcgcacctgagcaagcaccccaagttcgaggagatcctcacccgcctgc gtctgcagaagaggggtacaggtggcgtggacacagctgccgtgggctcagtatttgacg tgtccaacgctgatcggctgggctcgtccgaagtagaacaggtgcagctggtggtggatg gtgtgaagctcatggtggaaatggagaagaagttggagaaaggccagtccattgacgaca tgatccccgcccagaagtaggcgcctgcccacctgccaccgactgctggaacccagccag tgggagggcctggcccaccagagtcctgctccctcactcctcgccccgccccctgtccca gagtcccacctgggggctctctccacccttctcagagttccagtttcaaccagagttcca accaatgggctccatcctctggattctggccaatgaaatatctccctggcagggtcctct tcttttcccagagctccaccccaaccaggagctctagttaatggagagctcccagcacac tcggagcttgtgctttgtctccacgcaaagcgataaataaaagcattggtggccttaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 173 cbe_3770440 gbh_af217505 Homo sapiens uncharacterized bone marrow protein BM028 mRNA, length = 1725 cctcaaaagaagaagaaatgtgtcatatatcaatttggggatataagcaaatcctagtca SEQ ID NO: 164 cagtcgttttctaaaaagtattgttttctggaaaaacctagtttttaagaatgatgccac agcgaagttctattttaactttttaatttgatttttttttctttgttacagaagaagaca atgatgaaattaaggattggggacctcatgtaagaatgggaggggtgttccaaaggacat accaggggtctaggaggagtctaggaaggaagtcctgtgttatatcattctgggagtacc tattttccatgaggggatgaaatactggagctgttgtagaagaaaaacttctgattttaa tacattcttagcccaagagggctgtacaaaagggaaacacatgtggactaaaaaagatgc tgggaaaaaagttgttccatgtagacatgactggcatcagactggaggtgaagttaccat ttcagtatatgctaaaaactcacttccagaacttagccgagtagaagcaaatagcacatt gttaaatgtgcatattgtatttgaaggagagaaggaatttgatcaaaatgtgaaattatg gggtgtgattgatgtaaagcgaagttatgtaactatgactgcaacaaagattgaaatcac tatgagaaaagctgaaccgatgcagtgggcaagccttgaactgcctgcagctaaaaagca ggaaaaacaaaaagatgacacaacagattgagtgggagatggaaggaaggctattacatt atttccgaatttttaatactgtgtgaagtggtggcttgctgcgtgtaatcttttgttttg ttgttgtgttactgaatgtggcatttcagggttaacattaggttcttaaaagccaaagtc agtttgtctttttgtgcctctcatctttcttttgtgttatgtaagattgattattcattt ctccctactggtaggaaccatagttgtgtcctatacttgaagaggctggaaagtagccca taaccataattgcagtatttctttgtatttctctgttaagcaaagaaatattaaggaaca ttttttttatgtttttgtattattccataattagtaaagcaagatgaaatgtcaaatttt aatcagttttttcatgggatttgtgttcttacagtacttgaaaatatttaaggaagagat gaagctctgcagttttttctatgtgggatgattacttttttaaggaggattaattctgag gtagtatagtaactaaaggggaatatatgaattgtttaacaaattagaatttgtttacaa ctacttgaatttttaaattatgtcaaaacttacattacttgccaagcagtatgatgttat aggaaacataaataagattacagaggtatcaatttggttaaaattcaccattttataaga ctaagcaataatcttaacaacctctttcctgaatatttaaatgtgtttgtatggtgttat gactaattgttactgatttagagactaagccctcttaaaacctttagttaaatataaaaa gaaattatatatatcttgcctccctgatggaaaactatataaaattgtagacttaaaagg tttgtggaaatacattaggatatcagaaaactaaatatatggagttgctttatgactatt acatgttaaataaaaatagcttaattgttttggaaaaaaaaaaaa

TABLE 174 cbe_3772244 PIGQ phosphatidylinositol glycan, class Q length = 2878 cagcgagcgccgtcgtctgcccgggcccgcccatcggggtccccaaccccatccggaccc SEQ ID NO: 165 cgccgcccgagcgcgcggccccggaagcacccgcctcccggcatggtgctcaaggccttc ttccccacgtgctgcgtctcgacggacagcgggctgctggtgggacggtgggtgccggag cagagcagcgccgtggtcctggcggtcctgcactttcccttcatccccatccaggtcaag cagctcctggcccaggtgcggcaggccagccaggtgggcgtggccgtgctgggcacctgg tgccactgccggcaggagcccgaggagagcctgggccgcttcctggagagcctgggtgct gtcttcccccatgagccctggctgcggctgtgccgggagagaggcggcacgttctggagc tgcgaggccacccaccggcaagcgcccactgcccccggtgcccctggtgaggaccaggtc atgctcatcttctatgaccagcgccaggtgttgctgtcacagctacacctgcccaccgtc ctgcccgaccgccaggctggagccaccactgccagcacggggggcctggctgccgtcttc gacacggtagcacgcagtgaggtgctcttccgcagtgaccgctttgatgagggccccgtg cggctgagccactggcagtcggagggcgtggaggccagcatcctcgcggagctggccagg cgagcctcgggacccatttgcctgctgttggccagcctgctgtcgctggtctcagctgtc agtgcctgccgagtgttcaagctctggcccctgtccttcctcgggagcaaactctccacg tgcgaacagctccggcaccggctggagcacctcacgctaatcttcagtacacggaaggcg gagaaccctgcccagctgatgaggaaggccaacacggtggcctctgtgctgctggacgtg gccctgggcctcatgctgctgtcctggctccacgggagaagccgcatcgggcatctggcc gacgccctcgttcctgtggctgaccacgtggccgaggagctccagcatctgctgcagtgg ctgatgggtgctcccgccgggctcaagatgaaccgtgcactggaccaggtgctgggccgc ttcttcctctaccacatccacctgtggatcagctacatccacctcatgtcccccttcgtg gagcacatcctttggcacgtgggcctctcggcctgcctgggcctgacggtggccctgtcc ctcctctcggacattatcgccctcctcaccttccacatctactgcttttacgtctatgga gccaggctgtactgcctgaagatccatggcctgtcctcactgtggcgtctgttccggggg aagaagtggaacgttctgcgccagcgcgtggactcctgttcctatgacctggaccagctg ttcatcgggactctgctcttcaccatcctgctcttcctcctgcctaccacagccctgtac tacctggtgttcaccctgctccggctcctggtggtcgccgtgcagggcctgatccatctg ctcgtggacctcatcaactccctgccgctgtactcactgggtcttcggctctgccggccc tacaggctggcggataaacccactgccctacagccgcgtggtgcacacctaccgcctccc cagctgtggctgccaccccaagcactcctggggcgccctgtgccgcaagctgttccttgg ggagctcatctacccctggaggcagagaggggacaagcaggactgagggaactgctggct cgcctggcaccaccacacggccacagccagccatctgctctgccagggtggcaccagctc agctggcgcatgtcctgtgctttgtggacgctgctgtgtgctcctgaacacggcaggccc tgctatcacaccttgggcttggaggtcattgggagtgagcagatgtgggggtggccagcc aggctggccgcactccatcactggcactgcctgccttgggacccgcttcccacctgctgc ggtcaccatggtggcgagcacagcaaccccaggtgtccagagcactgccccatgcccacc ctgtgtacccaggtccagagggtccgtccaccacagcagccccaggtggagggctggtct ccctgggggctccccagtggctctgccctggctgtgggggtggagggaccttgccaggat gaaccccccagtcccaggcaccctctagctccctcagccgaacagcaccctgcatctggg ggattgaagcagtcgctgacccccgtccccagcgggcccgggccctcactccctgaacca cacggggtttatttgcggatgttccctggagaggtcgctttgtgaagaaaccatcagcag gctgtgagcatcgccaggctgctgtgggggcgggagcagcctcagtgtcaagggcccgcc cactgacccagccgtacctattcgtccacggtgccccgtagcagcaggtcctgcggccaa atctgtctcccttcatgggcctcccagggaaggaggaagccctgctgtgcagacacctct gtggccccccaggagtgtgagtggcctggggagggggccgtggcactgaggccgaaagtg cctgccagacggcacggtctgggtgcgggtgttccctgtgagcccgagtccgcttcagga ggggagcctgcaggtgccggctggtgaggggatgacgcgctgtgggtgggaggaggcagc gcccatctcagcagcaccaggactgcctgggactccctggcaacccagcaccggggaagc cgtcagctgctgtgacaataaaacctgccccgtgtctggaaaaaaaaaaaaaaaaaaa

TABLE 175 cbe_3773649 EEF1A1L14 eukaryotic translation elongation factor 1 alpha 1-like 14 length = 2106 gtatacgaaatcataaaatctcatagatgtatcctgagtagggcggggcccgtgaaaccc SEQ ID NO: 166 tctgaatctgcggccaccacccggtaaggctaaatactaatcagacaccgatagtgaact agtaccgtgagggaaaggtgaaaagaacccgagaggggagtgaaatagattctgaaacca tttacttacaagtggtccatttacttacaagtgtcagagcacgttaaagtgtgatggcgt acatcttgcagtatgggccggcgagttatgttaatatgcaaggttaagcagaaaaaagcg gagccgtagggaaaccgagtctgaatagggcgactttagtatattggcatatacccgaaa tcaggtgatctatccatgagcaggttgaagcttaggtaaaactaagtggaggaccgaacc gtagtacgctaaaaagtgcccggatggacttgtggatagtggtgaaattccaatcgaacc tggagatagctggttctcttcgaaatagctttagggctagcgtatagtattgtttaatgg gggtagagcactgaatgtggaatggcggcatctagctgtactgactataatcaaactccg aataccattaaaattaagctatgcagtcggaacgtggtatcaccattgatatctccttgt ggaaatttgagaccagcaagtactatgtgactatcattgatgccccaggacacagagact ttatccaaaacatgattacagggacctctcaggctgactgtgctgtcctgattgttgctg ctggtgttggtgaatttgaagctggtatctccaagaatgggcagacccgagagcatgccc ttctggcttacacactgggtgtgaaacaactaattgtcggtgttaacaaaatggattcca ctgagccaccctacagccagaagagatatgaggaaattgttaaggaagtcagcacttaca ttaagaaaattggctacaaccccgacacagtagcatttgtgccaatttctggttggaatg gtgacaacatgctggagccaagtgctaacatgccttggttcaagggatggaaagtcaccc gtaaggatggcaatgccagtggaaccacgctgcttgaggctctggactgcatcctaccac caactcgtccaactgacaagcccttgggcctgcctctccaggatgtctacaaaattggtg gtattggtactgttcctgttggccgagtggagactggtgttctcaaacccggtatggtgg tcacctttggtccagtcaacgttacaacggaagtaaaatctgtcgaaatgcaccatgaag ctttgggtgaagctcttcctggggacaatgtgggcttcaatgtcaagaatgtgtctgtca aggatgttcgtcgtggcaacgttgctggtgacagcaaaaatgacccaccaatggaagcag ctggcttccctgctcaggtgattatcctgaaccatccaggccaaataagcgccggctatg cccctgtattggattgccacacggctcacattgcatgcaagtttgctgagctgaaggaaa agattgatcgccgttctggtaaaaagctggaagatggccctaaattcttgaagtctggtg atgctgccattgttgatatggttcctggcaagcccatgtgtgttgagagcttctcagact atccacctttgggctgctttgctgttcgtgatatgagacagacagttgcggtgggtgtca tcaaagcagtggacaagaaggctgctggagctggcaaggtcaccaagtctgcccagaaag ctcagaaggctaaatgaatattatccctaatcctcccaccccactcttaatcagtggtgg aagaccggtctcagaactgtttgtttcaattgccatttaagtttagtagtaaaagactgg ttaatgataacaatgcatcgtaaaacctttcagaaggaaaggagaatgttttgtggacac gttggttttcttttttgcgtgtggcagttttagttattagtttttaaaatcagtactttt taatggaaacaacttgacccccaaatttgtcacagaattttgggacccattaaaaggtta actggg

TABLE 176 cbe_3787129 LOC55828 zinc finger protein ZNF140-like protein length = 2978 ggaggccctgctgaggactccggcaagtgtgggtcgcggcgacggcggggctaaggccct SEQ ID NO: 167 gggtccgcgcgcggtttgaccacggccggggccttgggcatttcctggccttcctgttga gccgtgtaaacgcggggtgatgacggcgccgacctcttggcactgttgtgagagcgaagt gggcgcgagagcagacgccagctacagtttttttgggttatgtcgtcatgaagccggcgc tttcagttgtgcaaccttgaacaaatgggacactgcccatctctaagataagaacctgga aaggggactctgttggccattggaaattgcagaataatgtctcaggtgacatttagtgat gtggctatagacttctctcatgaagagtgggcatgcctagattctgctcagagggactta tacaaggatgtgatggtccagaattatgagaacctggtctctgtaggtctttccgtaact aagccatatgtgatcatgttattggaggatggaaaagagccctggatgatggagaaaaaa ctgtcaaaagcttacccatttcctttatcacactctgttcctgcttctgtgaactttgga ttctctgctctatttgagcattgttcagaagtcactgaaatatttgagttgtcagaacta tgtgttttctgggtgcttcatttcttatccaattctcctaattccactgtagaagctttt tcaagaagtaaaaaaaaaaaaaaaaaaaaaaaaaaaaggcagtgctttgctttcttgata tatttcagattgggaatcaagatgggaaaacaaggaattatcaacaaagaaggatattta tatgaagattcaccccaaccagtaacaatggaaaaagttgtaaaacaaagttatgaattt tcaaattctaataagaatttggaatatacagaatgcgacacatttagaagcacctttcat tcaaagtctactctttctgaaccacaaaacaattctgctgaagggaattcacacaaatat gatatattaaagaagaatttatcaaaaaagtcagttataaaaagtgagagaataaatggt ggaaagaaacttttaaattctaataaaagtggggcagccttcaaccagagcaaatctctt acccttccccagacttgtaatagagagaaaatctatacatgcagtgaatgtgggaaagcc tttggcaaacagtcaatcctcagtcgccactggagaattcatacaggagagaagccctat gaatgtcgtgaatgtgggaagacttttagccatggttcatcccttacacgacatcagata agccatagtggagagaaaccttacaaatgcattgaatgtgggaaggcctttagccatggc tcatcacttactaaccatcagagcactcacacgggagagaaaccgtatgaatgtatgaac tgtggaaagtcttttagtcgtgtgtcccttctcattcagcatctaagaattcatacgcaa gaaaaacgctatgagtgtcgtatatgtggaaaggccttcattcatagttcgtctctcatt caccatcagaaaagccatactggagagaagccttatgaatgtagagaatgtgggaaagct ttctgctgtagctcacaccttactcaacatcaaagaattcacagtatgaagaaaaaatat gaatgcaacaaatgtctcaaggtctttagtagcttctcatttcttgttcaacatcagagt attcatactgaagaaaaaccgtttgaagtttagaaatgcaggaaatccttcaaccagctt gaatcactgaatatgcatttgagaaatcacattagattgaaaccctacgaatgcagtata tgtgggaaagcctttagtcataggtcgtccctgcttcaacatcacagtattcatactgga gagaaaccttacgaatgtattaaatgtgggaagaccttcagctgtagttcaaaccttact gtacatcagagaattcatactggagaaaagccatataaatgtagtgagtgtgggaaagct tttagcaaaggctcgaatcttactgcccatcaaagagtacataatggagagaaacccaat agtgtggtaagtgtggaaaagcctttagatcatatgaatccctatacatgtgagaaatct tacagaagagaagcagtgtttatcacggtaaacttcattcatagatcctcccttatttaa catcagaaaaatgtatactggggaaaagttgtatgaaggtggtgaacatgggagactttt agcaatgatgcagatttttttattagagtttatactgtagagaaatcatatgaagtcaat aaatgtgggaaagcctttgtcagtattaatcccttaattgaccntaagtatactcacact aggaaaaatctgtgtacatgtagcaaatgtgggaaagactataggcaataggaatctcct gcaaactcctacaggagaaaagttgtatgaatgtggaaactttagaaattgaaggaattt ttccagttccaagtgcatcccttattctataggaaataaactggagacaaatctcattta agagatgcagcaaagtgttcactaagagtgtttatcttgccagacataagaagatgaatg gtagagcaacctgaaggatttagaaattacatataaatctttgcagttatgctatttgta aacaggattatataggagagcaaataaacataagtatgcatttcttagagcagtagcttg cagtttcagttgagttctacttagaaattctttttagctagtgggcatgtgaagatattt agtcacccagaggagccagtaaatgttataatgttaaaaattaaagctgcaaaagaaata aaatggtgttaataaaaattttggcatctaataaaatcattttgtatatcaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 177 cbe_3789063 AP2M1 adaptor-related protein complex 2, mu 1 subunit length = 1936 ccgaggcagcgggcagacgagcagggggcgggcggacatcttgggatccggagagtggcc SEQ ID NO: 168 gggccggcagagcagggggccgaggacaccaggtctgttctcagagcgatgggccgcgga gactgatctgccgccatgattggaggcttattcatctataatcacaagggggaggtgctc atctcccgagtctaccgagatgacatcgggaggaacgcagtggatgcctttcgggtcaat gttatccatgcccggcagcaggtgcgcagccccgtcaccaacattgctcgcaccagcttc ttccacgttaagcggtccaacatttggctggcagcagtcaccaagcagaatgtcaacgct gccatggtcttcgaattcctctataagatgtgtgacgtgatggctgcctactttggcaag atcagcgaggaaaacatcaagaacaattttgtgctcatatatgagctgctggatgagatt ctagactttggctacccacagaattccgagacaggcgcgctgaaaaccttcatcacgcag cagggcatcaagagtcagcatcagacaaaagaagagcagtcacagatcaccagccaggta actgggcagattggctggcggcgagagggtatcaagtatcgtcggaatgagctcttcctg gatgtgctggagagtgtgaacctgctcatgtccccacaagggcaggtgctgagtgcccat gtgtcgggccgggtggtgatgaagagctacctgagtggcatgcctgaatgcaagtttggg atgaatgacaagattgttattgaaaagcagggcaaaggcacagctgatgaaacaagcaag agcgggaagcaatcaattgccattgatgactgcaccttccaccagtgtgtgcgactcagc aagtttgactctgaacgcagcatcagctttatcccgccagatggagagtttgagcttatg aggtatcgcacaaccaaggacatcatccttcccttccgggtgatcccgctagtgcgagaa gtgggacgcaccaaactggaggtcaaggtggtcatcaagtccaactttaaaccctcactg ctggctcagaagatcgaggtgaggatcccaaccccactgaacacaagcggggtgcaggtg atctgcatgaaggggaaggccaagtacaaggccagcgagaatgccatcgtgtggaagatc aagcgcatggcaggcatgaaggaatcgcagatcagcgcagagattgagcttctgcctacc aacgacaagaagaaatgggctcgaccccccatttccatgaactttgaggtgccattcgcg ccctctggcctcaaggtgcgctacttgaaggtgtttgaaccgaagctgaactacagcgac catgatgtcatcaaatgggtgcgctacattggccgcagtggcatttatgaaactcgctgc tagctgccactaggcagctagcccacctccccagccaccctcctccacaggtccaggtgc cgctccctcccccaccacacatcagtgtctcctccctcctgctttgctgccttccctttg caccagcccgagtctaggtctgggccaagcacattacaagtgggaccggtggagcagccc ctgggctccctgggcaggggagttctgaggctcctgctctcccatccacctgtctgtcct ggcctaatgccaggctctgagttctgtgaccaaagccaggtgggttccctttccttccca cccctgtggccacagctctggagtgggagggttggttgcccctcacctcagagctccccc aaaggccagtaatggatccccggcctcagtccctactctgctttgggatagtgtgagctt cattttgtacacgtgtgacttcgtccagttacaaacccaataaactctgtagagtggaaa aaaaaaaaaaaaaaaa

TABLE 178 cbe_3800240 IVD isovaleryl Coenzyme A dehydrogenase length = 2216 tttccgcagttaggggctgctatttcaacgcagggagataaaaagaaaaaaacacttgct SEQ ID NO: 169 cttctaccccgctaaaaacactcatcctagggagcacgccagcatttgcagcgttcgggg cagggccactcggcctgcggccgttgcactggctggaagctggcaggcgatcacggttga ttggctcgggtgcggtccaagggcagcaacgccttcggcgggccgcctagggtgattggc tgctgcagcccaccccctagccggtttggtgggcggcgaagcctggattggtggagctaa gagctggctcagtttcagcgctggctcttcgtgcatggcagagatggcgactgcgactcg gctgctggggtggcgtgtggcgagctggaggctgcggccgccgcttgccggcttcgtttc ccagcgggcccactcgcttttgcccgtggacgatgcaatcaatgggctaagcgaggagca gaggcagcttcgtcagaccatggctaagttccttcaggagcacctggcccccaaggccca ggagatcgatcgcagcaatgagttcaagaacctgcgagaattttggaagcagctggggaa cctgggcgtattgggcatcacagcccctgttcagtatggcggctccggcctgggctacct ggagcatgtgctggtgatggaggagatatcccgagcttccggagcagtggggctcagtta cggtgcccactccaacctctgcatcaaccagcttgtacgcaatgggaatgaggcccagaa agagaagtatctcccgaagctgatcagtggtgagtacatcggagccctggccatgagtga gcccaatgcaggctctgatgttgtctctatgaagctcaaagcggaaaagaaaggaaatca ctacatcctgaatggcaacaagttctggatcactaatggccctgatgctgacgtcctgat tgtctatgccaagacagatctggctgctgtgccagcttctcggggcatcacagccttcat tgtggagaagggtatgcctggctttagcacctctaagaagctggacaagctggggatgag gggctctaacacctgtgagctaatctttgaagactgcaagattcctgctgccaacatcct gggccatgagaataagggtgtctacgtgctgatgagtgggctggacctggagcggctggt gctggccggggggcctcttgggctcatgcaagcggtcctggaccacaccattccctacct gcacgtgagggaagcctttggccagaagatcggccacttccagttgatgcaggggaagat ggctgacatgtacacccgcctcatggcgtgtcggcagtatgtctacaatgtcgccaaggc ctgcgatgagggccattgcactgctaaggactgtgcaggtgtgattctttactcagctga gtgtgctacacaggtagccctggacggcattcagtgttttggtggcaatggctacatcaa tgactttcccatgggccgctttcttcgagatgccaagctgtatgagataggggctgggac cagcgaggtgaggcggctggtcatcggcagagccttcaatgcagactttcactagtcctg agacccttcgcccccttttcctgcacctagtggcctttcttgggaagtagagatgtggcg gctttcccaccctgcccacagcaggccctcctgcccagctgctcttgtcagccctctggc ctctggatgaggttgagttctccacaacagctcccaagcatcatgggcctcgcagccggg cctgtgccacggctagtgttgtgtgatttaaaatggactcagcaggaagcatattgtctg gggattgttgggacaggttttggtgactctgtgcccttgctctctaacttctgagcccac ctcccagggtaggcacctgggggcatgcaggtgcccacctcccagggtaggcacctgggg gcatgcaggtacccacctctttctcttgggtgaggctctggcaaggagatctctctgctc aagcacagcagaatcatggcccctctccatgaattggaacttggtacaggttaagtatcc ctaatcctgaaatctgaaacacttgtggttccaagcattttggataaggcaaattcaact ttcagtctcttttctgggggaaaaaaataataaacctagcctagccaggcgtggtg

TABLE 179 cbe_3810032 gbh_af142421 Homo sapiens QUAKING isoform 5 (QUAKING) mRNA, complete cds. length = 1497 ccgggggcttctcagttttattttatcaatctatatgcatatccttatgccagtctcaca SEQ ID NO: 170 cagtgttaattactgtagctttgtagtcagttttgaaatcaagaagtatgagtccttcgt tcttatttttcaaaattatcttggctgttctgtgtcccgtgtgtttctagataaatttta ggatcatcttgtcaatttctggggatattggctgggttcttggtttacttccatgtgttc tctttaaatggctagactgggctttggttttttcagtatcgggttggaatctgagagggg aaatggaaacgaaggagaagccgaagcccaccccagattacctgatgcagctgatgaacg acaagaagctcatgagcagcctgcccaacttctgcgggatcttcaaccacctcgagcggc tgctggacgaagaaattagcagagtacggaaagacatgtacaatgacacattaaatggca gtacagagaaaaggagtgcagaattgcctgatgctgtgggacctattgttcagttacaag agaaactttatgtgcctgtaaaagaatacccagattttaattttgttgggagaatccttg gacctagaggacttacagccaaacaacttgaagcagaaaccggatgtaaaatcatggtcc gaggcaaaggctcaatgagggataaaaaaaaggaggagcaaaatagaggcaagcccaatt gggagcatctaaatgaagatttacatgtactaatcactttggaagatgctcagaacagag cagaaatcaaattgaagagagcagttgaagaagtgaagaaattattggtacctgcagcag aaggagaagacagcctgaagaagatgcagctgatggagcttgcgattctgaatggcacct acagagatgccgacattaaatcaccagcccttgccttttctcttgcagcaacagcccagg ctgctccaaggatcattactgggcctgcgccggttctcccaccagctgccctgcgtactc ctacgccagctggccctaccataatgcctttgatcagacaaatacagaccgctgtcatgc caaacggaactcctcacccaactgctgcaatagttcctccagggcccgaagctggtttaa tctatacaccctatgagtacccctacacattggcaccagctacatcaatccttgagtatc ctattgaacctagtggtgtattaggtgcggtggctactaaagttcgaaggcacgatatgc gtgtccatccttaccaaaggattgtgaccgcagaccgagccgccaccggcaactaaccta tgaccttctgacctctgaactcttcacccaatgatgacctgaccatgcctgcctgctgat cagttaactggtaatcgcctttgcttgcctgtcgtcagtgcagcgagctgaggcacttgt ccgttcgtcttaccatctaaccaaacaaaagacaaagaaattgttgtcctccaactc

TABLE 180 cbe_3810791 EPHB1 EphB1 length = 3865 cacatgcacacccacacccacgcgcgcccgcaccgccccacgcgcacacactcctgccca SEQ ID NO: 171 cgcccacgcagcgctccgggaagtccggtccgggcgagagcgcgaaaggataccgagaag ccacccgcggagagcgcagcggcgccctgggacgcggcgctctcccggcgctgctgcctc ggcttggtctcggcctgcgggccgtcggccggcgatggccctggattatctactactgct cctcctggcatccgcagtggctgcgatggaagaaacgttaatggacaccagaacggctac tgcagagctgggctggacggccaatcctgcgtccgggtgggaagaagtcagtggctacga tgaaaacctgaacaccatccgcacctaccaggtgtgcaatgtcttcgagcccaaccagaa caattggctgctcaccaccttcatcaaccggcggggggcccatcgcatctacacagagat gcgcttcactgtgagagactgcagcagcctccctaatgtcccaggatcctgcaaggagac cttcaacttgtattactatgagactgactctgtcattgccaccaagaagtcagccttctg gtctgaggccccctacctcaaagtagacaccattgctgcagatgagagcttctcccaggt ggactttgggggaaggctgatgaaggtaaacacagaagtcaggagctttgggcctcttac tcggaatggtttttacctcgcttttcaggattatggagcctgtatgtctcttctttctgt ccgtgtcttcttcaaaaagtgtcccagcattgtgcaaaattttgcagtgtttccagagac tatgacaggggcagagagcacatctctggtgattgctcggggcacatgcatccccaacgc agaggaagtggacgtgcccatcaaactctactgcaacggggatggggaatggatggtgcc tattgggcgatgcacctgcaagcctggctatgagcctgagaacagcgtggcatgcaaggc ttgccctgcagggacattcaaggccagccaggaagctgaaggctgctcccactgcccctc caacagccgctcccctgcagaggcgtctcccatctgcacctgtcggaccggttattaccg agcggactttgaccctccagaagtggcatgcactagcgtcccatcaggtccccgcaatgt tatctccatcgtcaatgagacgtccatcattctggagtggcaccctccaagggagacagg tgggcgggatgatgtgacctacaacatcatctgcaaaaagtgccgggcagaccgccggag ctgctcccgctgtgacgacaatgtggagtttgtgcccaggcagctgggcctgacggagtg ccgcgtctccatcagcagcctgtgggcccacaccccctacacctttgacatccaggccat caatggagtctccagcaagagtcccttccccccacagcacgtctctgtcaacatcaccac aaaccaagccgccccctccaccgttcccatcatgcaccaagtcagtgccactatgaggag catcaccttgtcatggccacagccggagcagcccaatggcatcatcctggactatgagat ccggtactatgagaaggaacacaatgagttcaactcctccatggccaggagtcagaccaa cacagcaaggattgatgggctgcggcctggcatggtatatgtggtacaggtgcgtgcccg cactgttgctggctacggcaagttcagtggcaagatgtgcttccagactctgactgacga tgattacaagtcagagctgagggagcagctgcccctgattgctggctcggcagcggccgg ggtcgtgttcgttgtgtccttggtggccatctctatcgtctgtagcaggaaacgggctta tagcaaagaggctgtgtacagcgataagctccagcattacagcacaggccgaggctcccc agggatgaagatctacattgaccccttcacttatgaggatcccaacgaagctgtccggga gtttgccaaggagattgatgtatcttttgtgaaaattgaagaggtcatcggagcagggga gtttggagaagtgtacaaggggcgtttgaaactgccaggcaagagggaaatctacgtggc catcaagaccctgaaggcagggtactcggagaagcagcgtcgggactttctgagtgaggc gagcatcatgggccagttcgaccatcctaacatcattcgcctggagggtgtggtcaccaa gagtcggcctgtcatgatcatcacagagttcatggagaatggtgcattggattctttcct caggcaaaatgacgggcagttcaccgtgatccagcttgtgggtatgctcaggggcatcgc tgctggcatgaagtacctggctgagatgaattatgtgcatcgggacctggctgctaggaa cattctggtcaacagtaacctggtgtgcaaggtgtccgactttggcctctcccgctacct ccaggatgacacctcagatcccacctacaccagctccttgggagggaagatccctgtgag atggacagctccagaggccatcgcctaccgcaagttcacttcagccagcgacgtttggag ctatgggatcgtcatgtgggaagtcatgtcatttggagagagaccctattgggatatgtc caaccaagatgtcatcaatgccatcgagcaggactaccggctgcccccacccatggactg tccagctgctctacaccagctcatgctggactgttggcagaaggaccggaacagccggcc ccggtttgcggagattgtcaacaccctagataagatgatccggaacccggcaagtctcaa gactgtggcaaccatcaccgccgtgccttcccagcccctgctcgaccgctccatcccaga cttcacggcctttaccaccgtggatgactggctcagcgccatcaaaatggtccagtacag ggacagcttcctcactgctggcttcacctccctccagctggtcacccagatgacatcaga agacctcctgagaataggcatcaccttggcaggccatcagaagaagatcctgaacagcat tcattctatgagggtccagataagtcagtcaccaacggcaatggcatgagaactcttgtt tcttggggaaggagaggagggaaaaggaccagggtcaagggggaccagaggttgaccact gtggaatgtactggagagactggcttctcagctgaggaatgcatttccatcagtgaagaa tcaaccggacctgttgctagcaggcaatctccatttctcagtgacagaagcatgtttgag atgccgtgggaaaccaaatatataataataaaaatataaaaaggtgatgttcaacagaag tgaagacaaaacaatatgcatcaggagaacaagagtaaacccagctcccactctcagtgg gctgcagttgcccaaccacaggaagaaagggaaggaggtagagggaagaaacagaagcag tgttccattttcttcctcaccaatgacattcttttcttttctcctttcgtactcctccct gagagtcccctcccttctcccacactcgtttccctttgctcatgactcctgtagggaagt ttcttcaaacaaaacccagctcctgagtctccagatgttgttctgtcagttgccaaagga ctttgctgaccactgcatggggatccaaccaattcaattaatgtcttcatattgaagaag agatgtaccttcaattgaaaacctcgtttttcttttgtttgcattttctgcaaaaaggaa aaagaaaccacaaattggggaattc

TABLE 181 cbe_3820530 PGAM1 phosphoglycerate mutase 1 (brain) length = 1709 gggcggggtgccgcatccccagcccgccgccatggccgcctacaaactggtgctgatccg SEQ ID NO: 172 gcacggcgagagcgcatggaacctggagaaccgcttcagcggctggtacgacgccgacct gagcccggcgggccacgaggaggcgaagcgcggcgggcaggcgctacgagatgctggcta tgagtttgacatctgcttcacctcagtgcagaagagagcgatccggaccctctggacagt gctagatgccattgatcagatgtggctgccagtggtgaggacttggcgcctcaatgagcg gcactatgggggtctaaccggtctcaataaagcagaaactgctgcaaagcatggtgaggc ccaggtgaagatctggaggcgctcctatgatgtcccaccacctccgatggagcccgacca tcctttctacagcaacatcagtaaggatcgcaggtatgcagacctcacagaagatcagct accctcctgtgagagtctgaaggatactattgccagagctctgcccttctggaatgaaga aatagttccccagatcaaggaggggaaacgtgtactgattgcagcccatggcaacagcct ccggggcattgtcaagcatctggagggtctctctgaagaggctatcatggagctgaacct gccgactggtattcccattgtctatgaattggacaagaacttgaagcctatcaagcccat gcagtttctgggggatgaagagacggtgcgcaaagccatggaagctgtggctgcccaggg caaggccaagaagtgaaggccggcggggaggatactgtccccaggagcaccctccctgcc cgtcttgtccctctgcccctcccacctgcacatgtcacactgaccacatctgtagacatc ttgagttgtagctgcagacggggaccagtggctcccattttcattttagccattttgtcg cctgcacccactcccttcatacaatctagtcagaatagcagttctagagcacaggttctc agtctaagctatggaaaagctccccttatccaacagagtttaaaagtagtgacttgggtt tttgcgagtgctttgtttactaaggactttggggaggaaccatgctaagccatgaccagt gaggagaagcaacagagcctgtctgtccccatgagcggagtctgtcctctgctcttctgc agtcaggtcactgcctactgcctgggggctctagtcattccagtggaagacgaatgtaac ctgcgtggtgatgtgacaactgtttcctccctgaccccagaggatctggctctaggttgg gatcaatcctgaatttcgttatgtgttaatttacttttattaaaaaagtatagtatatat aatacaaaacaataacccttctggggtttcttgtggcggttgaaatagtcccacatgtgg tcatcagaaatagcattcctcataccaatataggatcagctccttgacctctgaggggtc aggagtgcttcctggtgtgtgtattagaatcccttcctgccttgtttcatggcagtgaaa tgcctcttggtcctgtccagtgtatctttcactgatttctgaatcatgttctagttgctt gaccctgccacatgggtccagtgttcatctgagcataactgtactaaatcctttttccat atcagtataataaaggagtgatgtgcaat

TABLE 182 cbe_3825897 POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa length = 392 agtctgggacgcgccgccgccatgatcatccctgtacgctgcttcacttgtggcaagatc SEQ ID NO: 173 gtcggcaacaagtgggaggcttacctggggctgctgcaggccgagtacaccgagggggac gcgctggatgccctgggcctgaagcgctactgctgccgccggatgctgctggcccacgtg gacctgatcgagaagctgctcaattatgcacccctggagaagtgaccacgctgaaaccca cccacccgctgtgctgaccatgggccctgagcgtcctaccccgaattcacgaggctgagg catccgggagctggcgtaatgcctggccgcagtgtgtgtgtatcccataccccactctgg aaggaaccatccagtaaaggtctttcagaacc

TABLE 183 cbe_3826540 NYD-TSP1 testis-specific protein NYD-TSP1 length = 1880 ctttcccacccttcctccccacaaggctgtctgagatgccaccttccacctaaacatcat SEQ ID NO: 174 ctcccaaattttaatccttaactttggtctctgacttctgcttgattccacagtctccac ccacatttgcacaaaggaccatcacctgtccttcctggaatctctaaagttttctgcttt ccttctgtcctgatggccagctctgctaagtcagctgagatgcccaccatctccaaaacc cttaaccctactcctgatcctcatcaagaatatctggaccctaggattaccattgcctta ttcgaaattggatcacattccccttcctcctggggctctctccctttcctaaagaatagc agccatcaagttacagaacaacagactgcacagaagtttaacaatctcttaaaagaaatt aaagatattcttaaaaatatggcaggttttgaagagaagatcacagaagcaaaagaactt tttgaggaaaccaatattactgaggatgtgtcagcccacaaagaaaatatcagaggactt gacaaaatcaatgaaatgttatcaacaaacctgcctgttagtttagccccagagaaagaa gacaatgaaaagaaacaggagatgatattggaaaccaatattactgaggatgtgtcagcc cacaaagaaaatatcagaggacttgacaaaatcaatgaaatgttatcaacaaacctgcct gttagtttagccccagagaaagaagacaatgaaaagaaacagcagatgataatggaaaac cagaactctgagaacaccgcacaagtttttgcaagagatttggtaaatcgtttagaagaa aaaaaagtccttaacgaaactcaacaaagtcaggaaaaagcaaaaaacagacttaatgtt caagaagaaactatgaaaattaggaacaacatggagcagttactacaggaagcagaacac tggagtaaacaacatactgagctcagtaaactgataaaatcctatcagaaatctcagaaa gacataagtgaaactcttggaaataatggagtcggtttccaaacccagccaaataatgaa gtgtcggctaagcatgagctggaggaacaggtgaagaaactgagccatgacacctattca ttgcagttgatggcagctttgctagagaatgaatgccaaatcttacagcagagagtagag attctcaaggaactccatcatcagaaacagggaactctgcaagagaagccaattcagata aactataaacaggacaagaaaaatcagaagccatcagaagcaaagaaagtagaaatgtat aagcagaacaagcaagcaatgaagggtacattttggaaaaaagacagatcctgtagaagc ctggatgtttgtcttaataagaaagcttgcaatacccagttcaatattcatgttgcaaga aaagctcttaggggaaaaatgaggtcagctagcagcctaagatagaaaataccaaaagca gatgaaaaggtgaatccttaaaaaactacatctgttacctccaacttgtcagtcatgatc aatcatcaaaccttgggcagatctgctggttcaaccaagaaagagctatagaataaggag attgacacttatattactcattacttcagcagttatgtaagtctggtctttaatgaccat tgtgtctacatcaagttcataacttttcacctttacaatctgcttgttttttttgtaatt attagatagacagcctagagtgagaagttaaaggtccaattaagttaagatctaaataaa aaccagaatacaagggaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaa

TABLE 184 cbe_3833533 TRIM29 tripartite motif-containing 29 length = 3018 ctcctcacaggtgtgtctctagtcctcgtggttgcctgccccactccctgccgagacgcc SEQ ID NO: 175 tgccagaaaggtcacctatcctgaaccccagcaagcctgaaacagctcagccaagcaccc tgcgatggaagctgcagatgcctccaggagcaacgggtcgagcccagaagccagggatgc ccggagcccgtcgggccccagtggcagcctggagaatggcaccaaggctgacggcaagga tgccaagaccaccaacgggcacggcggggaggcagctgagggcaagagcctgggcagcgc cctgaagccaggggaaggtaggagcgccctgttcgcgggcaatgagtggcggcgacccat catccagtttgtcgagtccggggacgacaagaactccaactacttcagcatggactctat ggaaggcaagaggtcgccgtacgcagggctccagctgggggctgccaagaagccacccgt tacctttgccgaaaagggcgagctgcgcaagtccattttctcggagtcccggaagcccac ggtgtccatcatggagcccggggagacccggcggaacagctacccccgggccgacacggg ccttttttcacggtccaagtccggctccgaggaggtgctgtgcgactcctgcatcggcaa caagcagaaggcggtcaagtcctgcctggtgtgccaggcctccttctgcgagctgcatct caagccccacctggagggcgccgccttccgagaccaccagctgctcgagcccatccggga ctttgaggcccgcaagtgtcccgtgcatggcaagacgatggagctcttctgccagaccga ccagacctgcatctgctacctttgcatgttccaggagcacaagaatcatagcaccgtgac agtggaggaggccaaggccgagaaggagacggagctgtcactgcaaaaggagcagctgca gctcaagatcattgagattgaggatgaagctgagaagtggcagaaggagaaggaccgcat caagagcttcaccaccaatgagaaggccatcctggagcagaacttccgggacctggtgcg ggacctggagaagcaaaaggaggaagtgagggctgcgctggagcagcgggagcaggatgc tgtggaccaagtgaaggtgatcatggatgctctggatgagagagccaaggtgctgcatga ggacaagcagacccgggagcagctgcatagcatcagcgactctgtgttgtttctgcagga atttggtgcattgatgagcaattactctctccccccacccctgcccacctatcatgtcct gctggagggggagggcctgggacagtcactaggcaacttcaaggacgacctgctcaatgt atgcatgcgccacgttgagaagatgtgcaaggcggacctgagccgtaacttcattgagag gaaccacatggagaacggtggtgaccatcgctatgtgaacaactacacgaacagcttcgg gggtgagtggagtgcaccggacaccatgaagagatactccatgtacctgacacccaaagg tggggtccggacatcataccagccctcgtctcctggccgcttcaccaaggagaccaccca gaagaatttcaacaatctctatggcaccaaaggtaactacacctcccgggtctgggagta ctcctccagcattcagaactctgacaatgacctgcccgtcgtccaaggcagctcctcctt ctccctgaaaggctatccctccctcatgcggagccaaagccccaaggcccagccccagac ttggaaatctggcaagcagactatgctgtctcactaccggccattctacgtcaacaaagg caacgggattgggtccaacgaagccccatgagctcctggcggaaggaacgaggcgccaca cccctgctcttcctcctgaccctgctgctcttgccttctaagctactgtgcttgtctggg tgggagggagcctggtcctgcacctgccctctgcagccctctgccagcctcttgggggca gttccggcctctccgacttccccactggccacactccattcagactcctttcctgccttg tgacctcagatggtcaccatcattcctgtgctcagaggccaacccatcacaggggtgaga taggttggggcctgccctaacccgccagcctcctcctctcgggctggatctgggggctag cagtgagtacccgcatggtatcagcctgcctctcccgcccacgccctgctgtctccaggc ctatagacgtttctctccaaggccctatcccccaatgttgtcagcagatgcctggacagc acagccacccatctcccattcacatggcccacctcctgcttcccagaggactggccctac gtgctctctctcgtcctacctatcaatgcccagcatggcagaacctgcagcccttggcca ctgcagatggaaacctctcagtgtcttgacatcaccctacccaggcggtgggtctccacc acagccactttgagtctgtggtccctggagggtggcttctcctgactggcaggatgacct tagccaagatattcctctgttccctctgctgagataaagaattcccttaacatgatataa tccacccatgcaaatagctactggcccagctaccatttaccatttgcctacagaatttca ttcagtctacactttggcattctctctggcgatggagtgtggctgggctgaccgcaaaag gtgccttacacactgcccccaccctcagccgttgccccatcagaggctgcctcctccttc tgattaccccccatgttgcatatcagggtgctcaaggattggagaggagacaaaaccagg agcagcacagtggggacatctcccgtctcaacagccccaggcctatgggggctctggaag gatgggccagcttgcaggggttggggagggagacatccagcttgggctttcccctttgga ataaaccattggtctgtc

TABLE 185 cbe_3834015 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) length = 915 atgatttacacaatgaagaaagtacatgcactttgggcttctgtatgcctgctgcttaat SEQ ID NO: 176 cttgcccctgcccctcttaatgctgattctgaggaagatgaagaacacacaattatcaca gatacggagttgccaccactgaaacttatgcattcattttgtgcattcaaggcggatgat ggcccatgtaaagcaatcatgaaaagatttttcttcaatattttcactcgacagtgcgaa gaatttatatatgggggatgtgaaggaaatcagaatcgatttgaaagtctggaagagtgc aaaaaaatgtgtacaagagataatgcaaacaggattataaagacaacattgcaacaagaa aagccagatttctgctttttggaagaagatcctggaatatgtcgaggttatattaccagg tatttttataacaatcagacaaaacagtgtgaacgtttcaagtatggtggatgcctgggc aatatgaacaattttgagacactggaagaatgcaagaacatttgtgaagatggtccgaat ggtttccaggtggataattatggaacccagctcaatgctgtgaataactccctgactccg caatcaaccaaggttcccagcctttttgaatttcacggtccctcatggtgtctcactcca gcagacagaggattgtgtcgtgccaatgagaacagattctactacaattcagtcattggg aaatgccgcccatttaagtacagtggatgtgggggaaatgaaaacaattttacttccaaa caagaatgtctgagggcatgtaaaaaaggtttcatccaaagaatatcaaaaggaggccta attaaaaccaaaagaaaaagaaagaagcagagagtgaaaatagcatatgaagaaattttt gttaaaaatatgtga

TABLE 186 cbe_3842044 PSMB3 proteosome (prosome, macropain) subunit, beta type, 3 length = 784 gagcggttgcgcagtgaaggctagacccggtttactggaattgctctggcgatcgagggg SEQ ID NO: 177 tcctagtacaccgcaatcatgtctattatgtcctataacggaggggccgtcatggccatg aaggggaagaactgtgtggccatcgctgcagacaggcgcttcgggatccaggcccagatg gtgaccacggacttccagaagatctttcccatgggtgaccggctgtacatcggtctggcc gggctcgccactgacgtccagacagttgcccagcgcctcaagttccggctgaacctgtat gagttgaaggaaggtcggcagatcaaaccttataccctcatgagcatggtggccaacctc ttgtatgagaaacggtttggcccttactacactgagccagtcattgccgggttggacccg aagacctttaagcccttcatttgctctctagacctcatcggctgccccatggtgactgat gactttgtggtcagtggcacctgcgccgaacaaatgtacggaatgtgtgagtccctctgg gagcccaacatggatccggatcacctgtttgaaaccatctcccaagccatgctgaatgct gtggaccgggatgcagtgtcaggcatgggagtcattgtccacatcatcgagaaggacaaa atcaccaccaggacactgaaggcccgaatggactaaccctgttcccagagcccacttttt tttctttttttgaaataaaatagcctgtctttcaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaa

TABLE 187 cbe_3845697 Hs. 191063 Human DNA sequence from clone RP1-63M2 on chromosome 20 Contains the gene for CBFA2T2 (core-binding factor, runt domain, alpha subunit 2; translocated to, 2), part of a gene for a protein similar to ACTIN, the E2F1 (E2F transcription factor 1) gene, a nov length = 532 tttggcatggacacaagtggggcatcacctttattgccataaagtagggccctgtgggta SEQ ID NO: 178 ggcagctggactggcattctctgaactggcagtggttggggagattcaaactgcagttca aaatgagggtcccatgggtcccaaataccttctcctggcccagaaagggtatgggggtga cccatccagtcagctccaacctccaggaggaccctgccagctccaaacacttgactcttt agatagagagctgtcccccaacgcagtgccaccccccccagtccagcctgactcagttga acacatcgtacagcagcctggagccacactcctggtacatggcccgagttatccagcggc gctggaaggagtgcagggaggccaccatggagccgccggtccacacagccatgccacgcc catgcttggccaccaggtggggccgcagggccgcgtagccgtgccgccggcactgcgcct ncagctccttgtccaggcgctcggcgaagccaggaaacagtgtggagccgcc

TABLE 188 cbe_3849002 CKLF1 chemokine-like factor 1 length = 689 gcaagagagcgggaagccgagctgggcgagaagtaggggagggcggtgctccgccgcggt SEQ ID NO: 179 ggcggttgctatcgcttcgcagaacctactcaggcagccagctgagaagagttgagggaa agtgctgctgctgggtctgcagacgcgatggataacgtgcagccgaaaataaaacatcgc cccttctgcttcagtgtgaaaggccacgtgaagatgctgcggctggcactaactgtgaca tctatgaccttttttatcatcgcacaagcccctgaaccatatattgttatcactggattt gaagtcaccgttatcttatttttcatacttttatatgtactcagacttgatcgattaatg aagtggttattttggcctttgcttgatattatcaactcactggtaacaacagtattcatg ctcatcgtatctgtgttggcactgataccagaaaccacaacattgacagttggtggaggg gtgtttgcacttgtgacagcagtatgctgtcttgccgacggggcccttatttaccggaag cttctgttcaatcccagcggtccttaccagaaaaagcctgtgcatgaaaaaaaagaagtt ttgtaattttatattactttttagtttgatactaagtattaaacatatttctgtattctt ccaaaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 189 cbe_3880186 FLJ20343 hypothetical protein FLJ20343 length = 2784 gatgccccgcccgcgcccatggcgcagccacacacgacctcggtcccgtacttcgcgcgc SEQ ID NO: 180 tctcctgcaccgccgccgccatctcgctcaggagctcctccacaaccgccggcaacacta cggccatcgcgccgcaggacacgccctccacgaccggcggaccgccgcgacgctccagct gactgcgcctacctgtggaggatcctgaccccccgccggggcagggcgagacggagtgac gtcggggcgcgtcatcgcgcgtgcggacgcagggatgtcctgctcagtcgtcagggcccg gccaatccggagggcgctcggcgcgtggtcgggggccaggagcgcgtctggcctgcagtg cgcagaggacgcggcgggagcatgttccggctcctgagctggagcctgggccgaggcttc ctgcgggccgcggggcggcggtgccggggctgctccgcgcgcctgctcccggggctggca ggaggtccggggcccgaggtgcaggtgccgccatcccgagtcgcgccgcacggccggggc ccaggcctgctgccgctgctggcagcgctcgcctggttctcgaggcccgctgcggcagag gaggaggagcagcagggagccgacggggccgctgccgaggacggggcggacgaggccgag gcagagatcatccagctgctgaagcgagccaagttgagcattatgaaagatgagccagaa gaggctgagttaattttgcatgacgctcttcgtctcgcctatcagactgataacaagaag gccatcacttacacttatgatttgatggccaacttagcatttatacggggtcagcttgaa aatgctgaacaactttttaaagcaacaatgagttacctccttggagggggcatgaagcag gaggacaatgcaataattgaaatttccctaaagctggccagtatctatgctgcgcagaac agacaggaatttgctgttgctggctatgaattctgcatttcaactctagaggaaaaaatt gaaagagaaaaggaattagcagaagacattatgtcagtggaagagaaagccaatacccac ctcctcttgggcatgtgcttagacgcctgtgctcgctaccttctgttctccaagcagccg tcacaggcacaaaggatgtatgaaaaagctctgcagatttctgaagaaatacaaggagaa agacacccacagaccattgtgctgatgagtgacctggctactaccctggatgcacagggc cgctttgatgaggcctatatttatatgcaaagggcatcagatctggcaagacagataaat catcctgagctacacatggtactcagtaatctagctgcagttttgatgcacagagaacga tatacacaagcaaaagagatctaccaggaagcactgaagcaagcaaagctgaaaaaagat gaaatttctgtacaacacatcagggaagagttggctgagctgtcaaagaaaagtagacct ttgacaaattctgtcaagctctaaatccatttttgtgtagggagaataatgtctagtaat gtggaagaatagctatcattcctgtctctgtggcacccgatcaatggcttaaatctgtcg tttttgatattcaggtttcctcaatttagccttagtgaaggaggggttgtacacactgcc atttttgtattttaaaggaaaaatgactttcattcccaactgattatgacctttcaggat gtcgtcaagtgatgctttcagttgtaacacgtgacttggtgctgtccctgctggtctaag tagaactgtagattcatatgggctggtgttcctgtgcgctgtgggtgtggtgattcagcc tggcatttctaccataagtttttggtctgctgatttgctgccctgtcttctcttacttta ctttatcaatacctggcaaactgaccagaattaccttcctcatggcgaagggggattatg gtgaattgttgttcttatagtctgtttcatgaagcacaagtggaatttaatacataaaag agaaaaatatcttagtttgctaccagcatccagcatgaagttgtaaagtggggattaggc acgtgacagtatagcacccatttgaatttaaataaaagtgaaccatatttatctggttat ataaaactaaaaatgggggtgtttatataaaactaaaaactaagaatgatgtaacctttt gtctgtgttatctgaacactctacttcctttgcagccttagtcacacaactgagtcatct caagtactctttaaggacacacagcccaggctgttctgagtcagaataggcccctacagg tatattttaaaactcttcgtaattctaatgtgtactgctggtatagctgaactactgacc tggatcttagtcctagcctttttgcttttgcaatttcagtatcttcatctctaaactagg gaaacactgggattctttcttagctgtgggggaaggtatttggttagatgactttgaatg aatagactgctgtgctgaaagagctttatcacactgtctcaaagtatgtaaagatacata ggtggatgctcttactgcagcagtcatgaatacatttttagccatttacctaaggaaaaa gacagtttttctaggtaccatgaaggaagattgaccctgttggtatgcctgtgggggtgg gatgtgagtgggactgataaactgatacttttggttcgtatgtacatactggaagaatct tcataataaatgagactacacaac

TABLE 190 cbe_3884811 RCP Rab coupling protein length = 2112 cccgcttctggagtgttatcgtcaccatgtccctaatggtctcggctggccggggcctgg SEQ ID NO: 181 gggccgtgtggtccccaacccacgtgcaggtgacggtgctgcaggcgcggggcctgcggg ccaagggccccgggggcacgagcgacgcgtacgcggtgatccaggtgggcaaggagaagt acgccacctccgtgtcggagcgcagcctgggcgcgcccgtgtggcgcgaggaggccacct tcgagctgccatcgctgctgtcctccggacccgcggccgccgccaccctgcagctcaccg tgctgcaccgcgcgctgctcggcctcgacaagttcctgggccgcgccgaggtggacctgc gggatctgcaccgcgaccagggccgcaggaagacgcagtggtataagttgaaatccaaac caggaaagaaggacaaggagcgaggagaaattgaggttgacatccagtttatgagaaaca acatgactgccagcatgtttgacctttctatgaaagacaagtctcggaatccatttggaa agctgaaggacaagatcaaggggaagaataaggacagtgggtcagacaccgcctccgcca tcatccctagcacgacaccttcggtcgacagtgatgatgagtctgtggttaaagacaaga aaaagaaatcaaagatcaagaccttactttccaagtcaaatttgcagaagacgcctcttt cccagtccatgtctgtcctgccgacttcaaagccagaaaaagtgctgcttcgtcccggag actttcagtcccagtgggatgaagatgacaatgaggatgagtcctcctcggcctcggatg tcatgtctcacaagagaacagcgagtacggatcttaagcaactgaaccaggtcaacttta cccttcccaagaaggaaggactttcctttcttggtggccttcggtctaagaatgatgtcc tttcccgctctaatgtctgcatcaatgggaaccatgtttacctggagcagccccaaccca ccggtgagatcaaggatagcagcccgtcctcctccccatcccccaagggtttcagaaaga aaacattgttctcttctacagagaacctggcggctgggtcttggaaggagcctgctgaag gaggtgggctgtctactgacagggatgtctccgaatcttccaccaaggactccttgaagt ctatgaccttgccgacctaccgacctgccccactgatcagtggggacctcagggaaaaaa tggcccccgcaaactcagaggccacaaaagaagctaaggagagcaagaagccagagagca ggaggtcctctttgctgtctctgatgacggggaagaaggatgtggctaagggcagtgaag gtgaaaaccttctcacggtcccagggagggagaaggaaggcatgctgatgggggttaagc cgggggaggacgcatcggggcctgctgaagaccttgtgagaagatctgagaaagatactg cagctgttgtctccagacagggcagctccctgaacctctttgaagatgtgcagatcacag aaccagaagctgagccagagtccaagtctgaaccgagacctccaatttcctctccgaggg ctccccagaccagagctgtcaagccccgacttcatcctgtgaagccaatgaatgccacgg ccaccaaggttgctaactgcagcttgggaactgccaccatcatcagtgagaacttgaaca atgaggtcatgatgaagaaatacagcccctcggaccctgcatttgcatatgcgcagctga cccacgatgagctgattcagctggtcctcaaacagaaggaaacgataagcaagaaggagt tccaggtccgcgagctggaagactacattgacaacctgcttgtcagggtcatggaagaaa cccccaatatcctccgcatcccgactcaggttggcaaaaaagcaggaaagatgtaaatca gcagaaaaaaaacaccgagacgtttctgtgacttcactttcacctgctccaggggtcaag gacttgccttgcctgataaccagccagcaggctccgaatcaccatctccctcacatgtta tccggcaagagt

TABLE 191 cbe_4138433 KIFAP3 kinesin-associated protein 3 length = 2997 caagaggtgcagagcaagcgcatgcgtcgtgacggcccggcttaggcgactctgggcggg SEQ ID NO: 182 tctgggccgctccagtgttttggggcacagaagctgtgggaggagctggaggcttcaccg tggtaaccacagcgccgctgctgccccgccttgcaggcctcaggactgtcatcgcctctg ggtgtgagggtactttggccaccgtccccggaaataaccgcgcctgcctctcaagatacc ccatcctctccacgccgctgccgctgccgccatgcaaggggaggacgccagatacctcaa aaggaaagttaaaggagggaatatagatgtacatccatcagaaaaagcactcattgttca ctatgaagtggaagctaccattcttggagaaatgggggaccccatgttgggagaacgaaa agaatgtcaaaaaatcattcgacttaagagtctcaatgccaacacagatataacttccct ggcaaggaaggtggttgaagaatgtaaactcattcatccttcaaaactaaatgaggtaga acagctgttgtactatctacagaaccgccgtgattcattgtcaggaaaagagaaaaaaga aaaatcaagcaagcctaaagatccacctccttttgaaggaatggagattgatgaagttgc taacattaatgacatggatgaatatattgagttattatatgaagatattcctgacaaagt tcggggttctgctttgatcctgcagcttgctcgaaatcctgataacttggaagaactact attgaatgaaactgcccttggtgcattagcaagggtcctgagagaagactggaagcaaag tgtcgagttagctacaaacataatttacatctttttttgtttctccagcttttctcaatt tcatggacttattactcactataaaattggagctctgtgtatgaatattattgatcatga gttaaaaagacatgagctttggcaagaagaactctcaaagaagaagaaagctgttgatga agaccctgaaaaccaaaccttgagaaaggattatgaaaaaacctttaaaaagtaccaggg gcttgtggtaaaacaggaacagctattacgagttgctctttatttgcttctgaatcttgc tgaggatactcgtaccgaactgaaaatgaggaacaagaacatagttcacatgttggtgaa agcccttgatcgggacaattttgagctgctaattttagttgtgtcattcttgaagaaact cagcatttttatggagaataaaaatgatatggtggaaatggatattgttgaaaaactggt gaaaatgataccttgtgagcatgaagacctgctgaatatcaccctccgacttttactaaa cctatcctttgacacaggactgaggaataagatggtacaagttggactgcttcccaagct cactgcactcctaggcaatgacaactacaaacaaatagcaatgtgtgttctttaccacat aagcatggatgaccgctttaaatcaatgtttgcatacactgactgtataccacagttaat gaagatgctgtttgaatgttcagatgaacgaattgacttggaactcatttctttctgcat taatcttgctgctaacaaaagaaatgtacagcttatctgtgaaggaaatgggctgaagat gctcatgaagagggctctgaagtttaaggatccattgctgatgaaaatgattagaaacat ttctcagcatgatggaccaactaaaaatctgtttattgattatgttggggaccttgcagc ccagatctctaatgatgaagaagaggagtttgtgattgaatgtttgggaactcttgcaaa cttgaccattccagacttagactgggaattggttcttaaagaatataagttggttccata cctcaaggataaactaaaaccaggtgctgcagaagatgatcttgttttagaagtggttat aatgattggaactgtatccatggatgactcttgtgctgcattgctagccaaatctggcat aatccctgcactcattgaattgctaaatgctcaacaagaagatgatgaatttgtgtgtca gataatttatgtcttctaccagatggttttccaccaagccacaagagacgtcataatcaa ggaaacacaggctccagcatatctcatagacctaatgcatgataagaataatgaaatccg aaaggtctgtgataatacattagatattatagcggaatatgatgaagaatgggctaagaa aattcagagtgaaaagtttcgctggcataactctcagtggctggagatggtagagagtcg tcagatggatgagagtgagcagtacttgtatggtgatgatcgaattgagccatacattca tgaaggagatattctcgaaagacctgaccttttctacaactcagatggattaattgcctc tgaaggagccataagtcccgatttcttcaatgattaccaccttcaaaatggagatgttgt tgggcagcattcatttcctggcagccttggaatggatggctttggccaaccagttggcat tcttggacgccctgccacagcatatggattccgccctgatgaaccttactactatggcta tggatcttgataaagtatctgtttccatgtgtaatctcagcttagaagaaatctgtgtgg gttgggttaattttggatctttgcctaataatgcatgttgatgttattgtgggtctgtgt ttgtttttatttttatatgttgttagctgcagattaaccccagcccctctgtcttctgtt aagtacagttgatactgacattgttcactcatcaaaccacatcttgatgctaagtaacat ttcccatgagcctcaaaactgaatgctgaaaagctactagactggaaaacaaacactgca ttatgtatgttaagtgactaatttaatttcaattaaaaagcgtaaagtgaaaatgaa

TABLE 192 cbe_422204 Prey2335 PathCalling Prey Sequence 2335 length = 394 aaggaaggaaggaaggaaggaaggaaggaaggaaagaaagaaattcatccagcatgtccc SEQ ID NO: 183 tttcttctcctatgggatttaccaactgacaaattctagtgctcctgccatcacccacac atgtgcagcaaagcctccacatttgcaaaatctaagtcaatctctaaaagatgcttcgag gaagcacccagttccttctgctaataaccgcagtgtgtcatgtgacacctccccctcccc caaccagttctctctgaaaactacccacccaccccaccaataaagtagcatgacgtctgt ccttcagctgccaatatctacaatcaaccaacaagtcattaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaagaa

TABLE 193 cbe_422227 Prey277610 PathCalling Prey Sequence 277610 length = 140 gtctgagtgctactgaagaggacgtcgtcacttctggaccaagccctgcccaacgacgtc SEQ ID NO: 184 ctcttcagtagcacgtacccttctctccccaagtcgatcccgttgaggaggccttcttac accttaggaatgaaatcgct

TABLE 194 cbe_422236 BCR1 PathCalling Prey Sequence 1759 length = 553 ggcagaggggttacaactcaggttcccacacctcgcttttcacagcctccgagggcagca SEQ ID NO: 185 gtgcacatgggggagacatctcccacgaggccaaggcctccagtgctcaccgatgccctc tgtgaagttggggtagaactcgtcagtgaaaaggggctcgggcagctcacggaagtacag cttcagcatgcctgcgatggcgttcacgtccatctcgctcatcatcaccgacacgtcctt gttatctggaaagagcatggaaatgcagcggcctccttgaagatcctgataaatgaagaa aagacacagagaaggatgtgacatgcctgggccgtggagcactctgagatctcatcgcgg acaccactgcccacacctccatcccgtcctgcgcaggccggcactcactgacgttgaagc ctgccttcagtgcctggatgtccgtggccaccccagacatgcggtagatgcccacctcct ccatgcctcggcgcttgatctcctcacacactggcgcacgatgtagggcacttggacctc tctctcctgcgga

TABLE 195 cbe_4279962 DKKL1-pending soggy-1 gene length = 908 aaaattcggcacgaggccgggctgtggtctagcataaaggcggagcccagaagaaggggc SEQ ID NO: 186 ggggtatgggagaagcctccccacctgcccccgcaaggcggcatctgctggtcctgctgc tgctcctctctaccctggtgatcccctccgctgcagctcctatccatgatgctgacgccc aagagagctccttgggtctcacaggcctccagagcctactccaaggcttcagccgacttt tcctgaaaggtaacctgcttcggggcatagacagcttattctctgcccccatggacttcc ggggcctccctgggaactaccacaaagaggagaaccaggagcaccagctggggaacaaca ccctctccagccacctccagatcgacaagatgaccgacaacaagacaggagaggtgctga tctccgagaatgtggtggcatccattcaaccagcggaggggagcttcgagggtgatttga aggtacccaggatggaggagaaggaggccctggtacccatccagaaggccacggacagct tccacacagaactccatccccgggtggccttctggatcattaagctgccacggcggaggt cccaccaggatgccctggagggcggccactggctcagcgagaagcgacaccgcctgcagg ccatccgggatggactccgcaaggggacccacaaggacgtcctagaagaggggaccgaga gctcctcccactccaggctgtccccccgaaagacccacttactgtacatcctcaggccct ctcggcagctgtaggggtggggaccggggagcacctgcctgtagcccccatcagaccctg ccccaagcaccatatggaaataaagttctttcttacatctaaaaaaaaaaaaaaaaaaaa aaaaaaaa

TABLE 196 cbe_4281271 CRYAB crystallin, alpha B length = 691 gacccctcacactcacctagccaccatggacatcgccatccaccacccctggatccgccg SEQ ID NO: 187 ccccttctttcctttccactcccccagccgcctctttgaccagttcttcggagagcacct gttggagtctgatcttttcccgacgtctacttccctgagtcccttctaccttcggccacc ctccttcctgcgggcacccagctggtttgacactggactctcagagatgcgcctggagaa ggacaggttctctgtcaacctggatgtgaagcacttctccccagaggaactcaaagttaa ggtgttgggagatgtgattgaggtgcatggaaaacatgaagagcgccaggatgaacatgg tttcatctccagggagttccacaggaaataccggatcccagctgatgtagaccctctcac cattacttcatccctgtcatctgatggggtcctcactgtgaatggaccaaggaaacaggt ctctggccctgagcgcaccattcccatcacccgtgaagagaagcctgctgtcaccgcagc ccccaagaaatagatgccctttcttgaattgcattttttaaaacaagaaagtttccccac cagtgaatgaaagtcttgtgactagtgctgaagcttattaatgctaagggcaggcccaaa ttatcaagctaataaaatatcattcagcaac

TABLE 197 cbe_4344185 SRA1 steroid receptor RNA activator 1 length = 2069 ttatagcaaaatcagtgcaaataaaaatccctcagtgacctcactggatgtgagtatatt SEQ ID NO: 188 gggcctgggacagggctgggggctaacaccctgtgtgagatgagtgtctttgtgtctgtg cttgatgttggtggctctctgtagtcacatgacagcatgggtgtgatggagatctgactt cattcaacaaacatattttctaaggagttccctgtgccaggcactaagctgggcactggg aatgtaataaaatagtcaaggtcccaccttctaagactgtccgacagggaaacgaacaag agtcaaataaggcagaagatgtgatgtaatacacctacgaaatctcagagggttgtaggg tcgtgggagctcaagtgagacacttaacctggcctgagacattccagaaggcctcctgaa gaactgacatctgaactgagaactgaaggaagatgagtactagtgaggctaccggacgtg aatgtggagattgtgcagggcaatgcaagaggaggctgtagaagtcaacctggctagatc acagcggggtgtatgtggggcaggagcttctttgtttgaatttgctcctgagaggatgag gcctcctagagcactggctcctggacagcaacctcctttggtgccttgtgaccagggccc tgatggttcattagatggagccttcgagtcttagggagttgccgcagggtccccacagcg gctcccgacggttgtgaaccagcatccattctccacggattccggcaacccgcctggccc tggacgtgtctcaactggcccgcgtgaggggccgccccggaaatgacgcgctgccccgct ggccaagcggaagtggagatggcggagctgtacgtgaagccgggcaacaaggaacgcggc tggaacgacccgccgcagttctcatacgggctgcagacccaggccggcggacccaggcgc tcgctgcttaccaagagggtagccgcaccccaggatggatcccccagagtccccgcatca gagacttctcctgggcctcccccaatggggcctccacctccttcaagtaaggctcccagg tccccacctgtggggagtggtcctgcctctggcgtggagcccacaagtttcccagtcgag tctgaggctcgactgatggaggatgtgctgagacctttggaacaggcattggaagactgc cgtggccacacaaggaagcaggtatgtgatgacatcagccgacgcctggcactgctgcag gaacagtgggctggaggaaagttgtcaatacctgtaaagaagagaatggctctactggtg caagagctttcaagccaccggtgggacgcagcagatgacatccaccgctccctcatggtt gaccatgtgactgaggtcagtcagtggatggtaggagttaaaagattaattgcagaaaag aggagtctgttttcagaggaggcagccaatgaagagaaatctgcagccacagctgagaag aaccataccataccaggcttccagcaggcttcataatcctcggttccccagactcaccgg acaccatcccctatgccttggagaccttctgtcacttggctcccttcttaccaccaccaa gactgtcccactgggcctgacccacctatgagggaagaagtcccacctgggccagaggga gttcatgtgttactcataacatgcatttcaataaaaacatctctgcggtgggccttgggt aggagagatgaacccttccggtgccaagctagtcccctctggtgtcctcgactgccctgc tccctgtgtatctgcaaacctctgttctcccttctccattcatcaggaagggatctgctg ggtaaagtcagactactgcctaccactttttcccaaagtagactgaaagcacatcctgtg ctgggcggagcagctgtgtttggatggtttcatttcagcatgagaacagactcaaataga acggggagacttttccctcaacaaaaggaaagacagtcctatttgcactgtatcaccctt gagatactactgttacagagattagaacc

TABLE 198 cbe_4383836 KIAA0905 yeast Sec31p homolog length = 4129 gacgagcgctgcactaacgcaggatccggctgccgaaggtcctcgccagcaggatgaagt SEQ ID NO: 189 taaaggaagtagatcgtacagccatgcaggcatggagccctgcccagaatcaccccattt acctagcaacaggaacatctgctcagcaattggatgcaacatttagtacgaatgcttccc ttgagatatttgaattagacctctctgatccatccttggatatgaaatcttgtgccacat tctcctcttctcacaggtaccacaagttgatttgggggccttataaaatggattccaaag gagatgtctctggagttctgattgcaggtggtgaaaatggaaatattattctctatgatc cttctaaaattatagctggagacaaggaagttgtgattgcccagaatgacaagcatactg gcccagtgagagccttggatgtgaacattttccagactaatctggtagcttctggtgcta atgaatctgaaatctacatatgggatctaaataattttgcaaccccaatgacaccaggag ccaaaacacagccgccagaagatatcagctgcattgcatggaacagacaagttcagcata ttttagcatcagccagtcccagtggccgggccactgtatgggatcttagaaaaaatgagc caatcatcaaagtcagtgaccatagtaacagaatgcattgttctgggttggcatggcatc ctgatgttgctactcagatggtccttgcctccgaggatgaccggttaccagtgatccaga tgtgggatcttcgatttgcttcctctccacttcgtgtcctggaaaaccatgccaggggga ttttggcaattgcttggagcatggcagatcctgaattgttactgagctgtggaaaagatg ctaagattctctgctccaatccaaacacaggagaggtgttatatgaacttcccaccaaca cacagtggtgcttcgatattcagtggtgtccccgaaatcctgctgtcttatcagctgctt cgtttgatgggcgtatcagtgtttattctatcatgggaggaagcacagatggtttaagac agaaacaagttgacaagctttcatcatcttttgggaatcttgatccctttggcacaggac agccccttcctccgttacaaattccacagcagactgctcagcatagtatagtgctgcctc tgaagaagccgcccaagtggattcgaaggcctgttggtgcttctttttcatttggaggca aactggttacgtttgagaatgtcagaatgccttctcatcagggagctgagcagcagcagc agcagcaccatgtgttcattagtcaggttgtaacagaaaaggagttcctcagccgatcag accaacttcagcaggctgtgcagtcacaaggatttatcaattattgccaaaaaaaaattg atgcttctcagactgaatttgagaaaaatgtgtggtcctttttgaaggtaaactttgagg atgattctcgtggaaaataccttgaacttctaggatacagaaaagaagatctaggaaaga agattgctttggccttgaacaaagtggatggagccaatgtggctcttaaagactctgacc aagtagcacagagtgatggggaggagagccctgctgctgaagagcagctcttgggagagc acattaaagaggaaaaagaagaatctgaatttctaccctcatctggaggaacatttaata tctctgtcagtggggacattgatggtttaattactcaggctttgctgacgggcaattttg agagtgctgttgacctttgtttacatgataaccgcatggccgatgccattatattggcca tagcaggtggacaagaactcttggctcgaacccagaaaaaatacttcgcaaaatcccaaa gcaaaattaccaggctcatcactgcagtggtgatgaagaactggaaagagattgttgagt cttgtgatcttaaaaattggagagaggctttagctgcagtattgacttatgcaaagccgg atgaattttcagccctttgtgatcttttgggaaccaggcttgaaaatgaaggagatagcc tcctgcagactcaagcatgtctctgctatatttgtgcagggaatgtagagaaattagttg catgttggactaaagctcaagatggaagccaccctttgtcacttcaggatctgattgaga aagttgtcatcctgcgaaaagctgtgcaactcactcaagccatggacactagtactgtag gagttctcttggctgcgaagatgagtcagtatgccaatttgttggcagctcagggcagta ttgctgcagccttggcttttcttcctgacaacaccaaccagccaaatatcatgcagcttc gtgacagactttgtagagcacaaggagagcctgtagcaggacatgaatcacctaaaattc cgtacgagaaacagcagctccccaagggcaggcctggaccagttgctggccaccaccaga tgccaagagttcaaactcaacaatattatccccatggagaaaatcctccacctccgggtt tcataatgcatggaaatgttaatccaaatgcttctggtcagcttcccacatctccaggtc atatgcacacccaggtaccaccttatccacagccacagccttatcaaccagcccagccgt atcccttcggaacaggggggtcagcaatgtatcgacctcagcagcctgttgctcctccta cttcaaacgcttaccctaacaccccttacatatcttctgcttcttcctatactgggcagt ctcagctgtacgcagcacagcaccaggcctcttcacctacctccagccctgctacttctt tccctcctcccccttcctctggagcatccttccagcatggcggaccaggagctccaccat catcttcagcttatgcactgcctcctggaacaacaggtacactgcctgctgccagtgagc tgcctgcgtcccaaagaacaggtcctcagaatggttggaatgaccctccagctttgaaca gagtacccaaaaagaagaagatgcctgaaaacttcatgcctcctgttcccatcacatcac caatcatgaacccgttgggtgacccccagtcacaaatgctgcagcaacagccttcagctc cagtaccactgtcaagccagtcttcattcccacagccacatcttccaggtggccagccct tccatggcgtacagcaacctcttggtcaaacaggcatgccaccatctttttcaaagccca atattgaaggtgccccaggggctcctattggaaataccttccagcatgtgcagtctttgc caacaaaaaaaattaccaagaaacctattccagatgagcacctcattctaaagaccacat ttgaggatcttattcagcgctgcctttcttcagcaacagaccctcaaaccaagaggaagc tagatgatgccagcaaacgtttggagtttctgtatgataaacttagggaacagacacttt caccaacaatcaccagtggtttacacaacattgcaaggagcattgaaactcgaaactact cagaaggattgaccatgcatacccacatagttagcaccagcaacttcagtgagacctctg ctttcatgccagttctcaaagttgttctcacccaggccaataagctgggtgtctaaaagg acagcttctcttccactcaatattgccatttttccaaagaaacatgttaaaaaaaaaaat tataagacatggactagtcctcattagcatgtttgcatagcaaccagtcaagagcattta cactatttctgctgatatactcaccttagaactgctcagaaccctggtgctttatttttg ttttaatcttttgttgccagtgatgattttcctattctgcaaatagtgtatttcctggat tacacatagtatggtttcctgaagtattctgataaatgtgtttttttaaaacctcaatat actttttagaaaaggagcatctggttatgcataaagcagagctaaaactaaatttctttc atgtcctccctacttcctcagtgtcaatcagattaaagtgtgtaatcct

TABLE 199 cbe_4465094 Prey1053092 PathCalling Prey Sequence 1053092 length = 452 TCACAAACAAGCCTTCAGAATCAGATGAATGGAGGACCTTTTTATAGCCAGAATCCAGTT SEQ ID NO: 190 TCAGATACACCACCTCCACCGCCACCTGTGGAAGAACCAGTCTTTGATGAGTCTCCCCCA CCTCCTCCTCCTCCAGAAGATTACGAAGAGGAGGAAGCTGCTGTGGTTGAGTATAGTGAT CCTTATGCTGAAGAGGACCCACCGTGGGCTCCACGTTCTTACTTGGAAAAGGTTGTGGCA ATTTATGACTATACAAAAGACAAGGAAGATGAGCTGTCCTTTCAGGAAGGAGCCATTATT TATGTCATCAAGAAGAATCACGATGTATTAAAAACAAAGCAAGCTGAGTCTGAACAAATG GATCTTTCTGCCATCATTTGTACAATCCTGAGCTGTCTGGATTGAAATAAAATGACCATT TTTATGTATGTCAAAAAAAAAAAAAAAAACCC

TABLE 200 cbe_4540466 PUM1 pumilio homolog 1 (Drosophila) length = 5390 gggggtgaaaggtaagggggagcgagagcgccagagagagaagatcggggggctgaaatc SEQ ID NO: 191 catcttcatcctaccgctccgcccgtgttggtggaatgagcgttgcatgtgtcttgaaga gaaaagcagtgctttggcaggactctttcagcccccacctgaaacatcaccctcaagaac cagctaatcccaacatgcctgttgttttgacatctggaacagggtcgcaagcgcagccac aaccagctgcaaatcaggctcttgcagctgggactcactccagccctgtcccaggatcta taggagttgcaggccgttcccaggacgacgctatggtggactacttctttcagaggcagc atggtgagcagcttgggggaggaggaagtggaggaggcggctataataatagcaaacatc gatggcctactggggataacattcatgcagaacatcaggtgcgttccatggatgaactga atcatgattttcaagcacttgctctggagggaagagcgatgggagagcagctcttgccag gtaaaaagttttgggaaacagatgaatccagcaaagatggaccaaaaggaatattcctgg gtgatcaatggcgagacagtgcctggggaacatcagatcattcagtttcccagccaatca tggtgcagagaagacctggtcagagtttccatgtgaacagtgaggtcaattctgtactgt ccccacgatcggagagtgggggactaggcgttagcatggtggagtatgtgttgagctcat ccccgggcgattcctgtctaagaaaaggaggatttggcccaagggatgcagacagtgatg aaaacgacaaaggtgaaaagaagaacaagggtacgtttgatggagataagctaggagatt tgaaggaggagggtgatgtgatggacaagaccaatggtttaccagtgcagaatgggattg atgcagacgtcaaagattttagccgtacccctggtaattgccagaactctgctaatgaag tggatcttctgggtccaaaccagaatggttctgagggcttagcccagctgaccagcacca atggtgccaagcctgtggaggatttctccaacatggagtcccagagtgtccccttggacc ccatggaacatgtgggcatggagcctcttcagtttgattattcaggcacgcaggtacctg tggactcagcagcagcaactgtgggactttttgactacaattctcaacaacagctgttcc aaagacctaatgcgcttgctgtccagcagttgacagctgctcagcagcagcagtatgcac tggcagctgctcatcagccgcacatcggtttagctcccgctgcgtttgtccccaatccat acatcatcagcgctgctcccccagggacggacccctacacagctggattggctgcagcag cgacactaggcccagctgtggtccctcaccagtattatggagttactccctggggagtct accctgccagtcttttccagcagcaagctgccgctgccgctgcagcaactaattcagcta atcaacagaccaccccacaggctcagcaaggacagcagcaggttctccgtggaggagcca gccaacgtcctttgaccccaaaccagaaccagcagggacagcaaacggatccccttgtgg cagctgcagcagtgaattctgcccttgcatttggacaaggtctggcagcaggcatgccag gttatccggtgttggctcctgctgcttactatgaccaaactggtgcccttgtagtgaatg caggcgcgagaaatggtcttggagctcctgttcgacttgtagctcctgccccagtcatca ttagttcctcagctgcacaagcagctgttgcagcagccgcagcttcagcaaatggagcag ctggtggtcttgctggaacaacaaatggaccatttcgccctttaggaacacagcagcctc agccccagccccagcagcagcccaataacaacctggcatccagttctttctacggcaaca actctctgaacagcaattcacagagcagctccctcttctcccagggctctgcccagcctg ccaacacatccttgggattcggaagtagcagttctctcggcgccaccctgggatccgccc ttggagggtttggaacagcagttgcaaactccaacactggcagtggctcccgccgtgact ccctgactggcagcagtgacctttataagaggacatcgagcagcttgacccccattggac acagtttttataacggccttagcttttcctcctctcctggacccgtgggcatgcctctcc ctagtcagggaccaggacattcacagacaccacctccttccctctcttcacatggatcct cttcaagcttaaacctgggaggactcacgaatggcagtggaagatacatctctgctgctc caggcgctgaagccaagtaccgcagtgcaagcagcgcctccagcctcttcagcccgagca gcactcttttctcttcctctcgtttgcgatatggaatgtctgatgtcatgccttctggca ggagcaggcttttggaagattttcgaaacaaccggtaccccaatttacaactgcgggaga ttgctggacatataatggaattttcccaagaccagcatgggtccagattcattcagctga aactggagcgtgccacaccagctgagcgccagcttgtcttcaatgaaatcctccaggctg cctaccaactcatggtggatgtgtttggtaattacgtcattcagaagttctttgaatttg gcagtcttgaacagaagctggctttggcagaacggattcgaggccacgtcctgtcattgg cactacagatgtatggctgccgtgttatccagaaagctcttgagtttattccttcagacc agcagaatgagatggttcgggaactagatggccatgtcttgaagtgtgtgaaagatcaga atggcaatcacgtggttcagaaatgcattgaatgtgtacagccccagtctttgcaattta tcatcgatgcgtttaagggacaggtatttgccttatccacacatccttatggctgccgag tgattcagagaatcctggagcactgtctccctgaccagacactccctattttagaggagc ttcaccagcacacagagcagcttgtacaggatcaatatggaaattatgtaatccaacatg tactggagcacggtcgtcctgaggataaaagcaaaattgtagcagaaatccgaggcaatg tacttgtattgagtcagcacaaatttgcaagcaatgttgtggagaagtgtgttactcacg cctcacgtacggagcgcgctgtgctcatcgatgaggtgtgcaccatgaacgacggtcccc acagtgccttatacaccatgatgaaggaccagtatgccaactacgtggtccagaagatga ttgacgtggcggagccaggccagcggaagatcgtcatgcataagatccggccccacatcg caactcttcgtaagtacacctatggcaagcacattctggccaagctggagaagtactaca tgaagaacggtgttgacttagggcccatctgtggcccccctaatggtatcatctgaggca gtgtcacccgctgttccctcattcccgctgacctcactggcccactggcaaatccaacca gcaaccagaaatgttctagtgtagagtctgagacgggcaagtggttgctccaggattact ccctcctccaaaaaaggaatcaaatccacgagtggaaaagcctttgtaaatttaatttta ttacacataacatgtactattttttttaattgactaattgccctgctgttttactggtgt ataggatacttgtacataggtaaccaatgtacatgggaggccacatattttgttcactgt tgtatctatatttcacatgtggaaactttcagggtggttggtttaacaaaaaaaaaaagc tttaaaaaaaaaagaaaaaaaggaaaaggtttttagctcatttgcctggccggcaagttt tgcaaatagctcttccccacctcctcattttagtaaaaaacaaacaaaaacaaaaaaacc tgagaagtttgaattgtagttaaatgaccccaaactggcatttaacactgtttataaaaa atatatatatatatatatatatataatgaaaaaggtttcagagttgctaaagcttcagtt tgtgacattaagtttatgaaattctaaaaaatgccttttttggagactatattatgctga agaaggctgttcgtgaggaggagatgcgagcacccagaacgtcttttgaggctgggcggg tgtgattgtttactgcctactggatttttttctattaacattgaaaggtaaaatctgatt atttagcatgagaaaaaaaaatccaactctgcttttggtcttgcttctataaatatatag tgtatacttggtgtagactttgcatatatacaaatttgtagtattttcttgttttgatgt ctaatctgtatctataatgtaccctagtagtcgaacatacttttgattgtacaattgtac atttgtatacctgtaatgtaaatgtggagaagtttgaatcaacataaacacgttttttgg taagaaaagagaattagccagccctgtgcattcagtgtatattctcaccttttatggtcg tagcatatagtgttgtatattgtaaattgtaatttcaaccagaagtaaatttttttcttt tgaaggaataaatgttctttatacagcctagttaatgtttaaaaagaaaaaaatagcttg gttttatttgtcatctagtctcaagtatagcgagattctttctaaatgttattcaagatt gagttctcactagtgtttttttaatcctaaaaaagtaatgttttgattttgtgacagtca aaaggacgtgcaaaagtctagccttgcccgagctttccttacaatcagagcccctctcac cttgtaaagtgtgaatcgcccttcccttttgtacagaagatgaactgtattttgcatttt gtctacttgtaagtgaatgtaacatactgtcaattttccttgtttgaatatagaattgta acactacacggtgtacatttccagagccttgtgtatatttccaatgaacttttttgcaag cacacttgtaaccatatgtgtataattaacaaacctgtgtatgcttatgcctgggcaact attttttgtaactcttgtgtagattgtctctaaacaatgtgtgatctttattttgaaaaa tacagaactttggaatctgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 201 cbe_4567083 LOC157378 hypothetical protein BC017881 length = 2604 ggctgggcacgcaccccaagaaggagcccatggaggcgctgaacacggcgcagggcgcgc SEQ ID NO: 192 gcgacttcatctacagcctgcactccacggagaggagctgcctgctcaaagagctgcacc gcttcgagtctattgccattgcccaagaaaaattggaagctccaccacccaccccaggac agctgagatatgtattcatccacaatgcgatacctttcatagggtttggctttttggata atgcaattatgattgttgctggaacccatattgaaatgtctattggaattattttgggaa tttcaactatggcagctgctgctttgggaaatcttgtgtcagatctagctggacttggac ttgcaggctacgttgaagcattggcttccaggttaggcctgtcaattcctgatctcacac caaagcaagttgacatgtggcaaacacgtcttagtacacatttgggcaaagctgttgggg tgactattggctgcattctaggaatgtttcctttaattttctttggaggaggtgaagaag atgaaaaactggaaacgaaaagttaatcctcttagaatacctataaaaagatgtaaacta atgtacctcagtaattaaatatgctgtcacaacatttaggaattaagacagtaacagtat agatatgggatcaaataatttagcatgtattatggaaaacactaacttattgtggcttga tcttcttaggacatcttttttaaaaagctgtttagtatcattttgtgtatattgttgaaa tgctttttcatcaatagcagtcaacattttatcctttctttttatattcataatgttatt taagtgtcattgatgtactgtattgacttggggtttgcttatttgttacttaacatgtgt acatgcatgaaagcatttttcgttgttccctgatagttacatttcaaccttgggattttt ccaaattacttaagatgtttaatgtcagttaaagatttttttaccctctttttgggaaca tcaattttgtactgttatgcagtaaacatttataataatataatttcagtcatttcttaa ctgtcacatctattgaaaatggatatagatacaggttttaagtattttaagtatatatta cttattttaattttctgactttactattttaagggccagagggttaatcacaaagagcaa ttatgtggtctccctgctacatgaaaccgtgtatactaacaagcgtacaatttttagttg attttttttaaccttttagtttcccagttttgaataattacatggtggattctgactttt gaggggaagcaaatgattattttagagtctttgaaatggggattgtggaattagattgaa ctaagggatttaacatgatgcttggaaattaagagactaaagctttttttaaaaaaaggt ggaaaataggaactgtcaagaaggtttatggtataaatgatgaagttgaagtgatgtttg aaagattaatgagatacaatttatattatttggtaaggtttttttttttccctccaaaga tgtcatcttctcatctgaatggaataagtctgaataccccatattcatactcctaatctc attatatcttatttagtgaattttatttatgaataatttctgttgaagtgaaaactagat atttaatattttgcttttttgctacatagtctactcaaaaattacatgaggagaaatcct ttttccctttgtttttcttttttcttcttttgtggtatttaaagcatattttaggttgaa gttacttatttctagtcttgtacttctggcttaagtataaccatgtaagaattataaatt ttagttttctgaacccttaaacttttttagcatgtggtctgttacacatgctaaaaaatt agtcttacttgtaacagcgtaattaaacacatcatggaggagagaaacttaaaatagtat tttggcttttgaagttatttgtgttgctaaatagatgcagaggttttacagcagtttatt ttaaggttttatttatacataattactttgaactcttcagagtagatattttttcacaag gcagtttgtcataaattctctcatgcgcttcagaatgcataagtgccatcctttaatcat agactttgaggagagaaagcataaaaatatagcatataatctaaaaataaatatataaca tgcacaaataatgtgacattcttactgaatcaaatcatgattctagaacttgagatctta aatagaattccggtttgtatcttccatataataaccacacacagataaccacacaaaaaa tcctttgtaaaatttctgattgataggattagagtgcttaaatttttggggggggaaggg tggggtaaagtgtaagtgctttcttttgtccctaacttgtgtattgatggcagtccactc tgttttctaaaaatgtattttactgtggtgcttaacttcttattaattaaatcccgtatc agaaaccttgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaa

TABLE 202 cbe_552305 Prey2354 PathCalling Prey Sequence 2354 length = 241 aaggaaggaaggaaggaaggaaggaaggaaggaaagaaagaaattcatccagcatgtccc SEQ ID NO: 193 tttcttctcctatgggatttaccaactgacaaattctagtgctcctgccatcacccacac atgtgcagcaaagcctccacatttgcaaaatctaagtcaatctctaaaagatgcttcgag gaagcacccagttccttctgctaataaccgcagtgtgtcatgtgacacctccccctcccc g

TABLE 203 cbe_552975 HPV 1a E1 Human Papillomavirus 1a E1 length = 1839 atggcagataataaaggtactgaaaacgattggtttttggtggaggcgacagattgtgag SEQ ID NO: 194 gaaacgttagaggaaacctcacttggtgacctagataatgtttcttgtgttagcgactta tctgatttattagacgaggcgccgcaaagccaggggaattccctggaattgttccacaag caagaatcgctggaaagcgaacaggaacttaatgctttaaaacgaaagttactttacagt cctcaggcgagaagcgcggacgaaacagacattgctagcattagtcctagattagaaact atttctattacaaagcaagacaaaaaaaggtatcgaaggcaactgttttctcaggatgat agtggtttagagctatcgctgcttcaggatgaaactgaaaatattgatgaatcgacacag gtagatcaacagcagaaagaacatactggggaagttggggccgctggggtgaacattttg aaagctagtaatatccgcgccgcattattaagcagatttaaagatacggctggcgtcagt tttacagacctgacgcggtcgtacaagagcaacaaaacctgttgtggagattgggttttg gcagtttggggtgtccgtgaaaatttaattgacagtgtaaaagaattattgcaaacccat tgtgtgtatattcaattggaacatgcagtaactgaaaaaaatagatttttatttttattg gtacgatttaaagcccagaaaagtagagagactgtgataaaacttataaccacaattctt ccagttgatgctagctatattttgtctgagcctccaaaatcaagaagtgtggctgctgca ttattttggtataaaagatctatgtcttcaactgtttttacatggggtacaactttggag tggattgcacagcaaacccttattaatcatcagttagattccgaaagtccctttgagctt tgtaaaatggttcagtgggcctatgataatggacatacagaagagtgtaaaattgcatat tattatgctgttttagcagatgaggatgaaaatgcaagggcatttctaagctctaattca caggcaaaatatgtgaaagactgtgcacaaatggtaagacactatttacgtgctgagatg gcacaaatgtctatgtcagagtggatttttagaaaactagataatgtagaaggttctggt aattggaaagaaattgtaagatttttaagatttcaagaagttgaatttataagctttatg attgcatttaaagatttgttatgtggtaagccaaagaaaaactgtttgttaatatttgga cctccaaatacaggaaaatcaatgttttgtacaagtttattaaagttgttaggagggaaa gtgatttcatactgtaacagtaaaagtcagttttggttgcagcctctggctgatgctaag atagggctattagatgatgcaacaaagccatgttgggattatatggacatttatatgaga aatgcattggatggtaacactatttgtattgatttaaaacatagagctcctcaacaaatt aaatgcccacctttacttattactagtaatattgatgttaaatcagatacctgttggatg tatttgcatagtagaatatcagcttttaaatttgctcatgagtttccatttaaagacaat ggtgatccaggattttccttaacagacgaaaattggaaatctttctttgaaaggttttgg caacagttagaattaagtgaccaagaagacgagggaaacgatggaaaacctcagcagtcg cttagacttactgcaagagcagctaatgaacctatatga

TABLE 204 cbe_552976 HPV 11 L2 Human papillomavirus 11 L2 length = 1368 atgaaacctagggcacgcagacgtaaacgtgcgtcagccacacaactatatcaaacatgc SEQ ID NO: 195 aaggccactggtacatgtcccccagatgtaattcctaaagttgaacatactactattgca gatcaaatattaaaatggggaagcttaggggttttttttggtgggttaggtattggtaca ggggctggtagtggcggtcgtgcagggtatatacccttgggaagctctcccaagcctgct attactggggggccagcagcacgtccgccagtgcttgtggagcctgttgccccttccgat ccctccattgtgtccttaattgaggagtctgctattattaatgctggtgcacctgaggtg gtaccccctacacagggtggctttactataacatcatctgaatcgactacacctgctatt ttagatgtgtctgttaccaatcacactaccactagtgtgtttcaaaatcccctgtttaca gaaccgtctgtaatacagccccaaccacctgtggaggccagtggtcacatacttatatct gccccaacaataacatcccaacatgtagaagacattccactagacacttttgttgtatcc tctagtgatagtggacctacatccagtactcctcttcctcgtgcttttcctcggcctcgg gtgggtttgtatagtcgtgccttacagcaggtacaggttacggaccccgcgtttttgtcc acgccacagcgattggtaacttatgacaaccctgtctatgaaggagaagatgtaagttta caatttacccatgagtctatccacaatgcacctgatgaagcatttatggatattattaga ctacatagaccagctataacgtccagacggggtcttgtgcgttttagtcgcattgggcaa cgggggtccatgtacacacgcagtggacaacatataggtgcccgcatacattattttcag gacatttcaccagttacacaagctgcagaggaaatagaactgcaccctctagtggctgca gaaaatgacacgtttgatatttatgctgaaccatttgaccctatccctgaccctgtccaa cattctgttacacagtcttatcttacctccacacctaataccctttcacaatcgtggggt aataccacagtcccattgtcaatccctagtgactggtttgtgcagtctgggcctgacata acttttcctactgcatctatgggaacaccctttagtcctgtaactcctgctttacctaca ggccctgtttttattacaggttctgacttctatttgcatcctacatggtactttgcacgc agacgccgtaaacgtattcccttattttttacagatgtggcggcctag

TABLE 205 cbe_6464 Hs. 19954 603029812F1 Homo sapiens cDNA, 5′ end length = 959 ctggcggcggcggccactctaaccagcgcaaaatgtccctggaacaggaggaggaaacgc SEQ ID NO: 196 aacctgggcggctcctaggacgcagagacgccgtccccgccttcattgagcccaacgtgc gcttctggatcaccgagcgccaatcctttattcgacgatttcttcaatggacagaattat tagatcctacaaatgtgttcatttcagttgaaagtatagaaaactcgaggcaactattgt gcacaaatgaagatgtttccagccctgcctcggcggaccaaaggatacaagaagcttgga agcggagtcttgcaacagtgcatcccgacagcagcaacctgatccccaagctttttcgac ctgcagcgttcctgcctttcatggcgcccacggtatttttgtcaatgacgccactgaaag ggatcaagtccgtgattttacctcaggttttcctctgtgcctacatggcagcgttcaaca gcatcaatggaaacagaagttacacttgtaagccactagaaagatcattactaatggcgg gagccgttgcttcttcaactttcttaggagtaatccctcagtttgtccagatgaagtatg gcctgactggcccttggattaaaagactcttacctgtgatcttcctcgtgcaagccagtg gaatgaatgtctacatgtcccgaagtcttgaatccattaaggggattgcggtcatggaca aggaaggcattgtcctgggtcattcccagaattgctgggacaaaggctgttagagaaaac gctagccatccagaaatagtgcatgtttgggaccctcagttcttgattcctgaagttctt caacctaactttttaaaaggacccagtatttcaggaaaaacccaggtcatgtggatttga aactgtcttgtaactgtcctggcatggaactgatggtggcatttcttttaatttttcaa

TABLE 206 cbe_71919 FLJ13236 hypothetical protein FLJ13236 length = 1854 ctccaaccctctgctcccgtttctccctctggttcatagcccgcgggacagagcagccct SEQ ID NO: 197 ggattgggaggctcctcaggtctcaggctcaggtgcagaagcagagcccctaactggaag gctcggaggtgggccggtgaggcaagcaagccctgtggggggttgaggacagcttgggtt ggatgtccctcactgcagcctgtccgtggatgtctctgccttaagggaattggaggtgga accatccagtcttgaaggtcaacggagcgtgaagagaggagcgtgcagcttgagggtcta aggataactctggggccatgacagccatgagtctcacagaggaccccgagacttctgtgc tgcgagtaaccggacttgttctgagacctttgccctagaggatggccaaggggctcctgg tgacctatgccctctgggctgtggggggccctgctgggctccaccacctgtacctgggaa gggacagccacgccctgctctggatgctgaccctggggggaggtgggctgggctggctct gggagttctggaagctcccaagctttgtagctcaggccaacagagcccagggacagaggc agagccccagaggggtgacaccccctctgagtcccattcgctttgctgcccaggtgatag ttggcatctattttggccttgtggcactgattagcctttcttccatggtcaacttctata ttgtggccctcccactggcagttggcttaggggtcttgctggtggctgctgttggcaacc agacctcagactttaagaacactctggggtcagcatttctcacttcacctatcttctatg gccgccccatagccatactgcccattagcgtggccgccagcattacagctcagaggcatc gccgctacaaagctttggtggcatcagagccgctcagtgtgcggctctatcgtctgggct tggcttaccttgctttcacaggcccactggcatacagtgccctctgcaacacagctgcca ccctcagctatgtggcagaaacctttggctccttcttgaattggttcagcttcttccccc ttcttggccgcctcatggagtttgtcctccttctgccttaccggatctggaggctactga tgggggagactggcttcaacagcagctgctttcaggagtgggcgaagctctatgagtttg ttcacagttttcaggatgagaagcgtcagctggcttaccaggttttgggcctctcagaag gggcaacaaatgaagaaatacatcggagttaccaggagctagtgaaggtctggcacccag accacaacctggaccagacagaggaggcacagaggcacttcctggagatccaggctgcgt atgaagtcctgagtcaacccaggaagccctggggatcccggaggtgaaaagaaacttccc cctgaggactgactcttcctagcagagctgggcaacttgtcccaaatctagctttgccca cgaatggcatcccaacagagttaaagaaactgcttgcaggggctgggcgtggtggctcat gcctgtaatcccggcactttgggaggccgaggcgggcagatcacgaggtcaggagttcga gaccagcagcctggcdaatatggtgaaacttcgtctctactaaaaatacaaaaaattggc caggagtggtggcaggcacctgtagtcccagctacttgggaggctgaggcaggagaatca cctgaacctgagaggcggaggttgcagtgagccgagatcacgccactgcactccagcctg ggcaacaagagtgaaactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

TABLE 207 cbe_92628 FTHP1 ferritin, heavy polypeptide pseudogene 1 length = 2083 catcaaaagaatgaagaacataagaaaaggtaactacatcagtaaatatattgctttttt SEQ ID NO: 198 cttcttatttaaatgctttaaaagagaattgattgtttaaataaaaatatcaatgtaggc tacatgcagtggctcacacctataatcccagcactttgggaggctgaggtgggtggatca cttgaggtcagaatgttcaagaccagcctggccaacatggtgatctttgtgtctattaaa aaatacaaaaataagccaggcgtggtggcgggcacctgtaatccagctactctaaggctg aggcaagagatcacttgaatccaggaggcagaggctgcagtcagccaaaattactccact gccctccagcctaggcaacagagtgagaatctgtctcaaaaataaaaataaaaataaatc aatgtagtatcagacttatatgtagaaattaaatatttgacaaaataacatgaaattata aggagagaaattaaaatttattattttaaggttcttaatatacaaactagtatattatca gttgaagatagtctgcaataatttaaagctatatactataaacactaaagcaaccattaa tatagcaaaattgaaaatatgaagttaatagggcaacaaaggagataaaatgtaatttta agaaatatacaaataattacaaaaagacagcataatagtaaaagagaatgaacagataaa acaattataaaacaaacaccaagctgagagacttaaacctaatcacacgataatcacact aaatgtaaatggtccaaatacccccatcaaaaaggagagactttcaaatagataatgaaa attcaagacctaaccacaaaaaaaacacacttagaatataaagtcacagatagggtaaaa gtggaagaatgacaaaagaagagacattcttcaccaagagtcctcggggtttcctgcttc agcagtgcttggacggaacccggcacttgtcccccacccaggccagctgcccatagccag ccctccgtcacgtcttcactgcaccctcagaccaccccaaggcccccaccgccgctccag cgccacgcagccaccgccgccgcagcctctccttagtcattgccatgatgactgcatcca actcgcaggtgcgccagaactaccaccaggactcagaggccgccatcaaccgccagatca acctggagctctacgcctcctactttaacctctccatgtcttactactttgaccgtgatg atgcggctttgaagaactttgccaaatactttcttcaccaatctcatgaggagagggagc atgctgagaaactgatgaaactgcagaaccaacaaggtggctgaattttccttcaggata tcaagaaaccagactgatgactgggatagtgggctgaatgtgatagagtgtgcattacat ttggaaaaaaatgtgaatcagtcactactggaactgcacaaactggccactgacaaaaat gacccccatttgtgtgacttcattgagacacattacctgaatgagcaggtgaaagccatc aaagaattgggtgaacgtgaccaacttgcacaagatgggagcacccgaatctggcttggc agaatatctctttgacaagcacaccctgggagaaagtgataatgaaagctaagcctcagg ctaatttccccatagctgtggggtgacttccctggtcaccaaggcagtgcatgcatgttg gggtttcctttaccttttctataagttgtaccaaaacatccacttaagttcttttgattt gtaccattccttcaaataaagaaatctggtacccccccccaaaaaagaatgacaaaagat agcacatgtgaatacaaataaaaagtaagctactgtggctacattcatgtcagacaaagt aaatttcagagtagagaatattaccagtaataaatgattatttcatagtgataaaggggt caattcatgaaaaagacataatcctaaacctaatacaacagttcaaaataaatgcagcaa aaactggaaggagaaagaaacagatcctctagagtcgacctgc

Other Embodiments

Although particular embodiments have been disclosed herein in detail, this has been done by way of example for purposes of illustration only, and is not intended to be limiting with respect to the scope of the appended claims, which follow. In particular, it is contemplated by the inventors that various substitutions, alterations, and modifications may be made to the invention without departing from the spirit and scope of the invention as defined by the claims. The choice of nucleic acid starting material, clone of interest, or library type is believed to be a matter of routine for a person of ordinary skill in the art with knowledge of the embodiments described herein. Other aspects, advantages, and modifications considered to be within the scope of the following claims. The claims presented are representative of the inventions disclosed herein. Other, unclaimed inventions are also contemplated. Applicants reserve the right to pursue such inventions in later claims.

REFERENCES

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1. A purified complex comprising a first polypeptide and a second polypeptide, wherein said first polypeptide comprises an amino acid sequence of a polypeptide selected from the group consisting of the polypeptides recited in Table 1 through 7, column 2, and wherein said second polypeptide comprises an amino acid sequence of the corresponding polypeptide recited in Tables 1 through 7, column 5, wherein said first polypeptide binds said second polypeptide.
 2. The complex of claim 1, wherein said first polypeptide is labeled with a detectable substance.
 3. The complex of claim 1, wherein said second polypeptide is labeled is labeled with a detectable substance.
 4. A chimeric polypeptide comprising six or more amino acids of the first polypeptide of claim 1 covalently linked to six or more amino acids of the second polypeptide of claim
 1. 5. A nucleic acid encoding the chimeric polypeptide of claim
 4. 6. A vector comprising the nucleic acid of claim
 5. 7. A cell comprising the vector of claim
 8. 8. An antibody which specifically binds the complex of claim
 1. 9. The antibody of claim 8, wherein said antibody binds to the complex of claim 1 with higher affinity than it binds to said first or second polypeptide when said polypeptides are not complexed.
 10. A pharmaceutical composition comprising the complex of claim
 1. 11. A kit comprising a reagent which can specifically detect the complex of claim
 1. 12. The kit of claim 11, wherein said reagent is selected from the group consisting of an antibody specific for said complex, an antibody specific for said first polypeptide, and an antibody specific for said second polypeptide.
 13. A method of identifying an agent which disrupts a polypeptide complex, the method comprising: (a) providing the complex of claim 1; (b) contacting the complex with a test agent; and (c) detecting the presence of a polypeptide displaced from said complex, wherein the presence of displaced polypeptide indicates said agent disrupts said complex.
 14. A method for identifying an agent which disrupts a polypeptide complex comprising at least one HPV-associated protein or HPV interactor protein, the method comprising: (a) providing the complex of claim 1; (b) contacting said complex with a test agent; and (c) detecting the presence of a polypeptide displaced from said complex, wherein the presence of displaced polypeptide indicates said agent disrupts said complex.
 15. A method of identifying a polypeptide complex in a subject, the method comprising: (a) providing a biological sample from said subject; and (b) detecting, if present, the polypeptide complex of claim 1 in said sample, thereby identifying said complex.
 16. A method of detecting a polypeptide in a biological sample, the method comprising: (a) providing a biological sample comprising the first polypeptide of claim 1; (b) contacting said biological sample with the second polypeptide of claim 1 under conditions suitable for formation of a complex comprising said first and second polypeptides; and (c) detecting the presence of a complex of said first and second polypeptide, wherein the presence of said complex indicates the presence of said first polypeptide in said sample.
 17. A method of detecting a polypeptide in a biological sample, the method comprising: (a) providing a biological sample comprising the second polypeptide of claim 1; (b) contacting said biological sample with the first polypeptide of claim 1 under conditions suitable for formation of a complex comprising said first and second polypeptides; and (c) detecting the presence of a complex of said first and second polypeptide, wherein the presence of said complex indicates the presence of said second polypeptide in said sample.
 18. A method of removing a polypeptide from a biological sample, the method comprising: (a) providing a biological sample comprising the first polypeptide of claim 1; (b) contacting said biological sample with the second polypeptide of claim 1 under conditions suitable for formation of a complex comprising said first and second polypeptide; and (c) removing said complex from said sample, thereby removing said first polypeptide from said sample.
 19. A method of determining altered expression of a polypeptide in a subject, the method comprising: (a) providing a biological sample from said subject, (b) measuring the level of the complex of claim 1 in said sample; and (c) comparing the level of said complex from step (b) to the level of said complex in a reference sample whose level of the complex of claim 1 is known, thereby determining whether said subject has altered expression of said first or second polypeptide.
 20. A method of treating or preventing a disease or disorder involving altered levels of the complex of claim 1, the method comprising: administering a therapeutically-effective amount of least one molecule that modulates the function of said complex to a subject in need thereof.
 21. A method of screening for pre-cancerous cervical lesions comprising contacting a patient derived cervical cell with a molecule that binds specifically to HPV E6 or E7 protein, detecting binding of said molecule, thereby identifying pre-cancerous cervical lesions.
 22. The method of claim 21, wherein said E6 or E7 protein are proteins from HPV types selected from the group consisting of HPV 1a, HPV 11 and HPV
 16. 23. A method of classifying an HPV infection in a patient, comprising contacting a patient derived cell with a molecule that binds specifically to a subset of HPV E6 or E7 proteins, said molecule selected from a keratinocyte library, detecting binding of said molecule thereby classifying an HPV infection in said patient.
 24. The method of claim 23, wherein the cell is obtained from the site of HPV infection.
 25. The method of claim 23, wherein the cell is selected from head, neck, larynx, skin, anogenital, epithelial, mucosal or cervical tissue. 